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Hip platelet rich plasma

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https://www.readbyqxmd.com/read/30410938/the-role-of-wnt-pathway-in-the-pathogenesis-of-oa-and-its-potential-therapeutic-implications-in-the-field-of-regenerative-medicine
#1
REVIEW
Maria De Santis, Berardo Di Matteo, Emanuele Chisari, Gilberto Cincinelli, Peter Angele, Christian Lattermann, Giuseppe Filardo, Nicolò Danilo Vitale, Carlo Selmi, Elizaveta Kon
Introduction: Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation, subchondral damage, and bone remodelling, affecting most commonly weight-bearing joints, such as the knee and hip. The loss of cartilage leads to joint space narrowing, pain, and loss of function which could ultimately require total joint replacement. The Wnt/ β catenin pathway is involved in the pathophysiology of OA and has been proposed as a therapeutic target. Endogenous and pharmacological inhibitors of this pathway were recently investigated within innovative therapies including the use of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30360727/new-advances-in-stem-cell-therapy-for-osteonecrosis-of-the-femoral-head
#2
Wei Zhou, Ming Qu, Yajie Lv, Jinyu Zhu
Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease with multiple etiologies that more frequently occurs in middle-aged and young people. ONFH is the main cause of hip replacement in young patients. Since Professor Hernigou first reported the use of stem cells in the treatment of early stage ONFH, a large number of studies have demonstrated the potential of stem cells in the treatment of adult patients with ONFH. With the rise of interdisciplinary, stem cell therapy combined with platelet-rich plasma therapy, gene therapy or other methods are gradually attracted the attention of researchers...
October 25, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30353479/current-clinical-recommendations-for-use-of-platelet-rich-plasma
#3
REVIEW
Adrian D K Le, Lawrence Enweze, Malcolm R DeBaun, Jason L Dragoo
PURPOSE OF REVIEW: This review evaluates current clinical literature on the use of platelet-rich plasma (PRP), including leukocyte-rich PRP (LR-PRP) and leukocyte-poor PRP (LP-PRP), in order to develop evidence-based recommendations for various musculoskeletal indications. RECENT FINDINGS: Abundant high-quality evidence supports the use of LR-PRP injection for lateral epicondylitis and LP-PRP for osteoarthritis of the knee. Moderate high-quality evidence supports the use of LR-PRP injection for patellar tendinopathy and of PRP injection for plantar fasciitis and donor site pain in patellar tendon graft BTB ACL reconstruction...
December 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/30290603/the-clinical-efficacy-of-using-autologous-platelet-rich-plasma-in-total-hip-arthroplasty-a-retrospective-comparative-study
#4
COMPARATIVE STUDY
Xi Wang, Jianbin Ma, Zhiyuan Wang, Lin Xiao
This study evaluated whether intra-articular platelet-rich plasma (PRP) might prevent postoperative bleeding in total hip arthroplasty (THA).In this study, 260 hips that underwent THA were evaluated randomly by paramedical staffs, 130 of which involved the intraoperative use of PRP, and 130 of which served as control group. Postoperative blood loss (drain bag volume), estimated blood loss, and change in hemoglobin (Hb) at day 1, 2, 4, and 7 were analyzed, respectively.PRP-treated group had a significant decrease in mean postoperative blood loss (92...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30274850/platelet-rich-plasma-myth-or-reality
#5
A Martínez-Martínez, F Ruiz-Santiago, J García-Espinosa
Platelet-rich plasma (PRP) is a preparation for therapeutic purposes that is increasingly accepted for various musculoskeletal disorders, due to its theoretical potential to repair tissues with poor healing capacity. Several randomised clinical trials have investigated the capacity of PRP to repair tendons, ligaments, muscles and cartilage, and to date there is level 1a evidence to support its use for lateral epicondylitis, osteoarthritis of the knee, plantar fasciitis and rotator cuff tendinopathy; and level 1b for patellar tendinopathy and osteoarthritis of the hip...
September 28, 2018: Radiología
https://www.readbyqxmd.com/read/30241561/a-double-blind-randomised-control-trial-investigating-the-efficacy-of-platelet-rich-plasma-versus-placebo-for-the-treatment-of-greater-trochanteric-pain-syndrome-the-hippo-trial-a-protocol-for-a-randomised-clinical-trial
#6
Eshan Oderuth, Mohammed Ali, Ismael Atchia, Ajay Malviya
BACKGROUND: Greater trochanteric pain syndrome (GTPS) is a painful condition characterised by pain around the greater trochanter usually affecting middle-aged women. The majority of patients will improve with conservative management such as physiotherapy and non-steroidal anti-inflammatory drugs (NSAIDs); however, if this fails then more invasive treatments including corticosteroid injections and surgery may be required. Platelet-rich plasma (PRP) is an autologous blood product, which has a higher concentration of growth factors postulated to provide enhanced healing and anti-inflammatory properties...
September 21, 2018: Trials
https://www.readbyqxmd.com/read/30132395/hyperacute-serum-has-markedly-better-regenerative-efficacy-than-platelet-rich-plasma-in-a-human-bone-oxygen-glucose-deprivation-model
#7
Gabriella Vácz, Bálint Major, Dorottya Gaál, Laura Petrik, Dénes Balázs Horváthy, Weiping Han, Tünde Holczer, Melinda Simon, Jeffrey M Muir, István Hornyák, Zsombor Lacza
AIM: Platelet-rich plasma (PRP) and hyperacute serum (HAS) were compared in a novel human model of ex vivo bone damage induced by oxygen-glucose deprivation (OGD). MATERIALS & METHODS: Osteoarthritic subchondral bone pieces were harvested from discarded femoral heads during hip replacement surgery and subjected to transient OGD. RESULTS: Proteome profiling revealed that PRP is more angiopoietic, whereas HAS is more antiangiopoietic in composition...
July 1, 2018: Regenerative Medicine
https://www.readbyqxmd.com/read/30084822/effectiveness-of-thrombin-collagen-and-autologous-platelet-rich-plasma-in-total-hip-arthroplasty-hemostasis-a-prospective-randomized-controlled-trial
#8
RANDOMIZED CONTROLLED TRIAL
Eric N Bowman, Michael P McCabe, Kevin B Cleveland
Bovine derived thrombin-collagen combined with autologous platelet-rich plasma (PRP) has shown promise as a topical, surgical hemostatic agent. The purpose of this study was to determine the effect of thrombin-collagen-PRP on perioperative blood loss in total hip arthroplasty (THA). A prospective, single-blinded, randomized, controlled study comparing thrombin-collagen-PRP use to standard treatment was performed. All patients undergoing elective primary THA for osteoarthritis by a single physician at a single institution were included...
December 0: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/30046854/-joint-preserving-operative-treatment-of-avascular-necrosis-of-the-femoral-head
#9
REVIEW
C Lüring, C Benignus, J Beckmann
The cause of avascular necrosis of the femoral head is multifactorial. Conservative treatment is only an option in the early stages. It is only symptomatic and not causative treatment. The implantation of an artificial hip joint should be postponed as the typically affected middle-aged males are right in the middle of their working life. Therefore, some joint-preserving operative therapies might be considered in stages ARCO I-III. Those range from core decompression to osteotomies and grafts, the advantages and disadvantages of which have to be weighted in each case...
September 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29923073/perioperative-platelet-rich-plasma-prp-in-total-hip-arthroplasty-through-the-hardinge-approach-protocol-to-study-the-effectiveness-for-gluteus-medius-healing
#10
Anni Aavikko, J Puhakka, J Haapala, J Kukkonen, K Mäkelä, J Kosola
BACKGROUND: Platelet-rich plasma (PRP) has been used to support tendon regeneration mainly in sports medicine. PRP is a concentrate of platelet-rich plasma proteins derived from whole blood by centrifugation to remove erythrocytes and leukocytes. PRP has high amounts of platelets which may promote healing tendons affected by degenerative conditions. These platelets contain growth factors and are known to facilitate the regeneration of injured tendon structures. Total hip arthroplasty (THA) through the Hardinge approach may leave the patient with impaired gait and poor regeneration of the gluteus medius tendon if the tendon is not reattached properly after closure of the surgical wound...
June 19, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29868405/arthroscopic-treatment-of-hip-chondral-defect-with-microfracture-and-platelet-rich-plasma-infused-micronized-cartilage-allograft-augmentation
#11
Michael S Schallmo, Alejandro Marquez-Lara, T David Luo, Samuel Rosas, Allston J Stubbs
Over the past decade, arthroscopic microfracture has become increasingly popular to treat full-thickness (Outerbridge grade IV) chondral defects of the hip. This procedure borrows marrow stimulation treatment principles and techniques from knee arthroscopy, with similar mixed clinical outcomes that may be more favorable in the short term (<2 years) and poorer in the long term. Despite these varied outcomes, microfracture remains the most frequently used technique to treat small focal chondral defects because of the relative ease and cost-effectiveness of the procedure...
April 2018: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29675502/survival-analysis-after-core-decompression-in-association-with-platelet-rich-plasma-mesenchymal-stem-cells-and-synthetic-bone-graft-in-patients-with-osteonecrosis-of-the-femoral-head
#12
Riccardo D'Ambrosi, Elena Biancardi, Giulia Massari, Vincenza Ragone, Renato Mario Facchini
Purpose  The aim of this study was to report the rate of survivorship in patients with osteonecrosis of the femoral head treated with core decompression in association with mesenchymal stem cells (MSCs) implantation, platelet-rich plasma (PRP) injection, and synthetic bone graft. Methods  We evaluated 24 hips in 16 patients, according to Ficat classification, treated by core decompression, injection of PRP and MSCs, and backfilling of the core tract with synthetic bone graft. Survivorship was estimated using Kaplan-Meier curves...
March 2018: Joints
https://www.readbyqxmd.com/read/29626641/platelet-rich-plasma-versus-hyaluronic-acid-in-patients-with-hip-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#13
REVIEW
Ye Ye, Xiang Zhou, Shuiwei Mao, Jun Zhang, Bingmin Lin
BACKGROUND: This study aims to compare the efficacy of intra-articular injection of hyaluronic acid (HA) and platelet-rich plasma (PRP) for treating hip osteoarthritis (OA). METHODS: We performed systematic searches in PubMed, EmBase, ScienceDirect Web of science and the Cochrane Library for relevant literature published in or before February 2018. Only randomized controlled trials (RCTs) were included. The risk of bias assessment was performed using the tool recommended in the Cochrane Handbook for Systematic Reviews of Interventions (version 5...
May 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29601399/reply-to-the-letter-to-the-editor-stem-cells-combined-with-platelet-rich-plasma-effectively-treat-corticosteroid-induced-osteonecrosis-of-the-hip-a-prospective-study
#14
Matthew T Houdek, Cody C Wyles, Mark S Collins, Benjamin M Howe, Andre Terzic, Atta Behfar, Rafael J Sierra
No abstract text is available yet for this article.
May 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29601389/letter-to-the-editor-stem-cells-combined-with-platelet-rich-plasma-effectively-treat-corticosteroid-induced-osteonecrosis-of-the-hip-a-prospective-study
#15
Nicolas S Piuzzi
No abstract text is available yet for this article.
May 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29529675/corr-insights%C3%A2-stem-cells-combined-with-platelet-rich-plasma-effectively-treat-corticosteroid-induced-osteonecrosis-of-the-hip-a-prospective-study
#16
Thomas Parker Vail
No abstract text is available yet for this article.
February 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29529674/stem-cells-combined-with-platelet-rich-plasma-effectively-treat-corticosteroid-induced-osteonecrosis-of-the-hip-a-prospective-study
#17
Matthew T Houdek, Cody C Wyles, Mark S Collins, Benjamin M Howe, Andre Terzic, Atta Behfar, Rafael J Sierra
BACKGROUND: Randomized trials have shown the benefits of injecting bone marrow-derived mesenchymal stem cells (BmMSCs) after standard hip decompression in patients with osteonecrosis of the femoral head. However, the combination of BmMSCs and platelet-rich plasma (PRP) injected into the femoral head after decompression has not been reported previously. This study reports the results in a preliminary series of patients with osteonecrosis of the femoral head treated with BmMSCs plus PRP...
February 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29509237/do-the-trace-elements-play-a-role-in-the-etiopathogenesis-of-developmental-dysplasia-of-hip
#18
S Guner, S I Guner, M A Gokalp, M F Ceylan, S S Unsal, H Demir
OBJECTIVE: Alterations in the connective tissue of the hip joint capsule and ligaments might account for the increased laxity seen in patients with developmental dysplasia of the hip. The tensile features of the connective tissue depend on collagen. A number of prior studies have noted the association between the trace elements and collagen biosynthesis. The aim of this research is to determine whether there exists an association between the trace elements and developmental dysplasia of the hip...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29411077/regenerative-therapies-increase-survivorship-of-avascular-necrosis-of-the-femoral-head-a-systematic-review-and-meta-analysis
#19
REVIEW
Luca Andriolo, Giulia Merli, Carlos Tobar, Sante Alessandro Altamura, Elizaveta Kon, Giuseppe Filardo
PURPOSE: The aim of this study was to document the available evidence on the use of regenerative techniques for the treatment of femoral head osteonecrosis (or avascular necrosis of femoral head, AVN) and to understand their benefit compared to core decompression (CD) alone in avoiding failure and the need for total hip replacement (THR). METHODS: The search was conducted on three medical electronic databases according to PRISMA guidelines. The studies reporting number and timing of failures were included in a meta-analysis calculating cumulative survivorship with a Kaplan-Mayer curve...
July 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29293361/the-effectiveness-of-platelet-rich-plasma-injections-in-gluteal-tendinopathy-a-randomized-double-blind-controlled-trial-comparing-a-single-platelet-rich-plasma-injection-with-a-single-corticosteroid-injection
#20
Jane Fitzpatrick, Max K Bulsara, John O'Donnell, Paul Robert McCrory, Ming Hao Zheng
BACKGROUND: Gluteus medius/minimus tendinopathy is a common cause of lateral hip pain or greater trochanteric pain syndrome. HYPOTHESIS: There would be no difference in the modified Harris Hip Score (mHHS) between a single platelet-rich plasma (PRP) injection compared with a corticosteroid injection in the treatment of gluteal tendinopathy. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: There were 228 consecutive patients referred with gluteal tendinopathy who were screened to enroll 80 participants; 148 were excluded (refusal: n = 42; previous surgery or sciatica: n = 50; osteoarthritis, n = 17; full-thickness tendon tear, n = 17; other: n = 22)...
March 2018: American Journal of Sports Medicine
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