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https://www.readbyqxmd.com/read/28222502/subclinical-doses-of-atp-sensitive-potassium-channel-modulators-prevent-alterations-in-memory-and-synaptic-alterations-in-memory-and-synaptic-%C3%AE
#1
Karla Salgado-Puga, Javier Rodríguez-Colorado, Roberto A Prado-Alcalá, Fernando Peña-Ortega
In addition to coupling cell metabolism and excitability, ATP-sensitive potassium channels (KATP) are involved in neural function and plasticity. Moreover, alterations in KATP activity and expression have been observed in Alzheimer's disease (AD) and during amyloid-β (Aβ)-induced pathology. Thus, we tested whether KATP modulators can influence Aβ-induced deleterious effects on memory, hippocampal network function, and plasticity. We found that treating animals with subclinical doses (those that did not change glycemia) of a KATP blocker (Tolbutamide) or a KATP opener (Diazoxide) differentially restrained Aβ-induced memory deficit, hippocampal network activity inhibition, and long-term synaptic plasticity unbalance (i...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28220846/cmt-linked-loss-of-function-mutations-in-gdap1-impair-store-operated-ca-2-entry-stimulated-respiration
#2
Paloma González-Sánchez, David Pla-Martín, Paula Martínez-Valero, Carlos B Rueda, Eduardo Calpena, Araceli Del Arco, Francesc Palau, Jorgina Satrústegui
GDAP1 is an outer mitochondrial membrane protein involved in Charcot-Marie-Tooth (CMT) disease. Lack of GDAP1 gives rise to altered mitochondrial networks and endoplasmic reticulum (ER)-mitochondrial interactions resulting in a decreased ER-Ca(2+) levels along with a defect on store-operated calcium entry (SOCE) related to a misallocation of mitochondria to subplasmalemmal sites. The defect on SOCE is mimicked by MCU silencing or mitochondrial depolarization, which prevent mitochondrial calcium uptake. Ca(2+) release from de ER and Ca(2+) inflow through SOCE in neuroblastoma cells result in a Ca(2+)-dependent upregulation of respiration which is blunted in GDAP1 silenced cells...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220591/transcriptome-analysis-of-root-knot-nematode-meloidogyne-incognita-infected-tomato-solanum-lycopersicum-roots-reveals-complex-gene-expression-profiles-and-metabolic-networks-of-both-host-and-nematode-during-susceptible-and-resistance-responses
#3
Neha Shukla, Rachita Yadav, Pritam Kaur, Simon Rasmussen, Shailendra Goel, Manu Agarwal, Arun Jagannath, Ramneek Gupta, Amar Kumar
Root knot nematodes (RKNs, Meloidogyne incognita) are economically important endoparasites having a wide-host range. We have taken a comprehensive transcriptomic approach to investigate the expression of both tomato and RKN genes in tomato roots at five infection time intervals from susceptible plants and two infection time intervals from resistant plants, grown under soil conditions. Differentially expressed genes during susceptible (1827-tomato, 462-RKN) and resistance (25-tomato, 160-RKN) interactions were identified...
February 21, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28220550/metabolomic-profiling-in-umbilical-venous-plasma-reveals-effects-of-dietary-rumen-protected-arginine-or-n-carbamylglutamate-supplementation-in-nutrient-restricted-hu-sheep-during-pregnancy
#4
L Sun, H Zhang, Y Fan, Y Guo, G Zhang, H Nie, F Wang
Maternal nutrient restriction during pregnancy is a major problem worldwide for human and animal production. Arginine (Arg) is critical to health, growth and reproduction. N-carbamylglutamate (NCG), a key enzyme in arginine synthesis, is not extensively degraded in rumen. The aim of this study was to investigate ameliorating effects of rumen-protected arginine (RP-Arg) and NCG supplementation on dietary in undernourished Hu sheep during gestation. From day 35 to 110 of gestation, 32 Hu ewes carrying twin foetuses were randomly divided into four groups: a control (CG) group (n = 8; fed 100% National Research Council (NRC) requirements for pregnant sheep), a nutrient-restricted (RG) group (n = 8; fed 50% NRC requirements, which included 50% mineral-vitamin mixture) and two treatment (Arg and NCG) groups (n = 8; fed 50% NRC requirements supplemented with 20 g/day RP-Arg or 5 g/day NCG, which included 50% mineral-vitamin mixture)...
February 20, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28220065/prediction-of-mild-cognitive-impairment-conversion-using-a-combination-of-independent-component-analysis-and-the-cox-model
#5
Ke Liu, Kewei Chen, Li Yao, Xiaojuan Guo
Mild cognitive impairment (MCI) represents a transitional stage from normal aging to Alzheimer's disease (AD) and corresponds to a higher risk of developing AD. Thus, it is necessary to explore and predict the onset of AD in MCI stage. In this study, we propose a combination of independent component analysis (ICA) and the multivariate Cox proportional hazards regression model to investigate promising risk factors associated with MCI conversion among 126 MCI converters and 108 MCI non-converters from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28219933/akt-signalling-as-a-mediator-of-cardiac-adaptation-to-low-birth-weight
#6
Kimberley Cw Wang, Kimberley J Botting, Song Zhang, Caroline McMillen, Doug A Brooks, Janna L Morrison
Intrauterine insults, such as poor nutrition and placental insufficiency, can alter cardiomyocyte development and this can have significant long-term implications for heart health. Consequently, epidemiological studies have shown that low birth weight babies have an increased risk of death from cardiovascular disease in adult life. In addition, intrauterine growth restriction can result in increased left ventricular hypertrophy, which is the strongest predictor for poor health outcomes in cardiac patients. The mechanisms responsible for these associations are not clear, but a suboptimal intrauterine environment can program alternative expression of genes such as cardiac IGF-2/H19, IGF-2R and AT1R through either an increase or decrease in DNA methylation or histone acetylation at specific loci...
February 20, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28219524/the-function-and-transcriptome-analysis-of-a-bzip-transcription-factor-cgap1-in-colletotrichum-gloeosporioides
#7
Xiaoyu Li, Yateng Wu, Zhiqiang Liu, Chenghui Zhang
Colletotrichum gloeosporioides is an important pathogen of anthracnose, which is able to infect numerous crops in tropical and subtropical regions, causing great economic losses. To investigate the fungal response to host-generated reactive oxygen species (ROS), we cloned and characterized the CgAP1 gene of C. gloeosporioides. CgAP1 encoded a bZIP transcription factor which had a bZIP DNA-binding domain and two cysteine-rich domains structurally and functionally related to Saccharomyces cerevisiae YAP1. Deletion of CgAP1 in C...
April 2017: Microbiological Research
https://www.readbyqxmd.com/read/28217809/-generation-and-phenotype-analysis-of-zebrafish-mutations-of-obesity-related-genes-lepr-and-mc4r
#8
Fei Fei, Shao-Yang Sun, Yu-Xiao Yao, Xu Wang
Obesity has become a severe public health problem across the world, and seriously affects the health and life quality of human beings. Here we generated lepr and mc4r mutant zebrafish via the CRISPR/Cas9 technique, and performed morphological and functional characterizations of those mutants. We observed that there was no significant phenotypic difference between homozygous mutants and wild-type controls before 2.5 months post-fertilization (mpf). However, the adult lepr(-/-) and mc4r(-/-) individuals displayed increased food intake, heavier weight, and higher body fat percentage, the characteristics of obesity phenotypes...
February 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28217746/integrated-regulatory-and-metabolic-networks-of-the-marine-diatom-phaeodactylum-tricornutum-predict-the-response-to-rising-co2-levels
#9
Jennifer Levering, Christopher L Dupont, Andrew E Allen, Bernhard O Palsson, Karsten Zengler
Diatoms are eukaryotic microalgae that are responsible for up to 40% of the ocean's primary productivity. How diatoms respond to environmental perturbations such as elevated carbon concentrations in the atmosphere is currently poorly understood. We developed a transcriptional regulatory network based on various transcriptome sequencing expression libraries for different environmental responses to gain insight into the marine diatom's metabolic and regulatory interactions and provide a comprehensive framework of responses to increasing atmospheric carbon levels...
January 2017: MSystems
https://www.readbyqxmd.com/read/28217689/multiple-roles-of-myc-in-integrating-regulatory-networks-of-pluripotent-stem-cells
#10
REVIEW
Luca Fagnocchi, Alessio Zippo
Pluripotent stem cells (PSCs) are defined by their self-renewal potential, which permits their unlimited propagation, and their pluripotency, being able to generate cell of the three embryonic lineages. These properties render PSCs a valuable tool for both basic and medical research. To induce and stabilize the pluripotent state, complex circuitries involving signaling pathways, transcription regulators and epigenetic mechanisms converge on a core transcriptional regulatory network of PSCs, thus determining their cell identity...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28217130/transcriptome-analyses-reveal-candidate-genes-potentially-involved-in-al-stress-response-in-alfalfa
#11
Wenxian Liu, Conghui Xiong, Longfeng Yan, Zhengshe Zhang, Lichao Ma, Yanrong Wang, Yajie Liu, Zhipeng Liu
Alfalfa is the most extensively cultivated forage legume, yet most alfalfa cultivars are not aluminum tolerant, and the molecular mechanisms underlying alfalfa responses to Al stress are largely unknown. In this study, we aimed to understand how alfalfa responds to Al stress by identifying and analyzing Al-stress-responsive genes in alfalfa roots at the whole-genome scale. The transcriptome changes in alfalfa roots under Al stress for 4, 8, or 24 h were analyzed using Illumina high-throughput sequencing platforms...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28217095/endogenous-protein-interactome-of-human-udp-glucuronosyltransferases-exposed-by-untargeted-proteomics
#12
Michèle Rouleau, Yannick Audet-Delage, Sylvie Desjardins, Mélanie Rouleau, Camille Girard-Bock, Chantal Guillemette
The conjugative metabolism mediated by UDP-glucuronosyltransferase enzymes (UGTs) significantly influences the bioavailability and biological responses of endogenous molecule substrates and xenobiotics including drugs. UGTs participate in the regulation of cellular homeostasis by limiting stress induced by toxic molecules, and by controlling hormonal signaling networks. Glucuronidation is highly regulated at genomic, transcriptional, post-transcriptional and post-translational levels. However, the UGT protein interaction network, which is likely to influence glucuronidation, has received little attention...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28216505/-effect-of-hypoxia-on-expression-of-multidrug-resistance-protein-2-and-its-regulation-mechanism
#13
Bingfeng Luo, Wenbin Li, Rong Wang, Hui Lu, Tao Yang, Zhengping Jia
Drug efflux transporters plays a key role in pharmacokinetics parameters changes. In recent years, in addition to P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), MRP2 has become an advanced research hotspot. Several signaling pathways andtranscription factors have been reported to be involved in regulation of MRP2 expression in hypoxic microenvironment of tumor, such as peroxisome proliferators-activated receptors (PPARα), nuclear factor κB (NF-κB), pregnane X receptor (PXR), farnesoid X receptor (FXR), constitutive androstane receptor (CAR) and microRNA...
January 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28215897/effects-of-body-condition-monensin-and-essential-oils-on-ruminal-lipopolysaccharide-concentration-inflammatory-markers-and-endoplasmatic-reticulum-stress-of-transition-dairy-cows
#14
C Drong, S Bühler, J Frahm, L Hüther, U Meyer, D von Soosten, D K Gessner, K Eder, H Sauerwein, S Dänicke
Evidence exists that dairy cows experience inflammatory-like phenomena in the transition period. Rumen health and alterations in metabolic processes and gene networks in the liver as the central metabolic organ might be key factors for cows' health and productivity in early lactation. This study made use of an animal model to generate experimental groups with different manifestations of postpartal fat mobilization and ketogenesis. In total, 60 German Holstein cows were allocated 6 wk antepartum to 3 high-body condition score (BCS) groups (BCS 3...
February 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28215419/comparative-metabolite-and-genome-analysis-of-tuber-bearing-potato-species
#15
Riccardo Aversano, Felice Contaldi, Maria Grazia Adelfi, Vincenzo D'Amelia, Gianfranco Diretto, Nunziatina De Tommasi, Carmen Vaccaro, Antonio Vassallo, Domenico Carputo
The cultivated potato Solanum tuberosum is unrivalled among crop plants for its wild relatives, which potentially represent an important source of genetic diversity to improve the nutritional value of potato varieties and understand metabolism regulation. The main aim of this research was to profile human health-related metabolites in a number of clones from 13 Solanum species. Results from HPLC-DAD and LC-ESI-MS analyses highlighted a high interspecific variability in the level of metabolites analysed. Ascorbic acid was confirmed to be the most abundant antioxidant in potato and chlorogenic acid the primary polyphenol...
February 16, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28214524/bile-acid-control-of-metabolism-and-inflammation-in-obesity-type-2-diabetes-dyslipidemia-and-nafld
#16
Oscar Chávez-Talavera, Anne Tailleux, Philippe Lefebvre, Bart Staels
Bile acids are signaling molecules, which coordinately regulate metabolism and inflammation via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 (TGR5). These receptors activate transcriptional networks and signaling cascades controlling the expression and activity of genes involved in bile acid, lipid and carbohydrate metabolism, energy expenditure, and inflammation by acting predominantly in entero-hepatic tissues, but also in peripheral organs. In this review, we discuss the most recent findings on the inter-organ signaling and interplay with the gut microbiota of bile acids and their receptors in meta-inflammation, with a focus on their pathophysiological roles in obesity, type 2 diabetes, dyslipidemia and non-alcoholic steatohepatitis and their potential therapeutic applications...
February 15, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28213348/the-plant-economic-spectrum-in-bryophytes-a-comparative-study-in-subalpine-forest
#17
Zhe Wang, Xin Liu, Maaike Y Bader, Defeng Feng, Weikai Bao
PREMISE OF THE STUDY: Tradeoffs among functional traits of vascular plants are starting to be better understood, but it is unclear whether bryophytes possess similar tradeoffs or how trait relationships, or the 'economic spectrum', differ between the two groups. METHODS: We determined functional-trait values [including shoot mass per area (SMA), light-saturated assimilation rate (Amass), dark respiration rate (Rdmass), N and P concentrations (Nmass and Pmass), and photosynthetic N and P use efficiency (PNUE and PPUE)] and their bivariate relationships for 28 bryophytes growing in a subalpine old-growth fir forest on the eastern Tibetan Plateau...
February 17, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28213065/requiring-collaboration-hippocampal-prefrontal-networks-needed-in-spatial-working-memory-and-ageing-a-multivariate-analysis-approach
#18
C Zancada-Menendez, P Alvarez-Suarez, P Sampedro-Piquero, M Cuesta, A Begega
Ageing is characterized by a decline in the processes of retention and storage of spatial information. We have examined the behavioural performance of adult rats (3 months old) and aged rats (18 months old) in a spatial complex task (delayed match to sample). The spatial task was performed in the Morris water maze and consisted of three sessions per day over a period of three consecutive days. Each session consisted of two trials (one sample and retention) and inter-session intervals of five minutes. Behavioural results showed that the spatial task was difficult for middle aged group...
February 14, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28212624/understanding-the-response-to-endurance-exercise-using-a-systems-biology-approach-combining-blood-metabolomics-transcriptomics-and-mirnomics-in-horses
#19
Núria Mach, Yuliaxis Ramayo-Caldas, Allison Clark, Marco Moroldo, Céline Robert, Eric Barrey, Jesús Maria López, Laurence Le Moyec
BACKGROUND: Endurance exercise in horses requires adaptive processes involving physiological, biochemical, and cognitive-behavioral responses in an attempt to regain homeostasis. We hypothesized that the identification of the relationships between blood metabolome, transcriptome, and miRNome during endurance exercise in horses could provide significant insights into the molecular response to endurance exercise. For this reason, the serum metabolome and whole-blood transcriptome and miRNome data were obtained from ten horses before and after a 160 km endurance competition...
February 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28212377/optimality-principles-reveal-a-complex-interplay-of-intermediate-toxicity-and-kinetic-efficiency-in-the-regulation-of-prokaryotic-metabolism
#20
Jan Ewald, Martin Bartl, Thomas Dandekar, Christoph Kaleta
A precise and rapid adjustment of fluxes through metabolic pathways is crucial for organisms to prevail in changing environmental conditions. Based on this reasoning, many guiding principles that govern the evolution of metabolic networks and their regulation have been uncovered. To this end, methods from dynamic optimization are ideally suited since they allow to uncover optimality principles behind the regulation of metabolic networks. We used dynamic optimization to investigate the influence of toxic intermediates in connection with the efficiency of enzymes on the regulation of a linear metabolic pathway...
February 2017: PLoS Computational Biology
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