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Knee platelet rich plasma

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https://www.readbyqxmd.com/read/30320755/clinical-protocol-of-producing-adipose-tissue-derived-stromal-vascular-fraction-for-potential-cartilage-regeneration
#1
Jaewoo Pak, Jung Hun Lee, Natalie Jieun Pak, Kwang Seung Park, Jeong Ho Jeon, Byeong Chul Jeong, Sang Hee Lee
Osteoarthritis (OA) is one of the most common debilitating disorders. Recently, numerous attempts have been made to improve the functions of the knees by using different forms of mesenchymal stem cells (MSCs). In Korea, bone marrow concentrates and cord blood-derived stem cells have been approved by the Korean Food and Drug Administration (KFDA) for cartilage regeneration. In addition, an adipose tissue-derived stromal vascular fraction (SVF) has been allowed by the KFDA for joint injections in human patients...
September 29, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30300216/optimizing-clinical-use-of-biologics-in-orthopaedic-surgery-consensus-recommendations-from-the-2018-aaos-nih-u-13-conference
#2
Constance R Chu, Scott Rodeo, Nidhi Bhutani, Laurie R Goodrich, Johnny Huard, James Irrgang, Robert F LaPrade, Christian Lattermann, Ying Lu, Bert Mandelbaum, Jeremy Mao, Louis McIntyre, Allan Mishra, George F Muschler, Nicolas S Piuzzi, Hollis Potter, Kurt Spindler, John M Tokish, Rocky Tuan, Kenneth Zaslav, William Maloney
Concern that misinformation from direct-to-consumer marketing of largely unproven "biologic" treatments such as platelet-rich plasma and cell-based therapies may erode the public trust and the responsible investment needed to bring legitimate biological therapies to patients have resulted in calls to action from professional organizations and governing bodies. In response to substantial patient demand for biologic treatment of orthopaedic conditions, the American Academy of Orthopaedic Surgeons convened a collaborative symposium and established a consensus framework for improving and accelerating the clinical evaluation, use, and optimization of biologic therapies for musculoskeletal diseases...
October 8, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/30274850/platelet-rich-plasma-myth-or-reality
#3
A Martínez-Martínez, F Ruiz-Santiago, J García-Espinosa
Platelet-rich plasma (PRP) is a preparation for therapeutic purposes that is increasingly accepted for various musculoskeletal disorders, due to its theoretical potential to repair tissues with poor healing capacity. Several randomised clinical trials have investigated the capacity of PRP to repair tendons, ligaments, muscles and cartilage, and to date there is level 1a evidence to support its use for lateral epicondylitis, osteoarthritis of the knee, plantar fasciitis and rotator cuff tendinopathy; and level 1b for patellar tendinopathy and osteoarthritis of the hip...
September 28, 2018: Radiología
https://www.readbyqxmd.com/read/30258340/the-quality-of-online-resources-available-to-patients-interested-in-knee-biologic-therapies-is-poor
#4
Benedict U Nwachukwu, Ryan C Rauck, Cynthia A Kahlenberg, Chukwuma Nwachukwu, William W Schairer, Riley J Williams, David W Altchek, Answorth A Allen
Background: As the use of biologic therapies for the management of knee pathology continues to expand, it is more likely that patients will turn to the Internet to gather information on this topic. Given the lack of scientific consensus on the use of biologics, care providers must understand what information is available online. Questions/Purposes: The purpose of this study was to evaluate the quality of websites that patients may use to educate themselves on knee biologics...
October 2018: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/30215165/platelet-rich-plasma-and-the-knee-applications-in-orthopedic-surgery
#5
REVIEW
Alexander Wasserman, Graeme Matthewson, Peter MacDonald
PURPOSE OF REVIEW: To consolidate and synthesize the most recent evidence on the effects of platelet-rich plasma (PRP) in the knee with respect to osteoarthritis, meniscal injuries, ACL reconstruction, total knee arthroplasty (TKA), and high tibial osteotomy. RECENT FINDINGS: PRP has been shown to be more beneficial in the context of knee osteoarthritis compared to both placebo and hyaluronic acid. Direct comparison with corticosteroid injections has been sparsely studied...
September 13, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/30195704/treatment-of-knee-meniscus-pathology-rehabilitation-surgery-and-orthobiologics
#6
REVIEW
Paul S Chirichella, Steven Jow, Stephen Iacono, Hannah E Wey, Gerard A Malanga
The meniscal tear treatment paradigm traditionally begins with conservative measures such as physical therapy with referral for operative management for persistent or mechanical symptoms. As a result, the partial meniscectomy is performed more than any other orthopedic procedure in the United States. This treatment paradigm has shifted because the recent literature has supported the attempt to preserve or repair the meniscus whenever possible given its importance for the structural integrity of the knee joint and the risk of early osteoarthritis associated after meniscus excision...
September 7, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/30189436/what-is-the-price-and-claimed-efficacy-of-platelet-rich-plasma-injections-for-the-treatment-of-knee-osteoarthritis-in-the-united-states
#7
Nicolas S Piuzzi, Mitchell Ng, Ariel Kantor, Kenneth Ng, Stephanie Kha, Michael A Mont, George F Muschler
Platelet-rich plasma (PRP) injections are often used for the treatment of knee osteoarthritis (OA), despite clinical value and cost-effectiveness not being definitely established. PRP injections are considered as a potential means of reducing pain and improving function in patients with knee OA, in the hope of delaying or avoiding the need for surgical intervention. Centers that offer PRP injections usually charge patients out of pocket and directly market services. Therefore, the purpose of this study was to quantify the current (1) prices and (2) marketed clinical efficacy of autologous PRP injections for knee OA...
September 6, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/30186448/clinical-therapy-of-hyaluronic-acid-combined-with-platelet-rich-plasma-for-the-treatment-of-knee-osteoarthritis
#8
Wenxing Yu, Peng Xu, Guiling Huang, Lin Liu
Knee osteoarthritis is the most common degenerative disease of the joints caused by articular cartilage injury, degradation of the joint edge and subchondral bone hyperplasia. Various treatments are used to alleviate the symptoms of patients with knee osteoarthritis, including analgesics and intra-articular injections. Platelet-rich plasma (PRP) is an autologous and multifunctional platelet concentrate of the blood, which stimulates the cartilage healing process and improves the damage caused by articular disease...
September 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30128934/clinical-and-radiographic-comparison-of-a-single-lp-prp-injection-a-single-hyaluronic-acid-injection-and-daily-nsaid-administration-with-a-52-week-follow-up-a-randomized-controlled-trial
#9
David Buendía-López, Manuel Medina-Quirós, Miguel Ángel Fernández-Villacañas Marín
BACKGROUND: Knee osteoarthritis (OA) is a disease with a high prevalence in the adult population. Nonsteroidal anti-inflammatory drugs (NSAID) or intra-articular injections [hyaluronic acid (HA) or platelet-rich plasma (PRP)] can provide clinical benefit. Magnetic resonance imaging (MRI) has proven to be useful for the evaluation of cartilage volume and thickness in knee osteoarthritis. The purpose of this study was to evaluate the benefit provided by PRP injection in comparison with hyaluronic acid and NSAID in knee OA patients and to compare the radiographic evolution at the 52-week follow-up...
August 20, 2018: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/30055602/efficacy-of-intra-articular-injections-of-platelet-rich-plasma-as-a-symptom-and-disease-modifying-treatment-for-knee-osteoarthritis-the-restore-trial-protocol
#10
Kade L Paterson, David J Hunter, Ben R Metcalf, Jillian Eyles, Vicky Duong, Jessica Kazsa, Yuanyuan Wang, Rachelle Buchbinder, Flavia Cicuttini, Andrew Forbes, Anthony Harris, Shirley P Yu, Bing Hui Wang, David Connell, James Linklater, Kim L Bennell
BACKGROUND: Knee osteoarthritis (OA) causes substantial pain, physical dysfunction and impaired quality of life. There is no cure for knee OA, and for some people, the disease may involve progressive symptomatic and structural deterioration over time. Platelet-rich plasma (PRP) is a therapeutic agent that aims to address underlying biological processes responsible for OA pathogenesis. As such, it has the potential to improve both symptoms and joint structure. The aim of this clinical trial is to determine whether a series of injections of PRP into the knee joint will lead to a significantly greater reduction in knee pain, and less loss of medial tibial cartilage volume over 12 months when compared to a series of placebo saline injections in people with knee OA...
July 28, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30038838/the-use-of-serial-platelet-rich-plasma-injections-with-early-rehabilitation-to-expedite-grade-iii-medial-collateral-ligament-injury-in-a-professional-athlete-a-case-report
#11
Michael S Bagwell, Kevin E Wilk, Ricardo E Colberg, Jeffrey R Dugas
Background: Medial collateral ligament (MCL) injuries are one of the most commonly treated knee pathologies in sports medicine. The MCL serves as the primary restraint to valgus force. The large majority of these injuries do not require surgical intervention. Case Subject Description: A 30-year-old professional wrestling athlete presented to the clinic with acute complaints of right medial knee pain resulting from a traumatic valgus force. Physical exam revealed Grade 3 MCL injury...
June 2018: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/30036140/effect-of-platelet-rich-plasma-on-chondrogenic-differentiation-of-adipose-and-bone-marrow-derived-mesenchymal-stem-cells
#12
Jr-Jiun Liou, Benjamin B Rothrauff, Peter G Alexander, Rocky S Tuan
Post-traumatic and focal cartilage defects of the knee affect over 3 million Americans annually. Autologous cell-based cartilage repair, for example, autologous chondrocyte implantation, is limited by the need for ex vivo chondrocyte expansion and donor site morbidity. Mesenchymal stem cells (MSCs), owing to their relative ease of isolation, higher replication activity, and chondrogenic potential, represent an alternative reparative cell type. Platelet-rich plasma (PRP) is an autologous, growth factor-rich biologic preparation that has recently received increasing attention and use as a therapeutic adjunct for the treatment of degenerative joint diseases, and there is evidence suggesting that PRP acts by promoting stem cell proliferation and tissue healing...
October 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/30020117/nonoperative-treatments-for-knee-osteoarthritis-an-evaluation-of-treatment-characteristics-and-the-intra-articular-placebo-effect-a-systematic-review
#13
Christopher Vannabouathong, Mohit Bhandari, Asheesh Bedi, Vickas Khanna, Patrick Yung, Vijay Shetty, Moin Khan
BACKGROUND: Guidelines recommending various nonoperative treatments for patients with knee osteoarthritis remain inconsistent. Much of this controversy relates to what constitutes a clinically important effect. The purposes of the present study were to compare treatment effect sizes from recent meta-analyses evaluating pharmacological or medical device interventions for the treatment of knee osteoarthritis and to further assess the clinical impact that the intra-articular placebo effect may have on intra-articular injection therapies...
July 2018: JBJS Reviews
https://www.readbyqxmd.com/read/29998744/nondestructive-assessment-of-articular-cartilage-electromechanical-properties-after-osteochondral-autologous-and-allogeneic-transplantation-in-a-goat-model
#14
Tomas Mickevicius, Alius Pockevicius, Audrius Kucinskas, Rimtautas Gudas, Justinas Maciulaitis, Arvydas Usas
Objective To determine the applicability of a minimally invasive diagnostic device to evaluate the quality of articular cartilage following autologous (OAT) and allogeneic (OCA) osteochondral graft transplantation in goat model. Design OAT grafts were harvested from lateral femoral condyles (LFCs) and transplanted into osteochondral defects created in medial femoral condyles (MFCs) of contralateral knees. OCA grafts were transplanted into MFC condyles after in vitro storage. Autologous platelet-rich plasma (PRP) was administered intraarticularly after the surgery and at 1 and 2 months postoperatively...
July 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29997901/platelet-rich-plasma-prp-therapy-for-knee-arthritis-a-feasibility-study-in-primary-care
#15
Liam G Glynn, Alaa Mustafa, Monica Casey, Janusz Krawczyk, Jeanete Blom, Rose Galvin, Ailish Hannigan, Colum P Dunne, Andrew W Murphy, Christian Mallen
Background: Platelet-rich plasma (PRP) is a concentrate of autologous blood growth factors which has been shown to provide some symptomatic relief in early osteoarthritis (OA) of the knee. The objective of this study was to test the feasibility and efficacy potential of platelet rich plasma (PRP) in primary care. Methods: Feasibility study to assess safety of the intervention procedures and assess primary and secondary outcome measures. Consecutive patients presenting with symptomatic knee OA were recruited in a primary care setting in Ireland...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29963845/musculoskeletal-therapies-musculoskeletal-injection-therapy
#16
REVIEW
Chad Hulsopple
Injections often are used in the management of common musculoskeletal conditions. Physicians should understand the disease pathophysiology and evidence supporting available injections when determining appropriate therapy. These therapies include corticosteroid injections (CSIs), hyaluronic acid (HA) injections, hypertonic dextrose prolotherapy, platelet-rich plasma (PRP) injections, mesenchymal stem cell (MSC) injections, and trigger point injections (TPIs). CSIs are recommended conditionally by the American College of Rheumatology for osteoarthritis (OA) management...
July 2018: FP Essentials
https://www.readbyqxmd.com/read/29927631/therapeutic-effects-of-the-addition-of-platelet-rich-plasma-to-bioimplants-and-early-rehabilitation-exercise-on-articular-cartilage-repair
#17
Nai-Jen Chang, Yanjmaa Erdenekhuyag, Pei-Hsi Chou, Chih-Jou Chu, Chih-Chan Lin, Ming-You Shie
BACKGROUND: Treating articular cartilage lesions is clinically challenging. However, whether the addition of autologous platelet-rich plasma (PRP) to bioimplants along with early rehabilitation exercise provides therapeutic effects and regenerates the osteochondral defect remains uninvestigated. HYPOTHESIS: The addition of PRP to a polylactic-co-glycolic acid (PLGA) scaffold along with continuous passive motion (CPM) in osteochondral defects may offer beneficial in situ microenvironment changes to facilitate hyaline cartilage and subchondral bone tissue repair...
July 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29921309/is-local-platelet-rich-plasma-injection-clinically-superior-to-hyaluronic-acid-for-treatment-of-knee-osteoarthritis-a-systematic-review-of-randomized-controlled-trials
#18
Yalong Di, Changxu Han, Liang Zhao, Yizhong Ren
BACKGROUND: In this study, we evaluated whether platelet-rich plasma (PRP) is superior to hyaluronic acid (HA) in the treatment of knee osteoarthritis. METHODS: The Cochrane Central Register of Controlled Trials, PubMed, and Embase databases were searched for English-language, human in vivo studies on the treatment of symptomatic knee osteoarthritis with intra-articular PRP compared with HA. The following keywords were used for the search: "platelet-rich plasma," "PRP," "platelet-rich fibrin," "PRF," "platelet," "plasma," "arthritis," "osteoarthritis," "gonarthrosis," and "degeneration...
June 19, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29909689/intra-articular-injections-in-the-treatment-of-symptoms-from-ankle-arthritis-a-systematic-review
#19
Christopher Vannabouathong, Gina Del Fabbro, Brendan Sales, Christopher Smith, Chuan Silvia Li, Darryl Yardley, Mohit Bhandari, Bradley A Petrisor
BACKGROUND: Intra-articular (IA) injections are commonly used to treat knee arthritis pain; however, whether their efficacy generalizes to ankle arthritis remains debatable. We aimed to evaluate the evidence for IA therapies in the management of this patient population. METHODS: We performed a literature search for observational and randomized controlled trials (RCTs). Treatments included corticosteroids (CS), hyaluronic acid (HA), platelet-rich plasma (PRP), and mesenchymal stem cells (MSC)...
October 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29896019/osteochondritis-dissecans-does-platelet-rich-plasma-really-help
#20
Deepak Kumar Sharma, Narendra Kumar, Hitesh Lal, Binay Kumar Sahu, Sumon Singphow Saikia
Osteochondritis dissecans is a common disorder of knee and can be treated by various methods, depending on age of patient and stability of chondral fragment. In Osteochondritis dissecans ICRS type III lesion i.e. articular cartilage discontinuity but no dislocation, variable rate of union as well as high rate of non-union was observed in previous studies when treated with arthroscopic or open reduction and fixation. In previous study it has been also shown that platelet rich plasma help in fracture healing...
April 2018: Journal of Clinical Orthopaedics and Trauma
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