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Myocardial infarction type 2

Hiroto Oshima, Takayuki Miki, Atsushi Kuno, Masashi Mizuno, Tatsuya Sato, Masaya Tanno, Toshiyuki Yano, Kei Nakata, Yukishige Kimura, Koki Abe, Wataru Ohwada, Tetsuji Miura
BACKGROUND: Mechanism by which sodium glucose cotransporter 2 (SGLT2) inhibitors reduce cardiac events in diabetic patients remains unclear. Here we examined effects of an SGLT2 inhibitor on the acute survival rate after myocardial infarction (MI) in an animal model of type 2 diabetes mellitus (DM) and possible involvement of modification of cardiac metabolomes and anti-oxidative proteins. METHODS AND RESULTS: MI was induced in DM rats (OLETF) and control rats (LETO)...
December 14, 2018: Journal of Pharmacology and Experimental Therapeutics
Susanne Buhse, Nadine Kuniss, Kathrin Liethmann, Ulrich Alfons Müller, Thomas Lehmann, Ingrid Mühlhauser
OBJECTIVE: To translate an informed shared decision-making programme (ISDM-P) for patients with type 2 diabetes from a specialised diabetes centre to the primary care setting. DESIGN: Patient-blinded, two-arm multicentre, cluster randomised controlled trial of 6 months follow-up; concealed randomisation of practices after patient recruitment and acquisition of baseline data. SETTING: 22 general practices providing care according to the German Disease Management Programme (DMP) for type 2 diabetes...
December 14, 2018: BMJ Open
Pedro R Pereira, Marta Guimarães, Tiago Morais, Sofia S Pereira, Mário Nora, Mariana P Monteiro
Background/Objetives: Obesity and obesity related co-morbidities are well-recognized risks for cardiovascular (CV) disease and mortality. Weight loss improves CV risk factors and the efficacy of bariatric surgery in decreasing CV mortality is now well-established. Our aim was to assess CV risk progression and occurrence of CV events in a cohort of patients that underwent Roux-en-Y gastric bypass (RYGB) for obesity treatment in a single academic public center. Subjects and Methods: Ten year CV risk was estimated using the Framingham Equation at baseline and 2 years after RYGB surgery in our patients cohort ( n = 260)...
2018: Frontiers in Endocrinology
Andrei C Sposito, Otávio Berwanger, Luiz Sérgio F de Carvalho, José Francisco Kerr Saraiva
Patients with type 2 diabetes (T2DM) have a substantial risk of developing cardiovascular disease. The strong connection between the severity of hyperglycaemia, metabolic changes secondary to T2DM and vascular damage increases the risk of macrovascular complications. There is a challenging demand for the development of drugs that control hyperglycaemia and influence other metabolic risk factors to improve cardiovascular outcomes such as cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina and heart failure (major adverse cardiovascular events)...
December 13, 2018: Cardiovascular Diabetology
Guangqiang Wang, Na Zhao, Chuanhuan Zhang, Shu Zhong, Xuexun Li
RATIONALE: The lambda-like ST-elevation electrocardiography (ECG) pattern is extremely rare in patients with type 2 myocardial infarction (T2MI) triggered by coronary spasm. When this ECG pattern appears, sudden cardiac death (SCD) caused by lethal ventricular arrhythmia may occur because clinicians do not pay sufficient attention to this phenomenon. PATIENT CONCERNS: We describe a 41-year-old man who presented with steep down-sloping ST-segment elevation, paroxysmal ventricular tachycardia, severe sinus bradycardia, and intermittent complete atrioventricular block on ECG during the sudden recurrence of clinical symptoms...
December 2018: Medicine (Baltimore)
Min Yuan, Wen-Feng Cao, Xu-Fang Xie, Huang-Yan Zhou, Xiao-Mu Wu
BACKGROUND: Lots of previous reports have suggested a potential association of atopic dermatitis (AD) with stroke and myocardial infarction (MI). However, the result is still controversial, Consequently, we conducted this meta-analysis to estimate the relationship of AD with Stroke and MI. METHODS: PubMed, Embase, and Web of Science databases were searched from inception to June 2018. Stroke and MI were considered as a composite endpoint. We calculated pooled hazard ratios (HRs) with 95% confidence intervals (CIs)...
December 2018: Medicine (Baltimore)
Christoph B Olivier, Hillary Mulder, William R Hiatt, W Schuyler Jones, F Gerry R Fowkes, Frank W Rockhold, Jeffrey S Berger, Iris Baumgartner, Peter Held, Brian G Katona, Lars Norgren, Juuso Blomster, Manesh R Patel, Kenneth W Mahaffey
Importance: Patients with peripheral artery disease (PAD) are at high risk for myocardial infarction (MI). Objective: To characterize the incidence and types of MI in a PAD population, identify factors associated with MI, and determine the association of MI with cardiovascular mortality and acute limb ischemia. Design, Setting, and Participants: The Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease (EUCLID) was a double-blind randomized clinical trial conducted at 811 sites in 28 countries that randomized 13 885 patients with symptomatic PAD to monotherapy with ticagrelor or clopidogrel...
December 12, 2018: JAMA Cardiology
Hong Kyu Lee
Cardio-renal protective effect of Sodium Glucose Co-transporter-2 (SGLT2) inhibitors is well established by three large clinical trials; Empagliflozin, Cardiovascular Outcome Events Trial in Type 2 Diabetes Patients (EMPA-REG OUTCOME), Canagliflozin Cardiovascular Assessment Study (CANVAS), and most recently Dapagliflozin Effect on Cardiovascular Events Trial 58 by the Thrombolysis in Myocardial Infarction Study Group (DECLARE-TIMI 58). Three different SGLT2 inhibitors, empagliflozin, canagliflozin and dapagliflozin, were proven effective not only for their glucose lowering effect, but in reducing deterioration of renal function and prevented hospitalization due to heart failure...
December 9, 2018: Journal of Diabetes Investigation
Etienne Puymirat, Marc Bonaca, Maxime Fumery, Victoria Tea, Nadia Aissaoui, Gilles Lemesles, Laurent Bonello, Grégory Ducrocq, Guillaume Cayla, Jean Ferrières, François Schiele, Tabassome Simon, Nicolas Danchin
BACKGROUND: Guidelines recommend using risk stratification tools in acute myocardial infarction (AMI) to assist decision making. The TIMI Risk Score for Secondary Prevention (TRS-2P) has been recently developed to characterize long term risk in patients with MI. HYPOTHESIS: We aimed to assess the TRS-2P in the FAST-MI registries. METHODS: We used data from 3 one-month French registries, conducted 5 years apart, from 2005 to 2015, including 13,130 patients with AMI (52% ST-elevation myocardial infarction (STEMI))...
December 7, 2018: Clinical Cardiology
Kris G Vargas, Paul M Haller, Bernhard Jäger, Maximilian Tscharre, Ronald K Binder, Christian Mueller, Bertil Lindahl, Kurt Huber
OBJECTIVE: Classifying myocardial infarction into type 1 (T1MI) or type 2 (T2MI) remains a challenge in clinical practice. We aimed to identify factors contributing to variation in the classifications of MI into type 1 or type 2. In addition, pooled analyses of long-term mortality and reinfarction outcomes were performed. METHODS: We searched Medline, Embase and Web of Science through January 2018 for observational studies or clinical trials classifying patients as either T1MI or T2MI...
December 7, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Dhvani Shah, Nancy A Risebrough, Johnna Perdrizet, Neeraj N Iyer, Cory Gamble, Tam Dang-Tan
Background: The Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcomes Results (LEADER) clinical trial demonstrated that liraglutide added to standard-of-care (SoC) therapy for type 2 diabetes (T2D) with established cardiovascular disease (CVD) or elevated cardiovascular (CV) risk was associated with lower rates of death from CVD, nonfatal myocardial infarction (MI), or nonfatal stroke than SoC alone. Objective: The objective of this study was to assess the cost-effectiveness (CE) and budget impact of liraglutide vs SoC in T2D patients with established CVD or elevated CV risk, over a lifetime horizon from a US managed care perspective...
2018: ClinicoEconomics and Outcomes Research: CEOR
I E Vereshchagin, V I Ganyukov, R S Tarasov, N A Kochergin, D L Shukevich, O L Barbarash
Analysed herein are the in-hospital and remote (12 months) results of transcutaneous coronary interventions (TCI) carried out in patients with non-ST elevation acute coronary syndrome (nSTE-ACS) and multivessel coronary artery disease with the use of extracorporeal membrane oxygenation (ECMO). From 2013 to 2015, the study included a total of 18 patients with nSTE-ACS and multivessel coronary artery disease who had been denied "open" surgical myocardial revascularization. The mean values (scores) of the scales in the group were as follows: GRACE - 119...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Alyssa M Corley, Malachy J Sullivan, Scott E Friedman, Daniel J O'Rourke, Robert T Palac, Anthony S Gemignani
Patients with cancer are at increased risk for venous thromboembolism (VTE). However, the relationship of cancer type to the risk of arterial thrombosis in patients with high VTE risk has not been described. The goal of this study is to determine the rate of arterial thrombosis in patients with different types of solid tumors stratified by VTE risk. Using the 2012 National Inpatient Sample, we identified 373,789 hospitalizations involving patients ≥18 years associated with solid tumors, stratified by type...
November 24, 2018: American Journal of Cardiology
Henrik Svanström, Peter Ueda, Mads Melbye, Björn Eliasson, Ann-Marie Svensson, Stefan Franzén, Soffia Gudbjörnsdottir, Kristian Hveem, Christian Jonasson, Björn Pasternak
BACKGROUND: Trial evidence shows that the glucagon-like peptide-1 receptor agonist liraglutide significantly reduces the risk of major cardiovascular events among patients with type 2 diabetes who have established cardiovascular disease or are at high cardiovascular risk. We aimed to assess the cardiovascular effectiveness of liraglutide in routine clinical practice. METHODS: We used data from nationwide registers in Denmark and Sweden for the period from Jan 1, 2010, to Dec 31, 2016, to investigate the risk of major cardiovascular events associated with use of liraglutide, compared with an active comparator drug class, dipeptidyl peptidase-4 (DPP-4) inhibitors, in patients with type 2 diabetes...
December 5, 2018: Lancet Diabetes & Endocrinology
Kenshiro Yamamoto, Yasutaka Kurata, Yumiko Inoue, Maya Adachi, Motokazu Tsuneto, Junichiro Miake, Kazuhide Ogino, Haruaki Ninomiya, Akio Yoshida, Yasuaki Shirayoshi, Yoshiko Suyama, Shunjiro Yagi, Motonobu Nishimura, Kazuhiro Yamamoto, Ichiro Hisatome
Introduction: Cell sheets using myoblasts have been developed for the treatment of heart failure after myocardial infarction (MI) bridging to heart transplantation. Stem cells are supposed to be better than myoblasts as a source of cells, since they possess a potential to proliferate and differentiate into cardiomyocytes, and also have capacity to secrete angiogenic factors. Adipose-derived stem cells (ASCs) obtained from fat tissues are expected to be a new cell source for ASC sheet therapies...
December 2018: Regenerative Therapy
Selvalakshmi Rathinavelu, Crissy Guidry-Elizondo, Jameela Banu
Diabetes is a common disease affecting majority of populations worldwide. Since 1980, there has been an increase in the number of people diagnosed as prediabetic and diabetic. Diabetes is characterized by high levels of circulating glucose and leads to most microvascular and macrovascular complications such as retinopathy, nephropathy, neuropathy, stroke, and myocardial infarction. Bone marrow vascular disruption and increased adiposity are also linked to various complications in type II diabetes mellitus. In addition to these complications, type 2 diabetic patients also have fragile bones caused by faulty mineralization mainly due to increased adiposity among diabetic patients that affects both osteoblast and osteoclast functions...
2018: Journal of Diabetes Research
Kristina Lambrakis, John K French, Ian A Scott, Tom Briffa, David Brieger, Michael E Farkouh, Harvey White, Anthony Ming-Yu Chuang, Kathryn Tiver, Stephen Quinn, Billingsley Kaambwa, Matthew Horsfall, Erin Morton, Derek P Chew
BACKGROUND: Elevated troponin level findings among patients presenting with suspected acute coronary syndrome (ACS) or another intercurrent illness undeniably identifies patients at increased risk of mortality. Whilst enhancing our capacity to discriminate risk, the use of high-sensitivity troponin assays frequently identifies patients with myocardial injury (i.e. troponin rise without acute signs of myocardial ischemia) or type 2 myocardial infarction (T2MI; oxygen supply-demand imbalance)...
October 25, 2018: American Heart Journal
M Hrebenyk, L Zelenenka, L Zoria, S Maslii
The clinical experience implies poor prognosis in women with myocardial infarction (MI). We performed a retrospective cohort study of 1395 patients - 987 (70,75%) men and 408 (29,25%) women) aged of 64,63±11,43 years with myocardial infarction and comorbidity hospitalized between 2010-2016. This study shows an increase of mortality in women with myocardial infarction during the last 4 years from 23,1% to 34,2%. We observed more frequent cases of non-STEMI (p=0,014) and recurrent myocardial infarction in females compared with males (р<0,0001)...
October 2018: Georgian Medical News
D Minukhina, V Babadzhan, D Minukhin, A Krasnoyaruzhskiy, D Yevtushenko
The combination of cardiac pathology and metabolic disorders, namely type 2 diabetes mellitus, is one of the most frequent comorbid pathologies and the main cause of death from cardiovascular complications at an early stage of the disease. Despite the wide range of antithrombogenic measures, prevention of thrombotic complications of acute myocardial infarction remains an urgent problem of cardiology. The study involved examination of 73 patients with acute myocardial infarction with concomitant type 2 diabetes mellitus, who were distributed into clusters according to severity by the main indices of lipid and carbohydrate metabolism using hierarchical analysis...
October 2018: Georgian Medical News
Miho Shimizu, Kengo Furuichi, Tadashi Toyama, Tomoaki Funamoto, Shinji Kitajima, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Toshinari Takamura, Kiyoki Kitagawa, Mitsuhiro Yoshimura, Shuichi Kaneko, Hitoshi Yokoyama, Takashi Wada
AIMS/INTRODUCTION: This retrospective study investigated the impact of renal arteriosclerosis (AS) and hypertension (HT) on long-term renal and cardiovascular outcomes in Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy. MATERIALS AND METHODS: A total of 185 patients were enrolled. Patients were divided into four groups stratified by renal AS status and presence of HT. The outcomes for this study were the first occurrence of renal events (a need for dialysis or a 30% decline in estimated glomerular filtration rate from baseline) and cardiovascular events (cardiovascular death, nonfatal myocardial infarction, coronary intervention, or nonfatal stroke)...
December 5, 2018: Journal of Diabetes Investigation
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