keyword
https://read.qxmd.com/read/38520066/the-endometrial-transcriptome-of-infertile-women-with-and-without-implantation-failure
#1
JOURNAL ARTICLE
Bich Ngoc Bui, Viktorija Kukushkina, Alvin Meltsov, Catharina Olsen, Nienke van Hoogenhuijze, Signe Altmäe, Femke Mol, Gijs Teklenburg, Jan-Peter de Bruin, Dagmar Besselink, Linda Stevens Brentjens, Darina Obukhova, Masoud Zamani Esteki, Ron van Golde, Andrea Romano, Triin Laisk, Gaby Steba, Shari Mackens, Andres Salumets, Frank Broekmans
INTRODUCTION: Implantation failure after transferring morphologically "good-quality" embryos in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) may be explained by impaired endometrial receptivity. Analyzing the endometrial transcriptome analysis may reveal the underlying processes and could help in guiding prognosis and using targeted interventions for infertility. This exploratory study investigated whether the endometrial transcriptome profile was associated with short-term or long-term implantation outcomes (ie success or failure)...
March 22, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38514025/fatal-outcome-of-bk-virus-encephalitis-in-an-allogeneic-stem-cell-transplantation-recipient
#2
Kyosuke Yamaguchi, Hisashi Yamamoto, Koji Izutsu, Mitsuhiro Yuasa, Daisuke Kaji, Aya Nishida, Kazuya Ishiwata, Shinsuke Takagi, Go Yamamoto, Yuki Asano-Mori, Naoyuki Uchida, Shuichi Taniguchi
BK virus (BKV) encephalitis is a rare complication after hematopoietic stem cell transplantation (HSCT). A 43-year-old woman with recurrent follicular lymphoma after autologous HSCT received allogeneic bone marrow transplantation from a human leukocyte antigen-matched related donor. Neutrophil engraftment was achieved on post-transplant day 13. Memory loss and noncooperative attitude toward the medical staff were observed on day 16, and her mental status worsened progressively. Magnetic resonance imaging (MRI) showed nonspecific findings on day 19; however, cerebrospinal fluid (CSF) analysis including real-time polymerase chain reaction on day 20 revealed elevated levels of BKV 4...
March 19, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/38505751/establishment-and-validation-of-a-nomogram-for-subsequent-first-cycle-live-births-in-patients-diagnosed-with-recurrent-implantation-failure-a-population-based-analysis
#3
RANDOMIZED CONTROLLED TRIAL
Yunian Zhang, Xiaoyun Gong, Manli Zhang, Yuejie Zhu, Peng Wang, Zhihui Wang, Chen Liu, Xiaolin La, Jianbing Ding
BACKGROUND: The inability of patients with recurrent implantation failure (RIF) to achieve pregnancy and a live birth after multiple high-quality embryo transfer treatments has been recognized as a major obstacle to successful application of artificial reproductive technologies. The objective of this study was to establish and validate a nomogram for prediction of subsequent first-cycle live births to guide clinical practice in patients diagnosed with RIF. METHODS: A total of 538 patients who underwent in vitro fertilization/intracytoplasmic sperm injection treatment and were first diagnosed with RIF at the Reproductive Center of the First Affiliated Hospital of Xinjiang Medical University between January 2017 and December 2020 were enrolled...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38505459/combination-therapy-with-platelet-rich-plasma-prp-and-granulocyte-colony-stimulating-factor-g-csf-for-thin-endometrium-a-case-report
#4
Sudhanshu M Dakre, Akash More, Shilpa Dutta, Shradha M Ulhe, Namrata Choudhary
This case study highlights the challenges faced by a couple with a history of two failed in-vitro fertilization (IVF) attempts, including miscarriage and ectopic pregnancy. After treating the female partner for pelvic inflammatory disease (PID) with ceftriaxone and doxycycline, the decision was made to proceed with intra-cytoplasmic sperm injection (ICSI) and fresh embryo transfer. Despite the transfer of two good-quality (4AB and 3AA) day five embryos, the human chorionic gonadotropin (β-hCG) test yielded a negative result...
February 2024: Curēus
https://read.qxmd.com/read/38495807/best-practice-recommendations-for-infertility-management
#5
JOURNAL ARTICLE
Jaideep Malhotra, M Gouri Devi, Madhuri Patil
AIM: The objective of this document is to provide guidance to the infertility specialist, gynecologist, embryologist, and counselors on the management of sub-fertility and brief them with the recent advances in the field. These recommendations will aid the aforementioned healthcare professionals in everyday clinical decisions about appropriate and effective care of their patients with the best available evidence. PARTICIPANTS: Extensive deliberations, discussion, and brainstorming was done between different reproductive medicine (RM) specialists, to develop the recommendations...
February 2024: Journal of Human Reproductive Sciences
https://read.qxmd.com/read/38479679/impact-of-mirnas-in-the-pathoetiology-of-recurrent-implantation-failure
#6
REVIEW
Mohadeseh Fathi, Mohammad Amin Omrani, Sepideh Kadkhoda, Akram Ghahghaei-Nezamabadi, Soudeh Ghafouri-Fard
Recurrent implantation failure (RIF) is a condition with a multifactorial basis. Recent research has focused on the role of genetic factors in the pathophysiology of RIF. Of particular note, miRNAs have been found to contribute to the pathogenesis of RIF. Several miRNA polymorphisms have been investigated in this context. Moreover, dysregulation of expression of a number of miRNAs, including miR-374a-5p, miR-145-5p, miR-30b-5p, miR-196b-5p, miR-22, miR-181 and miR-145 has been found in RIF. This review concentrates on the role of miRNAs in RIF to help in identification of the molecular basis for this condition and design of more effective methods for management of RIF, especially in a personalized manner that relies on the expression profiles of miRNAs in the peripheral blood or endometrium...
March 13, 2024: Molecular and Cellular Probes
https://read.qxmd.com/read/38456991/meta-analysis-of-endometrial-transcriptome-data-reveals-novel-molecular-targets-for-recurrent-implantation-failure
#7
JOURNAL ARTICLE
Venkatlaxmi Chettiar, Alpesh Patel, Shiva Shankaran Chettiar, Devendrasinh D Jhala
PURPOSE: Gene expression analysis of the endometrium has been shown to be a useful approach for identifying the molecular signatures and pathways involved in recurrent implantation failure (RIF). Nevertheless, individual studies have limitations in terms of study design, methodology and analysis to detect minor changes in expression levels or identify novel gene signatures associated with RIF. METHOD: To overcome this, we conducted an in silico meta-analysis of nine studies, the systematic collection and integration of gene expression data, utilizing rigorous selection criteria and statistical techniques to ensure the robustness of our findings...
March 8, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38455805/mechanical-hatching-as-a-therapeutic-intervention-for-improving-implantation-rate-in-a-32-year-old-female-with-recurrent-implantation-failures-a-case-report
#8
Rabia Kakatikar, Pranita A Bawaskar, Ujwal Gajbe, Akash More, Nancy Nair
This case report explores the application of mechanical hatching as a successful intervention in the treatment of primary infertility for a couple with a consanguineous marriage history and recurrent implantation failure. A 32-year-old female patient and her 37-year-old spouse, after six years of unsuccessful attempts to conceive, underwent multiple intrauterine insemination (IUI) and in vitro fertilization (IVF) and embryo transfer (ET) cycles without success. Normal parameters were observed in semen analysis and hormone tests for the male and female partners, respectively...
February 2024: Curēus
https://read.qxmd.com/read/38452358/does-recurrent-implantation-failure-exist-prevalence-and-outcomes-of-five-consecutive-euploid-blastocyst-transfers-in-123%C3%A2-987-patients
#9
JOURNAL ARTICLE
Pavan Gill, Baris Ata, Ana Arnanz, Danilo Cimadomo, Alberto Vaiarelli, Human M Fatemi, Filippo Maria Ubaldi, Juan A Garcia-Velasco, Emre Seli
STUDY QUESTION: What are the clinical pregnancy and live birth rates in women who underwent up to two more euploid blastocyst transfers after three failures in the absence of another known factor that affects implantation? SUMMARY ANSWER: The fourth and fifth euploid blastocyst transfers resulted in similar live birth rates of 40% and 53.3%, respectively, culminating in a cumulative live birth rate of 98.1% (95% CI = 96.5-99.6%) after five euploid blastocyst transfers...
March 7, 2024: Human Reproduction
https://read.qxmd.com/read/38447535/hospital-readmissions-for-fluid-overload-among-individuals-with-diabetes-and-diabetic-kidney-disease-risk-factors-and-multivariable-prediction-models
#10
JOURNAL ARTICLE
Jiashen Cai, Dorothy Huang, Hanis Binte Abdul Kadir, Zhihua Huang, Li Choo Ng, Andrew Ang, Ngiap Chuan Tan, Yong Mong Bee, Wei Yi Tay, Chieh Suai Tan, Cynthia C Lim
AIMS: Hospital readmissions due to recurrent fluid overload in diabetes and diabetic kidney disease can be avoided with evidence-based interventions. We aimed to identify at-risk patients who can benefit by developing risk prediction models for readmissions for fluid overload in people living with diabetes. METHODS: Single-center retrospective cohort study of 1531 adults with diabetes and hospitalized for fluid overload, including congestive heart failure, pulmonary edema and generalized edema, between 2015 and 2017...
March 6, 2024: Nephron
https://read.qxmd.com/read/38447289/sars-cov-2-infection-in-pregnant-patients-on-tnf%C3%AE-inhibitor-real-life-data-with-a-review-of-literature
#11
JOURNAL ARTICLE
Yiqi Yu, Jiaying Pan, Yiqi Zhao, Xiaoyan Guo, Wenting Yu, Feifei Zhou, Jing Shu, Qiongxiao Huang
Tumor necrosis factor alpha (TNFα) is involved in the occurrence of negative pregnancy outcomes. The study aimed to evaluate the safety and efficacy of the immunosuppressive TNFα inhibitors (TNFαi) in the treatment of patients with a history of recurrent reproductive failure in the context of COVID-19 pandemics. We reviewed 85 patients who received TNFαi (certolizumab pegol) during Mainland China's first wave of COVID-19 pandemic, from 21st Nov 2022-11 th Jan 2023. We also collected corresponding data from 130 pregnant patients who never used TNFαi for comparison...
February 21, 2024: Journal of Reproductive Immunology
https://read.qxmd.com/read/38445292/dynamic-changes-in-ai-based-analysis-of-endometrial-cellular-composition-analysis-of-pcos-and-rif-endometrium
#12
JOURNAL ARTICLE
Seungbaek Lee, Riikka K Arffman, Elina K Komsi, Outi Lindgren, Janette Kemppainen, Keiu Kask, Merli Saare, Andres Salumets, Terhi T Piltonen
BACKGROUND: The human endometrium undergoes a monthly cycle of tissue growth and degeneration. During the mid-secretory phase, the endometrium establishes an optimal niche for embryo implantation by regulating cellular composition (e.g., epithelial and stromal cells) and differentiation. Impaired endometrial development observed in conditions such as polycystic ovary syndrome (PCOS) and recurrent implantation failure (RIF) contributes to infertility. Surprisingly, despite the importance of the endometrial lining properly developing prior to pregnancy, precise measures of endometrial cellular composition in these two infertility-associated conditions are entirely lacking...
December 2024: Journal of Pathology Informatics
https://read.qxmd.com/read/38445125/a-case-series-based-on-the-mixed-double-embryo-transfer-mdet-outcome-in-patients-with-recurrent-implantation-failure
#13
Shilpa Dutta, Akash More, Sanket Mahajan, Neha Nawale, Deepti Shrivastava, Namrata Choudhary
Successful implantation of embryos depends on the synchronous cross-talks between the endometrial wall and the competent blastocyst within the window of implantation (WOI). Hence, the WOI has a major significance in assisted reproductive technology (ART). However, in some cases, women do not have fixed WOI in ART cycles in order to enhance the rate of successful clinical pregnancy. However, there have been stances where women do not have a fixed WOI, and it shifts in subsequent menstrual periods. This contributes to the chances of recurrent implantation failure (RIF)...
February 2024: Curēus
https://read.qxmd.com/read/38435143/the-use-of-intralipid-infusions-in-the-prevention-of-embryo-implantation-failure
#14
Okorie C Anya, Eniola R Ajayi, Henry R Solanke, Adaeze I Ohanaka, Kokei D Ubana
Intralipids have been suggested to suppress uterine natural killer cell activity, which could potentially improve implantation rates in women with recurrent loss. We report a case of a 41-year-old African woman with recurrent pregnancy loss who had elevated uterine killer cell activity and for whom intralipid infusion was used to achieve pregnancy. We recommend routine uterine natural killer cell testing for women with recurrent pregnancy loss and further research on newer intravenous lipid emulsions in fertility medicine...
February 2024: Curēus
https://read.qxmd.com/read/38414707/the-effect-of-superoxide-dismutase-mimetic-drug-in-an-infertile-patient-with-thin-endometrium
#15
Sanket Mahajan, Akash More, Shilpa Dutta, Namrata Chaudhary, Neha Nawale
It has been observed that nowadays, millions of couples struggle with infertility, which may be attributed to various conditions. In this case study, a middle-aged couple with a history of recurrent implantation failure (RIF) visited an infertility clinic situated in a rural region in Wardha to seek treatment. The male was normozoospermic. After hysteroscopy, it was noticed that an aggregated level of reactive oxygen species (ROS) was a causative factor for thin endometrium contributing to infertility...
January 2024: Curēus
https://read.qxmd.com/read/38405193/acute-radiation-induced-pericarditis-complicated-by-polymicrobial-infectious-pericarditis-in-a-patient-with-mediastinal-sarcoma-a-case-report
#16
Kimberly L Yan, Yoo Jin Lee, Alan H Baik
BACKGROUND: Acute pericarditis is often caused by viral infections, autoimmune diseases, and radiation therapy (RT). Infectious pericarditis is rare and associated with high morbidity and mortality. We present a case of acute RT-induced pericarditis complicated by bacterial pericarditis and cardiac tamponade due to oesophageal bacterial translocation. CASE SUMMARY: A 65-year-old man with a recurrent mediastinal sarcoma complicated by oesophageal compression and recent oesophageal stenting presented with shortness of breath...
February 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38385050/zona-pellucida-removal-resulted-in-a-successful-live-birth-report-on-a-case-with-recurrent-implantation-failure-due-to-embryonic-bacteria-contamination
#17
Son Truong Dang, Huy Phuong Tran, Tuong Nguyen Ho, Loc Thai Ly, Tuyet Thi-Diem Hoang, Trang Nguyen-Khanh Huynh, Anh Tuan Do, Thuan Duc Nguyen, Phuong Thi Dao
KEY CLINICAL MESSAGE: In in vitro fertilization (IVF), laser offers several advantages. In this study, we employed laser to eliminate the zona pellucida of a contaminated embryo. This approach helps to rescue embryo with bacterial contamination, and improve embryo-endometrium interaction. ABSTRACT: To present a case report on the removal of a contaminated zona pellucida from an embryo of patient with a history of recurrent implantation failure (RIF), which was followed by a successful live birth...
February 2024: Clinical Case Reports
https://read.qxmd.com/read/38365686/sequential-embryo-transfer-combined-with-intrauterine-perfusion-improved-pregnancy-outcomes-in-patients-with-recurrent-implantation-failure
#18
JOURNAL ARTICLE
Wenda Zou, Dan Liu, Juan Peng, Zhijing Tang, Yukun Li, Juan Zhang, Ziwei Liu
OBJECTIVE: To compare the application of sequential embryo transfer, cleavage embryo transfer, and blastocyst transfer combined with intrauterine perfusion in frozen-thawed embryo transfer cycles in patients with recurrent implantation failure to provide a reference for reproductive clinicians. METHODS: The 166 patients who underwent frozen-thawed embryo transfer due to recurrent implantation failure in the reproductive center from January 2021 to March 2022 were retrospectively analyzed...
February 16, 2024: BMC Women's Health
https://read.qxmd.com/read/38352808/in-hospital-onset-of-transient-myoclonic-state-in-older-adults-a-case-report
#19
JOURNAL ARTICLE
Taku Harada, Kazushi Yamasato, Toshiyuki Nakanishi, Mori Nakai
BACKGROUND: Transient myoclonic (TM) state in older adults is a neurological condition characterised by short-lived, repetitive myoclonus without consciousness disturbance. First reported in 1992, it predominantly affects older individuals with chronic diseases. Despite its clear symptomatology, TM often remains under-recognised, leading to potential misdiagnoses. CASE DESCRIPTION: We report a case of a 68-year-old woman with a history of chronic heart failure who developed TM during hospitalisation following medication adjustment for acute heart failure...
2024: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/38350949/the-reproductive-potential-of-vitrified-warmed-euploid-embryos-declines-following-repeated-uterine-transfers
#20
JOURNAL ARTICLE
A Almohammadi, F Choucair, L El Taha, H Burjaq, M Albader, A B Cavanillas, Johnny T Awwad
BACKGROUND: Recurrent implantation failure (RIF) represents a vague clinical condition with an unclear diagnostic challenge that lacks solid scientific underpinning. Although euploid embryos have demonstrated consistent implantation capabilities across various age groups, a unanimous agreement regarding the advantages of preimplantation genetic testing for aneuploidy (PGT-A) in managing RIF is absent. The ongoing discussion about whether chromosomal aneuploidy in embryos significantly contributes to recurrent implantation failure remains unsettled...
February 13, 2024: Reproductive Biology and Endocrinology: RB&E
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