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MS OR Multiple Sclerosis

Wioletta Mikuľáková, Eleonóra Klímová, Lucia Kendrová, Miloslav Gajdoš, Marek Chmelík
BACKGROUND The objective of this study was to evaluate the effect of a rehabilitation program in changing the perception of fatigue in patients with multiple sclerosis. MATERIAL AND METHODS The study involved 65 respondents/patients with clinically confirmed multiple sclerosis (54 women, 11 men, average age 46.49 years). The evaluation of the effects of fatigue on the physical, psychological, and psychosocial aspects of life was assessed using the Modified Fatigue Impact Scale (MFIS). To test the effectiveness of the neurorehabilitation program, we enrolled 2 groups: the experimental group (EG, n=32, 29 women, 3 men, Expanded Disability Status Scale (EDSS) 4...
August 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Dejan Jakimovski, Matthew Topolski, Kana Kimura, Karen Marr, Sirin Gandhi, Deepa P Ramasamy, Niels Bergsland, Jesper Hagemeier, Bianca Weinstock-Guttman, Robert Zivadinov
BACKGROUND: Autonomic nervous system dysfunction has been previously observed in multiple sclerosis (MS) patients. OBJECTIVE: To assess associations between magnetic resonance imaging-detected neuroinflammatory and neurodegenerative pathology and postural venous flow changes indicative of autonomic nervous system function. METHODS: We used a standardized 3T magnetic resonance imaging protocol to scan 138 patients with MS and 49 healthy controls...
August 17, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
Rubika Balendra, Adrian M Isaacs
The discovery that repeat expansions in the C9orf72 gene are a frequent cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) has revolutionized our understanding of these diseases. Substantial headway has been made in characterizing C9orf72-mediated disease and unravelling its underlying aetiopathogenesis. Three main disease mechanisms have been proposed: loss of function of the C9orf72 protein and toxic gain of function from C9orf72 repeat RNA or from dipeptide repeat proteins produced by repeat-associated non-ATG translation...
August 17, 2018: Nature Reviews. Neurology
Wallace J Brownlee, Katherine A Miszkiel, Carmen Tur, Frederik Barkhof, David H Miller, Olga Ciccarelli
OBJECTIVE: To investigate the effect of including optic nerve involvement in dissemination in space (DIS) criteria for diagnosis of multiple sclerosis (MS) in patients with clinically isolated syndrome (CIS). METHODS: We studied 160 patients with CIS: 129 with optic neuritis (ON) and 31 with non-ON CIS. MRI brain/spinal cord was done at the time of presentation and a follow-up MRI brain after 3-12 months. We evaluated optic nerve involvement clinically or with visual evoked potentials (VEPs, n = 42)...
August 17, 2018: Neurology
Kassem Sharif, Abdulla Watad, Louis Coplan, Benjamin Lichtbroun, Alec Krosser, Michael Lichtbroun, Nicola Luigi Bragazzi, Howard Amital, Arnon Afek, Yehuda Shoenfeld
Stress is defined as the pscyophysiological reaction in which the steady state is disturbed or threatened. Stress is not always perceived as a negative response. Stress results when environmental demands exceed an individuals' adaptive capacities. Autoimmune diseases are heterogeneous group of chronic diseases which occur secondary to loss of self antigen tolerance. The etiopathogenesis of autoimmune disease is uncertain. Genetic factors as well as environmental factors appear to interplay, leading to a cascade of events resulting in disease onset...
August 14, 2018: Autoimmunity Reviews
Dalal Alali, Kirrie Ballard, Hans Bogaardt
BACKGROUND: Multiple Sclerosis (MS) refers to a chronic inflammation of the central nervous system including the brain and spinal cord. Dysphagia is one of the symptoms that represent challenges in clinical practice for the management of MS patients. Dysphagia can result in serious complications leading to morbidity and death in late stages of MS. However, little attention is given to dysphagia, its symptoms and how it affects the quality of life of adults with MS. OBJECTIVES: The purpose of this study is to identify the frequency of dysphagia in adults with MS and determine the main symptoms suggestive of dysphagia and its impact on the patients' quality of life...
August 8, 2018: Multiple Sclerosis and related Disorders
Irene Håkansson, Sandra Gouveia-Figueira, Jan Ernerudh, Magnus Vrethem, Nazdar Ghafouri, Bijar Ghafouri, Malin Nording
Although oxylipins are involved in inflammation, data on these lipid mediators in multiple sclerosis are sparse. In this study, a panel of oxylipins were analysed with liquid chromatography tandem mass spectrometry in cerebrospinal fluid (CSF) from 41 treatment naïve patients with clinically isolated syndrome (CIS) or relapsing remitting MS (RRMS) and 22 healthy controls. CSF levels of 9-hydroxyoctadecadienoic acid (9-HODE) and 13-hydroxyoctadecadienoic acid (13-HODE) were significantly higher in patients than in healthy controls (9-HODE median 380 nM (interquartile range 330-450 nM) in patients and 290 nM (interquartile range 250-340 nM) in controls, 13-HODE median 930 nM (interquartile range 810-1080 nM) in patients and 690 nM (interquartile range 570-760 nM) in controls, p < 0...
August 14, 2018: Prostaglandins & Other Lipid Mediators
Kennosuke Yorifuji, Yuko Uemura, Shinji Horibata, Goh Tsuji, Yoko Suzuki, Kazuya Miyagawa, Kazuhiko Nakayama, Ken-Ichi Hirata, Shunichi Kumagai, Noriaki Emoto
Bosentan, an endothelin receptor antagonist, has been widely used as a first-line drug for the treatment of pulmonary arterial hypertension (PAH). In addition, bosentan is approved for patients with digital ulcers related to systemic sclerosis. Liver dysfunction is a major adverse effect of bosentan and may lead to discontinuation of therapy. The purpose of this study was to identify genomic biomarkers to predict bosentan-induced liver injury. A total of 69 PAH patients were recruited into the study. An exploratory analysis of 1,936 single-nucleotide polymorphisms (SNPs) in 231 genes involved in absorption, distribution, metabolism, and elimination of multiple medications using Affimetrix DMET™ (Drug Metabolism Enzymes and Transporters) chips was performed...
August 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Stephen G Reich
Russell Nelson DeJong (1907-1990) became professor and chair of the Department of Neurology at the University of Michigan in 1950. A prolific author with more than 200 publications, DeJong wrote on virtually all areas of neurology. DeJong's classic monograph, The Neurologic Examination (1950), grew into an encyclopedic volume from lectures he gave to junior and senior medical students; DeJong saw it through four editions. He was one of the founders of the American Academy of Neurology (AAN), serving as its vice-president from 1961 to 1963 and as the first editor-in-chief of its journal, Neurology...
July 2018: Journal of the History of the Neurosciences
Laura Zamarian, Margarete Delazer, Rainer Ehling, Marie-Theres Pertl, Gabriel Bsteh, Johanna Wenter, Susanne Glatzl, Christian Brenneis, Thomas Benke, Thomas Berger
BACKGROUND: People with multiple sclerosis (MS) have to face important decisions with regard to their medical treatment. OBJECTIVE: To evaluate whether a targeted cognitive training reduces framing effects and thus improves medical judgements. METHODS: This was a randomised, double-blind, cross-over study enrolling relapsing-remitting MS (RRMS) patients and healthy controls (HC). Participants were randomly assigned to training order A (first week: numerical training, second week: control training) or B (reverse order)...
August 17, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Ilana Katz Sand
PURPOSE OF REVIEW: This review seeks to examine current research related to the role of diet in multiple sclerosis (MS). RECENT FINDINGS: Recent research in preclinical models, epidemiologic studies, and limited prospectively followed cohorts provide preliminary evidence that dietary factors influence MS incidence, disease course, and symptomatology. Current evidence for the effects of fatty acids, fruits and vegetables, whole grains, dairy, and salt are reviewed...
August 16, 2018: Current Nutrition Reports
Marcus D'Souza, Saskia Steinheimer, Jonas Dorn, Cecily Morrison, Jacques Boisvert, Kristina Kravalis, Jessica Burggraaff, Caspar Ep van Munster, Manuela Diederich, Abigail Sellen, Christian P Kamm, Frank Dahlke, Bernard Mj Uitdehaag, Ludwig Kappos
Motor dysfunction, particularly ataxia, is one of the predominant clinical manifestations in patients with multiple sclerosis (MS). Assessment of motor dysfunction suffers from a high variability. We investigated whether the clinical rating of ataxia can be improved through the use of reference videos, covering the spectrum of severity degrees as defined in the Neurostatus-Expanded Disability Status Scale. Twenty-five neurologists participated. The variability of their assessments was significantly lower when reference videos were used (SD = 0...
July 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Jindapa Srikajon, Sasitorn Siritho, Chanon Ngamsombat, Naraporn Prayoonwiwat, Niphon Chirapapaisan
Background: Optic neuritis (ON) is one of the common manifestations both in neuromyelitis-optica spectrum disorders (NMOSD) and in multiple sclerosis (MS). Objectives: The objective of this paper is to compare clinical presentations, laboratories and imaging findings in ON associated with MS and NMOSD. Methods: A retrospective chart review was performed in patients presenting with ON in 59 NMOSD patients with 72 eyes' involvement and 163 ON attacks, and 20 MS patients with 23 eyes' involvement and 36 ON attacks...
July 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Lara Diem, Krassen Nedeltchev, Timo Kahles, Lutz Achtnichts, Oliver Findling
Background: Natalizumab significantly reduces the disease activity in patients with relapsing-remitting multiple sclerosis but due to the risk of progressive multifocal leukoencephalopathy it is often discontinued. Fingolimod is seen as an alternative, but there are no long-term analyses of the efficacy of fingolimod in this setting using the no evidence of disease activity (NEDA)-3 criteria. We provide an assessment of patients who discontinued natalizumab and switched to fingolimod or other treatments by evaluating the proportion of patients who fulfil NEDA-3 criteria after prolonged follow-up periods...
2018: Therapeutic Advances in Neurological Disorders
Manish Verma, Zachary Wills, Charleen T Chu
Dysregulation of calcium homeostasis has been linked to multiple neurological diseases. In addition to excitotoxic neuronal cell death observed following stroke, a growing number of studies implicate excess excitatory neuronal activity in chronic neurodegenerative diseases. Mitochondria function to rapidly sequester large influxes of cytosolic calcium through the activity of the mitochondrial calcium uniporter (MCU) complex, followed by more gradual release via calcium antiporters, such as NCLX. Increased cytosolic calcium levels almost invariably result in increased mitochondrial calcium uptake...
2018: Frontiers in Neuroscience
Elisabet Guillamó, Álvaro Cobo-Calvo, Guillermo R Oviedo, Noémie Travier, Juan Álamo, Oscar A Niño-Mendez, Antonio Martínez-Yelamos, Sergio Martínez-Yelamos, Casimiro Javierre
Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS...
September 2018: Journal of Sports Science & Medicine
(no author information available yet)
No abstract text is available yet for this article.
August 2018: Australian Prescriber
Felix P Bernhard, Jennifer Sartor, Kristina Bettecken, Markus A Hobert, Carina Arnold, Yvonne G Weber, Sven Poli, Nils G Margraf, Christian Schlenstedt, Clint Hansen, Walter Maetzler
BACKGROUND: Deficits in gait and balance are common among neurological inpatients. Currently, assessment of these patients is mainly subjective. New assessment options using wearables may provide complementary and more objective information. METHODS: In this prospective cross-sectional feasibility study performed over a four-month period, all patients referred to a normal neurology ward of a university hospital and aged between 40 and 89 years were asked to participate...
August 16, 2018: BMC Neurology
Gemma Clarke, Elizabeth Fistein, Anthony Holland, Jake Tobin, Sam Barclay, Stephen Barclay
BACKGROUND: Dysphagia and other eating and drinking difficulties are common in progressive neurological diseases. Mealtimes can become a major source of difficulty and anxiety for patients and their families. Decisions about eating, drinking and care can become challenging as disease progresses, and the person in question loses the capacity to participate in decisions about their own care. We sought to investigate how patients and their family members make decisions about their future care as their condition deteriorates, with a particular focus on mealtimes, eating and drinking...
August 16, 2018: BMC Neurology
Romina Dastmalchi, Soudeh Ghafouri-Fard, Mir Davood Omrani, Mehrdokht Mazdeh, Arezou Sayad, Mohammad Taheri
Multiple sclerosis (MS) is a chronic autoimmune disorder in which dysregulation or aberrant expressions of several immune-related genes have been noted. More recently, the participation of long non-coding RNAs (lncRNAs) in regulation of immune responses has been highlighted. In the present study, we evaluated expression levels of three lncRNAs named Nuclear Paraspeckle Assembly Transcript 1 (NEAT1), P21 associated ncRNA DNA damage activated (PANDA) and Taurine-up-regulated gene 1 (TUG1) in peripheral blood of 50 relapsing-remitting MS patients and 50 matched healthy subjects...
August 1, 2018: Multiple Sclerosis and related Disorders
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