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https://www.readbyqxmd.com/read/30116009/impact-of-the-reticular-stress-and-unfolded-protein-response-on-the-inflammatory-response-in-endometrial-stromal-cells
#1
E Grasso, S Gori, E Soczewski, L Fernández, L Gallino, D Vota, G Martínez, M Irigoyen, C Ruhlmann, T F Lobo, G Salamone, R Mattar, S Daher, C Pérez Leirós, R Ramhorst
During decidualization, endometrial stromal cells undergo reticular stress (RS) and unfolded protein response (UPR), allowing the endoplasmic reticulum-expansion and immunomodulators production. Physiological RS generates the activation of sensing proteins, inflammasome activation and mature-IL-1β secretion, associated with pro-implantatory effects. We focus on the impact of RS and UPR on decidualized cells and whether they induce a physiological sterile inflammatory response through IL-1β production. Human endometrial stromal cell line (HESC) after decidualization treatment with MPA + dibutyryl-cAMP (Dec) increased the expression of RS-sensors (ATF6, PERK and IRE1α) and UPR markers (sXBP1 and CHOP) in comparison with Non-dec cells...
August 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30109142/increased-kr%C3%A3-ppel-like-factor-12-impairs-embryo-attachment-via-downregulation-of-leukemia-inhibitory-factor-in-women-with-recurrent-implantation-failure
#2
Chenyang Huang, Haixiang Sun, Zhilong Wang, Yang Liu, Xi Cheng, Jingyu Liu, Ruiwei Jiang, Xindong Zhang, Xin Zhen, Jidong Zhou, Linjun Chen, Lijun Ding, Guijun Yan, Yue Jiang
Recurrent implantation failure (RIF) caused by various etiological factors remains a challenge for fertility clinicians using assisted reproductive technology (ART) worldwide. Dysregulation of leukemia inhibitory factor (LIF) in the endometria of women with RIF is involved in impaired endometrial receptivity and embryo adhesion. However, the mechanism through which LIF expression is regulated in women with RIF is still poorly understood. Our previous study noted that the abnormally increased endometrial Krüppel-like factor 12 (KLF12) in RIF women led to impaired decidualization and embryo implantation...
2018: Cell Death Discovery
https://www.readbyqxmd.com/read/30081718/potential-marker-pathways-in-the-endometrium-that-may-cause-recurrent-implantation-failure
#3
Ercan Bastu, Irem Demiral, Tuba Gunel, Ege Ulgen, Ece Gumusoglu, Mohammad Kazem Hosseini, Ugur Sezerman, Faruk Buyru, John Yeh
The aim of this prospective cohort study was to identify altered biologic processes in the endometrium that may be potential markers of receptive endometrium in patients with repeated implantation failure (RIF) as compared with fertile controls. The study was conducted in a university-affiliated in vitro fertilization (IVF) gynecology clinic and molecular biology and genetics laboratory. Healthy fertile controls (n = 24) and patients with RIF (n = 24) were recruited. Window of implantation gene profiling associated with RIF was performed...
August 6, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/30027145/granulocyte-colony-stimulating-factor-may-improve-pregnancy-outcome-in-patients-with-history-of-unexplained-recurrent-implantation-failure-an-rct
#4
Soheila Arefi, Elham Fazeli, Manijeh Esfahani, Nasim Borhani, Nazila Yamini, Ahmad Hosseini, Fattaneh Farifteh
Background: Family of colony-stimulating factors (CSF) have an essential role on early cross talk between embryo and uterine endometrium. Objective: The aim of this study was to evaluate the effects of the single dose of Granulocyte-CSF (G-CSF) injection on clinical outcome of assisted reproductive technology cycle in patients with repeated implantation failures. Materials and Methods: This randomized control trial study was performed on 52 infertile women who referred to the clinic with the history of more than three previous In vitro fertilization/Intracytoplasmic sperm injection-embryo transfer failures...
May 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29973278/association-of-the-peripheral-blood-levels-of-circulating-micrornas-with-both-recurrent-miscarriage-and-the-outcomes-of-embryo-transfer-in-an-in-vitro-fertilization-process
#5
Qian Yang, Wen-Wen Gu, Yan Gu, Na-Na Yan, Yan-Yan Mao, Xing-Xing Zhen, Jian-Mei Wang, Jing Yang, Hui-Juan Shi, Xuan Zhang, Jian Wang
BACKGROUND: Implantation failure is not only a major cause of early pregnancy loss, but it is also an obstacle to assisted reproductive technologies. The identification of potential circulating biomarkers for recurrent miscarriage (RM) and/or recurrent implantation failure would contribute to the development of novel diagnosis and prediction techniques. METHODS: MiR (miR-23a-3p, 27a-3p, 29a-3p, 100-5p, 127-3p and 486-5p) expression in the villi, decidual tissues and peripheral blood plasma and serum were validated by qPCR, and the localization of miRs in the villi and decidual tissues of RM and normal pregnancy (NP) women were detected by in situ hybridization...
July 4, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29968069/oviductal-glycoprotein-1-ovgp1-is-expressed-by-endometrial-epithelium-that-regulates-receptivity-and-trophoblast-adhesion
#6
Saniya Laheri, Nancy Ashary, Purvi Bhatt, Deepak Modi
PURPOSE: To study the regulation and functions of oviductal glycoprotein 1 (OVGP1) in endometrial epithelial cells. METHODS: Expression of OVGP1 in mouse endometrium during pregnancy and in the endometrial epithelial cell line (Ishikawa) was studied by immunofluorescence, Western blotting, and RT-PCR. Regulation of OVGP1 in response to ovarian steroids and human chorionic gonadotropin (hCG) was studied by real-time RT-PCR. OVGP1 expression was knockdown in Ishikawa cells by shRNA, and expression of receptivity associated genes was studied by real-time RT-PCR...
June 30, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29929546/decreased-muc1-in-endometrium-is-an-independent-receptivity-marker-in-recurrent-implantation-failure-during-implantation-window
#7
Fangrong Wu, Xiaoyan Chen, Yingyu Liu, Bo Liang, Hui Xu, Tin Chiu Li, Chi Chiu Wang
BACKGROUND: It is postulated that women suffered from recurrent implantation failure (RIF) have different endometrial receptivity compared to those who experienced with idiopathic recurrent miscarriage (RM). In this study, expression of common endometrial markers Leukemia inhibitor factor (LIF), mucin 1 (MUC1) and integrin β3 were studied and compared. METHODS: Fourteen women with RIF, 25 with RM and 20 fertile controls were recruited for endometrial biopsy during implantation window on day LH +  7...
June 21, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29908776/effects-of-chronic-endometritis-therapy-on-in-vitro-fertilization-outcome-in-women-with-repeated-implantation-failure-a-systematic-review-and-meta-analysis
#8
Amerigo Vitagliano, Carlo Saccardi, Marco Noventa, Attilio Di Spiezio Sardo, Gabriele Saccone, Ettore Cicinelli, Sara Pizzi, Alessandra Andrisani, Pietro Salvatore Litta
OBJECTIVE: To evaluate the impact of antibiotic therapy for chronic endometritis (CE) on IVF outcome. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Infertile women with history of recurrent implantation failure, defined as two or more failed ETs, undergoing one or more IVF cycle(s). INTERVENTION(S): The review was registered in PROSPERO (CRD42017062494) before the start of the literature search...
July 1, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29904967/downregulation-of-ilt4-dendritic-cells-in-recurrent-miscarriage-and-recurrent-implantation-failure
#9
Su Liu, Hongxia Wei, Yuye Li, Chunyu Huang, Ruochun Lian, Jian Xu, Lanna Chen, Yong Zeng
PROBLEM: The role of ILT4+ DCs in healthy fertile controls and patients with recurrent miscarriages (RM) and recurrent implantation failure (RIF) is unclear. METHOD OF STUDY: We studied the expression of ILT4 from peripheral blood and endometrial samples from healthy controls and patients with RM and RIF by flow cytometry and immunohistochemistry analysis. Endometrial Foxp3 expression was also investigated using immunohistochemistry. RESULTS: In peripheral blood, there was a significant increase in the percentage of ILT4+ DCs in healthy fertile controls compared with patients with RM and RIF...
June 14, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29889670/implantation-failure-of-endometrial-origin-what-is-new
#10
José Bellver, Carlos Simón
PURPOSE OF REVIEW: To review recent findings related to possible causes of recurrent implantation failure of endometrial origin in normal uterus. RECENT FINDINGS: Recent evidences suggest that in apparently normal endometria, RIF may associate with molecular and functional changes in the uterus such as abnormal endometrial microbiota, including the presence of chronic endometritis, poor synchronization between the blastocyst and endometrium, and/or excessive uterine peristalsis...
August 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29785531/prevalent-genotypes-of-methylenetetrahydrofolate-reductase-mthfr-in-recurrent-miscarriage-and-recurrent-implantation-failure
#11
Yuanchang Zhu, Tonghua Wu, Lijun Ye, Guangui Li, Yong Zeng, Yaou Zhang
OBJECTIVE: To evaluate the association of two common methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms with recurrent miscarriage (RM) and repeated implantation failure (RIF) METHODS: The study comprised of 521 patients, with a history of RM (n = 370) or RIF (n = 151). One hundred forty-four women with fallopian tube blockages who had successfully conceived after the first in vitro fertilization embryo transfer treatment served as the control group. The MTHFR alleles, genotypes, and haplotypes were assessed in different groups...
May 21, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29778382/comparison-of-the-prevalence-of-chronic-endometritis-as-determined-by-means-of-different-diagnostic-methods-in-women-with-and-without-reproductive-failure
#12
Yingyu Liu, Xiaoyan Chen, Jin Huang, Chi-Chiu Wang, Mei-Yung Yu, Susan Laird, Tin-Chiu Li
OBJECTIVE: To compare the prevalence of chronic endometritis (CE) when different diagnostic methods are used. DESIGN: Prospective observational study. SETTING: University-affiliated hospital. PATIENT(S): Four groups of women were studied, including women with proven fertility (Fertile; n = 40), unexplained recurrent miscarriage (RM; n = 93), recurrent implantation failure (RIF; n = 39), and infertile subjects undergoing endometrial scratch in a natural cycle preceding frozen-thawed embryo transfer (Infertility; n = 48)...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29739285/association-between-mir-605a-g-mir-608g-c-mir-631i-d-mir-938c-t-and-mir-1302-3c-t-polymorphisms-and-risk-of-recurrent-implantation-failure
#13
Hyun Ah Lee, Eun Hee Ahn, Hyo Geun Jang, Jung Oh Kim, Ji Hyang Kim, Yu Bin Lee, Woo Sik Lee, Nam Keun Kim
Recurrent implantation failure (RIF) is diagnosed when pregnancy failure occurs after 2 consecutive in vitro fertilization-embryo transfers (IVF-ET) to the endometrium using at least 4 high-quality embryos. MicroRNAs (miRNAs) are a class of small noncoding RNA and reported to play an important role in cell proliferation as well as implantation process. Recently, it has been reported that miRNA can regulate RIF occurrence. So, we were to examine the association between the specific miRNA polymorphisms and RIF in Korean women...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29737471/does-the-endometrial-receptivity-array-really-provide-personalized-embryo-transfer
#14
Rawad Bassil, Robert Casper, Nivin Samara, Tzu-Bou Hsieh, Eran Barzilay, Raoul Orvieto, Jigal Haas
PURPOSE: The aim of the present study was to determine the percentage of infertility patients who are diagnosed with a non-receptive endometrium according to the endometrial receptivity array (ERA) test and to examine whether adjusting the embryo transfer day according to the proposed shift in the window of implantation improves the pregnancy rate compared to non-ERA-tested patients. METHODS: A single-center retrospective cohort study, including 53 consecutive good prognosis patients (0-2 previous frozen embryo transfers) admitted to our IVF unit for a mock cycle prior to their frozen day-5 embryo (blastocyst) transfer cycle...
July 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29667291/prevalence-of-hhv-6-in-endometrium-from-women-with-recurrent-implantation-failure
#15
Carolyn B Coulam, Mahmood Bilal, Maria D Salazar Garcia, Dimantha Katukurundage, Haidy Elazzamy, Emilio F Fernandez, Joanne Kwak-Kim, Kenneth Beaman, Svetlana V Dambaeva
PROBLEM: To study the prevalence of HHV-6 in endometrial biopsies among women experiencing recurrent implantation failure (RIF) after IVF/ET compared with controls. METHOD OF STUDY: Thirty women experiencing RIF after IVF/ET and 10 fertile women participated in the study. All women had endometrial biopsies taken in the luteal phase of their menstrual cycle for an endometrial immune profile (EIP) and HHV-6 mRNA as well as lymphocyte and granulocyte populations. The prevalence of HHV-6 in endometrial biopsies was determined, and biopsies for positive and negative expression of HHV-6 were compared with the results of their EIP and lymphocyte and granulocyte populations...
July 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29648896/does-the-dysregulation-of-matrix-metalloproteinases-contribute-to-recurrent-implantation-failure
#16
Mustapha Benkhalifa, Yosra Zayani, Véronique Bach, Henri Copin, Moncef Feki, Moncef Benkhalifa, Monia Allal-Elasmi
The progress in in vitro fertilization (IVF) techniques for infertility management has led to the investigation of embryo implantation site proteins such as Matrix metalloproteinases (MMPs), which may have a key role in embryo-endometrium crosstalk and in the molecular mechanisms of the embryo implantation. Areas covered: Numerous studies have generated much information concerning the relation between the different proteins at the site of implantation such as cytokines, growth factors, adhesion molecules and MMPs...
April 2018: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29617817/decreased-pecam1-mediated-tgf-%C3%AE-1-expression-in-the-mid-secretory-endometrium-in-women-with-recurrent-implantation-failure
#17
Feng Guo, Chenchen Si, Mingjuan Zhou, Jingwen Wang, Dan Zhang, Peter C K Leung, Bufang Xu, Aijun Zhang
STUDY QUESTION: Is recurrent implantation failure (RIF) associated with decreased expression of platelet and endothelial cell adhesion molecule 1 (PECAM1) and transforming growth factor β1 (TGF-β1) in the endometrium during the implantation window? SUMMARY ANSWER: The present study demonstrates that the expression of PECAM1 and TGF-β1 is significantly decreased in the mid-secretory endometrium in women with RIF, which may account for embryo implantation failure...
May 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29551013/the-interval-transfer-of-a-frozen-thawed-embryo-is-more-successful-than-a-fresh-embryo-transfer-for-women-undergoing-ivf-with-recurrent-implantation-failure-after-cleavage-stage-embryo-biopsy
#18
Jennifer C Pontré, John P Ryan, Andy Tan, Roger J Hart
BACKGROUND: Recurrent implantation failure (RIF) is repeated unsuccessful embryo transfers (ETs). AIMS: To identify predictive embryonic markers of implantation in RIF, following pre-implantation genetic screening (PGS) of cleavage stage embryos, after accounting for male and female factors. MATERIALS AND METHODS: Retrospective analysis of RIF patients undergoing PGS after correction of modifiable causes. RESULTS: Eighty-four patients underwent 140 in vitro ferilisation cycles...
March 18, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29543301/hysteroscopy-as-an-investigation-tool-in-recurrent-implantation-failure-in-vitro-fertilization
#19
Haifa A Al-Turki
OBJECTIVES: To evaluate the use of hysteroscopy in the assessment of uterine pathologies in infertile women with repeated implantation failure (RIF) after in vitro fertilization (IVF) and determine whether removal of such pathologies increased pregnancy rates in women with RIF. METHODS: This prospective study was conducted at King Fahd Hospital of the University, Al-Khobar, Kingdom of Saudi Arabia, between January 2010 and December 2015. The inclusion criteria were women who underwent IVF treatment cycles and ended in more than 2 RIF, and women who underwent hysterosalpingography (HSG)...
March 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29504735/does-autoimmunity-play-a-role-in-the-risk-of-implantation-failures
#20
Hanna Motak-Pochrzest, Andrzej Malinowski
158 non-pregnant women with recurrent implantation failures after IVF/ET procedures were tested for peripheral blood autoimmune profile. The control group consisted of 76 patients after first successful IVF procedure and pregnancy outcome. The objective of this study was to investigate different autoantibodies peripheral blood profile after excluding anatomical, endocrinological, endometrial and genetic disorders and to estimate the risk of implantation failures. The study's including criteria were 1.indications for IVF/ET determined by male factor and unexplained infertility 2...
February 2018: Neuro Endocrinology Letters
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