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D Chamil Codipilly, Karthik Ravi, Dharma Sunjaya, Hongfei Fang, Amindra Arora, David Katzka
No abstract text is available yet for this article.
October 17, 2018: Clinical Gastroenterology and Hepatology
Madhav Desai, David A Lieberman, Kevin F Kennedy, Nour Hamade, Prashanthi Thota, Sravanthi Parasa, Venkat Subhash Gorrepati, Ajay Bansal, Neil Gupta, Srinivas Gaddam, Patrick E Young, Sharad Mathur, Fouad J Moawad, Brooks D Cash, Richard Sampliner, John J Vargo, Gary W Falk, Prateek Sharma
INTRODUCTION: Data on time trends of dysplasia and esophageal adenocarcinoma (EAC) in Barrett's esophagus (BE) during the index endoscopy (ie, prevalent cases) are limited. Our aim was to determine the prevalence patterns of BE associated dysplasia on index endoscopy over the past 25 years. METHODS: The Barrett's esophagus study is a multicenter outcome project of a large cohort of BE patients. Proportion of patients with index endoscopy findings of no dysplasia (NDBE), low-grade dysplasia (LGD), high-grade dysplasia (HGD), and esophageal adenocarcinoma (EAC) were extracted per year of index endoscopy, and 5-yearly patient cohorts were tabulated over years 1990 to 2010+ (2010-current)...
October 17, 2018: Gastrointestinal Endoscopy
Tamika S Jaswani, Alexander J Williams, Douglas J Grider, Paul Yeaton, Mohammad H Shakhatreh
No abstract text is available yet for this article.
October 17, 2018: Gastrointestinal Endoscopy
Madhusudhan R Sanaka, Prashanthi N Thota, Malav P Parikh, Umar Hayat, Niyati M Gupta, Scott Gabbard, Rocio Lopez, Sudish Murthy, Siva Raja
BACKGROUND AND AIMS: Peroral endoscopic myotomy (POEM) may be associated with higher rates of gastroesophageal reflux disease (GERD) than laparoscopic Heller's myotomy with fundoplication (LHM), since POEM is not combined with a fundoplication. However, peri-esophageal anti-reflux barriers are preserved in POEM, which might prevent GERD. Hence, we sought to compare the objective esophageal pH study findings in achalasia patients after POEM and LHM. METHODS: Achalasia patients undergoing POEM from 2014 to 2015 at our institution were matched 1:3 with LHM patients using propensity score matching...
October 19, 2018: Surgical Endoscopy
Matea Kovačić, Josipa Unić, Zrinjka Mišak, Oleg Jadrešin, Vlatka Konjik, Sanja Kolaček, Iva Hojsak
BACKGROUND AND AIMS: Despite rising incidence of eosinophilic esophagitis (EoE), data on the follow-up and treatment outcomes in pediatric patients are scarce. Therefore, the aim of this study was to present data on the treatment outcomes in children diagnosed with EoE who were treated in a tertiary medical center. PATIENTS AND METHODS: A retrospective study involving patients younger than 18 years who were diagnosed with EoE in our center between January 2011 and June 2017...
October 19, 2018: Esophagus: Official Journal of the Japan Esophageal Society
Yo Fujimoto, Yasumi Katayama, Hideaki Tosaka, Masaya Tamano
No abstract text is available yet for this article.
October 16, 2018: Medicina Clínica
Jialin Meng, Xinyao Fan, Meng Zhang, Zongyao Hao, Chaozhao Liang
BACKGROUND: Currently, several studies have demonstrated that PRKAA1 polymorphisms conduce to the development of cancer. PRKAA1 gene encodes the AMP-activated protein kinase summit-α1, and plays an important role in cell metabolism. Thus, we performed a systematic review and meta-analysis of all enrolled eligible case-control studies to obtain a precise correlation between PRKAA1 polymorphism and cancer susceptibility. METHODS: Extensive retrieve was performed in Web of Science, Google Scholar, PubMed, EMbase, CNKI and Wanfang databases up to August 26, 2018...
October 19, 2018: BMC Medical Genetics
Shahida Tasneem, Muhammad Tahir Sarwar, Muhammad Rizwan Bashir, Hamid Hussain, Jawad Ahmed, Shahid Pervez
Esophageal squamous cell carcinoma (ESCC) is one of the aggressive malignancies and mechanisms underlying its pathogenesis remain unclear. Cyclooxygenase-2 (COX-2) enzyme system plays a crucial role in many gastrointestinal malignancies and is an important regulator of cell growth, proliferation, apoptosis, differentiation and transformation. More precise outcome of COX-2 in ESCC is less investigated. In this study we investigated the risk factors of ESCC and expression of COX-2 in Carcinoma in situ (CIS) and ESCC compared to normal esophageal mucosa...
2018: PloS One
Joonas H Kauppila, Asif Johar, Pernilla Lagergren
OBJECTIVE: To evaluate the impact of postoperative medical and surgical complications on health-related quality of life (HRQOL) in esophageal cancer. BACKGROUND: Complications after esophageal surgery negatively affect HRQOL, but it is unclear whether medical and surgical complications differ in effects. METHODS: This Swedish population-based, nationwide, and prospective cohort study enrolled 616 patients undergoing esophageal cancer surgery during 2001 to 2005, with 10 years of follow-up...
October 17, 2018: Annals of Surgery
Andrés José Del Pozo-García, Carlos Piedracoba-Cadahia, Fernando Sánchez-Gómez, José Carlos Marín-Gabriel, Sarbelio Rodríguez-Muñoz
We present a case of intractable dysphagia in a 23-year-old female with type 1 esophageal atresia (EA) and subsequent postsurgical refractory esophageal strictures. The patient was referred due to increasing symptomatology and a slight response to balloon dilations. A biodegradable polydioxanone stent (ELLA) was placed, but this did not relieve the dysphagia. After the sequential placement of two siliconated polypropylene stents (Polyflex™, Boston Scientifics), the dysphagia was definitively relieved. To our knowledge, this is the first published case with a full resolution of dysphagia using this strategy in an adult patient...
September 3, 2018: Revista Española de Enfermedades Digestivas
G Li, J S Wang, S D Qin, J Zhang, N DU, J Zhang, X Sun, H Ren
OBJECTIVE: To study the clinical effect of the oxygen drive aerosol in halation with budesonide and ambroxol in the prevention of adult post-thoracotomy pneumonia. METHODS: This was a randomized, open and parallel controlled trial. We chose 80 cases of patients in the department of thoracic surgery in the First Affiliated Hospital of Xi'an Jiaotong University which fitted our criteria as the research object. The selected patients were randomly divided into the active group and the control group, and the active group underwent oxygen drive aerosol inhalation (2 mg budesonide combined 60 mg ambroxol) for 3 days before operation, and the control group without preoperative aerosol inhalation, and their postoperative therapy was the same...
October 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Luigi Sivero, Donato Alessandro Telesca, Maurizio Gentile, Giovanni Aprea, Guido Massa, Giovanni Cestari, Michele Danzi, Stefania Sivero, Cesare Formisano
BACKGROUND AND AIMS: Ethical and medico-legal issues reviews of Percutaneous Endoscopic Gastrostomy (PEG) placement in elderly patients is an important topic of international medical literature. PEG is often inappropriately placed in patients with not spontaneous oral feeding intake, cause of unrealistic expectations. We performed a critical review of the literature for placement of PEG in geriatric patients. METHODS: A literature review was performed about the positioning of the PEG in geriatric patients with dementia and severe anorexia...
2018: Annali Italiani di Chirurgia
Iñigo Martincorena, Joanna C Fowler, Agnieszka Wabik, Andrew R J Lawson, Federico Abascal, Michael W J Hall, Alex Cagan, Kasumi Murai, Krishnaa Mahbubani, Michael R Stratton, Rebecca C Fitzgerald, Penny A Handford, Peter J Campbell, Kourosh Saeb-Parsy, Philip H Jones
The extent to which cells in normal tissues accumulate mutations throughout life is poorly understood. Some mutant cells expand into clones that can be detected by genome sequencing. We mapped mutant clones in normal esophageal epithelium from nine donors (age range, 20 to 75 years). Somatic mutations accumulated with age and were caused mainly by intrinsic mutational processes. We found strong positive selection of clones carrying mutations in 14 cancer genes, with tens to hundreds of clones per square centimeter...
October 18, 2018: Science
Zhenhua Fei, Wenyue Gu, Raoying Xie, Huafang Su, Yiyan Jiang
Radiotherapy plays an important therapeutic role in esophageal cancer (EC). However, acquired radioresistance impairs the efficacy of radiotherapy, often leading to treatment failure. Therefore, it is important to develop novel radiosensitizers to enhance the clinical treatment of EC. The purpose of this study was to investigate the role of artesunate (ART) on radiosensitivity of human EC cell line TE-1. We found that ART inhibited the proliferation of EC cells and enhanced the radiosensitivity of TE-1 cells (SER = 1...
September 29, 2018: Journal of Pharmacological Sciences
Wei Zhu, Ying-Hua Gao, Ping-Yong Liao, Dan-Ye Chen, Ning-Ning Sun, Phuong Anh Nguyen Thi, Yi-Jia Yan, Xiao-Feng Wu, Zhi-Long Chen
The development of novel photosensitizers is a challenging task for photodynamic therapy (PDT). Twelve novel photosensitizers (PSs), including porphins (P1-4), chlorins (C1-4) and bacteriochlorins (B1-4) were synthesized. The bacteriochlorins exhibited the longest absorption wavelength (λmax  = 736 nm), which is higher than that of porphins (λmax  = 630 nm) and chlorins (λmax  = 644 nm). In vitro photodynamic activities on Eca-109 human esophageal carcinoma cells were evaluated by standard assays and all PSs showed photodynamic activity...
October 11, 2018: European Journal of Medicinal Chemistry
Luc Biedermann, Alex Straumann
Eosinophilic esophagitis (EoE) refers to a relatively new chronic inflammatory disease of the esophagus, which according to the current understanding underlies an immune-mediated pathogenesis driven by exposure to allergens. While several open questions remain regarding ethiopathogenesis as well as treatment options and their positioning, one thing has increasingly been recognized. The disease is on the rise and will increasingly be of importance in everyday's clinical practice, not only in expert physicians but also gastroenterologists with a broad clinical spectrum, allergologists and even general practitioners...
October 15, 2018: Current Opinion in Pharmacology
Аlexander Khitaryan, Anastasiya Golovina, Arut Mezhunts, Kamil Veliev, Raisa Zavgorodnyaya, Аlexey Orekhov
INTRODUCTION: Complicated esophageal diverticulum is an extremely rare disease. The most widespread surgical tactic in such cases is drainage of the mediastinum and the position of a feeding gastrostomy or enterostomy. Our objective was to demonstrate the possibility of performing a one-step operation in case of giant esophageal diverticulum with necrotic diverticulitis and sepsis on the background of dilatation of the esophagus. PRESENTATION OF CASE: A 57-year-old woman complained of persistent nagging epigastric pain, heartburn, belching, daily vomiting of eaten food and liquid, impaired swallowing, fever up to 39° C...
October 8, 2018: International Journal of Surgery Case Reports
Salman Guraya
BACKGROUND: Literature has shown that aberrantly expressed microRNAs may have implications in certain cancers. A wealth of studies signal potential prognostic role of microRNA-21 in GIT cancers. This meta-analysis quantitatively determines prognostic significance of circulating microRNA-21 in esophageal squamous cell carcinoma (ESCC), pancreatic ductal adenocarcinoma (PDAC) and colorectal carcinoma (CRC). METHODS: Databases of Medline, Wiley online library, Cochrane library, Taylor and Francis Online, CINAHL, Springer, Proquest, ISI Web of knowledge, ScienceDirect, and Emerald were searched using MeSH terms serum/tissue microRNA-21, prognosis, esophagus squamous cell carcinoma, pancreatic ductal adenocarcinoma, colorectal cancer...
October 15, 2018: International Journal of Surgery
Ya-Wei Niu, Hua Liu, Guang-Hui Wang, Gui-Ying Yan
The last few decades have verified the vital roles of microRNAs in the development of human diseases and witnessed the increasing interest in the prediction of potential disease-miRNA associations. Owning to the open access of many miRNA-related databases, up until recently, kinds of feasible in silico models have been proposed. In this work, we developed a computational model of Maximal Entropy Random Walk on heterogenous network for MiRNA-disease Association prediction (MERWMDA). MERWMDA integrated known disease-miRNA association, pair-wise functional relation of miRNAs and pair-wise semantic relation of diseases into a heterogenous network comprised of disease and miRNA nodes full of information...
October 15, 2018: Mathematical Biosciences
Osayande Evbuomwan, Jaleelat Momodu, Khushica Purbhoo, Mboyo D T Vangu
OBJECTIVE: The aim of this study was to determine whether technetium-99m (Tc) nanocolloid was a suitable alternative tracer for carrying out milk scan studies in pediatric patients. PARTICIPANTS AND METHODS: Twenty-seven milk scans performed with Tc nanocolloid were retrospectively assessed for identification of significant esophageal hold-up, gastroesophageal reflux, pulmonary aspiration, and gastric emptying (GE). Scans were also assessed for liver, spleen, and bone marrow uptake...
October 17, 2018: Nuclear Medicine Communications
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