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https://www.readbyqxmd.com/read/30097809/recent-status-of-nanomaterial-fabrication-and-their-potential-applications-in-neurological-disease-management
#1
REVIEW
Khwaja Salahuddin Siddiqi, Azamal Husen, Sayed Sartaj Sohrab, Mensur Osman Yassin
Nanomaterials (NMs) are receiving remarkable attention due to their unique properties and structure. They vary from atoms and molecules along with those of bulk materials. They can be engineered to act as drug delivery vehicles to cross blood-brain barriers (BBBs) and utilized with better efficacy and safety to deliver specific molecules into targeted cells as compared to conventional system for neurological disorders. Depending on their properties, various metal chelators, gold nanoparticles (NPs), micelles, quantum dots, polymeric NPs, liposomes, solid lipid NPs, microparticles, carbon nanotubes, and fullerenes have been utilized for various purposes including the improvement of drug delivery system, treatment response assessment, diagnosis at early stage, and management of neurological disorder by using neuro-engineering...
August 10, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/30086021/ncrp-vision-for-the-future-and-program-area-committee-activities-in-2017
#2
John D Boice
The National Council on Radiation Protection and Measurements' (NCRP) vision for the future is to improve radiation protection for the general public and workers. This vision is embodied within NCRP's ongoing initiatives: preparedness for nuclear terrorism, increasing the number of radiation professionals critically needed for the nation, providing new guidance for radiation protection in the United States, addressing the protection issues surrounding the ever-increasing use of ionizing radiation in medicine, assessing the radiation doses to aircrew due to higher altitude and longer flights, providing guidance on emerging radiation issues such as the radioactive waste from hydraulic fracturing, focusing on difficult issues such as high-level waste management, and providing better estimates of radiation risks at low doses within the framework of the Million Person Study of Low Dose Radiation Health Effects...
February 2018: Health Physics
https://www.readbyqxmd.com/read/30073803/carbon-based-nanomaterials-for-cancer-therapy-via-targeting-tumor-microenvironment
#3
REVIEW
Jabran Saleem, Liming Wang, Chunying Chen
Cancer remains one of the major health problems all over the world and conventional therapeutic approaches have failed to attain an effective cure. Tumor microenvironments (TME) present a unique challenge in tumor therapy due to their complex structures and multiple components, which also serve as the soil for tumor growth, development, invasion, and migration. The complex TME includes immune cells, fibrous collagen structures, and tortuous blood vessels, in which conventional therapeutic approaches are rendered useless...
August 2, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30073717/label-free-optical-single-molecule-micro-and-nanosensors
#4
REVIEW
Sivaraman Subramanian, Hsin-Yu Wu, Tom Constant, Jolly Xavier, Frank Vollmer
Label-free optical sensor systems have emerged that exhibit extraordinary sensitivity for detecting physical, chemical, and biological entities at the micro/nanoscale. Particularly exciting is the detection and analysis of molecules, on miniature optical devices that have many possible applications in health, environment, and security. These micro- and nanosensors have now reached a sensitivity level that allows for the detection and analysis of even single molecules. Their small size enables an exceedingly high sensitivity, and the application of quantum optical measurement techniques can allow the classical limits of detection to be approached or surpassed...
August 2, 2018: Advanced Materials
https://www.readbyqxmd.com/read/30062964/a-review-on-quantum-dots-synthesis-to-in-silico-analysis-as-next-generation-antibacterial-agents
#5
Sounik Manna, Munmun Ghosh, Ranadhir Chakraborty, Sudipto Ghosh, Santi M Mandal
Succumbing to multi-drug resistant (MDR) bacteria is a great distress to recent health care system. Out of the several attempts that have been made to kill MDR pathogens, a few gained short-lived success. The failures, of the discovered or innovated antimicrobials, were mostly due to their high level of toxicity to hosts and the phenomenal rate of developing resistance by the pathogens against the new arsenal. Recently, a few quantum dots were tested against the pathogenic bacteria and therefore justified for potential stockpiling of next generation antibacterial agents...
July 31, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/30047324/extrapolation-of-phenolic-compounds-as-multi-target-agents-against-cancer-and-inflammation
#6
Naresh Kumar, Saurabh Gupta, Tara Chand Yadav, Vikas Pruthi, Pritish Kumar Varadwaj, Nidhi Goel
Natural product acquires massive structural and chemical diversity, which cannot be coordinated by any synthetic libraries for small molecules and they are continuing to inspire novel discoveries in health sciences. We have performed the computational calculations for geometry optimization and prediction of electronic and structural properties of some plant phenolic compounds through Gaussian 09 program. Energies of molecular orbitals were computed, to mimic out the stabilities arising from charge delocalization and intramolecular interactions...
July 26, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/30039489/reproductive-drugs-and-environmental-contamination-quantum-impact-assessment-and-control-strategies
#7
Harpreet Kaur, Madhu Bala, Gulshan Bansal
Industrial and municipal solid wastes, noise, pesticides, fertilizers and vehicular emission are visible pollutants responsible for environmental contamination and ill-effects on health of all living systems. But, environmental contamination due to drugs or medicines used for different purposes in humans and animals goes unseen largely and can affect the health of living system severely. During the last few decades, the usage of drugs has increased drastically, resulting in increased drug load in soil and water...
July 23, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30023562/multifunctional-biochar-for-highly-efficient-capture-identification-and-removal-of-toxic-metals-and-superbugs-from-water-samples
#8
Ye Gao, Avijit Pramanik, Salma Begum, Carrie Sweet, Stacy Jones, Azmain Alamgir, Paresh Chandra Ray
According to the World Health Organization, more than two billion people in our world use drinking water sources which are not free from pathogens and heavy metal contamination. Unsafe drinking water is responsible for the death of several millions in the 21st century. To find facile and cost-effective routes for developing multifunctional materials, which has the capability to resolve many of the challenges associated with drinking water problem, here, we report the novel design of multifunctional fluorescence-magnetic biochar with the capability for highly efficient separation, identification, and removal of pathogenic superbugs and toxic metals from environmental water samples...
November 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/30016094/polyethylenimine-capped-cds-quantum-dots-for-sensitive-and-selective-detection-of-nitrite-in-vegetables-and-water
#9
Hui-Hui Ren, You Fan, Bin Wang, Li-Ping Yu
In the present work, polyethylenimine-capped CdS quantum dots (PEI-CdS QDs) with bright green fluorescence were synthesized and applied for sensitively and selectively detecting the nitrite in vegetable and water samples. Highly fluorescent and environment-friendly PEI-CdS QDs (quantum yield about 8%) with diameters of ca. 5 nm were easily synthesized by using hyperbranched PEI as functional polymer. Formation of the PEI-CdS QDs was verified by transmission electron microscopy and UV-vis spectroscopy. The fluorescence intensity of the as-synthesized PEI-CdS QDs was enhanced pronouncedly by the increasing amount of PEI and was stable when the pH ranged from 5...
August 8, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29999322/cross-photoreaction-of-glyoxylic-and-pyruvic-acids-in-model-aqueous-aerosol
#10
Sha-Sha Xia, Alexis J Eugene, Marcelo I Guzman
Aerosols of variable composition, size, and shape are associated with public health concerns as well as with light-particle interactions that play a role in the energy balance of the atmosphere. Photochemical reactions of 2-oxocarboxylic acids in the aqueous phase are now known to contribute to the total secondary organic aerosol (SOA) budget. This work explores the cross reaction of glyoxylic acid (GA) and pyruvic acid (PA) in water, the two most abundant 2-oxocarboxylic acids in the atmosphere, under solar irradiation and dark thermal aging steps...
July 25, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29977739/genome-wide-transcriptional-analysis-of-oxidative-stress-related-genes-and-pathways-induced-by-cdte-aqqds-in-mice
#11
Ling Kong, Jiayi Li, Jilong Wang, Yue Hu, Peijun Meng, Yamin Xiong, Peili Huang
Objective: Quantum dots (QDs) has widely applied in the field of science, whose potential toxic effect has increasingly become a focus concern we need pay attention to in public health. The purpose of this article was to explore the toxicity mechanism with oxidative damage from treatment with QDs at the molecular level through a gene microarray. Methods: Mice were administered aqueously synthesized cadmium telluride QDs (CdTe aqQDs) via intravenous tail injection of a 2 µmol/kg solution (based on the molar mass of Cd), and their kidneys were collected at 1 day in strict accordance with the programs used for treated mice...
2018: Nanotheranostics
https://www.readbyqxmd.com/read/29957403/novel-method-for-in-situ-investigation-into-graphene-quantum-dots-effects-on-the-adsorption-of-nitrated-polycyclic-aromatic-hydrocarbons-by-crop-leaf-surfaces
#12
Haifeng Sun, Yanli Nan, Ruijie Feng, Ruiyao Ma
Nitrated polycyclic aromatic hydrocarbons (NPAHs) are PAH derivatives with more toxic effects to ecosystem, and the partitioning of NPAHs in crop system constitutes the potential exposure to human health through the dietary pathway. In the present study, a novel method for in situ detection of 9-nitroanthracene (9-NAnt) and 3-nitrofluoranthene (3-NFla) adsorbed onto the leaf surfaces of living soybean and maize seedlings was established based on the fiber-optic fluorimetry combined with graphene quantum dots (GQDs) as a fluorescent probe...
October 30, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29946358/the-%C3%AE-f-f-m-guided-supply-of-nitrogen-in-culture-medium-facilitates-sustainable-production-of-tag-in-nannochloropsis-oceanica-imet1
#13
Jiao Liu, Changhong Yao, Yingying Meng, Xupeng Cao, Peichun Wu, Song Xue
Background: Triacylglycerol (TAG) from photosynthetic microalgae is a sustainable feedstock for biodiesel production. Physiological stress triggers microalgal TAG accumulation. However excessive physiological stress will impair the photosynthesis system seriously thus decreasing TAG productivity because of the low biomass production. Hence, it is critical to quantitatively and timely monitor the degree of the stress while the microalgal cells growing so that the optimal TAG productivity can be obtained...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29938115/the-anticoagulant-properties-of-cadmium-telluride-quantum-dots
#14
Ciarán M Maguire, Michelle Lavin, Mairead Doyle, Mary Byrne, Adriele Prina-Mello, James S O'Donnell, Yuri Volkov
The size-dependent optical properties of quantum dots (QDs) are frequently exploited for use in medical imaging and labelling applications. Similarly, presented here, they also elicit profound size-dependent anticoagulant properties. Cadmium telluride quantum dot (QDs) (3.2 nm) were shown to have a dramatic anticoagulant effect centred on around the intrinsic coagulation pathway, compared to their 3.6 nm counterparts. Several clinically relevant diagnostic tests were carried out over a concentration range of the QDs and demonstrated that the 3...
April 2018: Journal of Interdisciplinary Nanomedicine
https://www.readbyqxmd.com/read/29914468/achievement-of-malaria-pre-elimination-in-cape-verde-according-to-the-data-collected-from-2010-to-2016
#15
Adilson José DePina, El Hadji Amadou Niang, Alex Jailson Barbosa Andrade, Abdoulaye Kane Dia, Antonio Moreira, Ousmane Faye, Ibrahima Seck
BACKGROUND: Malaria, despite being preventable and treatable, continues to be a major public health problem worldwide. The archipelago nation of Cape Verde is in a malaria pre-elimination phase with the highest potential to achieve the target goal of elimination in 2020. METHODS: Nationwide malaria epidemiological data were obtained from the Cape Verde health information system that includes the individual malaria case notification system from all of the country's health structures...
June 19, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29905983/understanding-the-rate-limiting-step-of-glycogenolysis-by-using-qm-mm-calculations-on-human-glycogen-phosphorylase
#16
Natércia F Brás, Pedro A Fernandes, Maria J Ramos
Liver glycogen phosphorylase (GP) is a key enzyme for human health, as its increased activity is associated with type 2 diabetes. The GP catalytic mechanism has been explored by quantum mechanics/molecular mechanics (QM/MM) methods. Herein, we propose a mechanism that proceeds by three steps: 1) it begins with transfer of a hydrogen atom from the phosphate group of the pyridoxal 5'-phosphate (HPO4 2- -PLP) cofactor to the phosphate substrate; 2) the glycosidic linkage is then cleaved through protonation of the glycosidic oxygen atom by a hydroxy group of the inorganic phosphate group; and 3) an oxygen atom of the phosphate performs a nucleophilic attack on the anomeric carbon atom of glucose, concomitant with the return of a proton from phosphate to PO4 3- -PLP, which finally leads to formation of the glucose-1-phosphate product and recovers the initial state of the PLP cofactor...
June 15, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29881931/recent-findings-in-the-genetics-of-blood-pressure-how-to-apply-in-practice-or-is-a-moonshot-required
#17
REVIEW
Sandosh Padmanabhan, Alisha Aman, Anna F Dominiczak
PURPOSE OF REVIEW: Hypertension is recognised as the biggest contributor to the global burden of disease, but it is controlled in less than a fifth of patients worldwide, despite being relatively easy to detect and the availability of inexpensive safe generic drugs. Blood pressure is regulated by a complex network of physiologic pathways with currently available drugs targeting key receptors or enzymes in the top pathways. Major advances in the dissection of both monogenic and polygenic determinants of blood pressure regulation and variation have not resulted in rapid translation of these discoveries into clinical applications or precision medicine...
June 7, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29876205/graphene-oxide-quantum-dots-reduce-oxidative-stress-and-inhibit-neurotoxicity-in-vitro-and-in-vivo-through-catalase-like-activity-and-metabolic-regulation
#18
Chaoxiu Ren, Xiangang Hu, Qixing Zhou
Both oxidative stress and neurotoxicity are huge challenges to human health, and effective methods and agents for resisting these adverse effects are limited, especially in vivo. It is shown here that, compared to large graphene oxide (GO) nanosheets, GO quantum dots (GOQDs), as nanozymes, efficiently reduce reactive oxygen species (ROS) and H2 O2 in 1-methyl-4-phenyl-pyridinium ion (MPP+ )-induced PC12 cells. In addition, GOQDs exert neuroprotective effects in a neuronal cell model by decreasing apoptosis and α-synuclein...
May 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29805211/prevalence-and-magnitude-of-acidosis-sequelae-to-rice-based-feeding-regimen-followed-in-tamil-nadu-india
#19
Rathinam Murugeswari, Chinnamani Valli, Raman Karunakaran, Venkatasubramanian Leela, Amaresan Serma Saravana Pandian
Background and Aim: In Tamil Nadu, a southern state of India, rice is readily available at a low cost, hence, is cooked (cooking akin to human consumption) and fed irrationally to cross-bred dairy cattle with poor productivity. Hence, a study was carried out with the objective to examine the prevalence of acidosis sequelae to rice-based feeding regimen and assess its magnitude. Materials and Methods: A survey was conducted in all the 32 districts of Tamil Nadu, by randomly selecting two blocks per districts and from each block five villages were randomly selected...
April 2018: Veterinary World
https://www.readbyqxmd.com/read/29799486/natural-products-for-drug-discovery-in-the-21st-century-innovations-for-novel-drug-discovery
#20
REVIEW
Nicholas Ekow Thomford, Dimakatso Alice Senthebane, Arielle Rowe, Daniella Munro, Palesa Seele, Alfred Maroyi, Kevin Dzobo
The therapeutic properties of plants have been recognised since time immemorial. Many pathological conditions have been treated using plant-derived medicines. These medicines are used as concoctions or concentrated plant extracts without isolation of active compounds. Modern medicine however, requires the isolation and purification of one or two active compounds. There are however a lot of global health challenges with diseases such as cancer, degenerative diseases, HIV/AIDS and diabetes, of which modern medicine is struggling to provide cures...
May 25, 2018: International Journal of Molecular Sciences
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