keyword
https://read.qxmd.com/read/38475547/chaenomelin-a-new-phenolic-glycoside-and-anti-helicobacter-pylori-phenolic-compounds-from-the-leaves-of-salix-chaenomeloides
#1
JOURNAL ARTICLE
Kyung Ah Kim, Dong-Min Kang, Yoon-Joo Ko, Moon-Jin Ra, Sang-Mi Jung, Jeong-Nam Yu, Mi-Jeong Ahn, Ki Hyun Kim
Salix chaenomeloides Kimura, commonly known as pussy willow, is a deciduous shrub and tree belonging to the Salicaceae family. The genus Salix spp. has been known as a healing herb for the treatment of fever, inflammation, and pain relief. The current study aimed to investigate the potential bioactive natural products from S. chaenomeloides leaves and evaluate their antibacterial activity against Helicobacter pylori . A phytochemical investigation of the ethanol (EtOH) extract of S. chaenomeloides leaves led to the isolation of 13 phenolic compounds ( 1 - 13 ) from the ethyl acetate (EtOAc) fraction, which showed antibacterial activity against H...
February 29, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38460649/a-ph-responsive-tannic-acid-quaternized-carboxymethyl-chitosan-oxidized-sodium-alginate-hydrogels-for-accelerated-diabetic-wound-healing-and-real-time-monitoring
#2
JOURNAL ARTICLE
Zhifei Yang, Chen Wang, Zhiyuan Zhang, Fangzheng Yu, Yu Wang, Jianqiang Ding, Zheng Zhao, Yichao Liu
Treatment of diabetic wounds is a major clinical issue. Diabetic wound dressings have higher requirements for anti-oxidant, antibacterial and wound monitoring properties compared to conventional wound dressings. In this study, a novel tannic acid (TA)/quaternized carboxymethyl chitosan (QCMCS)/oxidized sodium alginate (OSA)@carbon quantum dots (CQD) (TA/QCMCS/OSA@CQD) hydrogels for promoting diabetic wound healing and real-time monitoring have been developed. The TA/QCMCS/OSA@CQD hydrogels exhibited excellent self-healing, antibacterial and antioxidant properties...
March 7, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38426529/zno-based-0-3d-diverse-nano-architectures-films-and-coatings-for-biomedical-applications
#3
REVIEW
Suresh Babu Naidu Krishna, Jaroon Jakmunee, Yogendra Kumar Mishra, Jai Prakash
Thin-film nano-architecting is a promising approach that controls the properties of nanoscale surfaces to increase their interdisciplinary applications in a variety of fields. In this context, zinc oxide (ZnO)-based various nano-architectures (0-3D) such as quantum dots, nanorods/nanotubes, nanothin films, tetrapods, nanoflowers, hollow structures, etc. have been extensively researched by the scientific community in the past decade. Owing to its unique surface charge transport properties, optoelectronic properties and reported biomedical applications, ZnO has been considered as one of the most important futuristic bio-nanomaterials...
March 1, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38395101/cationized-orthogonal-triad-as-a-photosensitizer-with-enhanced-synergistic-antimicrobial-activity
#4
JOURNAL ARTICLE
Xiaoying Hao, Ying Tang, Ruiling Zhang, Zigeng Wang, Min Gao, Ran Wei, Yongxian Zhao, Xueluer Mu, Yingxi Lu, Xianfeng Zhou
Single-molecule-based synergistic phototherapy holds great potential for antimicrobial treatment. Herein, we report an orthogonal molecular cationization strategy to improve the reactive oxygen species (ROS) and hyperthermia generation of heptamethine cyanine (Cy7) for photodynamic and photothermal treatments of bacterial infections. Cationic pyridine (Py) is introduced at the meso-position of the asymmetric Cy7 with intramolecular charge transfer (ICT) to construct an atypical electron-transfer triad, which reduces ΔES1-S0 , circumvents rapid charge recombination, and simultaneously enhances intersystem crossing (ISC) based on spin-orbit charge-transfer ISC (SOCT-ISC) mechanism...
February 21, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38384556/molecular-structure-vibrational-spectral-electron-density-analysis-on-linaloe-oil-and-molecular-docking-efficacy-against-the-therapeutic-target-on-human-immunodeficiency-virus-1-organism-viral-protein
#5
JOURNAL ARTICLE
Chandramohan Uma Maheswari
Natural traditional medicine extensively uses certain terpenes and gives plants their flavor, aroma, and color. Treatments for bacterial infections, malaria, and cardiovascular disorders, anti-inflammatory, promote circulation, and heal wounds. 3,7-Dimethyl-1,6-octadien-3-ol (Linalool) is a naturally occurring monoterpene alcohol with no cycle and is a colorless liquid. Spectral analysis such as UV absorption spectra, NMR for structure determination, and IR and Raman for vibrational analysis. The Quantum mechanical approach uses DFT, ELF, and LOL-promolecular electron density, non-relaxed, and atomic density analysis...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38350008/on-shelf-and-operational-decay-dynamics-of-self-healing-quasi-two-dimensional-perovskite-light-emitting-devices
#6
JOURNAL ARTICLE
Wenbo Liu, Kai Wang, Guoping Wang, Xiao Wei Sun
Currently, the external quantum efficiency (EQE) performance of perovskite light-emitting diodes (PeLEDs) is approaching its theoretical limit. The main drawback of PeLEDs is their stability. Ion migration in the perovskite layer is one of the main causes of the operational decomposition of PeLEDs. Here, we find that butylammonium-based quasi-two-dimensional (quasi-2D) PeLEDs show self-healing ability, revealing the existence of ion migration in the fabricated perovskite layer. Then, on the basis of the analysis of ∼170 operational decay EQE curves, patterns of on-shelf and operational decay in self-healing quasi-2D PeLEDs have been identified...
February 13, 2024: Journal of Physical Chemistry Letters
https://read.qxmd.com/read/38329426/herbal-medicine-inspired-carbon-quantum-dots-with-antibiosis-and-hemostasis-effects-for-promoting-wound-healing
#7
JOURNAL ARTICLE
Xiaofei Zhu, Yu Zhou, Shihai Yan, Shining Qian, Yaohui Wang, Enguo Ju, Chunbing Zhang
Bleeding and bacterial infections are crucial factors affecting wound healing. The usage of herbal medicine-derived materials holds great potential for promoting wound healing. However, the uncertain intrinsic effective ingredients and unclear mechanism of action remain great concerns. Herein, inspired by the herbal medicine Ligusticum wallichii , we reported the synthesis of tetramethylpyrazine-derived carbon quantum dots (TMP-CQDs) for promoting wound healing. Of note, the use of TMP as the precursor instead of L...
February 8, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38325585/amyloid-%C3%AE-interferes-with-wound-healing-of-brain-microvascular-endothelial-cells-by-disorganizing-the-actin-cytoskeleton
#8
JOURNAL ARTICLE
Takuma Maeda, Keiya Shimamori, Hiroki Kurita, Kiyotaka Tokuraku, Masahiro Kuragano
Cerebral amyloid angiopathy (CAA) is a disease in which amyloid β (Aβ) is deposited in the cerebral blood vessels, reducing compliance, tearing and weakening of vessel walls, leading to cerebral hemorrhage. The mechanisms by which Aβ leads to focal wall fragmentation and intimal damage are not well understood. We analyzed the motility of human brain microvascular endothelial cells (hBMECs) in real-time using a wound-healing assay. We observed the suppression of cell migration by visualizing Aβ aggregation using quantum dot (QD) nanoprobes...
March 1, 2024: Experimental Cell Research
https://read.qxmd.com/read/38270107/one-stop-integrated-nanoagent-for-bacterial-biofilm-eradication-and-wound-disinfection
#9
JOURNAL ARTICLE
Wentao Wang, Wang Xu, Jianquan Zhang, Yan Xu, Jian Shen, Ninglin Zhou, Yuanyuan Li, Ming Zhang, Ben Zhong Tang
To meet the requirements of biomedical applications in the antibacterial realm, it is of great importance to explore nano-antibiotics for wound disinfection that can prevent the development of drug resistance and possess outstanding biocompatibility. Therefore, we attempted to synthesize an atomically dispersed ion (Fe) on phenolic carbon quantum dots (CQDs) combined with an organic photothermal agent (PTA) (Fe@SAC CQDs/PTA) via a hydrothermal/ultrasound method. Fe@SAC CQDs adequately exerted peroxidase-like activity while the PTA presented excellent photothermal conversion capability, which provided enormous potential in antibacterial applications...
January 25, 2024: ACS Nano
https://read.qxmd.com/read/38242410/a-review-on-multifaceted-biomedical-applications-of-heparin-nanocomposites-progress-and-prospects
#10
REVIEW
Mukesh Kumar Meher, Goutami Naidu, Amit Mishra, Krishna Mohan Poluri
Advances in polymer-based nanocomposites have revolutionized biomedical applications over the last two decades. Heparin (HP), being a highly bioactive polymer of biological origin, provides strong biotic competence to the nanocomposites, broadening the horizon of their applicability. The efficiency, biocompatibility, and biodegradability properties of nanomaterials significantly improve upon the incorporation of heparin. Further, inclusion of structural/chemical derivatives, fractionates, and mimetics of heparin enable fabrication of versatile nanocomposites...
January 17, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38237149/synthesis-of-tough-and-fluorescent-self-healing-elastomers-by-scandium-catalyzed-terpolymerization-of-pyrenylethenylstyrene-ethylene-and-anisylpropylene
#11
JOURNAL ARTICLE
Lin Huang, Yang Yang, Jingjing Shao, Gang Xiong, Haobing Wang, Masayoshi Nishiura, Zhaomin Hou
The synthesis of fluorescent self-healing polymers by the incorporation of a fluorophore-containing olefin into a polyolefin backbone through catalyst-controlled multicomponent copolymerization is of fundamental interest and practical importance, but such an approach has remained unexplored to date. Herein, we report for the first time the synthesis of tough and fluorescent self-healing polymers by sequence-controlled terpolymerization of 4-[2-(1-pyrenyl)ethenyl]styrene ( Pyr ), ethylene ( E ), and anisylpropylene ( AP ) using a sterically demanding half-sandwich scandium catalyst...
January 18, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38192259/higher-hydrogen-fractions-in-dielectric-polymers-boost-self-healing-in-electrical-capacitors
#12
JOURNAL ARTICLE
Vitaly V Chaban, Nadezhda A Andreeva
Electrical capacitors are omnipresent in modern electronic devices, in which they swiftly release large portions of energy on demand. The capacitors may suffer from arc discharges due to local structural heterogeneities in their components and inappropriate exploitation practices. High energies of the arc discharge are transferred as phonons to the electrode and dielectric film, which burn out locally. The dielectric breakdown takes place. The complete burnout leads to the isolation of the failed region and the capacitor's self-healing...
January 9, 2024: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/38175134/detecting-topological-index-of-randomly-scattered-v-point-singularities-using-stokes-correlations
#13
JOURNAL ARTICLE
Akanksha Gautam, Gauri Arora, P Senthilkumaran, Rakesh Kumar Singh
Topological defects in vector fields constitute polarization singularities that have numerous applications in classical and quantum optics. These beams are inhomogeneously polarized and are shown to self-heal under symmetric amplitude perturbations. Polarization singular beams are characterized using a singularity index that can be detected using Stokes polarimetry or other interferometric and diffraction approaches. However, the information about the singularity index is lost when these beams travel through random scattering media; this results in a spatially fluctuating polarization pattern known as polarization speckle...
January 1, 2024: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://read.qxmd.com/read/38091624/enhancement-of-nerve-regeneration-through-schwann-cell-mediated-healing-in-a-3d-printed-polyacrylonitrile-conduit-incorporating-hydrogel-and-graphene-quantum-dots-a-study-on-rat-sciatic-nerve-injury-model
#14
JOURNAL ARTICLE
Elham Hoveizi
Despite recent technological advancements, effective healing from sciatic nerve damage remains inadequate. Cell-based therapies offer a promising alternative to autograft restoration for peripheral nerve injuries, and 3D printing techniques can be used to manufacture conduits with controlled diameter and size. In this study, we investigated the potential of Wharton's jelly-derived mesenchymal stem cells (WJMSCs) differentiated into schwann cells, using a polyacrylonitrile (PAN) conduit filled with fibrin hydrogel and graphene quantum dots (GQDs) to promote nerve regeneration in a rat sciatic nerve injury model...
December 13, 2023: Biomedical Materials
https://read.qxmd.com/read/38042382/graphene-quantum-dots-based-on-cannabis-seeds-for-efficient-wound-healing-in-a-mouse-incisional-wound-model-link-with-stress-and-neurobehavioral-effect
#15
JOURNAL ARTICLE
Mohamed Amine Zarouki, Lahcen Tamegart, Lamia Hejji, Youssef Aoulad El Hadj Ali, Amina El Ayadi, Luis Pérez Villarejo, Zakaria Mennane, Badredine Souhail, AbdelmonaimAzzouz
Graphene quantum dots (GQDs) are promising biomaterials with potential applicability in several areas due to their many useful and unique features. Among different applications, GQDs are photodynamic therapy agents that generate single oxygen and improve antimicrobial activity. In the present study, and for the first time, GQD were isolated from the Cannabis sativa L. seeds to generate C-GQD as a new biomaterial for antibacterial and wound healing applications. Detailed characterization was performed using FTIR, UV-vis, Raman spectra, photoluminescence, TEM examination, HRTEM, ζ-potential, and XRD...
November 30, 2023: International Journal of Pharmaceutics
https://read.qxmd.com/read/38038266/in-vivo-wound-healing-in-drosophila-melanogaster-and-mouse-models-synergistic-effect-of-bovine-serum-albumin-and-graphene-quantum-dots
#16
JOURNAL ARTICLE
Shuvendu Shuvankar Purohit, Anuradha Biswal, Priyaranjan Mohapatra, Lokanath Mishra, Monalisa Mishra, Sashi Bhusan Biswal, Sarat K Swain
Bovine serum albumin (BSA)-based biomaterials have garnered significant attention for their remarkable potential in wound healing, primarily due to their effective biological actions in addressing the skin inflammation phase and mitigating hypoalbuminemia. Motivated by these attributes, a nanocomposite hydrogel is developed by blending BSA with poly(vinyl alcohol) (PVA), complemented by the incorporation of graphene quantum dot (GQD). The FTIR study establishes a hydrogen-bonding interaction between the -NH2 groups of BSA and the -OH group of PVA...
December 1, 2023: ACS Applied Bio Materials
https://read.qxmd.com/read/38011489/n-heterocycle-modified-graphene-quantum-dots-as-topoisomerase-targeted-nanoantibiotics-for-combating-microbial-infections
#17
JOURNAL ARTICLE
Yan Su, Jinyan Hu, Yang Wang, Yuan Li, Longfei Xiao, Xialing He, Zhenlin Zhang, Jinming Cai, Dengyu Pan, Yu Chen, Bijiang Geng, Ping Li, Longxiang Shen
Developing next-generation antibiotics to eliminate multidrug-resistant (MDR) bacteria/fungi and stubborn biofilms is challenging, because of the excessive use of currently available antibiotics. Herein, we report the fabrication of anti-infection graphene quantum dots (GQDs), as a new class of topoisomerase (Topo) targeting nanoantibiotics, by modification of rich N-heterocycles (pyridinic N) at edge sites. The membrane-penetrating, nucleus-localizing, DNA binding GQDs not only damage the cell walls/membranes of bacteria or fungi, but also inhibit DNA binding proteins, such as Topo I, thereby affecting DNA replication, transcription, and recombination...
November 27, 2023: Advanced Healthcare Materials
https://read.qxmd.com/read/37926604/a-literature-review-of-the-increased-intracellular-free-calcium-concentration-by-biofield-therapy-or-laser-exposure-an-explanation-by-using-a-theoretical-study-of-hydrated-calcium-ions
#18
REVIEW
Hordep Velásquez, Miguel Fernández, Fernando Ruette
INTRODUCTION: A revision of several experimental results on cells shows that electromagnetic radiation, either produced by biofield therapy (BFT) or laser, induced an increase in intracellular free calcium concentration. An explanation of this phenomenon is proposed. METHODS: Quantum chemistry calculations were performed on Ca2+ with different degrees of hydration with the DFT/r2 SCAN-3c method together with the implicit solvation model SMD. RESULTS: Ca2+ dehydration energy by quantum calculations, in an aqueous medium, coincides with the experimental results of the energy of the photon emitted in biofield therapies and lasers...
October 20, 2023: Explore: the Journal of Science and Healing
https://read.qxmd.com/read/37832617/synthesis-of-multicolor-luminescent-carbon-dots-based-on-carboxymethyl-chitosan-for-cell-imaging-and-wound-healing-application-in-vitro-and-in-vivo-studies
#19
JOURNAL ARTICLE
Mingrui Zong, Zheyuan Zhang, Xiao Ning, Huaiyi Cheng, Yifan Zhao, Jianing Ren, Yingyu Liu, Ran Zhang, Jiayu Cui, Yuxi Hou, Bing Li, Xiuping Wu
The construction of biomaterials that can facilitate wound healing is significantly challenging in the medical field, and bacterial infections increase this complexity. In this study, we selected the biomacromolecule carboxymethyl chitosan as a carbon source and citric acid as an auxiliary carbon source. We prepared carbon quantum dots with multicolor luminescence properties and higher quantum yields (QYs) using a facile one-pot hydrothermal method. We characterized them to select carbon dots (CDs) suitable for cell growth...
October 11, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37740314/asymmetric-fabrication-and-in-vivo-evaluation-of-the-wound-healing-potency-of-electrospun-biomimetic-nanofibrous-scaffolds-based-on-collagen-crosslinked-modified-chitosan-and-graphene-oxide-quantum-dot-nanocomposites
#20
JOURNAL ARTICLE
Koushik Dutta, Kunal Sarkar, Srikanta Karmakar, Bhuman Gangopadhyay, Arijita Basu, Sarbashri Bank, Sriparna De, Beauty Das, Madhusudan Das, Dipankar Chattopadhyay
Asymmetric scaffolds were developed through electrospinning by utilizing biocompatible materials for effective wound healing applications. First of all, the chitosan surface was modified with decanoyl chloride and crosslinked with collagen to synthesize collagen crosslinked modified-chitosan (CG-cross-CS- g -Dc). Then, the asymmetric scaffolds were fabricated through electrospinning, where the top layer was a monoaxial nanofiber of the PCL/graphene oxide quantum dot (GOQD) nanocomposite and the bottom layer was a coaxial nanofiber having PCL in the core and the CG-cross-CS- g -Dc/GOQD nanocomposite in the shell layer...
September 21, 2023: Journal of Materials Chemistry. B, Materials for Biology and Medicine
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