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https://www.readbyqxmd.com/read/30092828/analysis-of-differentially-expressed-genes-among-human-hair-follicle-derived-ipscs-induced-hepatocyte-like-cells-and-primary-hepatocytes
#1
Ziran Xu, Xia He, Xu Shi, Yuhan Xia, Xiaomei Liu, Haitao Wu, Pengdong Li, Hongyu Zhang, Weisi Yin, Xiubo Du, Lisha Li, Yulin Li
BACKGROUND: Differentiation of human induced pluripotent stem cells (hiPSCs) into hepatocytes has important clinical significance in providing a new stem cell source for cell therapy of terminal liver disease. The differential gene expression analysis of hiPSCs, induced hepatocyte-like cells (HLCs), and primary human hepatocytes (PHHs) provides valuable information for optimization of an induction scheme and exploration of differentiation mechanisms. METHODS: Human hair follicle-derived iPSCs (hHF-iPSCs) were induced in vitro by mimicking the environment of a developing liver for 19 days...
August 9, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30021121/leptin-restores-markers-of-female-fertility-in-lipodystrophy
#2
Lisa Eifler, Annett Hoffmann, Isabel Viola Wagner, Nora Klöting, Lena Sahlin, Thomas Ebert, Beate Jessnitzer, Ulrike Lössner, Michael Stumvoll, Olle Söder, Mathias Fasshauer, Susan Kralisch
OBJECTIVES: Female reproductive dysfunction occurs in patients with pathological loss of adipose tissue, i.e. lipodystrophy (LD). However, mechanisms remain largely unclear and treatment effects of adipocyte-derived leptin have not been assessed in LD animals. METHODS: In the current study, C57Bl/6 LD mice on a low-density lipoprotein receptor knockout background were treated with leptin or saline for 8 weeks and compared to non-LD controls. RESULTS: The number of pups born was 37% lower in breeding pairs consisting of LD female mice x non-LD male mice (n = 3...
July 23, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29985671/the-effects-of-12-week-progressive-strength-training-on-strength-functional-capacity-metabolic-biomarkers-and-serum-hormone-concentrations-in-healthy-older-women-morning-versus-evening-training
#3
Bohumila Krčmárová, Matúš Krčmár, Marianna Schwarzová, Peter Chlebo, Zuzana Chlebová, Radoslav Židek, Adriana Kolesárová, Katarína Zbyňovská, Eva Kováčiková, Simon Walker
Previous findings suggest that performing strength training (ST) in the evening may provide greater benefit for young individuals. However, this may not be optimal for the older population. The purpose of this study was to compare the effects of a 12-week ST program performed in the morning vs. evening on strength, functional capacity, metabolic biomarker and basal hormone concentrations in older women. Thirty-one healthy older women (66 ± 4 years, 162 ± 4 cm, 75 ± 13 kg) completed the study. Participants trained in the morning (M) (07:30, n = 10), in the evening (E) (18:00, n = 10), or acted as a non-training control group (C) (n = 11)...
July 9, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29961283/-effects-of-dyslipidemia-on-ivf-icsi-pregnancy-outcome-in-patients-with-polycystic-ovary-syndrome
#4
X Li, W Ding, J Y Liu, Y D Mao, J Huang, W Wang, X Ma
Objective: To investigate the impact of dyslipidemia on in-vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) pregnancy outcome in patients with polycystic ovary syndrome (PCOS) . Methods: From July 2013 to March 2016, 468 PCOS patients with antagonist protocol in IVF/ICSI of First Affiliated Hospital of Nanjing Medical University, cycles were divided into dyslipidemia group (108 cases) and normol blood lipids group (360 cases) according to the serum cholesterol, triglyceride (TG) , high-density lipoprotein, low density lipoprotein levels...
June 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29942936/thymoquinone-ameliorates-some-endocrine-parameters-and-histological-alteration-in-a-rat-model-of-polycystic-ovary-syndrome
#5
Sima Taghvaee Javanshir, Parichehreh Yaghmaei, Zahra Hajebrahimi
Background: Polycystic ovary syndrome (PCOS) is a common form of the endocrine disease which is associated with metabolic dysfunction. PCOS and type 2 diabetes mellitus are related in multiple aspects and are similar in many pathological features. Anti-diabetic effects of Nigella sativa and protective effects of it on reproductive system have been suggested in some reports. Objective: The aim of current study was to evaluate the effects of thymoquinone, the main components of Nigella sativa , on PCOS model of rats...
April 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29942726/armour%C3%A2-thyroid-rage-a-dangerous-mixture
#6
Joshua Coutinho, Justin B Field, Anupam A Sule
Armour® Thyroid (Forest Pharmaceuticals, LLC; affiliate of Allergan, Dublin, Ireland) is a natural porcine derivative thyroid supplement that is frequently used without physician monitoring by health enthusiasts as a weight loss supplement. Although there are no publications associating Armour Thyroid and major coronary events, significant drug interactions may exist. A 32-year-old male with a history of hypothyroidism, cystic acne, and solitary congenital kidney presented to the emergency room after experiencing crushing substernal chest pain radiating to his left shoulder, accompanied by diaphoresis and shortness of breath...
April 24, 2018: Curēus
https://www.readbyqxmd.com/read/29932432/serum-levels-of-angiopoietin-like-protein-2-and-obestatin-in-iranian-women-with-polycystic-ovary-syndrome-and-normal-body-mass-index
#7
Elham Rahmani, Samad Akbarzadeh, Ainaz Broomand, Fatemeh Torabi, Niloofar Motamed, Marzieh Zohrabi
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disease in women of reproduction age and a major cause of anovulatory infertility. Insulin resistance plays an important role in the development and durability of this disorder. ANGPTL2 is known as an inflammatory mediator derived from adipose tissue that links obesity to systemic insulin resistance, and obestatin has been identified as a hormone associated with insulin resistance that suppresses food reabsorption, inhibits gastric emptying and decreases weight gain...
June 22, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29887901/effect-of-chamomile-capsule-on-lipid-and-hormonal-related-parameters-among-women-of-reproductive-age-with-polycystic-ovary-syndrome
#8
Maryam Heidary, Zahra Yazdanpanahi, Mohammad Hossain Dabbaghmanesh, Mohammad Ebrahin Parsanezhad, Masoumeh Emamghoreishi, Marzieh Akbarzadeh
Background: According to traditional herbal medicine, chamomile has been considered as one of the herbal remedies for patients with polycystic ovary syndrome (PCOS). The study aimed to investigate the effect of chamomile on lipid and hormonal parameters in women of reproductive age with PCOS. Materials and Methods: This study is a randomized clinical trial which was conducted on 80 women (40 patients in each group) of childbearing age with PCO. The intervention group received 370 mg oral capsules of chamomile three times a day for 3 months...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29756169/vitellogenin-transcytosis-in-follicular-cells-of-the-honeybee-apis-mellifera-and-the-wasp-polistes-simillimus
#9
Virgínia Teles Dohanik, Wagner Gonzaga Gonçalves, Leandro Licursi Oliveira, José Cola Zanuncio, José Eduardo Serrão
Vitellogenin receptor (VgR) is a low-density lipoprotein receptor responsible for the mediated endocytosis of vitellogenin (Vg) during egg formation in insects. The maturing oocyte is enveloped by a follicular epithelium, which has large intercellular spaces during Vg accumulation (patency). However, Vg has been reported in the cytoplasm of follicular cells, indicating that there may be a transcellular route for its transport. This study verified the presence of VgR in the follicular cells of the ovaries of the honeybee Apis mellifera and the wasp Polistes simillimus in order to evaluate if Vg is transported via transcytosis in these insects...
May 13, 2018: Protoplasma
https://www.readbyqxmd.com/read/29745981/evaluation-of-biochemical-endocrine-and-metabolic-biomarkers-for-the-early-diagnosis-of-polycystic-ovary-syndrome-among-non-obese-saudi-women
#10
Maha H Daghestani
OBJECTIVE: To investigate the potential of selected biochemical, endocrine, and metabolic biomarkers for early diagnosis of polycystic ovary syndrome (PCOS) among non-obese women. METHODS: A prospective observational cross-sectional study was conducted at three medical centers in Makkah, Saudi Arabia, between July 15 and September 20, 2017. Eligible participants were non-obese women diagnosed with PCOS according to the Rotterdam criteria (n=44) and non-obese normo-ovulatory women without signs of PCOS (control group; n=44)...
August 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29603520/effect-of-pomegranate-extract-on-vagina-skeleton-metabolic-and-endocrine-profiles-in-an-ovariectomized-rat-model
#11
Isik Kaban, Alpaslan Kaban, Aysun F Tunca, Nurettin Aka, Hacer Kavak, Fugen Akar
AIM: Many women need estrogen therapy because of menopausal complaints. It is suggested that pomegranate plant has estrogenic effect. Aim of the study was to examine the effects of pomegranate seed extract on menopausal changes. METHODS: This study was conducted in an experimental environment with 23 Wistar Albino genus female rats. Sixteen rats were divided into two groups after ovariectomy. One group (SG) was fed with standard food and the pomegranate extract was added to drinking water of the other group (PG)...
June 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29603433/supplementation-with-sunflower-seeds-in-beef-cattle-did-not-impact-on-oocyte-and-in-vitro-embryo-production
#12
A L Baltazar, G M de Mattos, B M Ropelli, Smg Firetti, C Castilho, G Pugliesi, Mbc Maldonado, M Binelli, Jof Silva, G C Lupatini, B S Lafuente, Cmb Membrive
Supplementation with compounds rich in linoleic acid, including sunflower seed supplementation, promotes increase in conception rates in cows. We aimed to evaluate whether the sunflower seed (linoleic acid source) supplementation in beef donor females alters the plasma concentrations of cholesterol, triglycerides, HDL and LDL, increases the number and quality of oocytes, increases the cleavage rates and determines an improvement in number and quality of in vitro produced blastocysts. Thus, Nelore females were divided into two groups of 15 animals to receive supplementation with or without sunflower seed for 57 days...
June 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29465156/the-impact-of-serum-adropin-and-ischemia-modified-albumin-levels-based-on-bmi-in-pcos
#13
Zeynep Ozturk Inal, Sami Erdem, Yavuz Gederet, Cevdet Duran, Zehra Kucukaydin, Huseyin Kurku, Derya Kilic Sakarya
INTRODUCTION: The aim of this study was to evaluate the effects of polycystic ovary syndrome (PCOS) and body mass index (BMI) on serum adropin and ischemia modified albumin (IMA) levels. MATERIALS AND METHODS: This prospective cross-sectional study was performed with a total of 120 women [group1; non-PCOS = 60 (BMI < 25 = 30, BMI ≥25 = 30) and group 2; PCOS = 60 (BMI < 25 = 30, BMI ≥25 = 30)]. Blood samples were collected between the third and fifth days of the women's menstrual cycles after a night of fasting...
2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29462095/hormonal-metabolic-and-endometrial-safety-of-testosterone-vaginal-cream-versus-estrogens-for-the-treatment-of-vulvovaginal-atrophy-in-postmenopausal-women-a-randomized-placebo-controlled-study
#14
Tatiane Fernandes, Adriana O Pedro, Luiz F Baccaro, Lucia H Costa-Paiva
OBJECTIVE: The aim of the study was to evaluate the laboratory and endometrial safety of topical testosterone versus topical estrogen for the treatment of vaginal atrophy in postmenopausal women. METHODS: This was a randomized, placebo-controlled trial of 60 postmenopausal women aged 40 to 70 years at the Menopause Clinic of CAISM UNICAMP. Women were randomized into three vaginal treatment groups: estrogen, testosterone, or placebo. The treatment was applied 3 times a week for 12 weeks...
June 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29408750/diurnal-rhythm-of-follicle-stimulating-hormone-is-associated-with-nonalcoholic-fatty-liver-disease-in-a-chinese-elderly-population
#15
Xiaoming Li, Long Jing, Fang Lin, Huan Huang, Zhizhong Chen, Yan Chen, Lina Wang, Xing Lin, Tailin Guo, Jin Yang, Jingming Ruan, Kaiyang Lin, Chunjing Li, Zhebing You, Linlin He, Jiankang Chen, Zhuzhou Li, Pengli Zhu, Gang Chen
OBJECTIVE: Previous studies have found that impairment of the circadian clock appears to contribute to the development of nonalcoholic fatty liver disease (NAFLD) and the circulating follicle-stimulating hormone (FSH) level showed a diurnal cycle. A recent study reported that a lower FSH level was associated with NAFLD. However, the effects of the diurnal rhythm of FSH on NAFLD have not been reported. The aim of this study was to evaluate whether the diurnal rhythm of FSH was associated with NAFLD in an elderly population...
March 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29398911/influence-of-cigarette-smoking-on-hormone-and-lipid-metabolism-in-women-in-late-reproductive-stage
#16
Małgorzata Szkup, Anna Jurczak, Beata Karakiewicz, Artur Kotwas, Jacek Kopeć, Elżbieta Grochans
Background: The aim of the study was to analyze lipid and hormone metabolism, body mass index (BMI), and age parameters in late reproductive stage women in relation to cigarette smoking. Methods: The study enrolled 345 healthy late reproductive stage women living in Poland; 13.33% were smokers. The first part of the study assessed lipid metabolism (total cholesterol, high-density lipoprotein [HDL], low-density lipoprotein [LDL], and triglycerides) and hormone metabolism (estradiol [E2], follicle-stimulating hormone [FSH], and anti-Müllerian hormone [AMH] levels) in women in the early phase of the follicular menstrual cycle...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29387827/cxc-ligand-5-cytokine-serum-level-in-women-with-polycystic-ovary-syndrome-and-normal-body-mass-index-a-case-control-study
#17
Marzieh Zohrabi, Elham Rahmani, Niloofar Motamed, Samad Akbarzadeh
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disease and associated with insulin resistance. CXC Ligand 5 (CXCL5) is a new cytokine which is secreted from white adipose tissue during obesity and by blocking insulin signaling pathway inhibits the activity of insulin and promotes insulin resistance. Objective: The aim of this study was to assess serum level of CXCL5 in PCOS women with normal body mass index. Materials and Methods: In this case-control study, 30 PCOS women with normal body mass index as the case group and 30 non-PCOS women as the controls were enrolled...
October 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29281203/-analysis-of-serum-reproductive-hormone-levels-in-men-with-hyperlipemia-in-the-urban-area-of-shijiazhuang
#18
Chao-Ju Yang, Shu-Song Wang
Objective: To investigate the aging-related changes of reproductive hormones in hyperlipemia men in the urban area of Shijiazhuang and the relationship between the levels of reproductive hormones and that of blood lipid. METHODS: We enrolled 297 males aged 25-65 years in this study, determined the levels of serum total testosterone (TT), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), prolactin (PRL), triglyeride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and fasting blood glucose (FBG), and compared the parameters among different age groups...
November 2016: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29155477/oxidized-low-density-lipoprotein-suppresses-mouse-granulosa-cell-differentiation-through-disruption-of-the-hypoxia-inducible-factor-1-pathway
#19
Xiaoliang Chen, Yanhong Liu, Yanhong Shan, Xingyi Jin, Qingyang Shi, Chunshu Jia
Obesity predisposes women to reproductive disorders. One symptom of obesity in women is higher levels of oxidized Low-density lipoprotein (oxLDL) in serum and preovulatory follicles. The present study was designed to test the hypothesis that oxLDL might impair follicle differentiation and luteinization. Given that Hypoxia-inducible factor 1 (HIF1) plays crucial roles in supporting follicle differentiation and luteinization in mammals, we focused on oxLDL-mediated events that may affect the HIF1 pathway. We report that exposure to oxLDL diminished the expression of HIF1α and its target genes and suppressed the differentiation of mouse luteinized granulosa cells following induction by human Chorionic gonadotophin (hCG) under hypoxic conditions (1% oxygen)...
December 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29092018/the-function-of-high-density-lipoprotein-and-low-density-lipoprotein-in-the-maintenance-of-mouse-ovarian-steroid-balance
#20
Xin-Lian Chang, Lisheng Liu, Naiqiang Wang, Zi-Jiang Chen, Cong Zhang
The membrane proteins, low-density lipoprotein receptor (LDLR) and scavenger receptor class B member 1 (SR-BI, gene name Scarb1), are lipoprotein receptors that play central roles in lipoprotein metabolism. Cholesterol bound in high-density lipoprotein (HDL) and LDL is transported into cells mainly by SR-BI and LDLR. The relative contribution of LDL and HDL to the steroidogenic cholesterol pool varies among species and may vary among tissues within one species. To investigate which of these pathways is more important in the supply of cholesterol in mouse ovary, we utilized immunohistochemistry, western blotting, RNAi, and RT-PCR as well as Ldlr-/- mice to explore the uptake of HDL and LDL in the ovary...
January 1, 2017: Biology of Reproduction
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