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https://www.readbyqxmd.com/read/30538772/brain-theranostics-and-radiotheranostics-exosomes-and-graphenes-in-vivo-as-novel-brain-theranostics
#1
REVIEW
Minseok Suh, Dong Soo Lee
Brain disease is one of the greatest threats to public health. Brain theranostics is recently taking shape, indicating the treatments of stroke, inflammatory brain disorders, psychiatric diseases, neurodevelopmental disease, and neurodegenerative disease. However, several factors, such as lack of endophenotype classification, blood-brain barrier (BBB), target determination, ignorance of biodistribution after administration, and complex intercellular communication between brain cells, make brain theranostics application difficult, especially when it comes to clinical application...
December 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30526469/dpp-iv-inhibitory-phenanthridines-ligand-structure-based-design-and-synthesis
#2
Reema Abu Khalaf, Dalal Masalha, Dima Sabbah
BACKGROUND: Lately, diabetes has become a main health concern for millions of people around the world. Dipeptidyl peptidase-IV (DPP-IV) inhibitors have emerged as a new class of oral antidiabetic agents. Formerly, acridines, N4-sulfonamido-succinamic, phthalamic, acrylic and benzoyl acetic acid derivatives, and sulfamoyl-phenyl acid esters were designed and developed as new DPP-IV inhibitors. OBJECTIVE: This study aims to develop a pharmacophore model of DPP-IV inhibitors and to evaluate phenanthridines as a novel scaffold for inhibiting DPP-IV enzyme...
December 10, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/30523721/quantum-dot-induced-acute-changes-in-lung-mechanics-are-mouse-strain-dependent
#3
David K Scoville, Collin C White, Dianne Botta, Dowon An, Zahra Afsharinejad, Theo K Bammler, Xiaohu Gao, William A Altemeier, Terrance J Kavanagh
INTRODUCTION: Concerns have been raised regarding occupational exposure to engineered nanomaterials (ENMs). Potential impacts on lung function from inhalation exposures are of concern as the lung is a sensitive ENM target in animals. Epidemiological data suggest that occupational exposure to ENMs may impact respiratory and cardiovascular health. Quantum dots (QDs) are ENMs with outstanding semiconductor and fluorescent properties with uses in biomedicine and electronics. QDs are known to induce inflammation and cytotoxicity in rodents and high dose exposures impact lung function 2 weeks after exposure...
December 7, 2018: Inhalation Toxicology
https://www.readbyqxmd.com/read/30516708/beyond-a-single-country-s-borders-trade-in-services-uncovered-through-bibliometrics
#4
David C Benton, Stephanie L Ferguson
We live and work in an increasingly connected global environment where actions in one part of the world can have consequences for all of us. This article examines, through the use of bibliometric analysis, the extent to which nursing scholars are engaged in the policy debate surrounding trade in services. Results demonstrate that, in comparison to medical colleagues, the nursing profession is more regionally orientated, focused on more operational-based themes and orientated to Mode 4: Mobility of the Profession...
January 2019: Nursing Administration Quarterly
https://www.readbyqxmd.com/read/30453146/determinants-of-antenatal-care-utilization-in-india-a-spatial-evaluation-of-evidence-for-public-health-reforms
#5
A E John, Nilima, V S Binu, B Unnikrishnan
OBJECTIVE: The objective is to examine the spatial variations and to identify the determinants of antenatal care (ANC) utilization while controlling for the spatial dependence in the data. STUDY DESIGN: This is an ecological study on ANC utilization data from District Level Household Survey-4 (2012-2013) in India. METHODS: A secondary data analysis was performed on the derived data. The unit of analysis in this ecological study was 275 districts from 20 states of India...
November 16, 2018: Public Health
https://www.readbyqxmd.com/read/30452266/encapsulation-of-the-sulfur-compounds-by-cucurbit-7-uril-a-quantum-chemistry-study
#6
Osmair Vital de Oliveira, Gabriela de Carvalho Costa, Luciano T Costa
Benzothiophene (BT) and dibenzothiophene (DT) are the most important contaminants in the petroleum derivatives responsible for serious environmental and health problems. Therefore, we have investigated the absorption of these compounds by the first time considering cucurbit[7]uril (CB[7]) as the host molecule and using DFT//B3LYP-D3/6-31G(d) level of theory. The BT and DT absorbed into CB[7] do not undergo a significant structural change in the CB[7] structure. The energy gap of the S-compounds@CB[7] in water and hexane solvents was approximately of 5 eV, and this large value implies that the complexes have high chemical stability...
November 19, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/30405250/research-on-opioid-substitution-therapy-in-india-a-brief-narrative-review
#7
REVIEW
Atul Ambekar, Ravindra Rao, Alok Agrawal, Preethy Kathiresan
Opioid dependence is a significant clinical and public health issue in India. Opioid substitution therapy (OST) is the most evidence-based treatment for opioid dependence. Although available in India for about three decades now, Indian research on this treatment modality has not been adequately reviewed so far. We conducted a narrative review of Indian research on OST. We conducted an online search for relevant literature in the peer-reviewed journals as well as the general online search for books and monographs...
July 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/30372020/nitride-based-microarray-biochips-a-new-route-of-plasmonic-imaging
#8
Fan-Ching Chien, Jen-Long Lo, Xingwang Zhang, Ertugrul Cubukcu, Yu-Tang Luo, Kai-Lin Huang, Xiaofang Tang, Chien-Sheng Chen, Chii-Chang Chen, Kun-Yu Lai
The desire to improve human lives has led to striking development in biosensing technologies. While the ongoing research efforts are mostly dedicated to enhancing speed and sensitivity of the sensor, a third consideration that has become increasingly important is compactness, which is strongly desired in emergency situations and personal health management. Surface plasmon resonance imaging (SPRi) is one of the few techniques that can potentially fulfill all the three goals, considering its multiplexed assay capability...
November 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30370758/the-role-of-colloidal-stability-and-charge-in-functionalization-of-aqueous-quantum-dots
#9
Preston T Snee
Semiconductor quantum dots (QDs), also known as nanocrystals, have unique photophysical properties that have allowed them to find utility in many applications, including television and display technologies. They also have significant potential as imaging agents in the biomedical field. To gain the most value from the use of QDs as health-related fluorescent probes, they must be biologically targetable and sensitive to metabolic analytes such as pH and O2 , and the resulting signal must be quantifiable. To achieve these goals, QDs need to be conjugated to vectors such as antibodies or environmentally sensitive chromophores...
October 29, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/30360232/glutathione-capped-cdse-quantum-dots-synthesis-characterization-morphology-and-application-as-a-sensor-for-toxic-metal-ions
#10
Long Giang Bach, Trinh Duy Nguyen, Nguyen Thi Thuong, Ho Thi Thanh Van, Kwon Taek Lim
Glutathione (GSH) functionalized CdSe quantum dots (QDs) (GSH- f -CdSe QDs) were prepared via a simple one-pot strategy at low temperature. The as-synthesized CdSe QDs were characterized by FT-IR and XPS analyses. The morphology, physical structure and size distribution of GSH- f -CdSe QDs were investigated by TEM, XRD and DLS analyses, respectively. The GSH- f -CdSe QDs exhibited excellent stability of optical properties as investigated by UV-Vis absorption and photoluminescence (PL) spectroscopy. The high affinity of GSH towards heavy metal ions made the GSH- f -CdSe QDs quite susceptible to Pb2+ ion which poses serious threat to the health and environment...
February 1, 2019: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/30346792/nanothermometry-reveals-calcium-induced-remodeling-of-myosin
#11
Eric R Kuhn, Akshata R Naik, Brianne E Lewis, Keith M Kokotovich, Meishan Li, Timothy L Stemmler, Lars Larsson, Bhanu P Jena
Ions greatly influence protein structure-function and are critical to health and disease. A 10, 000-fold higher calcium in the sarcoplasmic reticulum (SR) of muscle suggests elevated calcium levels near active calcium channels at the SR membrane and the impact of localized high calcium on the structure-function of the motor protein myosin. In the current study, combined quantum dot (QD)-based nanothermometry and circular dichroism (CD) spectroscopy enabled detection of previously unknown enthalpy changes and associated structural remodeling of myosin, impacting its function following exposure to elevated calcium...
November 14, 2018: Nano Letters
https://www.readbyqxmd.com/read/30346163/neolignans-from-red-raspberry-rubus-idaeus-l-exhibit-enantioselective-neuroprotective-effects-against-h-2-o-2-induced-oxidative-injury-in-sh-sy5y-cells
#12
Le Zhou, Guo-Dong Yao, Li-Wei Lu, Xiao-Yu Song, Bin Lin, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song
Red raspberry has been well-known for its nutritional purpose. Although this fruit has been reported for its potent antioxidant activity and health-promoting properties, systematic studies responsible for the bioactive constituents were still insufficient. In the current study, three pairs of dihydrobenzofuran-type enantiomeric neolignans (1a/1b-3a/3b), including two new compounds (1b and 2a), were isolated from the fruit of Rubus idaeus. The structures of these enantiomers were determined through spectroscopic methods and quantum mechanical calculations...
October 31, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/30329158/influence-of-sudden-salinity-variation-on-the-physiology-and-domoic-acid-production-by-two-strains-of-pseudo-nitzschia-australis
#13
Nour Ayache, Fabienne Hervé, Véronique Martin-Jézéquel, Zouher Amzil, Amandine M N Caruana
Several coastal countries including France have experienced serious and increasing problems related to Pseudo-nitzschia toxic blooms. These toxic blooms occur in estuarine and coastal waters potentially subject to fluctuations in salinity. In this study, we document for the first time the viability, growth, photosynthetic efficiency, and toxin production of two strains of Pseudo-nitzschia australis grown under conditions with sudden salinity changes. Following salinity variation, the two strains survived over a restricted salinity range of 30-35, with favorable physiological responses, as the growth, effective quantum yield and toxin content were high compared to the other conditions...
October 17, 2018: Journal of Phycology
https://www.readbyqxmd.com/read/30316175/factors-associated-with-home-births-in-a-selected-ward-in-mberengwa-district-zimbabwe
#14
Wilfred Njabulo Nunu, Vuyelwa Ndlovu, Auther Maviza, Moreblessings Moyo, Oliver Dube
OBJECTIVE: Despite many efforts put by the Government to ensure that women give birth in health facilities under trained personnel supervision; statistics suggest that ward 2 in Mberengwa District in Zimbabwe has the highest home births. This study sought to assess factors that are associated with home births in ward 2 of Mberengwa District in Zimbabwe. DESIGN: Case- control. SETTING: Ward 2 in Mberengwa District in Zimbabwe. PARTICIPANTS: 35 and 105 women who gave birth at home and facilities, respectively...
October 3, 2018: Midwifery
https://www.readbyqxmd.com/read/30307113/ratiometric-fluorescence-nanosensors-based-on-core-shell-structured-carbon-cdte-quantum-dots-and-surface-molecularly-imprinted-polymers-for-the-detection-of-sulfadiazine
#15
Xiaoqiang Chen, Yu Luan, Ningwei Wang, Zhiping Zhou, Xiaoni Ni, Yunfei Cao, GuangShe Zhang, Yufeng Lai, Wenming Yang
Sulfadiazine is an environmental pollutant derived from abuse of antibiotics. Its content in environmental water is closely related to human health. Thus, a novel dual-emission surface molecularly imprinted nanosensor is designed for the specific adsorption and detection of sulfadiazine. In the system, blue emissive carbon quantum dots wrapped with silica served as the internal reference signal for eliminating background interference, while red emissive thioglycolic acid modified CdTe quantum dots (CdTe QDs), which are low dimensional semiconductor materials by the combination of cadmium and tellurium with excellent optical properties, were encapsulated in the imprinted layer to offer recognition signal...
October 11, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/30285766/conceptualising-production-productivity-and-technology-in-pharmacy-practice-a-novel-framework-for-policy-education-and-research
#16
D Baines, I Bates, L Bader, C Hale, P Schneider
CONTEXT AND BACKGROUND: People and health systems worldwide face serious challenges due to shifting disease demographics, rising population demands and weaknesses in healthcare provision, including capacity shortages and lack of impact of healthcare services. These multiple challenges, linked with the global push to achieve universal health coverage, have made apparent the importance of investing in workforce development to improve population health and economic well-being. In relation to medicines, health systems face challenges in terms of access to needed medicines, optimising medicines use and reducing risk...
October 3, 2018: Human Resources for Health
https://www.readbyqxmd.com/read/30283997/a-signal-on-electrochemiluminescence-sensor-for-clenbuterol-detection-based-on-zinc-based-metal-organic-framework-reduced-graphene-oxide-cdte-quantum-dot-hybrids
#17
Xiaoxia Hu, Han Zhang, Shihong Chen, Ruo Yuan, Junhao You
Clenbuterol (CLB) is harmful to human health when used long term, and it has been listed by the World Anti-Doping Agency (WADA). In this work, a novel zinc-based metal-organic frameworks-reduced graphene oxide-CdTe quantum dots (ZnMOF-RGO-CdTe QDs) hybrid was used to construct an electrochemiluminescence (ECL) sensor for detecting CLB. CdTe QDs, loaded by RGO, exhibited an enhanced ECL signal. In addition, the ZnMOFs catalyzed OH• generation by coreactant H2 O2 , which further strengthened the ECL signal of the CdTe QDs...
October 3, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/30227840/long-term-psychiatric-inpatients-perspectives-on-weight-gain-body-satisfaction-diet-and-physical-activity-a-mixed-methods-study
#18
Susanna Every-Palmer, Mark A Huthwaite, Jane L Elmslie, Eve Grant, Sarah E Romans
BACKGROUND: Obesity is a significant problem for people with serious mental illness. We aimed to consider body size from the perspective of long-stay psychiatric inpatients, focussing on: weight gain and its causes and impacts; diet and physical activity; and the perceived ability to make meaningful change in these domains. METHOD: A mixed methods study with 51 long-term psychiatric forensic and rehabilitation inpatients using semi-structured interviews combined with biometric and demographic data...
September 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/30184800/quantum-dots-attached-to-graphene-oxide-for-sensitive-detection-of-ascorbic-acid-in-aqueous-solutions
#19
Nandhini Arumugam, JongSung Kim
Water-soluble fluorescent carboxyl-functionalized CdSe-ZnS quantum dots (QDs) were immobilized on graphene oxide (GO) and used for sensitive detection of ascorbic acid in aqueous solutions. QDs were attached to the surface of graphene oxide using the EDC/NHS-sulfo coupling reaction. Ascorbic acid is known as an antioxidant. It plays a crucial role in health maintenance, bio synthetic pathways such as formation of collagen and regulates immune system. The photoluminescence (PL) intensity of as-prepared GO-QD hybrids in water was quenched by ascorbic acid at ambient temperature...
November 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30172510/highly-selective-and-sensitive-determination-of-uranyl-ion-by-the-probe-of-cdte-quantum-dot-with-a-specific-size
#20
Mengxia Hua, Sen Yang, Jiaqi Ma, Weiwei He, Liangju Kuang, Daoben Hua
Determination of trace amounts of uranyl ions is of great significance to environment and human health, but challenging. In this paper, we demonstrate a new approach for highly effective determination of uranyl ions by the probe of CdTe quantum dot (QD) with a specific size. The selectivity is relied on the probe of CdTe quantum dots; the selectivity, which was a function of QDs size, was optimum at 6.8 nm. The probe has a detection limit of 7.88 × 10-9 mol L-1 and responded linearly to uranyl ion concentration in the range of 2...
December 1, 2018: Talanta
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