Giuseppe Fanelli, Barbara Franke, Chiara Fabbri, Josefin Werme, Izel Erdogan, Ward De Witte, Geert Poelmans, I Hyun Ruisch, Lianne Maria Reus, Veerle van Gils, Willemijn J Jansen, Stephanie J B Vos, Kazi Asraful Alam, Aurora Martinez, Jan Haavik, Theresa Wimberley, Søren Dalsgaard, Ábel Fóthi, Csaba Barta, Fernando Fernandez-Aranda, Susana Jimenez-Murcia, Simone Berkel, Silke Matura, Jordi Salas-Salvadó, Martina Arenella, Alessandro Serretti, Nina Roth Mota, Janita Bralten
UNLABELLED: The co-occurrence of insulin resistance (IR)-related metabolic conditions with neuropsychiatric disorders is a complex public health challenge. Evidence of the genetic links between these phenotypes is emerging, but little is currently known about the genomic regions and biological functions that are involved. To address this, we performed Local Analysis of [co]Variant Association (LAVA) using large-scale (N=9,725-933,970) genome-wide association studies (GWASs) results for three IR-related conditions (type 2 diabetes mellitus, obesity, and metabolic syndrome) and nine neuropsychiatric disorders...
March 8, 2024: medRxiv