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Bispebjerg Hospital

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https://www.readbyqxmd.com/read/29950475/protocol-for-meal-time-administration-of-exenatide-for-glycaemic-control-in-type-1-diabetes-cases-the-mag1c-trial-a-randomised-double-blinded-placebo-controlled-trial
#1
Nicklas Järvelä Johansen, Thomas Fremming Dejgaard, Asger Lund, Tina Vilsbøll, Henrik Ullits Andersen, Filip Krag Knop
INTRODUCTION: Persons with type 1 diabetes require intensive insulin therapy to achieve glycaemic control, but side effects, including hypoglycaemia and weight gain, may reduce treatment compliance. We hypothesise that add-on treatment of the short-acting glucagon-like peptide-1 receptor agonist, exenatide, to insulin therapy in persons with type 1 diabetes will reduce insulin requirements, glycaemic excursions and body weight and improve glycaemic control without increasing the risk of hypoglycaemia...
June 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29864988/pain-assessment-and-post-operative-pain-management-in-orthopedic-patients
#2
W Schmelling, J N Poulsen, L Christrup, P Gazerani
Aims A fast-track based surgical treatment reduces morbidity and hospital stay by providing early mobilization. Sufficient postoperative pain management is mandatory for early mobilization and optimal utilization of rehabilitation measures. Insufficient postoperative pain management is however a widespread problem. Lack of knowledge about pain and pain treatment among health care professionals and general community has been considered as a major potential contributor in insufficient pain management. It has been suggested that severe postoperative pain might imply a potential risk of developing chronic pain...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29393044/early-warning-score-challenges-and-opportunities-in-the-care-of-deteriorating-patients
#3
REVIEW
John Asger Petersen
Clinical deterioration of patients hospitalized on general wards is often preceded by worsening vital signs. If identified early and acted upon quickly, it is conjectured that further deterioration can be prevented. To this means the early warning score (EWS) was implemented in all hospitals in the Capital Region of Denmark in 2013. EWS consists of an aggregated weighted track-and-trigger system (TTS), to identify at-risk patients early, and a treatment protocol to escalate care appropriately and determine the level of competency of the provider...
February 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29344612/association-of-disease-severity-with-skin-microbiome-and-filaggrin-gene-mutations-in-adult-atopic-dermatitis
#4
Maja-Lisa Clausen, Tove Agner, Berit Lilje, Sofie M Edslev, Thor Bech Johannesen, Paal Skytt Andersen
Importance: Skin microbiome correlates with disease severity for lesional and nonlesional skin, indicating a global influence of atopic dermatitis (AD). A relation between skin microbiome and filaggrin gene (FLG) mutations proposes a possible association between skin microbiome and host genetics. Objectives: To assess skin and nasal microbiome diversity and composition in patients with AD and compare with healthy controls, and to investigate the microbiome in relation to disease severity and FLG mutations in patients with AD...
March 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29314088/hyperkeratotic-hand-eczema-compared-to-other-subgroups-of-hand-eczema-a-retrospective-study-with-a-follow-up-questionnaire
#5
COMPARATIVE STUDY
Janique van der Heiden, Tove Agner, Thomas Rustemeyer, Kim K B Clemmensen
BACKGROUND: Only a few clinical trials on hand eczema have included further classification into subtypes, and there is a need for studies evaluating the present classifications. OBJECTIVES: To examine differences in demographic factors, lifestyle factors and severity between subgroups of hand eczema patients, with a focus on hyperkeratotic hand eczema. METHODS: This was a retrospective study including hand eczema patients referred to the outpatient dermatological clinic, Bispebjerg Hospital, between January 2013 and July 2014...
March 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29201290/ergospirometry-with-concurrent-fibre-optic-laryngoscopy-a-randomised-crossover-study
#6
Kiran Kafila Mirza, Emil Schwarz Walsted, Vibeke Backer
Background : Patients suffering from exercise-induced laryngeal obstruction (EILO) are subjected to several exhausting tests. We aimed to assess the feasibility of using a single test to obtain diagnostic measurements for maximum oxygen uptake (VO2 max) and exercise-induced laryngeal obstruction (EILO). Methods : Patients referred to the outpatient respiratory clinic at the University Hospital of Bispebjerg, Copenhagen with exercise-induced dyspnoea were evaluated for inclusion over 13 months. Eligible patients were aged 18-43 years, had a known EILO diagnosis (moderate or severe) and were inactive (self-reported activity) with less than 3 hours activity per week...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28675915/risk-factors-for-premature-death-in-diabetes-patients-who-undergo-amputations-below-ankle-level
#7
Therese E Wilbek, Rasmus B Jansen, Bo Jørgensen, Ole Lander Svendsen
AIM: To identify risk factors for early death in diabetes patients who undergo amputations below the ankle. METHODS: A retrospective study, where all hospital records of all diabetes patients who had undergone minimum one amputation below the ankle at the CWHC Bispebjerg Hospital, Denmark, in the period 1996-2013, were examined. The amputations were mainly trans-metatarsal amputations and partial amputations of toes. The participants were found via ICD10-codes. The included patients were followed from their first contact to the last registered contact...
January 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28594722/treatment-of-complex-fistula-in-ano-with-a-nitinol-proctology-clip
#8
Andreas Nordholm-Carstensen, Peter-Martin Krarup, Kikke Hagen
BACKGROUND: The treatment of complex anocutaneous fistulas remains a major therapeutic challenge balancing the risk of incontinence against the chance of permanent closure. OBJECTIVE: The purpose of this study was to investigate the efficacy of a nitinol proctology clip for closure of complex anocutaneous fistulas. DESIGN: This is a single-center cohort study with retrospective analysis of all of the treated patients. SETTINGS: Data were obtained from patient records and MRI reports, as well as follow-up telephone calls and clinical follow-up with endoanal ultrasonography...
July 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28349226/colonic-diverticulosis-is-associated-with-abdominal-wall-hernia
#9
E Oma, L N Jorgensen, S Meisner, N A Henriksen
PURPOSE: Colonic diverticulosis and abdominal wall hernia are common pathologies. Studies have suggested that connective tissue alterations play a role in the formation of both diverticulosis and abdominal wall hernia. The aim of this cohort study was to evaluate the association between diverticulosis and abdominal wall hernia in a large cohort of patients undergoing colonoscopy. METHODS: All consecutive patients who underwent colonoscopy between 2001 and 2013 at Bispebjerg Hospital were eligible for inclusion...
August 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28288465/atlas-of-illustrative-cases-of-tattoo-complications
#10
Jørgen Serup
Tattoos, and tattoo complications as well, are colorful and visually flashy. A clinical outlook provides important clues to diagnosis by pattern recognition. This atlas,which is a report of 79 case illustrations, is made as a practical tool and vade mecum for the clinician. The atlas can be used in the office and as a bedside tool. It includes characteristic photos, and each case is accompanied with a brief medical history, a comment with learning points, the final diagnosis, and a review of therapeutic options...
2017: Current Problems in Dermatology
https://www.readbyqxmd.com/read/28166524/papulo-nodular-reactions-in-black-tattoos-as-markers-of-sarcoidosis-study-of-92-tattoo-reactions-from-a-hospital-material
#11
Mitra Sepehri, Katrina Hutton Carlsen, Jørgen Serup
BACKGROUND/AIMS: Sarcoidosis is, from historical data, suggested to be more prevalent among patients with tattoo reactions. We aimed to evaluate this association in a systematic study. METHODS: This is a consecutive study of patients with tattoo complications, diagnosed in the "Tattoo Clinic" at Bispebjerg University Hospital in Copenhagen, Denmark, from 2008 to 2015, based on clinical assessment and histology. From the overall group of 494 tattoo complications in 406 patients, 92 reactions in 72 patients showed a papulo-nodular pattern studied for local and systemic sarcoidosis, since sarcoidosis is expected to be nodular...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28146245/comparison-of-physical-pretreatment-regimens-to-enhance-protoporphyrin-ix-uptake-in-photodynamic-therapy-a-randomized-clinical-trial
#12
RANDOMIZED CONTROLLED TRIAL
Christiane Bay, Catharina Margrethe Lerche, Bradford Ferrick, Peter Alshede Philipsen, Katrine Togsverd-Bo, Merete Haedersdal
Importance: Skin pretreatment is recommended for adequate penetration of topical photosensitizing agents and subsequent protoporphyrin IX (PPIX) accumulation in photodynamic therapy (PDT). Objective: To compare the relative potential of different physical pretreatments to enhance PPIX fluorescence in normal skin. Design, Setting, and Participants: This intraindividual, randomized clinical trial was performed from November 28 to December 20, 2014, at Bispebjerg Hospital, Copenhagen, Denmark, among 12 healthy volunteers 18 years or older...
April 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28137495/the-impact-of-dysfunctional-breathing-on-the-assessment-of-asthma-control
#13
Sandra Veidal, Maria Jeppegaard, Asger Sverrild, Vibeke Backer, Celeste Porsbjerg
BACKGROUND AND OBJECTIVE: Dysfunctional breathing (DB) is a respiratory disorder, which involves a pattern of breathing too deeply, too superficially and/or too rapidly. In asthma patients, DB may lead to an overestimation of the severity of asthma symptoms, and hence potentially to overtreatment. However, it is not known to which degree DB may affect estimates of asthma control, in a specialist clinical setting. METHODS: The MAPOut-study examined all patients referred consecutively over a 12-months period for specialist assessment of asthma at the Respiratory Outpatient Clinic at Bispebjerg Hospital in Copenhagen...
February 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27974717/classification-of-tattoo-complications-in-a-hospital-material-of-493-adverse-events
#14
Jørgen Serup, Mitra Sepehri, Katrina Hutton Carlsen
BACKGROUND/AIMS: Tattooing is a global trend. Clinical knowledge of complications is based on case reports collected over a century. Larger cohorts reflecting complications associated with contemporary trends are lacking. METHODS: The study was a retrospective review of a consecutive cohort of patients with tattoo complications diagnosed in the "Tattoo Clinic" of Bispebjerg University Hospital in Copenhagen, Denmark, from 2008 to 2015, based on patient history and systematic clinical examination...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27847679/opioid-usage-during-admission-in-hip-fracture-patients-the-effect-of-the-continuous-femoral-nerve-block
#15
Ida Helsø, Christopher Jantzen, Jes Bruun Lauritzen, Henrik Løvendahl Jørgensen
INTRODUCTION: The aim of this study was to investigate whether there was a difference in opioid usage during admission for hip fracture patients with continuous femoral nerve block (cFNB) when compared to patients nonfemoral nerve block (nFNB). METHODS AND MATERIALS: Patients were identified from the local database on all hip fracture patients admitted to Bispebjerg University Hospital, Denmark. Four hundred fifty-six hip fracture patients were included during the period September 2008 to October 2010...
December 2016: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/27685872/clinical-pharmacology-in-denmark-in-2016-40-years-with-the-danish-society-of-clinical-pharmacology-and-20-years-as-a-medical-speciality
#16
REVIEW
Kim Brøsen, Stig Ejdrup Andersen, Jeanett Borregaard, Hanne Rolighed Christensen, Palle Mark Christensen, Kim Peder Dalhoff, Per Damkier, Jesper Hallas, Jens Heisterberg, Niels Jessen, Gesche Jürgens, Jens Peter Konnerup Kampmann, Britt Elmedal Laursen, Torben Laursen, Lars Peter Nielsen, Birgitte Klindt Poulsen, Henrik Enghusen Poulsen, Ljubica Vukelic Andersen, Thomas Senderovitz, Jesper Sonne
The Danish Society of Clinical Pharmacology was founded in 1976, and mainly thanks to the persistent efforts of the society, clinical pharmacology became an independent medical speciality in Denmark in 1996. Since then, clinical pharmacology has gone from strength to strength. In the Danish healthcare system, clinical pharmacology has established itself as an indispensible part of the efforts to promote the rational, safe and economic use of drugs. Clinical pharmacologists are active in drug committees both in hospitals and in the primary sector...
December 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27551568/low-levels-of-hemoglobin-at-admission-are-associated-with-increased-30-day-mortality-in-patients-with-hip-fracture
#17
Katrine Praetorius, Christian M Madsen, Bo Abrahamsen, Henrik L Jørgensen, Jes B Lauritzen, Anne Sofie B Laulund
INTRODUCTION: Previous smaller studies suggest that anemia is a risk factor for mortality in patients with hip fracture. The purpose of this investigation was to assess the correlation between hemoglobin at admission with 30-day mortality following a hip fracture in a large-scale study. PATIENTS AND METHODS: From January 1996 to December 2012, all patients with hip fracture (>60 years of age) admitted to Bispebjerg Hospital, Copenhagen, were identified from a local hip fracture database...
September 2016: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/27437920/the-diabetic-foot-in-a-multidisciplinary-team-setting-number-of-amputations-below-ankle-level-and-mortality
#18
T E Wilbek, R B Jansen, B Jørgensen, O L Svendsen
Aim: To describe the number of minor lower extremity amputations and mortality for diabetes patients treated by a specialized multidisciplinary foot care team. Methods: A retrospective descriptive study of medical records from patients with diabetes treated with minor amputations at the Copenhagen Wound Healing Center (CWHC) at Bispebjerg Hospital from 1996-2013. Results: 777 diabetes patients treated with minor amputations were included. 77% were males and 23% were females. 80% had T2 diabetes and 20% had T1 diabetes...
October 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27366896/dynamic-optical-coherence-tomography-capillaroscopy-a-new-imaging-tool-in-autoimmune-connective-tissue-disease
#19
Hans Christian Ring, Lotte Themstrup, Christina Alette Banzhaf, Gregor B E Jemec, Mette Mogensen
Importance: Vasculopathy characterized by functional and structural abnormalities of the microcirculation plays an important role in systemic sclerosis and dermatomyositis. Although there are several advantages in using capillaroscopy, the method does not offer insight on the skin architecture, flow status, or morphology of the deeper dermal vessels. Dynamic optical coherence tomography (D-OCT) is a recently developed OCT technique that enables detection of high-speed changes in back-scattered light caused by moving cells in vessels...
October 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27239379/orthogeriatric-service-reduces-mortality-in-patients-with-hip-fracture
#20
Charlotte Stenqvist, Christian Medom Madsen, Troels Riis, Henrik Løvendahl Jørgensen, Benn Rønnow Duus, Jes Bruun Lauritzen, Susanne van der Mark
INTRODUCTION: Orthogeriatric service has been shown to improve outcomes in patients with hip fracture. The purpose of this study is to evaluate the effect of orthogeriatrics at Bispebjerg University Hospital, Denmark. The primary outcome is mortality inhospital and after 1, 3, and 12 months for patients with hip fracture. The secondary outcome is mortality for home dwellers and nursing home inhabitants. MATERIALS AND METHODS: This is a retrospective clinical cohort study with an historic control group including all patients with hip fracture admitted from 2007 to 2011...
June 2016: Geriatric Orthopaedic Surgery & Rehabilitation
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