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Pediatrics metabolic syndrome

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https://www.readbyqxmd.com/read/30300429/-body-fat-measurements-using-bioelectrical-impedance-in-pediatric-patientstreated-with-hematopoietic-cell-transplantation
#1
Wojciech Strojny, Dorota Drożdż, Kinga Klus-Kwiecińska, Danuta Pietrys, Walentyna Balwierz, Szymon Skoczeń
INTRODUCTION: In patients who have undergone hematopoietic cell transplantation (HCT), the metabolic syndrome may develop without obesity defined by Body Mass Index (BMI). AIM OF THE STUDY: The aim of the study was to compare body fat parameters measured using bioelectrical impedance (BIA) and using standard parameters of obesity in patients treated with HCT and healthy controls. MATERIAL AND METHODS: We compared body fat (BF) and body fat percentage (BF%) measured using BIA in 44 patients before HCT and 28 patients after HCT, versus 26 controls...
2018: Pediatric Endocrinology, Diabetes, and Metabolism
https://www.readbyqxmd.com/read/30289850/whole-exome-sequencing-of-adult-and-pediatric-cohorts-of-the-rare-vascular-disorder-systemic-capillary-leak-syndrome
#2
Richard Pierce, Weizhen Ji, Eunice C Chan, Zhihui Xie, Lauren M Long, Mustafa Khokha, Saquib Lakhani, Kirk M Druey
OBJECTIVE: Systemic capillary leak syndrome (SCLS) is a rare disorder that presents with episodes of hypovolemic shock. The extent to which genetic abnormalities contribute to SCLS is unknown. We identified pediatric and adult cohorts with characteristic clinical courses. We sought to describe the clinical characteristics of both cohorts, identify a possible genetic contribution to SCLS, and demonstrate that whole exome sequencing (WES) may be conducted by critical care providers. DESIGN: Prospective observational study of WES of nine adult and eight pediatric SCLS patients and available unaffected first-degree relatives...
October 4, 2018: Shock
https://www.readbyqxmd.com/read/30286566/type-2-diabetes-mellitus-in-children-and-adolescent-an-indonesian-perspective
#3
Aman Bhakti Pulungan, Ireska Tsaniya Afifa, Diadra Annisa
The prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents has increased globally over the past 2 decades. Metabolic syndrome, including obesity and overweight at a young age, increases the occurrence of T2DM. Studies in Indonesia have found that obese children and adolescents are more likely to have insulin resistance, a risk factor for T2DM. There are no data on the current incidence of T2DM in youth in Indonesia, but there has been a significant rise in the prevalence of overweight in adolescents...
September 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/30275001/combination-of-exome-sequencing-and-immune-testing-confirms-aicardi-gouti%C3%A3-res-syndrome-type-5-in-a-challenging-pediatric-neurology-case
#4
Gloria T Haskell, Mari Mori, Cynthia Powell, Timothy J Amrhein, Gillian I Rice, Lauren Bailey, Natasha Strande, Karen E Weck, James P Evans, Jonathan S Berg, Priya Kishnani
Exome sequencing is increasingly being used to help diagnose pediatric neurology cases when clinical presentations are not specific. However, interpretation of equivocal results that include variants of uncertain significance remains a challenge. In those cases, follow-up testing and clinical correlation can help clarify the clinical relevance of the molecular findings. In this report, we describe the diagnostic odyssey of a 4-year-old girl who presented with global developmental delay and seizures, with leukodystrophy seen on MRI...
October 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/30247365/acog-committee-opinion-no-756-optimizing-support-for-breastfeeding-as-part-of-obstetric-practice
#5
(no author information available yet)
As reproductive health experts and advocates for women's health who work in conjunction with other obstetric and pediatric health care providers, obstetrician-gynecologists are uniquely positioned to enable women to achieve their infant feeding goals. Maternity care policies and practices that support breastfeeding are improving nationally; however, more work is needed to ensure all women receive optimal breastfeeding support during prenatal care, during their maternity stay, and after the birth occurs. Enabling women to breastfeed is a public health priority because, on a population level, interruption of lactation is associated with adverse health outcomes for the woman and her child, including higher maternal risks of breast cancer, ovarian cancer, diabetes, hypertension, and heart disease, and greater infant risks of infectious disease, sudden infant death syndrome, and metabolic disease...
October 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30247361/acog-committee-opinion-no-756-summary-optimizing-support-for-breastfeeding-as-part-of-obstetric-practice
#6
(no author information available yet)
As reproductive health experts and advocates for women's health who work in conjunction with other obstetric and pediatric health care providers, obstetrician-gynecologists are uniquely positioned to enable women to achieve their infant feeding goals. Maternity care policies and practices that support breastfeeding are improving nationally; however, more work is needed to ensure all women receive optimal breastfeeding support during prenatal care, during their maternity stay, and after the birth occurs. Enabling women to breastfeed is a public health priority because, on a population level, interruption of lactation is associated with adverse health outcomes for the woman and her child, including higher maternal risks of breast cancer, ovarian cancer, diabetes, hypertension, and heart disease, and greater infant risks of infectious disease, sudden infant death syndrome, and metabolic disease...
October 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30237719/what-is-known-about-deferasirox-chelation-therapy-in-pediatric-hsct-recipients-two-case-reports-of-metabolic-acidosis
#7
Carmen Fucile, Francesca Mattioli, Valeria Marini, Massimo Gregori, Aurelio Sonzogni, Antonietta Martelli, Natalia Maximova
To date, in pediatric field, various hematological malignancies are increasingly treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Iron overload and systemic siderosis often occur in this particular cohort of patients and are associated with poor prognosis. We describe herein the case of two allo-HSCT patients, on treatment with deferasirox; they showed histopathological elements compatible with venoocclusive disease or vanishing bile duct syndrome in ductopenic evolution before deferasirox started...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/30234760/diet-and-exercise-in-pediatric-liver-transplant-recipients-behaviors-and-association-with-metabolic-syndrome
#8
Julia H Chambers, Melissa Zerofsky, Robert H Lustig, Philip Rosenthal, Emily R Perito
OBJECTIVE: To analyze the impact of physical activity and eating behaviors on precursors of cardiovascular disease-including overweight/obesity, hypertension, low HDL, and impaired glucose tolerance-in pediatric liver transplant (LT) recipients and matched controls. METHOD: Cross-sectional study of pediatric LT recipients 8-30 years, matched to controls from NHANES. Dietary intake assessed with 24-hour recall. Physical activity assessed by standardized questionnaires...
September 18, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30234512/anesthetic-management-of-a-pediatric-patient-with-bardet-biedl-syndrome
#9
Tuba Gencol, Demet Sergin, Taner Balcioglu
Bardet-Biedl syndrome is a rare autosomal recessive genetic disorder that affects many organ systems. In cases of Bardet-Biedl syndrome, since the risk of developing inspiratory, cardiovascular, and metabolic problems is high, endotracheal intubation and anesthesia management are difficult. In this report, we present our experience in the management of anesthesia during endoscopic sinus surgery that was performed for the first time on a 6-year-old pediatric patient diagnosed with Bardet-Biedl syndrome.
September 18, 2018: A&A practice
https://www.readbyqxmd.com/read/30189427/serum-calprotectin-level-in-children-marker-of-obesity-and-its-metabolic-complications
#10
Valeria Calcaterra, Mara De Amici, Maureen M Leonard, Annalisa De Silvestri, Gloria Pelizzo, Nicoletta Buttari, Alexandre Michev, Miriana Leggio, Daniela Larizza, Hellas Cena
AIM: Elevated calprotectin levels have been reported in obese adults but have not been evaluated in pediatric population. We investigated the characteristics of serum calprotectin in overweight and obese children and its association with metabolic comorbidities. METHODS: We enrolled 131 children (11.7 ± 4.1 years). According to body mass index (BMI), the subjects were divided into 3 groups: obese > 95th percentile; overweight BMI 75th-95th percentile, and normal weight BMI < 75th percentile...
2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/30186610/evaluation-and-characterization-of-tumor-lysis-syndrome-before-and-after-chemotherapy-among-pediatric-oncology-patients-in-tikur-anbessa-specialized-hospital-addis-ababa-ethiopia
#11
Haileleul Micho, Yasin Mohammed, Daniel Hailu, Solomon Genet
Background: Tumor lysis syndrome (TLS) is a life-threatening emergency disorder, caused by an abrupt release of intracellular metabolites after tumor cell death. It is characterized by a series of metabolic manifestations, especially hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia. The aim of this study was to evaluate and characterize the incidence of tumor lysis syndrome among pediatric oncology patients before and after treatment. Methods: Hospital based prospective cohort study was conducted for 6 months on 61 newly diagnosed pediatric oncology patients...
2018: BMC Hematology
https://www.readbyqxmd.com/read/30167749/perioperative-cerebral-oxygenation-metabolism-in-neonates-with-hypoplastic-left-heart-syndrome-or-transposition-of-the-great-arteries
#12
Felix Neunhoeffer, Michael Hofbeck, Christian Schlensak, Martin Ulrich Schuhmann, Jörg Michel
Optimizing oxygen delivery to the brain is one of the main goals in children with congenital heart defects after surgery. It has been shown that cerebral oxygen saturation (cSO2) is depressed within the first day after neonatal cardiopulmonary bypass surgery. However, peri-operative cerebral oxygen metabolism has not yet been assessed in previous studies. The aim of this study was to describe the peri-operative changes in cerebral oxygen metabolism in neonates with congenital heart defects following cardiopulmonary bypass surgery...
August 25, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/30153372/antithrombotic-therapy-management-of-adult-and-pediatric-cardiac-surgery-patients
#13
REVIEW
Lisa Baumann Kreuziger, Keyvan Karkouti, James Tweddell, M Patricia Massicotte
Despite the development of catheter-based interventions for ischemic and valvular heart disease, hundreds of thousands of people undergo open heart surgery annually for coronary artery bypass graft (CABG), valve replacement or cardiac assist device implantation. Cardiac surgery patients are unique because therapeutic anticoagulation is required during cardiopulmonary bypass. Developmental hemostasis and altered drug metabolism affect management in children. This narrative review summarizes the current evidence-based and consensus guidelines regarding perioperative, intraoperative and postoperative antithrombotic therapy in patients undergoing cardiac surgery...
August 28, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/30151522/untargeted-metabolomics-for-plasma-biomarker-discovery-for-early-chronic-kidney-disease-diagnosis-in-pediatric-patients-using-lc-qtof-ms
#14
S Benito, A Sánchez-Ortega, N Unceta, F Andrade, L Aldámiz-Echevarria, M A Goicolea, R J Barrio
Pediatric chronic kidney disease (CKD) is a clinical syndrome characterized by renal hypofunction occurring due to gradual and irreversible kidney damage that can further progress over time. New biomarkers may help early diagnosis of pediatric patients suffering from CKD and improve the outcome. Untargeted metabolomics based on LC-QTOF-MS has been used to find new biomarkers for the early diagnosis of CKD in plasma from pediatric patients. In order to avoid any bias in the determination of statistically significant entities as a consequence of the data analysis method followed, two different chemometric approaches have been used, Mass Profiler Professional (MPP) software and Matlab R2015a software...
September 10, 2018: Analyst
https://www.readbyqxmd.com/read/30139461/clinical-approach-to-proximal-renal-tubular-acidosis-in-children
#15
REVIEW
Gal Finer, Daniel Landau
Proximal renal tubular acidosis (pRTA) is an inherited or acquired clinical syndrome in which there is a decreased bicarbonate reclamation in the proximal tubule resulting in normal anion gap hyperchloremic metabolic acidosis. In children, pRTA may be isolated but is often associated with a general proximal tubular dysfunction known as Fanconi syndrome which frequently heralds an underlying systemic disorder from which it arises. When accompanied by Fanconi syndrome, pRTA is characterized by additional renal wasting of phosphate, glucose, uric acid, and amino acids...
July 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/30091111/evolution-of-body-mass-index-in-children-with-type-1-diabetes-mellitus
#16
Marijke De Keukelaere, Steffen Fieuws, Nele Reynaert, Eva Vandoorne, Kristel Vande Kerckhove, Willeke Asscherickx, Kristina Casteels
The prevalence of childhood overweight and obesity has risen during the last 30 years, not only in children with type 2 diabetes, but also those with type 1 (T1D) and this is linked with an increased cardiovascular risk. A better understanding of weight patterns in the years after diagnosis of T1D is important to identify those children with a risk for excess weight gain and strategies to decrease this. We retrospectively analyzed data of all children with T1D followed at the department of Pediatric Endocrinology Leuven and diagnosed between 1991 and 2015...
August 9, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/30090730/prevalence-of-pediatric-metabolic-syndrome-and-associated-risk-factors-among-school-age-children-of-10-16-years-living-in-district-shimla-himachal-pradesh-india
#17
Anmol Gupta, Amit Sachdeva, Narender Mahajan, Aakriti Gupta, Neha Sareen, Ravindra Mohan Pandey, Lakshmy Ramakrishnan, Hem Chandra Sati, Brij Sharma, Neetu Sharma, Umesh Kapil
Introduction: Recently, an increasing trend in the prevalence of pediatric metabolic syndrome (PMS) among school-age children has been documented in different parts of India. There is lack of data on the prevalence of PMS and its associated risk factors among school-age children living in district Shimla, Himachal Pradesh. Hence, to fill in the gap in the existing knowledge, the present study was conducted. Methodology: A cross-sectional study was conducted during 2015-2016...
May 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30086108/macrocephaly-solving-the-diagnostic-dilemma
#18
Ai Peng Tan, Kshitij Mankad, Fabrício Guimarães Gonçalves, Giacomo Talenti, Egloff Alexia
Macrocephaly is a relatively common clinical condition affecting up to 5% of the pediatric population. It is defined as an abnormally large head with an occipitofrontal circumference greater than 2 standard deviations above the mean for a given age and sex. Megalencephaly refers exclusively to brain overgrowth exceeding twice the standard deviation. Macrocephaly can be isolated and benign or may be the first indication of an underlying congenital, genetic, or acquired disorder, whereas megalencephaly is more often syndromic...
August 2018: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/30078024/outcome-of-continuous-renal-replacement-therapy-in-critically-ill-children-a-retrospective-cohort-study
#19
Tareq Al-Ayed, Naveed Ur Rahman, Abdullah Alturki, Fahad Aljofan
BACKGROUND: Continuous renal replacement therapy (CRRT) has become the preferred mode of dialysis to support critically ill children with acute kidney injury. However, there are limited pediatric data on CRRT use, especially in our region. OBJECTIVE: Determine the outcome of CRRT among critically ill children. DESIGN: Retrospective cohort study. SETTING: Pediatric intensive care unit. PATIENTS AND METHODS: The study included critically ill children 1-14 years of age who underwent CRRT from July 2009 to June 2015...
July 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/30066477/toxic-metabolic-neurologic-disorders-in-children-a-neuroimaging-review
#20
REVIEW
Marinos Kontzialis, Thierry A G M Huisman
There are multiple causes of neurotoxicity in children including medications, extrinsic toxins and insults, illicit drugs, built up of toxic metabolites due to genetic or acquired disorders, and metabolic abnormalities. The review is centered on causes of neurotoxicity affecting the pediatric brain and producing typical and easily recognized imaging manifestations. Early identification of common and less common imaging findings may point toward the correct direction, and may facilitate early diagnosis and institution of appropriate treatment to reverse or at least limit the injury to the developing brain...
July 31, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
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