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https://www.readbyqxmd.com/read/30339910/activation-of-blood-coagulation-after-aneurysmal-subarachnoid-haemorrhage-a-prospective-observational-trial-by-rotational-thromboelastometry-rotem%C3%A2
#1
Annukka S Vahtera, Eija K Junttila, L Ville Jalkanen, Heini S Huhtala, Ksenia V Katanandova, Pauli T Hélen, Anne H Kuitunen
OBJECTIVES: Aneurysmal subarachnoid haemorrhage (aSAH) is reported to actuate blood coagulation. Rotational thromboelastometry (ROTEM®) is a dynamic haemostatic test that can differentiate various coagulation abnormalities, for example, increased coagulation activity can be detected as a wider amplitude of tracing (maximal clot firmness [MCF]). Previously, ROTEM® has not been used to evaluate coagulation changes after aSAH. The aim of this prospective, observational study was to evaluate the on-going coagulation process in patients with aSAH by comparing their ROTEM assay results to the control values obtained from patients undergoing clipping of non-ruptured aneurysms...
October 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30339226/performance-of-idarucizumab-as-antidote-of-dabigatran-in-daily-clinical-practice
#2
Sake J van der Wall, Nienke van Rein, Bart van den Bemt, Marieke J H A Kruip, Karina Meijer, Liane C J Te Boome, Tim A Simmers, A Marco W Alings, Robert Tieleman, Frederikus A Klok, Menno V Huisman
Aims: Because practice-based data on the usage of idarucizumab for urgent dabigatran reversal is unavailable, we evaluated the appropriateness of idarucizumab usage, its haemostatic effectiveness and clinical outcomes. Methods and results: An observational cohort study was performed including consecutive patients who were treated with idarucizumab between 2016 and 2018. Appropriate usage was assessed with predefined criteria. Post-reversal effectiveness was evaluated according to International Society on Thrombosis and Haemostasis (ISTH) recommendations...
October 17, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/30322667/management-of-postpartum-haemorrhage-from-research-into-practice-a-narrative-review-of-the-literature-and-the-cardiff-experience
#3
REVIEW
P W Collins, S F Bell, L de Lloyd, R E Collis
Postpartum haemorrhage (PPH) is caused by obstetric complications but may be exacerbated by haemostatic impairment. In a 10-year programme of research we have established that haemostatic impairment is uncommon in moderate PPH and that fibrinogen falls earlier than other coagulation factors. Laboratory Clauss fibrinogen and the point-of-care surrogate measure of fibrinogen (FIBTEM A5 measured on the ROTEM® machine) are predictive biomarkers for progression from early to severe PPH, the need for blood transfusion and invasive procedures to control haemorrhage...
August 25, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/30317420/clinical-and-radiographic-evaluation-of-the-efficacy-of-sodium-hypochlorite-as-a-haemostatic-agent-compared-with-physiologic-saline-on-the-success-of-calcium-hydroxide-pulpotomies-in-primary-molars-an-in-vivo-study
#4
Hemavathi, J Nagarathna, S K Srinath, M C Hiremath
AIM: To evaluate, via clinical and radiographic assessment; the success of calcium hydroxide pulpotomies with the application of 5% sodium hypochlorite as a haemostatic agent compared with physiologic saline in primary molars and to evaluate if there is improved efficacy of increased concentration of sodium hypochlorite application in calcium hydroxide pulpotomies. METHODS: Thirty children aged between 3 and 8 years, having at least two vital primary molars (split mouth design) with deep carious lesions with probable exposure of the pulp, were selected...
October 13, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/30312978/the-clinical-significance-of-fibrin-monomers
#5
Majed A Refaai, Paul Riley, Tatsiana Mardovina, Phoenix D Bell
INTRODUCTION:  Fibrin monomer (FM) concentrations reflect pro-thrombin activity and have the potential to predict thrombotic events relatively earlier than other haemostatic markers. Most often, FM are compared with D-dimer (DD) as increased DD have been documented in disseminated intravascular coagulation (DIC), deep vein thrombosis (DVT) and pulmonary embolism. Although DD have a high sensitivity and negative predictive value, their specificity is much lower depending on the assay chosen, clinical pre-test probability and patient condition...
October 12, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/30306708/topical-haemostatic-powder-as-a-novel-endoscopic-therapy-for-severe-colonic-diverticular-bleeding
#6
Jia Lin Ng, Musfirah Marican, Ronnie Mathew
BACKGROUND: Although most diverticular bleeding resolve spontaneously, up to 30% can bleed torrentially, necessitating angioembolization, endoscopic or surgical intervention. Non-contact endoscopic therapies, such as topical haemostatic powders, do not require precise targeting and are attractive because identification of specific culprit diverticulum is difficult. While their use in non-variceal upper gastrointestinal bleeding is well established, its role in lower gastrointestinal bleeding remains unclear...
October 10, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/30302170/safety-analysis-of-endoscopic-haemostasis-using-a-high-frequency-live-tissue-electric-welding-device-ekvz300-patonmed
#7
Yegor Tryliskyy, Andrii Kebkalo, Chee S Wong, Sergii Rublenko, Mykhailo Rublenko, Mykola Ilnytskiy, Ievgenii Negria, Vladislav Hordovskiy
Introduction: The method of a bipolar high-frequency welding (HFEW) of soft living tissues of animals and humans has been used in various areas of surgery. However, it has not been utilized in endoscopic gastrointestinal procedures yet. HFEW has strong potential to be used in gastrointestinal endoscopic procedures due to the competitive cost of generator devices and due to its proven ability to coagulate vessels of wide diameter as compared to standard electrocautery devices. Aim: To investigate the effectiveness of the endoscopic haemostasis using HFEW generator device - 300 PATONMED - in a porcine model of arterial gastrointestinal bleeding...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/30296953/peritonsillar-infiltration-of-lidocaine-with-adrenaline-is-associated-with-increased-risk-of-secondary-post-tonsillectomy-haemorrhage
#8
H K Tolska, A J Takala, J Jero
OBJECTIVES: In order to evaluate the safety of tonsillectomy among children, we retrospectively studied the incidence of post-operative complications, adverse events and their association with peri-operative medication. METHODS: Data were collected from the medical records of 691 patients aged 1-16 years, including details of post-operative complications (any unplanned contact with the hospital), analgesics, dexamethasone, 5-HT3 antagonists, local anaesthetic and haemostatic agents...
October 9, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/30292526/management-of-bleeding-in-major-burn-surgery
#9
REVIEW
Harald Welling, Sisse Rye Ostrowski, Jakob Stensballe, Martin Risom Vestergaard, Søren Partoft, Jonathan White, Pär Ingemar Johansson
Major burn surgery is often associated with excessive bleeding and massive transfusion, and the development of a coagulopathy during major burn surgery is associated with increased morbidity and mortality. The aim of this study was to review the literature on intraoperative haemostatic resuscitation of burn patients during necrectomy to reveal strategies applied for haemostatic monitoring and resuscitation. We searched PubMed, EMBASE, and CENTRAL for studies published in the period 2006-2017 concerning bleeding issues related to burn surgery i...
October 3, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/30287682/catastrophic-haemorrhage-in-military-major-trauma-patients-a-retrospective-database-analysis-of-haemostatic-agents-used-on-the-battlefield
#10
Mark Winstanley, J E Smith, C Wright
OBJECTIVES: Catastrophic haemorrhage is a leading cause of morbidity and mortality in trauma, in both military and civilian settings. There are numerous studies looking at the effectiveness of different haemostatic agents in the laboratory but few in a clinical setting. This study analyses the use of haemostatic dressings used in patients injured on the battlefield and their association with survival. METHOD: A retrospective database review was undertaken using the UK Joint Theatre Trauma Registry from 2003 to 2014, during combat operations in Iraq and Afghanistan...
October 3, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/30287213/colchicine-reduces-platelet-aggregation-by-modulating-cytoskeleton-rearrangement-via-inhibition-of-cofilin-and-lim-domain-kinase-1
#11
Giovanni Cimmino, Roberta Tarallo, Stefano Conte, Andrea Morello, Grazia Pellegrino, Francesco S Loffredo, Gaetano Calì, Nicola De Luca, Paolo Golino, Bruno Trimarco, Plinio Cirillo
INTRODUCTION: Platelets activation/aggregation with subsequent thrombus formation is the main event in the pathophysiology of acute coronary syndrome. Once activated, platelets show an extensive cytoskeleton rearrangement that leads to recruitment of additional platelets to finally cause haemostatic plug formation. Thus, the cytoskeleton plays a pivotal role in this phenomenon. Colchicine (COLC) is an anti-inflammatory drug proven to reduce major cardiovascular events in patients with coronary artery disease...
October 1, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/30282560/the-anti-thrombotic-effects-of-vitamin-d-and-their-possible-relationship-with-antiphospholipid-syndrome
#12
M García-Carrasco, E A Jiménez-Herrera, J L Gálvez-Romero, C Mendoza-Pinto, S Méndez-Martínez, I Etchegaray-Morales, P Munguía-Realpozo, L Vázquez de Lara-Cisneros, F J Santa Cruz, R Cervera
The importance of the immunomodulatory effects of vitamin D has recently been associated with autoimmune and chronic inflammatory diseases. Vitamin D deficiency has been linked to the development of autoimmune conditions. Antiphospholipid syndrome is an autoimmune disease characterized by thrombotic events and obstetric complications in patients with antiphospholipid antibodies. Current data show that patients with antiphospholipid syndrome have a high prevalence of vitamin D deficiency even without classic risk factors...
October 3, 2018: Lupus
https://www.readbyqxmd.com/read/30281037/towards-increasing-shelf-life-and-haemostatic-potency-of-stored-platelet-concentrates
#13
Shailaja Hegde, Huzoor Akbar, Yi Zheng, Jose A Cancelas
PURPOSE OF REVIEW: Platelet transfusion is a widely used therapy in treating or preventing bleeding and haemorrhage in patients with thrombocytopenia or trauma. Compared with the relative ease of platelet transfusion, current practice for the storage of platelets is inefficient, costly and relatively unsafe, with platelets stored at room temperature (RT) for upto 5-7 days. RECENT FINDINGS: During storage, especially at cold temperatures, platelets undergo progressive and deleterious changes, collectively termed the 'platelet storage lesion', which decrease their haemostatic function and posttransfusion survival...
November 2018: Current Opinion in Hematology
https://www.readbyqxmd.com/read/30279053/rotational-thromboelastometry-rotem%C3%A2-guided-diagnosis-and-management-of-amniotic-fluid-embolism
#14
J A Loughran, T L Kitchen, S Sindhakar, M Ashraf, M Awad, E J Kealaher
Amniotic fluid embolism is a rare but often catastrophic emergency. The non-specific clinical features and lack of diagnostic tests make it a diagnosis of exclusion. Point-of-care visco-elastometric testing is being increasingly used during obstetric haemorrhage. We present a case of amniotic fluid embolism, diagnosed and managed using rotational thromboelastography. During a precipitous labour, a 21-year-old multiparous woman became pale, distressed and disorientated. The fetus was delivered using forceps...
September 11, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/30265883/management-and-outcome-of-major-bleeding-in-patients-receiving-vitamin-k-antagonists-for-venous-thromboembolism
#15
Farès Moustafa, Alexander Stehouwer, Pieter Kamphuisen, Joan Carles Sahuquillo, Ángel Sampériz, María Alfonso, Federica Pace, José María Suriñach, Ángeles Blanco-Molina, Patrick Mismetti, Manuel Monreal
BACKGROUND: The optimal management of major bleeding in patients receiving vitamin K antagonists (VKA) for venous thromboembolism (VTE) is unclear. METHODS: We used the RIETE (Registro Informatizado Enfermedad TromboEmbólica) registry to assess the management and 30-day outcomes after major bleeding in patients receiving VKA for VTE. RESULTS: From January 2013 to December 2017, 267 of 18,416 patients (1.4%) receiving long-term VKA for VTE had a major bleeding (in the gastrointestinal tract 78, intracranial 72, hematoma 50, genitourinary 20, other 47)...
September 22, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30258205/loss-of-the-mitochondrial-kinase-pink1-does-not-alter-platelet-function
#16
Tony G Walsh, Marion T J van den Bosch, Kirsty E Lewis, Christopher M Williams, Alastair W Poole
PTEN-induced putative kinase (PINK) 1 is regarded as a master regulator of cellular mitophagy such that loss of function mutations contribute to early onset Parkinson's disease, through aberrant mitochondrial control and function. Mitochondrial function is key to platelet procoagulant activity, controlling the haemostatic response to vessel injury, but can also predispose blood vessels to thrombotic complications. Here, we sought to determine the role of PINK1 in platelet mitochondrial health and function using PINK1 knockout (KO) mice...
September 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30235852/assessment-of-migration-of-human-mscs-through-fibrin-hydrogels-as-a-tool-for-formulation-optimisation
#17
Nasseem Salam, Sotiria Toumpaniari, Piergiorgio Gentile, Ana Marina Ferreira, Kenneth Dalgarno, Simon Partridge
Control of cell migration is fundamental to the performance of materials for cell delivery, as for cells to provide any therapeutic effect, they must migrate out from the delivery material. Here the influence of fibrinogen concentration on the migration of encapsulated human mesenchymal stem cells (hMSCs) from a cell spheroid through fibrin hydrogels is tracked over time. Fibrin was chosen as a model material as it is routinely employed as a haemostatic agent and more recently has been applied as a localised delivery vehicle for potential therapeutic cell populations...
September 19, 2018: Materials
https://www.readbyqxmd.com/read/30216187/topping-phenomenon-with-recurrent-spinal-stenosis-and-epidural-fibrosis-prevented-with-oxidized-cellulose-a-case-report
#18
Radek Hart
Lumbar spinal stenosis is a condition where the neural structures are compressed in the narrowed spinal canal and often situated only within a single specific segment of the spine, most frequently in the lumbar spine. A case report demonstrates a surgical solution of lumbar spinal stenosis with using oxidized cellulose as a prevention of post-operative adhesions and failed back syndrome. A female patient (68) with a significant pain of the lumbar spine lasting for a number of months due to advanced spondylosis, failing to respond to conservative treatment underwent instrumented, posterolateral fusion of affected segments...
2018: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/30211844/there-is-no-excuse-for-mortality-due-to-lack-of-competency-and-training-of-paediatric-endoscopists-in-gastrointestinal-bleeding-therapy-in-2018
#19
Mike Thomson
Acute upper gastrointestinal bleeding in children is possibly the last medical emergency which continues to lead to the death of a child due to the lack of competency/clinical judgement of the doctor, as opposed to the disease itself, leading to mortality despite optimum medical intervention. This is unacceptable in any circumstances in 2018. It occurs due to a number of conspiring factors including lack of appreciation of the clinical presentation requiring urgent endoscopic intervention; misapprehension of the urgency of timing required of such an intervention predicated on the severity of the gastrointestinal (GI) bleed; lack of application of a paediatric-specific validated score predicting for such endoscopic intervention; lack of skill in endo-haemostatic intervention techniques by paediatric endoscopists; poor training in such techniques among paediatric endoscopists; paucity of cases with lack of exposure of the paediatric endoscopist regularly to enable skills to be maintained, once acquired; reluctance of adult endoscopists in many centres to support paediatric GI bleeding services...
September 11, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30199093/network-meta-analysis-of-topical-haemostatic-agents-in-thyroid-surgery
#20
REVIEW
G Polychronidis, F J Hüttner, P Contin, K Goossen, L Uhlmann, M Heidmann, P Knebel, M K Diener, M W Büchler, P Probst
BACKGROUND: The objective of this study was to investigate the potential benefit of local haemostatic agents for the prevention of postoperative bleeding after thyroidectomy. METHODS: A systematic literature search was performed, and RCTs involving adult patients who underwent thyroid surgery using either active (AHA) or passive (PHA) haemostatic agents were included in the review. The main outcome was the rate of cervical haematoma that required reoperation. A Bayesian random-effects model was used for network meta-analysis with minimally informative prior distributions...
September 10, 2018: British Journal of Surgery
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