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https://www.readbyqxmd.com/read/30452456/foxo1-regulates-uterine-epithelial-integrity-and-progesterone-receptor-expression-critical-for-embryo-implantation
#1
Yasmin M Vasquez, Xiaoqiu Wang, Margeaux Wetendorf, Heather L Franco, Qianxing Mo, Tianyuan Wang, Rainer B Lanz, Steven L Young, Bruce A Lessey, Thomas E Spencer, John P Lydon, Francesco J DeMayo
Successful embryo implantation requires a receptive endometrium. Poor uterine receptivity can account for implantation failure in women who experience recurrent pregnancy loss or multiple rounds of unsuccessful in vitro fertilization cycles. Here, we demonstrate that the transcription factor Forkhead Box O1 (FOXO1) is a critical regulator of endometrial receptivity in vivo. Uterine ablation of Foxo1 using the progesterone receptor Cre (PgrCre) mouse model resulted in infertility due to altered epithelial cell polarity and apoptosis, preventing the embryo from penetrating the luminal epithelium...
November 19, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/30428300/identification-of-differentially-expressed-micrornas-in-outgrowth-embryos-compared-with-blastocysts-and-non-outgrowth-embryos-in-mice
#2
Jihyun Kim, Jaewang Lee, Jin Hyun Jun
Recurrent implantation failure (RIF) is one of the main causes for the repeated failure of IVF, and the major reason for RIF is thought to be a miscommunication between the embryo and uterus. However, the exact mechanism underlying embryo-uterus cross-talk is not fully understood. The aim of the present study was to identify differentially expressed microRNAs (miRNAs) among blastocysts, non-outgrowth and outgrowth embryos in mice using microarray analysis. A bioinformatics analysis was performed to predict the potential mechanisms of implantation...
November 15, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/30396553/the-role-of-immunotherapy-in-in-vitro-fertilization-and-recurrent-pregnancy-loss-a-systematic-review-and-meta-analysis
#3
Chiara Achilli, Montserrat Duran-Retamal, Wael Saab, Paul Serhal, Srividya Seshadri
OBJECTIVE: To study the current evidence on the role of immunotherapy in IVF and in the management of recurrent pregnancy loss (RPL). DESIGN: Systematic review and meta-analysis. SETTING: A literature search was performed using MEDLINE, PUBMED, CINAHL, and EMBASE until May 2017. Only randomized controlled trials were included, and a meta-analysis was carried out where appropriate. PATIENT(S): Women undergoing IVF treatment with or without a history of recurrent implantation failure and women with idiopathic RPL...
November 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/30390547/the-effect-of-prednisolone-on-endometrial-uterine-nk-cell-concentrations-and-pregnancy-outcome-in-women-with-reproductive-failure-a-retrospective-cohort-study
#4
Sophie Cooper, Susan M Laird, Najat Mariee, Tin Chiu Li, Mostafa Metwally
This retrospective study of prospectively collected data examines the effect of prednisolone therapy on raised uterine Natural Killer cell (uNK) concentrations and pregnancy outcomes in women with recurrent miscarriage (RM) and recurrent implantation failure (RIF) after IVF/ICSI treatment. 136 women diagnosed with RRF who had a timed midluteal endometrial biopsy taken for uNK cell analysis were included. Women with high uNK cell concentrations (n = 45) were treated with prednisolone (10 mg/day) for one month, after which a second biopsy was taken for repeat uNK cell analysis...
October 25, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/30376278/repeated-recovery-of-immature-oocytes-in-a-woman-with-a-previous-history-of-empty-follicle-syndrome
#5
Tarek K Al-Hussaini, Ali H Yosef, Ihab H El-Nashar, Omar M Shaaban
The empty follicle syndrome (EFS) is defined as a failure to aspirate any oocyte (s) from the follicles after ovarian hyperstimulation in preparation for IVF/ICSI. It is a frustrating and vague syndrome; and a controversial one concerning its existence, causes and possible treatment. Recurrent EFS or the recovery of immature oocytes thereafter is a more challenging problem. Delayed injection after leaving the immature oocytes for in vitro -maturation (IVM) has been suggested to be a possible option if immature oocytes are retrieved...
October 30, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/30332901/prevalence-of-candidate-single-nucleotide-polymorphisms-on-p53-il-11-il-10-vegf-and-apoe-in-patients-with-repeated-implantation-failure-rif-and-pregnancy-loss-rpl
#6
Azahara Turienzo, Belén Lledó, José A Ortiz, Ruth Morales, Juan Sanz, Joaquín Llácer, Rafael Bernabeu
Recurrent pregnancy loss (RPL; defined as the loss of three or more consecutive pregnancies) and recurrent implantation failure (RIF; when implantation is not achieved after at least three cycles of IVF) are two of the major challenges that reproductive medicine faces. Some polymorphisms have been identified as possible causes of an increased risk of these diseases. This paper studies the prevalence of the polymorphisms in p53, VEGF, IL-10, IL-11 and APOE in RIF and RPL patients that determines the risk for these pathologies...
October 18, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/30224291/what-to-do-when-good-quality-embryos-repeatedly-fail-to-implant
#7
REVIEW
Carol Coughlan
Recurrent implantation failure (RIF) is very distressing for couples and frustrating for their clinicians who seek to find a solution. RIF is defined as the failure to achieve a clinical pregnancy following the transfer of at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman of age below 40 years. An agreed local protocol regarding how couples with RIF should be further investigated and managed should be in place. Ovarian function should be assessed by measuring antral follicle count, FSH, and AMH...
August 2, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/30126420/multiple-occurrence-of-psychomotor-retardation-and-recurrent-miscarriages-in-a-family-with-a-submicroscopic-reciprocal-translocation-t-7-17-p22-p13-2
#8
Magdalena Pasińska, Ewelina Łazarczyk, Katarzyna Jułga, Magdalena Bartnik-Głaska, Beata Nowakowska, Olga Haus
BACKGROUND: Balanced reciprocal chromosomal translocations (RCTs) are the ones of the most common structural aberrations in the population, with an incidence of 1:625. RCT carriers usually do not demonstrate changes in phenotype, except when the translocation results in gene interruption. However, these people are at risk of production of unbalanced gametes during meiosis, as a result of various forms of chromosome segregation. This may cause infertility, non-implantation of the embryo, shorter embryo or foetus survival, as well as congenital defects and developmental disorders in children after birth...
August 20, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/30098685/the-role-of-immunotherapy-in-in-vitro-fertilization-a-guideline
#9
(no author information available yet)
Adjuvant immunotherapy treatments in in vitro fertilization (IVF) aim to improve the outcome of assisted reproductive technology (ART) in both the general ART population as well as subgroups such as patients with recurrent miscarriage or implantation failure. The purpose of this guideline is to evaluate the role of immunomodulating therapy in ART. Unfortunately, many of the evaluated therapies lack robust evidence from well-designed adequately powered randomized controlled trials to support their use. Immunotherapies reviewed in the present document are either not associated with improved live-birth outcome in IVF or have been insufficiently studied to make definitive recommendations...
August 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/30081718/potential-marker-pathways-in-the-endometrium-that-may-cause-recurrent-implantation-failure
#10
Ercan Bastu, Irem Demiral, Tuba Gunel, Ege Ulgen, Ece Gumusoglu, Mohammad Kazem Hosseini, Ugur Sezerman, Faruk Buyru, John Yeh
The aim of this prospective cohort study was to identify altered biologic processes in the endometrium that may be potential markers of receptive endometrium in patients with repeated implantation failure (RIF) as compared with fertile controls. The study was conducted in a university-affiliated in vitro fertilization (IVF) gynecology clinic and molecular biology and genetics laboratory. Healthy fertile controls (n = 24) and patients with RIF (n = 24) were recruited. Window of implantation gene profiling associated with RIF was performed...
August 6, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/30046446/the-role-of-hydroxychloroquine-in-catastrophic-antiphospholipid-syndrome-case-series-of-two-case-reports-and-review-of-literature
#11
Zakaria Hindi, Mosa Hussein, Abdallah Gad, Abdallah A Khaled, Talal Zahoor
Catastrophic antiphospholipid syndrome is a rare disorder that remains under-recognized causing a high mortality rate even with treatment. Factors such as infections and systemic lupus erythematosus flare play as an inciting event in the thrombotic crisis which underlies catastrophic antiphospholipid syndrome. The use of plasmapheresis has improved the outcome of such cases with a reduction in mortality rate from over 50% to less than 30%, according to some studies. However, the definitive treatment of this disabling and fatal condition remains an area warranting research...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/30027145/granulocyte-colony-stimulating-factor-may-improve-pregnancy-outcome-in-patients-with-history-of-unexplained-recurrent-implantation-failure-an-rct
#12
Soheila Arefi, Elham Fazeli, Manijeh Esfahani, Nasim Borhani, Nazila Yamini, Ahmad Hosseini, Fattaneh Farifteh
Background: Family of colony-stimulating factors (CSF) have an essential role on early cross talk between embryo and uterine endometrium. Objective: The aim of this study was to evaluate the effects of the single dose of Granulocyte-CSF (G-CSF) injection on clinical outcome of assisted reproductive technology cycle in patients with repeated implantation failures. Materials and Methods: This randomized control trial study was performed on 52 infertile women who referred to the clinic with the history of more than three previous In vitro fertilization/Intracytoplasmic sperm injection-embryo transfer failures...
May 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29973278/association-of-the-peripheral-blood-levels-of-circulating-micrornas-with-both-recurrent-miscarriage-and-the-outcomes-of-embryo-transfer-in-an-in-vitro-fertilization-process
#13
Qian Yang, Wen-Wen Gu, Yan Gu, Na-Na Yan, Yan-Yan Mao, Xing-Xing Zhen, Jian-Mei Wang, Jing Yang, Hui-Juan Shi, Xuan Zhang, Jian Wang
BACKGROUND: Implantation failure is not only a major cause of early pregnancy loss, but it is also an obstacle to assisted reproductive technologies. The identification of potential circulating biomarkers for recurrent miscarriage (RM) and/or recurrent implantation failure would contribute to the development of novel diagnosis and prediction techniques. METHODS: MiR (miR-23a-3p, 27a-3p, 29a-3p, 100-5p, 127-3p and 486-5p) expression in the villi, decidual tissues and peripheral blood plasma and serum were validated by qPCR, and the localization of miRs in the villi and decidual tissues of RM and normal pregnancy (NP) women were detected by in situ hybridization...
July 4, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29908776/effects-of-chronic-endometritis-therapy-on-in-vitro-fertilization-outcome-in-women-with-repeated-implantation-failure-a-systematic-review-and-meta-analysis
#14
Amerigo Vitagliano, Carlo Saccardi, Marco Noventa, Attilio Di Spiezio Sardo, Gabriele Saccone, Ettore Cicinelli, Sara Pizzi, Alessandra Andrisani, Pietro Salvatore Litta
OBJECTIVE: To evaluate the impact of antibiotic therapy for chronic endometritis (CE) on IVF outcome. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Infertile women with history of recurrent implantation failure, defined as two or more failed ETs, undergoing one or more IVF cycle(s). INTERVENTION(S): The review was registered in PROSPERO (CRD42017062494) before the start of the literature search...
July 1, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29785531/prevalent-genotypes-of-methylenetetrahydrofolate-reductase-mthfr-in-recurrent-miscarriage-and-recurrent-implantation-failure
#15
Yuanchang Zhu, Tonghua Wu, Lijun Ye, Guangui Li, Yong Zeng, Yaou Zhang
OBJECTIVE: To evaluate the association of two common methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms with recurrent miscarriage (RM) and repeated implantation failure (RIF) METHODS: The study comprised of 521 patients, with a history of RM (n = 370) or RIF (n = 151). One hundred forty-four women with fallopian tube blockages who had successfully conceived after the first in vitro fertilization embryo transfer treatment served as the control group. The MTHFR alleles, genotypes, and haplotypes were assessed in different groups...
August 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29739285/association-between-mir-605a-g-mir-608g-c-mir-631i-d-mir-938c-t-and-mir-1302-3c-t-polymorphisms-and-risk-of-recurrent-implantation-failure
#16
Hyun Ah Lee, Eun Hee Ahn, Hyo Geun Jang, Jung Oh Kim, Ji Hyang Kim, Yu Bin Lee, Woo Sik Lee, Nam Keun Kim
Recurrent implantation failure (RIF) is diagnosed when pregnancy failure occurs after 2 consecutive in vitro fertilization-embryo transfers (IVF-ET) to the endometrium using at least 4 high-quality embryos. MicroRNAs (miRNAs) are a class of small noncoding RNA and reported to play an important role in cell proliferation as well as implantation process. Recently, it has been reported that miRNA can regulate RIF occurrence. So, we were to examine the association between the specific miRNA polymorphisms and RIF in Korean women...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29737471/does-the-endometrial-receptivity-array-really-provide-personalized-embryo-transfer
#17
Rawad Bassil, Robert Casper, Nivin Samara, Tzu-Bou Hsieh, Eran Barzilay, Raoul Orvieto, Jigal Haas
PURPOSE: The aim of the present study was to determine the percentage of infertility patients who are diagnosed with a non-receptive endometrium according to the endometrial receptivity array (ERA) test and to examine whether adjusting the embryo transfer day according to the proposed shift in the window of implantation improves the pregnancy rate compared to non-ERA-tested patients. METHODS: A single-center retrospective cohort study, including 53 consecutive good prognosis patients (0-2 previous frozen embryo transfers) admitted to our IVF unit for a mock cycle prior to their frozen day-5 embryo (blastocyst) transfer cycle...
July 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29667291/prevalence-of-hhv-6-in-endometrium-from-women-with-recurrent-implantation-failure
#18
Carolyn B Coulam, Mahmood Bilal, Maria D Salazar Garcia, Dimantha Katukurundage, Haidy Elazzamy, Emilio F Fernandez, Joanne Kwak-Kim, Kenneth Beaman, Svetlana V Dambaeva
PROBLEM: To study the prevalence of HHV-6 in endometrial biopsies among women experiencing recurrent implantation failure (RIF) after IVF/ET compared with controls. METHOD OF STUDY: Thirty women experiencing RIF after IVF/ET and 10 fertile women participated in the study. All women had endometrial biopsies taken in the luteal phase of their menstrual cycle for an endometrial immune profile (EIP) and HHV-6 mRNA as well as lymphocyte and granulocyte populations. The prevalence of HHV-6 in endometrial biopsies was determined, and biopsies for positive and negative expression of HHV-6 were compared with the results of their EIP and lymphocyte and granulocyte populations...
July 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29648896/does-the-dysregulation-of-matrix-metalloproteinases-contribute-to-recurrent-implantation-failure
#19
Mustapha Benkhalifa, Yosra Zayani, Véronique Bach, Henri Copin, Moncef Feki, Moncef Benkhalifa, Monia Allal-Elasmi
The progress in in vitro fertilization (IVF) techniques for infertility management has led to the investigation of embryo implantation site proteins such as Matrix metalloproteinases (MMPs), which may have a key role in embryo-endometrium crosstalk and in the molecular mechanisms of the embryo implantation. Areas covered: Numerous studies have generated much information concerning the relation between the different proteins at the site of implantation such as cytokines, growth factors, adhesion molecules and MMPs...
April 2018: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29617817/decreased-pecam1-mediated-tgf-%C3%AE-1-expression-in-the-mid-secretory-endometrium-in-women-with-recurrent-implantation-failure
#20
Feng Guo, Chenchen Si, Mingjuan Zhou, Jingwen Wang, Dan Zhang, Peter C K Leung, Bufang Xu, Aijun Zhang
STUDY QUESTION: Is recurrent implantation failure (RIF) associated with decreased expression of platelet and endothelial cell adhesion molecule 1 (PECAM1) and transforming growth factor β1 (TGF-β1) in the endometrium during the implantation window? SUMMARY ANSWER: The present study demonstrates that the expression of PECAM1 and TGF-β1 is significantly decreased in the mid-secretory endometrium in women with RIF, which may account for embryo implantation failure...
May 1, 2018: Human Reproduction
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