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https://www.readbyqxmd.com/read/28936706/biodiversity-and-ecology-of-flower-associated-actinomycetes-in-different-flowering-stages-of-protea-repens
#1
Zander R Human, Casparus J Crous, Francois Roets, Stephanus N Venter, Michael J Wingfield, Z Wilhelm de Beer
Actinomycete bacteria have previously been reported from reproductive structures (infructescences) of Protea (sugarbush/suikerbos) species, a niche dominated by fungi in the genera Knoxdaviesia and Sporothrix. It is probable that these taxa have symbiotic interactions, but a lack of knowledge regarding their diversity and general ecology precludes their study. We determined the diversity of actinomycetes within Protea repens inflorescence buds, open inflorescences, young and mature infructescences, and leaf litter surrounding these trees...
September 21, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28935819/identification-of-truncated-form-of-nosp-as-a-transcription-factor-to-regulate-the-biosynthesis-of-nosiheptide
#2
Xuri Wu, Liang Jin, Hong Zhang, Ruinian Tong, Min Ma, Yijun Chen
Nosiheptide (NOS), a typical member of the thiopeptides, possesses strong activities against multidrug-resistant, gram-positive bacterial pathogens. Similar to other thiopeptides, the biosynthetic pathway of NOS belongs to a ribosomally synthesized and posttranslationally modified peptide system. Bioinformatics analysis of the NOS gene cluster suggests that nosP gene encodes a homologous protein of Streptomyces antibiotic regulatory protein (SARP) family. In the present study, the actual initiation codon of nosP was identified by comparison of potential initiation codons GUG and AUG...
September 21, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28935203/hr-lc-ms-based-analysis-of-two-antibacterial-metabolites-from-a-marine-sponge-symbiont-streptomyces-pharmamarensis-icn40
#3
Francis-Joseph Rosemary Sharmila Joseph, Appadurai Muthamil Iniyan, Samuel Gnana Prakash Vincent
On the effort to screen antibiotics against Methicillin resistant Staphylococcus aureus (MRSA), an actinomycete strain which can produce bactericidal compound was isolated from a marine sponge of Kanyakumari Coast, India. Two anti-MRSA compounds (PVI401 and PVI402) were isolated from the fermentation plates of Streptomyces pharmamarensis ICN40. TLC bioautography analysis yielded two active spots with Rf value of 0.75 (PVI401) and 0.8 (PVI402) from the crude extract. Both the compounds were characterized by HR-LC-MS analysis...
September 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28934499/co-produced-natural-ketolides-methymycin-and-pikromycin-inhibit-bacterial-growth-by-preventing-synthesis-of-a-limited-number-of-proteins
#4
Mashal M Almutairi, Maxim S Svetlov, Douglas A Hansen, Nelli F Khabibullina, Dorota Klepacki, Han-Young Kang, David H Sherman, Nora Vázquez-Laslop, Yury S Polikanov, Alexander S Mankin
Antibiotics methymycin (MTM) and pikromycin (PKM), co-produced by Streptomyces venezuelae, represent minimalist macrolide protein synthesis inhibitors. Unlike other macrolides, which carry several side chains, a single desosamine sugar is attached to the macrolactone ring of MTM and PKM. In addition, the macrolactone scaffold of MTM is smaller than in other macrolides. The unusual structure of MTM and PKM and their simultaneous secretion by S. venezuelae bring about the possibility that two compounds would bind to distinct ribosomal sites...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28932210/antibacterial-activity-of-endophytic-actinomycetes-isolated-from-the-medicinal-plant-vochysia-divergens-pantanal-brazil
#5
Francielly M W R Gos, Daiani C Savi, Khaled A Shaaban, Jon S Thorson, Rodrigo Aluizio, Yvelise M Possiede, Jürgen Rohr, Chirlei Glienke
Endophytic actinomycetes from medicinal plants produce a wide diversity of secondary metabolites (SM). However, to date, the knowledge about endophytes from Brazil remains scarce. Thus, we analyzed the antimicrobial potential of 10 actinomycetes isolated from the medicinal plant Vochysia divergens located in the Pantanal sul-mato-grossense, an unexplored wetland in Brazil. Strains were classified as belonging to the Aeromicrobium, Actinomadura, Microbacterium, Microbispora, Micrococcus, Sphaerisporangium, Streptomyces, and Williamsia genera, through morphological and 16S rRNA phylogenetic analyzes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28928426/cyanobacterial-sfp-type-phosphopantetheinyl-transferases-functionalize-carrier-proteins-of-diverse-biosynthetic-pathways
#6
Guang Yang, Yi Zhang, Nicholas K Lee, Monica A Cozad, Sara E Kearney, Hendrik Luesch, Yousong Ding
Cyanobacteria produce structurally and functionally diverse polyketides, nonribosomal peptides and their hybrids. Sfp-type phosphopantetheinyl transferases (PPTases) are essential to the production of these compounds via functionalizing carrier proteins (CPs) of biosynthetic megaenzymes. However, cyanobacterial Sfp-type PPTases remain poorly characterized, posing a significant barrier to the exploitation of cyanobacteria for biotechnological and biomedical applications. Herein, we describe the detailed characterization of multiple cyanobacterial Sfp-type PPTases that were rationally selected...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927873/genome-sequence-of-streptomyces-mangrovisoli-musc-149-t-isolated-from-intertidal-sediments
#7
Hooi-Leng Ser, Wen-Si Tan, Nurul-Syakima Ab Mutalib, Wai-Fong Yin, Kok-Gan Chan, Bey-Hing Goh, Learn-Han Lee
As the largest genus in Actinobacteria family, Streptomyces species have the ability to synthesize numerous compounds of diverse structures with bioactivities. Streptomyces mangrovisoli MUSC 149(T) was previously isolated as a novel streptomycete from mangrove forest in east coast of Peninsular Malaysia. The high quality draft genome of MUSC 149(T) comprises 9,165,825bp with G+C content of 72.5%. Through bioinformatics analysis, 21 gene clusters identified in the genome were associated with the production of bioactive secondary metabolites...
September 6, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28925983/structure-dependent-interfacial-properties-of-chaplin-f-from-streptomyces-coelicolor
#8
Mina Dokouhaki, Emma L Prime, Andrew Hung, Greg G Qiao, Li Day, Sally L Gras
Chaplin F (Chp F) is a secreted surface-active peptide involved in the aerial growth of Streptomyces. While Chp E demonstrates a pH-responsive surface activity, the relationship between Chp F structure, function and the effect of solution pH is unknown. Chp F peptides were found to self-assemble into amyloid fibrils at acidic pH (3.0 or the isoelectric point (pI) of 4.2), with ~99% of peptides converted into insoluble fibrils. In contrast, Chp F formed short assemblies containing a mixture of random coil and β-sheet structure at a basic pH of 10...
September 19, 2017: Biomolecules
https://www.readbyqxmd.com/read/28924834/diversity-of-family-gh46-chitosanases-in-kitasatospora-setae-km-6054
#9
Mina Zitouni, Pascal Viens, Mariana G Ghinet, Ryszard Brzezinski
The genome of Kitasatospora setae KM-6054, a soil actinomycete, has three genes encoding chitosanases belonging to GH46 family. The genes (csn1-3) were cloned in Streptomyces lividans and the corresponding enzymes were purified from the recombinant cultures. The csn2 clone yielded two proteins (Csn2BH and Csn2H) differing by the presence of a carbohydrate-binding domain. Sequence analysis showed that Csn1 and Csn2H were canonical GH46 chitosanases, while Csn3 resembled chitosanases from bacilli. The activity of the four chitosanases was tested in a variety of conditions and on diverse chitosan forms, including highly N-deacetylated chitosan or chitosan complexed with humic or polyphosphoric acid...
September 18, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28923725/petroleum-degradation-by-endophytic-streptomyces-spp-isolated-from-plants-grown-in-contaminated-soil-of-southern-algeria
#10
Hafida Baoune, Aminata Ould El Hadj-Khelil, Graciela Pucci, Pedro Sineli, Lotfi Loucif, Marta Alejandra Polti
Petroleum hydrocarbons are well known by their high toxicity and recalcitrant properties. Their increasing utilization around worldwide led to environmental contamination. Phytoremediation using plant-associated microbe is an interesting approach for petroleum degradation and actinobacteria have a great potential for that. For this purpose, our study aimed to isolate, characterize, and assess the ability of endophytic actinobacteria to degrade crude petroleum, as well as to produce plant growth promoting traits...
September 15, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28923323/a-unique-indolizinium-alkaloid-streptopertusacin-a-and-bioactive-bafilomycins-from-marine-derived-streptomyces-sp-hzp-2216e
#11
Xiufang Zhang, Lu Chen, Weiyun Chai, Xiao-Yuan Lian, Zhizhen Zhang
Streptopertusacin A, a unique indolizinium alkaloid existing as a zwitterion, and six bafilomycins including two previously undescribed ones of 21,22-en-bafilomycin D and 21,22-en-9-hydroxybafilomycin D were isolated from a culture of the seaweed-derived Streptomyces sp. HZP-2216E. Structures of these isolated compounds were determined based on extensive NMR spectroscopic analyses, HRESIMS and MS-MS data. The stereochemical assignments were achieved by NOE information, chemical degradation, Marfey's method, and electronic circular dichroism (ECD) calculation...
September 15, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28920834/streptomyces-xylanilyticus-sp-nov-isolated-from-soil
#12
Duangtip Moonmangmee, Pawina Kanchanasin, Wongsakorn Phongsopitanun, Somboon Tanasupawat, Somporn Moonmangmee
A novel actinomycete, strain SR2-123T, belonging to the genus Streptomyces, was isolated from a soil sample collected from the Sakaerat Environmental Research Station, Thailand Institute of Scientific and Technological Research, Nakhon Ratchasima Province, Thailand. The taxonomic position of the strain was characterized using a polyphasic study. Strain SR2-123T contained ll-diaminopimelic acid, glucose, mannose and ribose in whole-cell hydrolysates. The N-acyl type of muramic acid was acetyl. Menaquinones were MK-9(H6), MK-9(H8) and MK-9(H4)...
September 18, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28920128/incorporation-of-2-h1-1r-2r-and-2-h1-1s-2r-glycerols-into-the-antibiotic-nucleocidin-in-streptomyces-calvus
#13
Xuan Feng, Nawaf Al Maharik, Axel Bartholomé, Jeffrey E Janso, Usa Reilly, David O'Hagan
Deuterium incorporations from [(2)H1]-(1R,2R) and [(2)H1]-(1S,2R) glycerols into the fluorine containing antibiotic nucleocidin, in Streptomyces calvus indicate that one deuterium atom is incorporated at the C-5' site of nucleocidin from each of these isotopomers of glycerol. Two deuteriums become incorporated at C-5' of nucleocidin after a feeding experiment with [(2)H5]-glycerol. These observations indicate that there is no obligate oxidation of the pro-R hydroxymethyl group of glycerol as it progresses through the pentose phosphate pathway and becomes incorporated into the fluorinated antibiotic...
September 18, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28919250/purification-and-characterization-of-a-cellulase-free-thermostable-endo-xylanase-from-streptomyces-griseorubens-lh-3-and-its-use-in-biobleaching-on-eucalyptus-kraft-pulp
#14
Hao Wu, Xianbo Cheng, Yongfeng Zhu, Wei Zeng, Guiguang Chen, Zhiqun Liang
Xylanase is an important enzyme involved in degrading xylan. In this study, an extracellular cellulase-free, thermostable endo-xylanase which was produced by Streptomyces griseorubens LH-3 with bagasse semi-cellulose as a carbon source was purified and characterized. The xylanase was purified 4-fold with a recovery yield of 21.6% by precipitation with 25-55% (NH4)2SO4, Mono Q ion exchange chromatography and sephacryl S-200 HR gel filtration chromatography. It appeared as a monomeric protein on SDS-PAGE gel and had an apparent molecular weight of 45...
September 14, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28919037/a-link-between-linearmycin-biosynthesis-and-extracellular-vesicle-genesis-connects-specialized-metabolism-and-bacterial-membrane-physiology
#15
B Christopher Hoefler, Reed M Stubbendieck, N Kalyani Josyula, Sabrina M Moisan, Emma M Schulze, Paul D Straight
Specialized metabolites support bacterial competitive fitness as antibiotics, signals, pigments, and metal scavengers. Little is known about how specialized metabolites are processed and trafficked for their diverse competitive functions. Linearmycins A and B are linear polyketides with antifungal and antibacterial activity but are colony-localized in imaging mass spectrometry of Streptomyces sp. Mg1 (S. sp. Mg1). To decipher a connection between colony localization and antibiotic activity, we identified the linearmycin gene cluster and investigated linearmycin production and distribution by S...
August 24, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28918535/bioprospecting-of-novel-and-bioactive-compounds-from-marine-actinomycetes-isolated-from-south-china-sea-sediments
#16
Na Yang, Fuhang Song
Marine actinomycetes are less investigated compared to terrestrial strains as potential sources of natural products. To date, few investigations have been performed on culturable actinomycetes associated with South China Sea sediments. In the present study, twenty-eight actinomycetes were recovered from South China Sea sediments after dereplication by traditional culture-dependent method. The 16S rRNA gene sequences analyses revealed that these strains related to five families and seven genera. Twelve representative strains possessed at least one of the biosynthetic genes coding for polyketide synthase I, II, and nonribosomal peptide synthetase...
September 16, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28917933/the-complete-genome-sequence-of-the-actinobacterium-streptomyces-glaucescens-gla-o-dsm-40922-carrying-gene-clusters-for-the-biosynthesis-of-tetracenomycin-c-5-hydroxy-streptomycin-and-acarbose
#17
Vera Ortseifen, Jörn Kalinowski, Alfred Pühler, Christian Rückert
No abstract text is available yet for this article.
September 13, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28916864/sparticle-an-algorithm-for-the-analysis-of-filamentous-microorganisms-in-submerged-cultures
#18
Joost Willemse, Ferhat Büke, Dino van Dissel, Sanne Grevink, Dennis Claessen, Gilles P van Wezel
Streptomycetes are filamentous bacteria that produce a plethora of bioactive natural products and industrial enzymes. Their mycelial lifestyle typically results in high heterogeneity in bioreactors, with morphologies ranging from fragments and open mycelial mats to dense pellets. There is a strong correlation between morphology and production in submerged cultures, with small and open mycelia favouring enzyme production, while most antibiotics are produced mainly in pellets. Here we describe SParticle, a Streptomyces Particle analysis method that combines whole slide imaging with automated image analysis to characterize the morphology of submerged grown Streptomyces cultures...
September 15, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28913738/comparison-of-the-efficiency-of-bacterial-and-fungal-laccases-in-delignification-and-detoxification-of-steam-pretreated-lignocellulosic-biomass-for-bioethanol-production
#19
María De La Torre, Raquel Martín-Sampedro, Úrsula Fillat, María E Eugenio, Alba Blánquez, Manuel Hernández, María E Arias, David Ibarra
This study evaluates the potential of a bacterial laccase from Streptomyces ipomoeae (SilA) for delignification and detoxification of steam-exploded wheat straw, in comparison with a commercial fungal laccase from Trametes villosa. When alkali extraction followed by SilA laccase treatment was applied to the water insoluble solids fraction, a slight reduction in lignin content was detected, and after a saccharification step, an increase in both glucose and xylose production (16 and 6%, respectively) was observed...
September 14, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28912322/draft-genome-sequence-of-streptomyces-sp-xy006-an-endophyte-isolated-from-tea-camellia-sinensis
#20
Wenna Shan, Huihui Liu, Ying Zhou, Xiaomin Yu
Streptomyces sp. XY006 is an endophytic bacterium isolated from the young leaf material of the tea plant (Camellia sinensis). The draft genome consists of 8.2 Mb and encodes 7,415 putative open reading frames. This strain is found to contain a high capacity for the production of natural products.
September 14, 2017: Genome Announcements
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