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External fetal monitoring

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https://www.readbyqxmd.com/read/30084506/historical-control-data-on-developmental-toxicity-studies-in-rats
#1
Makiko Kuwagata, Yuko Sakai, Sho Tanaka, Hiromasa Takashima, Ryuichi Katagiri, Toshiki Matsuoka, Kenichi Noritake, Mika Senuma, Tatsuya Shimizu, Hitoshi Hojo, Kanata Ibi, Satoshi Kudo, Takafumi Ohta, Masayuki Ube, Yoji Miwa, Shimpei Kajita, Tohru Uesugi, Kaoru Yabe, Taishi Tateishi, Nao Nakano, Terumasa Taniguchi, Akihito Yamashita, Takayuki Hirano, Yuka Kirihata, Yumi Sakai, Shino Nishizawa, Michio Fujiwara, Hiroshi Mineshima, Masao Horimoto, Makoto Ema
Historical control data from prenatal developmental toxicity studies in rats have been used to evaluate whether toxicology outcomes were induced by exposure to a chemical or were within the range of spontaneous variation. These data are also important for monitoring animal characteristics. As a follow-up to historical control data from 1998 to 2010, this study analyzed control data from prenatal developmental studies performed in rats from 2011 to 2015. Data were collected from studies performed by 24 Japanese laboratories, including 15 pharmaceutical and chemical companies and nine contract research organizations, in Sprague-Dawley and two- substrains of Wistar Hannover rats...
August 7, 2018: Congenital Anomalies
https://www.readbyqxmd.com/read/29454359/change-in-practice-a-qualitative-exploration-of-midwives-and-doctors-views-about-the-introduction-of-stan-monitoring-in-an-australian-hospital
#2
M E Mayes, C Wilkinson, S Kuah, G Matthews, D Turnbull
BACKGROUND: The present study examines the introduction of an innovation in intrapartum foetal monitoring practice in Australia. ST-Analysis (STan) is a technology that adds information to conventional fetal monitoring (cardiotocography) during labour, with the aim of reducing unnecessary obstetric intervention. Adoption of this technology has been controversial amongst obstetricians and midwives, particularly as its use necessitates a more invasive means of monitoring (a scalp clip), compared to external monitoring from cardiotocography alone...
February 17, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29100065/toward-noninvasive-monitoring-of-ongoing-electrical-activity-of-human-uterus-and-fetal-heart-and-brain
#3
S Lew, M S Hämäläinen, Y Okada
OBJECTIVE: To evaluate whether a full-coverage fetal-maternal scanner can noninvasively monitor ongoing electrophysiological activity of maternal and fetal organs. METHODS: A simulation study was carried out for a scanner with an array of magnetic field sensors placed all around the torso from the chest to the hip within a horizontal magnetic shielding enclosure. The magnetic fields from internal organs and an external noise source were computed for a pregnant woman with a 35-week old fetus...
December 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29096560/a-novel-modality-for-intrapartum-fetal-heart-rate-monitoring
#4
Eran Ashwal, Shiri Shinar, Amir Aviram, Sharon Orbach, Yariv Yogev, Liran Hiersch
BACKGROUND: Intrapartum fetal heart rate (FHR) monitoring is well recommended during labor to assess fetal wellbeing. Though commonly used, the external Doppler and fetal scalp electrode monitor have significant shortcomings. Lately, non-invasive technologies were developed as possible alternatives. OBJECTIVE: The objective of this study is to compare the accuracy of FHR trace using novel Electronic Uterine Monitoring (EUM) to that of external Doppler and fetal scalp electrode monitor...
November 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28851241/obesity-s-impact-on-intrapartum-electronic-fetal-monitoring
#5
Brian Brocato, David Lewis, Madhuri Mulekar, Susan Baker
OBJECTIVE: The objective of this study is to evaluate the impact maternal obesity has on the percentage of unmonitored electronic fetal monitoring (EFM). STUDY DESIGN: Women undergoing induction of labor at term were categorized into three groups: Group 1 (body mass index (BMI) < 30 kg/m2), Group 2 (30 < BMI < 40 kg/m2), and Group 3 (BMI ≥ 40 kg/m2). External EFM tracings were reviewed from the time of induction of labor until amniotomy; the percentage of time off of EFM was calculated...
September 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28576973/caspase-9-has-a-nonapoptotic-function-in-xenopus-embryonic-primitive-blood-formation
#6
Hong Thi Tran, Mathias Fransen, Dionysia Dimitrakopoulou, Griet Van Imschoot, Nicolas Willemarck, Kris Vleminckx
Caspases constitute a family of cysteine proteases centrally involved in programmed cell death, which is an integral part of normal embryonic and fetal development. However, it has become clear that specific caspases also have functions independent of cell death. In order to identify novel apoptotic and nonapoptotic developmental caspase functions, we designed and transgenically integrated novel fluorescent caspase reporter constructs in developing Xenopus embryos and tadpoles. This model organism has an external development, allowing direct and continuous monitoring...
July 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28479738/prenatal-developmental-toxicity-study-of-glycosides-based-standardized-fenugreek-seed-extract-in-rats
#7
Pallavi O Deshpande, Vishwaraman Mohan, Mukul P Pore, Shailesh Gumaste, Prasad A Thakurdesai
CONTEXT: Glycoside-based standardized fenugreek seed extract (SFSE-G) demonstrated promising efficacy in animal models of immune-inflammatory conditions. AIM: The present study was aimed at embryo-fetal development toxicity evaluation of SFSE-G in Wistar rats as per guideline No. 414 of the Organization for Economic Co-operation and Development (OECD). MATERIAL AND METHODS: Mated female rats were randomized into four groups of 30 each and received oral doses of either SFSE-G at 250, 500, and 1000 mg/kg or vehicle (water) during the period of gestation (postconception) from gestational day 5 (GD5, an implantation day) until 1 day before cesarean sections (GD19)...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27883332/effect-of-signal-acquisition-method-on-the-fetal-heart-rate-analysis-with-phase-rectified-signal-averaging
#8
J A M van Scheepen, M P H Koster, B Vasak, C Redman, A Franx, A Georgieva
Phase rectified signal averaging (PRSA) is increasingly used for fetal heart rate (FHR) monitoring, both with traces acquired with external Doppler cardiotocography (D-FHR), and with transabdominal fetal electrocardiography (ta-FHR). However, it is unclear to what extend the acquisition method influences the PRSA analysis, whether results from using one acquisition method are comparable to those based on FHR acquired by the other method, and if not, which should be the preferred method. To address these questions, we applied PRSA analysis to 28 antepartum synchronous recordings of the FHR using simultaneously D-FHR and ta-FHR...
December 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27822432/standard-external-doppler-fetal-heart-tracings-versus-external-fetal-electrocardiogram-in-very-preterm-gestation-a-pilot-study
#9
Gary Fruhman, Jeffrey A Gavard, Kristina McCormick, Judy Wilson-Griffin, Erol Amon, Gilad A Gross
Introduction Very preterm babies can be difficult to monitor using standard external Doppler fetal heart tracings (eFHR). External fetal electrocardiogram (fECG) is a potential alternative. Methods This was a prospective observational pilot study of hospitalized patients at 24 to 28 weeks' gestation. A total of 30 women were traced for up to 2 hours using eFHR followed by up to 2 hours using fECG. The percentage of time the fetal heart rate was traced during the 2-hour window for each modality was calculated...
October 2016: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/27756155/effect-of-tocolytic-drugs-on-fetal-heart-rate-variability-a-systematic-review
#10
REVIEW
Kim M J Verdurmen, Alexandra D J Hulsenboom, Judith O E H van Laar, S Guid Oei
INTRODUCTION: Tocolytics may cause changes in fetal heart rate (HR) pattern, while fetal heart rate variability (HRV) is an important marker of fetal well-being. We aim to systematically review the literature on how tocolytic drugs affect fetal HRV. MATERIALS AND METHODS: We searched CENTRAL, PubMed and EMBASE up to June 2016. Studies published in English, using computerized or visual analysis to describe the effect of tocolytics on HRV in human fetuses were included...
October 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27684833/use-of-the-glidescope-video-laryngoscope-for-intubation-during-ex-utero-intrapartum-treatment-in-a-fetus-with-a-giant-cyst-of-the-4th-branchial-cleft-a-case-report
#11
Sung Hye Byun, So Young Lee, Seong Yeon Hong, Taeha Ryu, Baek Jin Kim, Jin Yong Jung
INTRODUCTION: In fetuses who are predicted to be at risk of catastrophic airway obstruction at delivery, the ex utero intrapartum treatment (EXIT) procedure is useful for securing the fetal airway while maintaining fetal oxygenation via placental circulation. Factors, including poor posture of the fetus and physician, narrow visual field, and issues of contamination in the aseptic surgical field, make fetal intubation during the EXIT procedure difficult. Herein, we report our experience of the usefulness of the GlideScope video laryngoscope (GVL) for intubation during the EXIT procedure...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27349243/development-of-computational-pregnant-female-and-fetus-models-and-assessment-of-radiation-dose-from-positron-emitting-tracers
#12
Tianwu Xie, Habib Zaidi
PURPOSE: Molecular imaging using PET and hybrid (PET/CT and PET/MR) modalities nowadays plays a pivotal role in the clinical setting for diagnosis and staging, treatment response monitoring, and radiation therapy treatment planning of a wide range of oncologic malignancies. The developing embryo/fetus presents a high sensitivity to ionizing radiation. Therefore, estimation of the radiation dose delivered to the embryo/fetus and pregnant patients from PET examinations to assess potential radiation risks is highly praised...
December 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/26984160/fetal-heart-rate-monitoring-of-short-term-variation-stv-a-methodological-observational-study
#13
Stina Wretler, Malin Holzmann, Sophie Graner, Pelle Lindqvist, Susanne Falck, Lennart Nordström
BACKGROUND: Cardiotocography (CTG) has high sensitivity, but less specificity in detection of fetal hypoxia. There is need for adjunctive methods easy to apply during labor. Low fetal heart rate short term variation (STV) is predictive for hypoxia during the antenatal period. The objectives of our study were to methodologically evaluate monitoring of STV during labor and to compare two different monitors (Sonicaid™ and EDAN™) for antenatal use. METHODS: A prospective observational study at the obstetric department, Karolinska University hospital, Stockholm (between September 2011 and April 2015)...
March 16, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/26812057/epidemiology-of-birth-defects-based-on-a-birth-defect-surveillance-system-from-2005-to-2014-in-hunan-province-china
#14
Donghua Xie, Tubao Yang, Zhiyu Liu, Hua Wang
OBJECTIVE: To describe the epidemiology of birth defects (BDs) in perinatal infants in Hunan Province, China, between 2005 and 2014. METHODS: The BD surveillance data of perinatal infants (for stillbirth, dead fetus or live birth between 28 weeks of gestation and 7 days after birth) were collected from 52 registered hospitals of Hunan between 2005 and 2014. The prevalence rates of BDs with 95% confidence interval (CI) and crude odds ratio (ORs) were calculated to examine the associations of infant gender, maternal age, and region (urban vs rural) with BDs...
2016: PloS One
https://www.readbyqxmd.com/read/26737621/monitoring-the-fetal-heart-rate-variability-during-labor
#15
B Moslem, A Mohydeen, O Bazzi
In respect to the main goal of our ongoing work for estimating the heart rate variability (HRV) from fetal electrocardiogram (FECG) signals for monitoring the health of the fetus, we investigate in this paper the possibility of extracting the fetal heart rate variability (HRV) directly from the abdominal composite recordings. Our proposed approach is based on a combination of two techniques: Periodic Component Analysis (PiCA) and recursive least square (RLS) adaptive filtering. The Fetal HRV of the estimated FECG signal is compared to a reference value extracted from an FECG signal recorded by using a spiral electrode attached directly to the fetal scalp...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/26694901/arteriovenous-malformation-of-vein-of-galen-as-a-rare-non-hypoxic-cause-of-changes-in-fetal-heart-rate-pattern-during-labor
#16
Kamil Biringer, Pavol Zubor, Erik Kudela, Branislav Kolarovszki, Mirko Zibolen, Jan Danko
The aim of this case report is to describe a rare non-hypoxic cause of pathological changes in fetal heart rate pattern during labor, and to determine management, including a description of important prenatal aspects when pathologic cardiotocographic recording is performed during labor. A fetus with rare arteriovenous malformation of the vein of Galen, which represents less than 1% of all intracranial arteriovenous malformations, was monitored by intrapartum external cardiotocography in the 37 + 5 gestational week...
March 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/26231368/the-pregnancy-exposome
#17
REVIEW
Oliver Robinson, Martine Vrijheid
The exposome concept takes a holistic approach facilitated by new and emerging technologies to describe 'the totality of human environmental (i.e. non-genetic) exposures from conception onwards, complementing the genome'. It provides a framework to advance the environmental epidemiology field that has until now focused almost exclusively on single-exposure health effects. The exposome includes an external domain, measured by methods including geo-spatial modelling, questionnaire and biomonitoring of external exposures while the internal domain is commonly assessed through molecular omics platforms...
June 2015: Current Environmental Health Reports
https://www.readbyqxmd.com/read/26001868/maternal-and-perinatal-outcomes-of-pregnancies-delivered-at-23-weeks-gestation
#18
Joan M G Crane, Laura A Magee, Tang Lee, Anne Synnes, Peter von Dadelszen, Leanne Dahlgren, Dane A De Silva, Robert Liston
OBJECTIVE: To evaluate the maternal and perinatal outcomes of pregnancies delivered at 23+0 to 23+6 weeks' gestation. METHODS: This prospective cohort study included women in the Canadian Perinatal Network who were admitted to one of 16 Canadian tertiary perinatal units between August 1, 2005, and March 31, 2011, and who delivered at 23+0 to 23+6 weeks' gestation. Women were included in the network if they were admitted with spontaneous preterm labour with contractions, a short cervix without contractions, prolapsing membranes with membranes at or beyond the external os or a dilated cervix, preterm premature rupture of membranes, intrauterine growth restriction, gestational hypertension, or antepartum hemorrhage...
March 2015: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/25889343/human-neural-stem-cell-transplantation-in-als-initial-results-from-a-phase-i-trial
#19
Letizia Mazzini, Maurizio Gelati, Daniela Celeste Profico, Giada Sgaravizzi, Massimo Projetti Pensi, Gianmarco Muzi, Claudia Ricciolini, Laura Rota Nodari, Sandro Carletti, Cesare Giorgi, Cristina Spera, Frondizi Domenico, Enrica Bersano, Francesco Petruzzelli, Carlo Cisari, Annamaria Maglione, Maria Francesca Sarnelli, Alessandro Stecco, Giorgia Querin, Stefano Masiero, Roberto Cantello, Daniela Ferrari, Cristina Zalfa, Elena Binda, Alberto Visioli, Domenico Trombetta, Antonio Novelli, Barbara Torres, Laura Bernardini, Alessandro Carriero, Paolo Prandi, Serena Servo, Annalisa Cerino, Valentina Cima, Alessandra Gaiani, Nicola Nasuelli, Maurilio Massara, Jonathan Glass, Gianni Sorarù, Nicholas M Boulis, Angelo L Vescovi
BACKGROUND: We report the initial results from a phase I clinical trial for ALS. We transplanted GMP-grade, fetal human neural stem cells from natural in utero death (hNSCs) into the anterior horns of the spinal cord to test for the safety of both cells and neurosurgical procedures in these patients. The trial was approved by the Istituto Superiore di Sanità and the competent Ethics Committees and was monitored by an external Safety Board. METHODS: Six non-ambulatory patients were treated...
January 27, 2015: Journal of Translational Medicine
https://www.readbyqxmd.com/read/25886031/effect-of-external-airflow-resistive-load-on-postural-and-exercise-associated-cardiovascular-and-pulmonary-responses-in-pregnancy-a-case-control-study
#20
RANDOMIZED CONTROLLED TRIAL
Jung-Hyun Kim, Raymond J Roberge, Jeffrey B Powell
BACKGROUND: Facial coverings (e.g., balaclavas, niqabs, medical/surgical masks, respirators, etc.), that impose low levels of airflow resistive loads, are worn by millions of pregnant women worldwide, but little data exist addressing their impact on pregnancy-associated cardiovascular and pulmonary responses. METHODS: 16 pregnant and 16 non-pregnant women were monitored physiologically (heart rate, blood pressure, mean arterial pressure, total peripheral resistance, stroke volume, cardiac output, oxygen saturation, transcutaneous carbon dioxide, fetal heart rate) and subjectively (exertion) for 1 h of mixed sedentary postural activity (sitting, standing) and moderate exercise (bicycle ergometer) with and without wearing N95 filtering facepiece respirators with filter resistive loads of 94...
February 22, 2015: BMC Pregnancy and Childbirth
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