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Knee platelet rich plasma

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https://www.readbyqxmd.com/read/30055602/efficacy-of-intra-articular-injections-of-platelet-rich-plasma-as-a-symptom-and-disease-modifying-treatment-for-knee-osteoarthritis-the-restore-trial-protocol
#1
Kade L Paterson, David J Hunter, Ben R Metcalf, Jillian Eyles, Vicky Duong, Jessica Kazsa, Yuanyuan Wang, Rachelle Buchbinder, Flavia Cicuttini, Andrew Forbes, Anthony Harris, Shirley P Yu, Bing Hui Wang, David Connell, James Linklater, Kim L Bennell
BACKGROUND: Knee osteoarthritis (OA) causes substantial pain, physical dysfunction and impaired quality of life. There is no cure for knee OA, and for some people, the disease may involve progressive symptomatic and structural deterioration over time. Platelet-rich plasma (PRP) is a therapeutic agent that aims to address underlying biological processes responsible for OA pathogenesis. As such, it has the potential to improve both symptoms and joint structure. The aim of this clinical trial is to determine whether a series of injections of PRP into the knee joint will lead to a significantly greater reduction in knee pain, and less loss of medial tibial cartilage volume over 12 months when compared to a series of placebo saline injections in people with knee OA...
July 28, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30038838/the-use-of-serial-platelet-rich-plasma-injections-with-early-rehabilitation-to-expedite-grade-iii-medial-collateral-ligament-injury-in-a-professional-athlete-a-case-report
#2
Michael S Bagwell, Kevin E Wilk, Ricardo E Colberg, Jeffrey R Dugas
Background: Medial collateral ligament (MCL) injuries are one of the most commonly treated knee pathologies in sports medicine. The MCL serves as the primary restraint to valgus force. The large majority of these injuries do not require surgical intervention. Case Subject Description: A 30-year-old professional wrestling athlete presented to the clinic with acute complaints of right medial knee pain resulting from a traumatic valgus force. Physical exam revealed Grade 3 MCL injury...
June 2018: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/30036140/effect-of-platelet-rich-plasma-on-chondrogenic-differentiation-of-adipose-and-bone-marrow-derived-mesenchymal-stem-cells
#3
Jr-Jiun Liou, Benjamin B Rothrauff, Peter G Alexander, Rocky S Tuan
Post-traumatic and focal cartilage defects of the knee affect over 3 million Americans annually. Autologous cell-based cartilage repair, for example, autologous chondrocyte implantation, is limited by the need for ex vivo chondrocyte expansion and donor site morbidity. Mesenchymal stem cells (MSCs), owing to their relative ease of isolation, higher replication activity, and chondrogenic potential, represent an alternative reparative cell type. Platelet-rich plasma (PRP) is an autologous, growth factor-rich biologic preparation that has recently received increasing attention and use as a therapeutic adjunct for the treatment of degenerative joint diseases, and there is evidence suggesting that PRP acts by promoting stem cell proliferation and tissue healing...
July 23, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/30020117/nonoperative-treatments-for-knee-osteoarthritis-an-evaluation-of-treatment-characteristics-and-the-intra-articular-placebo-effect-a-systematic-review
#4
Christopher Vannabouathong, Mohit Bhandari, Asheesh Bedi, Vickas Khanna, Patrick Yung, Vijay Shetty, Moin Khan
BACKGROUND: Guidelines recommending various nonoperative treatments for patients with knee osteoarthritis remain inconsistent. Much of this controversy relates to what constitutes a clinically important effect. The purposes of the present study were to compare treatment effect sizes from recent meta-analyses evaluating pharmacological or medical device interventions for the treatment of knee osteoarthritis and to further assess the clinical impact that the intra-articular placebo effect may have on intra-articular injection therapies...
July 2018: JBJS Reviews
https://www.readbyqxmd.com/read/29998744/nondestructive-assessment-of-articular-cartilage-electromechanical-properties-after-osteochondral-autologous-and-allogeneic-transplantation-in-a-goat-model
#5
Tomas Mickevicius, Alius Pockevicius, Audrius Kucinskas, Rimtautas Gudas, Justinas Maciulaitis, Arvydas Usas
Objective To determine the applicability of a minimally invasive diagnostic device to evaluate the quality of articular cartilage following autologous (OAT) and allogeneic (OCA) osteochondral graft transplantation in goat model. Design OAT grafts were harvested from lateral femoral condyles (LFCs) and transplanted into osteochondral defects created in medial femoral condyles (MFCs) of contralateral knees. OCA grafts were transplanted into MFC condyles after in vitro storage. Autologous platelet-rich plasma (PRP) was administered intraarticularly after the surgery and at 1 and 2 months postoperatively...
July 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29997901/platelet-rich-plasma-prp-therapy-for-knee-arthritis-a-feasibility-study-in-primary-care
#6
Liam G Glynn, Alaa Mustafa, Monica Casey, Janusz Krawczyk, Jeanete Blom, Rose Galvin, Ailish Hannigan, Colum P Dunne, Andrew W Murphy, Christian Mallen
Background: Platelet-rich plasma (PRP) is a concentrate of autologous blood growth factors which has been shown to provide some symptomatic relief in early osteoarthritis (OA) of the knee. The objective of this study was to test the feasibility and efficacy potential of platelet rich plasma (PRP) in primary care. Methods: Feasibility study to assess safety of the intervention procedures and assess primary and secondary outcome measures. Consecutive patients presenting with symptomatic knee OA were recruited in a primary care setting in Ireland...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29963845/musculoskeletal-therapies-musculoskeletal-injection-therapy
#7
Chad Hulsopple
Injections often are used in the management of common musculoskeletal conditions. Physicians should understand the disease pathophysiology and evidence supporting available injections when determining appropriate therapy. These therapies include corticosteroid injections (CSIs), hyaluronic acid (HA) injections, hypertonic dextrose prolotherapy, platelet-rich plasma (PRP) injections, mesenchymal stem cell (MSC) injections, and trigger point injections (TPIs). CSIs are recommended conditionally by the American College of Rheumatology for osteoarthritis (OA) management...
July 2018: FP Essentials
https://www.readbyqxmd.com/read/29927631/therapeutic-effects-of-the-addition-of-platelet-rich-plasma-to-bioimplants-and-early-rehabilitation-exercise-on-articular-cartilage-repair
#8
Nai-Jen Chang, Yanjmaa Erdenekhuyag, Pei-Hsi Chou, Chih-Jou Chu, Chih-Chan Lin, Ming-You Shie
BACKGROUND: Treating articular cartilage lesions is clinically challenging. However, whether the addition of autologous platelet-rich plasma (PRP) to bioimplants along with early rehabilitation exercise provides therapeutic effects and regenerates the osteochondral defect remains uninvestigated. HYPOTHESIS: The addition of PRP to a polylactic-co-glycolic acid (PLGA) scaffold along with continuous passive motion (CPM) in osteochondral defects may offer beneficial in situ microenvironment changes to facilitate hyaline cartilage and subchondral bone tissue repair...
July 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29921309/is-local-platelet-rich-plasma-injection-clinically-superior-to-hyaluronic-acid-for-treatment-of-knee-osteoarthritis-a-systematic-review-of-randomized-controlled-trials
#9
Yalong Di, Changxu Han, Liang Zhao, Yizhong Ren
BACKGROUND: In this study, we evaluated whether platelet-rich plasma (PRP) is superior to hyaluronic acid (HA) in the treatment of knee osteoarthritis. METHODS: The Cochrane Central Register of Controlled Trials, PubMed, and Embase databases were searched for English-language, human in vivo studies on the treatment of symptomatic knee osteoarthritis with intra-articular PRP compared with HA. The following keywords were used for the search: "platelet-rich plasma," "PRP," "platelet-rich fibrin," "PRF," "platelet," "plasma," "arthritis," "osteoarthritis," "gonarthrosis," and "degeneration...
June 19, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29909689/intra-articular-injections-in-the-treatment-of-symptoms-from-ankle-arthritis-a-systematic-review
#10
Christopher Vannabouathong, Gina Del Fabbro, Brendan Sales, Christopher Smith, Chuan Silvia Li, Darryl Yardley, Mohit Bhandari, Bradley A Petrisor
BACKGROUND: Intra-articular (IA) injections are commonly used to treat knee arthritis pain; however, whether their efficacy generalizes to ankle arthritis remains debatable. We aimed to evaluate the evidence for IA therapies in the management of this patient population. METHODS: We performed a literature search for observational and randomized controlled trials (RCTs). Treatments included corticosteroids (CS), hyaluronic acid (HA), platelet-rich plasma (PRP), and mesenchymal stem cells (MSC)...
June 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29896019/osteochondritis-dissecans-does-platelet-rich-plasma-really-help
#11
Deepak Kumar Sharma, Narendra Kumar, Hitesh Lal, Binay Kumar Sahu, Sumon Singphow Saikia
Osteochondritis dissecans is a common disorder of knee and can be treated by various methods, depending on age of patient and stability of chondral fragment. In Osteochondritis dissecans ICRS type III lesion i.e. articular cartilage discontinuity but no dislocation, variable rate of union as well as high rate of non-union was observed in previous studies when treated with arthroscopic or open reduction and fixation. In previous study it has been also shown that platelet rich plasma help in fracture healing...
April 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29881226/the-use-of-platelet-rich-fibrin-with-platelet-rich-plasma-support-meniscal-repair-surgery
#12
Masahiko Kemmochi, Shigeru Sasaki, Masako Takahashi, Tomitaka Nishimura, Chisa Aizawa, Jun Kikuchi
Introduction: Platelet-rich fibrin (PRF) is the only autologous blood product that releases growth factors and has scaffolding properties. We hypothesized that the use of PRF and Platelet-rich plasma (PRP) would improve operative results, including the recovery of function and repaired meniscus. Materials and Methods: Seventeen patients underwent arthroscopic meniscus repair with PRF and PRP (PRF group) using our novel device for the injection of the PRF into the joint...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29878617/clinical-outcomes-are-associated-with-changes-in-ultrasonographic-structural-appearance-after-platelet-rich-plasma-treatment-for-knee-osteoarthritis
#13
Hamada S Ahmad, Sherief E Farrag, Amr E Okasha, Aisha O Kadry, Tamer B Ata, Amir A Monir, Ibrahim Shady
BACKGROUND: Hyaluronic acid (HA) and platelet-rich plasma (PRP) are two treatment options used for knee osteoarthritis (KOA) but studies comparing the efficacy of the two yield conflicting results. In addition, the association of clinical outcomes of PRP intra-articular injections with changes in the ultrasonography structural appearance of the knee has not been investigated. AIM: To compare the efficacy of PRP and HA intra-articular injections as mono-therapeutic options for primary KOA, and to determine whether the clinical outcomes are associated with changes in the ultrasonography structural appearance...
May 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29871367/stem-cells-for-the-treatment-of-knee-osteoarthritis-a-comprehensive-review
#14
Lei Zhao, Alan D Kaye, Alaa Abd-Elsayed
BACKGROUND: Knee osteoarthritis (KOA) is a very challenging condition to treat and can be resistant to medications, procedures, and even surgery. Surgery may not be an option for some patients due to obesity or comorbidities. Regenerative medicine utilizing stem cells, platelet rich plasma (PRP), amniotic fluid, and cytokine modulation is very promising in the treatment of KOA. OBJECTIVE: This is a review article to evaluate the current evidence about regenerative medicine therapies in the treatment of KOA...
May 2018: Pain Physician
https://www.readbyqxmd.com/read/29868405/arthroscopic-treatment-of-hip-chondral-defect-with-microfracture-and-platelet-rich-plasma-infused-micronized-cartilage-allograft-augmentation
#15
Michael S Schallmo, Alejandro Marquez-Lara, T David Luo, Samuel Rosas, Allston J Stubbs
Over the past decade, arthroscopic microfracture has become increasingly popular to treat full-thickness (Outerbridge grade IV) chondral defects of the hip. This procedure borrows marrow stimulation treatment principles and techniques from knee arthroscopy, with similar mixed clinical outcomes that may be more favorable in the short term (<2 years) and poorer in the long term. Despite these varied outcomes, microfracture remains the most frequently used technique to treat small focal chondral defects because of the relative ease and cost-effectiveness of the procedure...
April 2018: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29849470/systematic-clinical-evidence-review-of-nasha-durolane-hyaluronic-acid-for-the-treatment-of-knee-osteoarthritis
#16
REVIEW
Ross Leighton, Jane Fitzpatrick, Helen Smith, Daniela Crandall, Carl R Flannery, Thierry Conrozier
Background: Pain and limitations in joint mobility associated with knee osteoarthritis (OA) are clinically challenging to manage, and advanced progression of disease can often lead to total knee arthroplasty. Intra-articular injection of hyaluronic acid (HA), also referred to as viscosupplementation, is a non-surgical treatment approach for OA, the effectiveness of which may depend on the HA composition, and the length of time over which it resides in the joint. One of the available options for such therapies includes NASHA (Durolane HA), a non-animal, biofermentation-derived product, which is manufactured using a process that stabilizes the HA molecules to slow down their rate of degradation and produce a unique formulation with a terminal half-life of ~1 month...
2018: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29806425/-effect-of-intra-articular-injection-of-platelet-rich-plasma-on-interleukin-17-expression-in-synovial-fluid-and-venous-plasma-of-knee-osteoarthritis-patients
#17
Haisen Zhang, Yuming Bai, Chang Liu, Shengli Jin, Ke Su, Ying Liu, Zhichang Lü
Objective: To investigate the interleukin-17 (IL-17) levels changes in both synovial fluid and venous plasma of patients with primary knee osteoarthritis (OA) after intra-articular injection of platelet-rich plasma (PRP). Methods: Between January 2015 and January 2016, 30 patients with primary knee OA were treated by intra-articular injection of PRP once a week for 3 weeks (trial group). Thirty healthy individuals were recruited into the study as control. There was no significant difference in gender, age, and body mass index between 2 groups ( P >0...
August 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29803179/platelet-rich-plasma-stromal-vascular-fraction-and-autologous-conditioned-serum-in-treatment-of-knee-osteoarthritis
#18
REVIEW
Ali Fotouhi, Arash Maleki, Sanam Dolati, Ali Aghebati-Maleki, Leili Aghebati-Maleki
Osteoarthritis (OA) is a multifactorial chronic disease, causing several problems on patients, hygiene and community care systems. Conventional therapies, such as non-pharmacological mediations, systemic drug treatment and intra-articular therapies are applying previously; however, controlling and management approaches of the disease mainly remain insufficient. Injections of intra-articular therapies directly into the joint evade conservative obstacles to joint entry, rise bioavailability and minor systemic toxicity...
August 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29741923/effect-of-intraoperative-platelet-rich-plasma-treatment-on-postoperative-donor-site-knee-pain-in-patellar-tendon-autograft-anterior-cruciate-ligament-reconstruction-a-double-blind-randomized-controlled-trial
#19
Brian L Walters, David A Porter, Sarah J Hobart, Benjamin B Bedford, Daniel E Hogan, Malachy M McHugh, Devon A Klein, Kendall Harousseau, Stephen J Nicholas
BACKGROUND: Donor site morbidity in the form of anterior knee pain is a frequent complication after bone-patellar tendon-bone (BPTB) autograft anterior cruciate ligament (ACL) reconstruction. Hypothesis/Purpose: The purpose was to examine the effect of the intraoperative administration of platelet-rich plasma (PRP) on postoperative kneeling pain. It was hypothesized that PRP treatment would reduce knee pain. STUDY DESIGN: Randomized controlled trial; Level of evidence, 2...
July 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29732431/platelet-rich-plasma-injections-an-emerging-therapy-for-chronic-discogenic-low-back-pain
#20
REVIEW
Suja Mohammed, James Yu
Autologous platelet-rich plasma (PRP) injections have been investigated in recent years as an emerging therapy for various musculoskeletal conditions, including lumbar degenerative disc disease. Although PRP has received increasing attention from medical science experts, comprehensive clinical reports of its efficacy are limited to those treating knee osteoarthritis and epicondylitis. Use of PRP is gaining popularity in the area of degenerative disc disease, but there is a clear need for reliable clinical evidence of its applications and effectiveness...
March 2018: Journal of Spine Surgery (Hong Kong)
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