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cyclodipeptides, quorum sensing, bioactive compounds

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https://www.readbyqxmd.com/read/22709011/antimicrobial-and-biofilm-inhibiting-diketopiperazines
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M P de Carvalho, W-R Abraham
Diketopiperazines are the smallest cyclic peptides known. 90% of Gram-negative bacteria produce diketopiperazines and they have also been isolated from Gram-positive bacteria, fungi and higher organisms. Biosynthesis of cyclodipeptides can be achieved by dedicated nonribosomal peptide synthetases or by a novel type of synthetases named cyclopeptide synthases. Since the first report in 1924 a large number of bioactive diketopiperazines was discovered spanning activities as antitumor, antiviral, antifungal, antibacterial, antiprion, antihyperglycemic or glycosidase inhibitor agents...
2012: Current Medicinal Chemistry
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