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Streptomyces

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https://www.readbyqxmd.com/read/28230357/streptenols-f-i-isolated-from-the-marine-derived-streptomyces-misionensis-bat-10-03-023
#1
Guillermo Tarazona, Carmen Schleissner, Pilar Rodríguez, Marta Pérez, Librada Ma Cañedo, Carmen Cuevas
A marine-derived bacterium, Streptomyces misionensis BAT-10-03-123, has produced four new streptenol derivatives, F, G, H, and I (1-4), as well as the known streptenols A and C (5 and 6). Their planar structures were elucidated by detailed analysis of spectroscopic data. The absolute configurations of the new streptenol compounds were determined by chemical and spectroscopic methods, including Mosher's ester method. All of the compounds were tested for cytotoxicity against four selected cancer cell lines.
February 23, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28229018/-genomic-data-mining-of-the-marine-actinobacteria-streptomyces-sp-h-kf8-unveils-insights-into-multi-stress-related-genes-and-metabolic-pathways-involved-in-antimicrobial-synthesis
#2
Agustina Undabarrena, Juan A Ugalde, Michael Seeger, Beatriz Cámara
Streptomyces sp. H-KF8 is an actinobacterial strain isolated from marine sediments of a Chilean Patagonian fjord. Morphological characterization together with antibacterial activity was assessed in various culture media, revealing a carbon-source dependent activity mainly against Gram-positive bacteria (S. aureus and L. monocytogenes). Genome mining of this antibacterial-producing bacterium revealed the presence of 26 biosynthetic gene clusters (BGCs) for secondary metabolites, where among them, 81% have low similarities with known BGCs...
2017: PeerJ
https://www.readbyqxmd.com/read/28228366/leupeptazin-a-highly-modified-tripeptide-isolated-from-cultures-of-a-streptomyces-sp-inhibits-cathepsin-k
#3
Natasha Kruglyak, David E Williams, Henry Chen, Simon Law, Jadwiga Kaleta, Ivan Villanueva, Julian E Davies, Raymond J Andersen, Dieter Brömme
Using a human cathepsin K-targeting inhibitor screen, a new leupeptin analogue, leupeptazin (1), containing an unprecedented piperidinotriazine moiety, was isolated from a liquid culture of soil Streptomyces sp. IS2-4 collected in northern Italy. The structure of leupeptazin was established using HRESIMS as well as 1D and 2D NMR data. The inhibitory activity of the compound towards the collagenase cathepsin K was tested in vitro to reveal moderate activity with an inhibition constant, Ki, of 44μM.
February 5, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28225766/marine-actinobacteria-as-a-source-of-compounds-for-phytopathogen-control-an-integrative-metabolic-profiling-bioactivity-and-taxonomical-approach
#4
Luz A Betancur, Sandra J Naranjo-Gaybor, Diana M Vinchira-Villarraga, Nubia C Moreno-Sarmiento, Luis A Maldonado, Zulma R Suarez-Moreno, Alejandro Acosta-González, Gillermo F Padilla-Gonzalez, Mónica Puyana, Leonardo Castellanos, Freddy A Ramos
Marine bacteria are considered as promising sources for the discovery of novel biologically active compounds. In this study, samples of sediment, invertebrate and algae were collected from the Providencia and Santa Catalina coral reef (Colombian Caribbean Sea) with the aim of isolating Actinobateria-like strain able to produce antimicrobial and quorum quenching compounds against pathogens. Several approaches were used to select actinobacterial isolates, obtaining 203 strains from all samples. According to their 16S rRNA gene sequencing, a total of 24 strains was classified within Actinobacteria represented by three genera: Streptomyces, Micromonospora, and Gordonia...
2017: PloS One
https://www.readbyqxmd.com/read/28225277/daryamide-analogues-from-a-marine-derived-streptomyces-species
#5
Peng Fu, Scott La, John B MacMillan
Three new cyclohexene amine derivatives, daryamides D-F (1-3), a new arylamine derivative, carpatamide D (4), and a new ornithine lactamization derivative, ornilactam A (5), were isolated from the marine-derived Streptomyces strain SNE-011. Their structures, including absolute configurations, were elucidated on the basis of spectroscopic analysis and chemical methods. The carpatamide skeleton could be considered as the biosynthetic precursor of the daryamides.
February 22, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28223778/gancidin-w-a-potential-low-toxicity-antimalarial-agent-isolated-from-an-endophytic-streptomyces-suk10
#6
Noraziah Mohamad Zin, Mohd Shukri Baba, Abu Hassan Zainal-Abidin, Jalifah Latip, Noor Wini Mazlan, RuAngelie Edrada-Ebel
Endophytic Streptomyces strains are potential sources for novel bioactive molecules. In this study, the diketopiperazine gancidin W (GW) was isolated from the endophytic actinobacterial genus Streptomyces, SUK10, obtained from the bark of Shorea ovalis tree, and it was tested in vivo against Plasmodium berghei PZZ1/100. GW exhibited an inhibition rate of nearly 80% at 6.25 and 3.125 μg kg(-1) body weight on day four using the 4-day suppression test method on male ICR strain mice. Comparing GW at both concentrations with quinine hydrochloride and normal saline as positive and negative controls, respectively, 50% of the mice treated with 3...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28223690/cytotoxic-rearranged-angucycline-glycosides-from-deep-sea-derived-streptomyces-lusitanus-scsio-lr32
#7
Xiangcheng Zhu, Yanwen Duan, Zhaomeng Cui, Zhen Wang, Zengxia Li, Yun Zhang, Jianhua Ju, Hongbo Huang
Two new rearranged linear angucycline glycosides, designated grincamycins G and H (1 and 2), together with three known congers P-1894B (vineomycin A1, 3), saquayamycin B (4) and vineomycin B2 (5), were obtained from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. The structures of 1 and 2 were elucidated by MS, 1D and 2D NMR techniques. Compounds 2-5 showed significant inhibitory effect on Jurkat T-cell proliferation with IC50 values of 3.0, 0.011, 0.037 and 0.3 μM, respectively.The Journal of Antibiotics advance online publication, 22 February 2017; doi:10...
February 22, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28221784/development-of-a-biosensor-concept-to-detect-the-production-of-cluster-specific-secondary-metabolites
#8
Yi-Qian Sun, Tobias Busche, Christian Rückert, Constanze Paulus, Yuriy Rebets, Renata Novakova, Joern Kalinowski, Andriy Luzhetskyy, Jan Kormanec, Olga N Sekurova, Sergey B Zotchev
Genome mining of actinomycete bacteria aims at the discovery of novel bioactive secondary metabolites that can be developed into drugs. A new repressor-based biosensor to detect activated secondary metabolite biosynthesis gene clusters in Streptomyces was developed. Biosynthetic gene clusters for undecylprodigiosin and coelimycin in the genome of Streptomyces lividans TK24, which encoded TetR-like repressors and appeared to be almost "silent" based on the RNA-seq data were chosen for the proof-of-principle studies...
February 21, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28217886/the-use-of-newly-isolated-streptomyces-strain-tn258-as-potential-biocontrol-agent-of-potato-tubers-leak-caused-by-pythium-ultimum
#9
Imen Sellem, Mohamed Ali Triki, Lobna Elleuch, Manel Cheffi, Ahlem Chakchouk, Slim Smaoui, Lotfi Mellouli
An actinomycete strain designated TN258, was isolated from Tunisian Sahara soil and selected for its antagonistic activity, especially against Pythium ultimum (P. ultimum) causing potato tubers leak. Based on the results of cultural characteristic of TN258 strain, the 16S rRNA gene nucleotide sequence (1433 bp, accession n° HE600071) and the phylogenetic analysis, we propose the assignment of our new isolate bacterium as Streptomyces TN258 strain. After culture optimization, the inhibitory effect of TN258 free cell supernatant against P...
February 20, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28216577/qm-hifsa-aided-structure-determination-of-succinilenes-a-d-new-triene-polyols-from-a-marine-derived-streptomyces-sp
#10
Munhyung Bae, So Hyun Park, Yun Kwon, Sang Kook Lee, Jongheon Shin, Joo-Won Nam, Dong-Chan Oh
Based on profiles of secondary metabolites produced by marine bacteria obtained using LC/MS, succinilenes A-D (1-4), new triene polyols, were discovered from a culture of a Streptomyces strain SAK1, which was collected in the southern area of Jeju Island, Republic of Korea. The gross structures of 1-4 were primarily determined through analysis of NMR spectra. The double bond geometries of the succinilenes, which could not be established from conventional ¹H NMR spectra because of the highly overlapped olefinic signals, were successfully deciphered using the recently developed quantum-mechanics-driven ¹H iterative full spin analysis (QM-HiFSA)...
February 14, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28211942/antifungal-activity-change-of-streptomyces-rimosus-my02-mediated-by-confront-culture-with-other-microorganism
#11
Jicheng Yu, Qiu Liu, Chao Chen, Xiaohui Qi
Streptomyces rimosus can produce antibacterial and antifungal antibiotics, which have important applications in medicine and agriculture. Seventy-nine microbial strains were employed to assay interaction between S. rimosus MY02 and different fungi, actinomyces, and bacteria when confront cultured on solid media. The results showed that the presence of a microorganism might affect the activity of another one. When S. rimosus MY02 confront cultured with other microorganisms, the inductive effect might be positive or negative...
February 17, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28211492/the-propensity-of-the-bacterial-rodlin-protein-rdlb-to-form-amyloid-fibrils-determines-its-function-in-streptomyces-coelicolor
#12
Wen Yang, Joost Willemse, Elizabeth B Sawyer, Fei Lou, Weibin Gong, Hong Zhang, Sally L Gras, Dennis Claessen, Sarah Perrett
Streptomyces bacteria form reproductive aerial hyphae that are covered with a pattern of pairwise aligned fibrils called rodlets. The presence of the rodlet layer requires two homologous rodlin proteins, RdlA and RdlB, and the functional amyloid chaplin proteins, ChpA-H. In contrast to the redundancy shared among the eight chaplins, both RdlA and RdlB are indispensable for the establishment of this rodlet structure. By using a comprehensive biophysical approach combined with in vivo characterization we found that RdlB, but not RdlA, readily assembles into amyloid fibrils...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210250/simultaneous-activation-of-iron-and-thiol-based-sensor-regulator-systems-by-redox-active-compounds
#13
Kang-Lok Lee, Ji-Sun Yoo, Gyeong-Seok Oh, Atul K Singh, Jung-Hye Roe
Bacteria in natural habitats are exposed to myriad redox-active compounds (RACs), which include producers of reactive oxygen species (ROS) and reactive electrophile species (RES) that alkylate or oxidize thiols. RACs can induce oxidative stress in cells and activate response pathways by modulating the activity of sensitive regulators. However, the effect of a certain compound on the cell has been investigated primarily with respect to a specific regulatory pathway. Since a single compound can exert multiple chemical effects in the cell, its effect can be better understood by time-course monitoring of multiple sensitive regulatory pathways that the compound induces...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28208722/zunyimycins-b-and-c-new-chloroanthrabenzoxocinones-antibiotics-against-methicillin-resistant-staphylococcus-aureus-and-enterococci-from-streptomyces-sp-fjs31-2
#14
Yuhong Lü, Meiyun Shao, Yinyin Wang, Shengyan Qian, Miao Wang, Yingquan Wang, Xiaoqian Li, Yuxin Bao, Chengmin Deng, Changwu Yue, Daishun Liu, Ning Liu, Minghao Liu, Ying Huang, Zehui Chen, Yonglin Hu
This study performed an optimization of the fermentation conditions to activate the expression of the zunyimycin family biosynthesis genes of the zunyimycin-producing streptomycetes strain Streptomyces sp. FJS31-2. Bioassay-guided isolation and purification by varied chromatographic methods yielded two new compounds of the zunyimycin derivatives, namely, 31-2-7 and 31-2-8, accompanied with three known anthrabenzoxocinones family members of zunyimycin A, BE24566B, and chloroanthrabenzoxocinone. Their structures were elucidated by NMR, HRESIMS, IR, UV, and CD...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28206772/cytotoxic-fusicoccane-type-diterpenoids-from-streptomyces-violascens-isolated-from-ailuropoda-melanoleuca-feces
#15
Dan Zheng, Li Han, Xiaodan Qu, Xiu Chen, Jialiang Zhong, Xiaoxu Bi, Jiang Liu, Yi Jiang, Chenglin Jiang, Xueshi Huang
Six new fusicoccane-type diterpenoids (2-7) were isolated from the fermentation broth of Streptomyces violascens, which was isolated from Ailuropoda melanoleuca (giant panda) feces. The structures of these new compounds were elucidated by a detailed spectroscopic data and X-ray crystallographic analysis. Compounds 5-7 demonstrated cytotoxicity against five human cancer cell lines, with IC50 values ranging from 3.5 ± 0.7 to 14.1 ± 0.8 μM. Cell adhesion, migration, and invasion assays showed that 6 inhibited the migration and invasion of human hepatocellular carcinoma SMMC7721 cells in a dose-dependent manner...
February 16, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28205416/ecological-implications-of-hypoxia-triggered-shifts-in-secondary-metabolism
#16
Kelley A Gallagher, Greg Wanger, Jane Henderson, Mark Llorente, Chambers C Hughes, Paul R Jensen
Members of the actinomycete genus Streptomyces are non-motile, filamentous bacteria that are well known for the production of biomedically relevant secondary metabolites. While considered obligate aerobes, little is known about how these bacteria respond to periods of reduced oxygen availability in their natural habitats, which include soils and ocean sediments. Here we provide evidence that the marine streptomycete strain CNQ-525 can reduce MnO2 via a diffusible mechanism. We investigated the effects of hypoxia on secondary metabolite production and observed a shift away from the antibiotic napyradiomycin towards 8-amino-flaviolin, an intermediate in the napyradiomycin biosynthetic pathway...
February 15, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28202308/nanaomycin-h-a-new-nanaomycin-analog
#17
Takuji Nakashima, Toru Kimura, Rei Miyano, Hirotaka Matsuo, Tomoyasu Hirose, Aoi Kimishima, Kenichi Nonaka, Masato Iwatsuki, Jun Nakanishi, Yōko Takahashi, Satoshi Ōmura
Physicochemical screening identified a new nanaomycin analog, nanaomycin H, which was isolated from a culture broth of Streptomyces rosa subsp. notoensis OS-3966. This microorganism is already known to produce seven nanaomycin compounds, (nanaomycin A to G). Structural elucidation of nanaomycin H showed it to be a pyranonaphthoquinone with a mycothiol moiety. A N-acetylcysteine S-conjugate of nanaomycin H, without α-glucosamine linked to myo-inositol moiety, mercapturic acid derivative, was also detected in the same culture broth...
February 12, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28198807/paenibacillus-polymyxa-nsy50-suppresses-fusarium-wilt-in-cucumbers-by-regulating-the-rhizospheric-microbial-community
#18
Lu Shi, Nanshan Du, Sheng Shu, Jin Sun, Shuzhan Li, Shirong Guo
Paenibacillus polymyxa (P. polymyxa) NSY50, isolated from vinegar residue substrate, suppresses the growth of Fusarium oxysporum in the cucumber rhizosphere and protects the host plant from pathogen invasion. The aim of the present study was to evaluate the effects of NSY50 application on cucumber growth, soil properties and composition of the rhizospheric soil microbial community after exposure to Fusarium oxysporum. Bacterial and fungal communities were investigated by Illumina sequencing of the 16S rRNA gene and the internal transcribed spacer (ITS) regions (ITS1 and ITS2)...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28198423/discovery-of-genes-coding-for-carbohydrate-active-enzyme-by-metagenomic-analysis-of-lignocellulosic-biomasses
#19
Salvatore Montella, Valeria Ventorino, Vincent Lombard, Bernard Henrissat, Olimpia Pepe, Vincenza Faraco
In this study, a high-throughput sequencing approach was applied to discover novel biocatalysts for lignocellulose hydrolysis from three dedicated energy crops, Arundo donax, Eucalyptus camaldulensis and Populus nigra, after natural biodegradation. The microbiomes of the three lignocellulosic biomasses were dominated by bacterial species (approximately 90%) with the highest representation by the Streptomyces genus both in the total microbial community composition and in the microbial diversity related to GH families of predicted ORFs...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196980/competition-and-co-regulation-of-spirotoamide-and-tautomycetin-biosynthesis-in-streptomyces-griseochromogenes-and-isolation-and-structural-elucidation-of-spirotoamide-c-and-d
#20
Dong Yang, Mostafa E Rateb, Nan Wang, Ben Shen
No abstract text is available yet for this article.
February 15, 2017: Journal of Antibiotics
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