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Sijie Lin, Kuancan Liu, Yongchun Zhang, Ming Jiang, Rong Lu, Christopher J Folts, Xia Gao, Mark D Noble, Tingting Zhao, Zhongren Zhou, Xiaopeng Lan, Jianwen Que
Drug repurposing with a better understanding of the underlying mechanism has provided new avenues to find treatment for malignancies. Esophageal adenocarcinoma (EAC) is a rapidly increasing cancer with a dismal 5-year survival rate of <15%. Lack of efficient treatment options contributes to the high mortality rate of EAC. To find new therapy against EAC we performed unbiased drug screening of an FDA-approved drug library and identified that the cardiac glycosides including Ouabain, Digoxin and Digitoxin efficiently inhibit the proliferation of EAC cell lines (OE33 and OE19) both in vitro and in vivo...
August 10, 2018: Cellular Signalling
Frans van Workum, Annelijn E Slaman, Mark I van Berge Henegouwen, Suzanne S Gisbertz, Ewout A Kouwenhoven, Marc J van Det, Frits J H van den Wildenberg, Fatih Polat, Misha D P Luyer, Grard A P Nieuwenhuijzen, Camiel Rosman
INTRODUCTION: Totally minimally invasive esophagectomy (TMIE) is increasingly used in treatment of patients with esophageal carcinoma. However, it is currently unknown if McKeown TMIE or Ivor Lewis TMIE should be preferred for patients in whom both procedures are oncologically feasible. METHODS: The study was performed in 4 high-volume Dutch esophageal cancer centers between November 2009 and April 2017. Prospectively collected data from consecutive patients with esophageal cancer localized in the distal esophagus or gastroesophageal junction undergoing McKeown TMIE or Ivor Lewis TMIE were included...
August 10, 2018: Annals of Surgery
Kyoichi Adachi, Takumi Notsu, Tomoko Mishiro, Mayumi Okada, Eiko Okimoto, Yoshikazu Kinoshita
Aim Esophageal mucosal breaks are considered to occur circumferentially in locations with high exposure to acid. In the present study, we investigated the circumferential localization of esophageal mucosal breaks based on their distance from the esophagogastric junction. Subjects and methods The vertical and circumferential localization of 625 esophageal longitudinal mucosal breaks was examined in 398 patients with mild reflux esophagitis. Results The number of mucosal breaks in which the distal end was located 0-1 cm from the esophagogastric junction was 454, while those in which the distal end was located 1-2, 2-3, and >3 cm from the junction were 125, 28, and 18, respectively...
August 10, 2018: Internal Medicine
Naoki Yoshida, Atsushi Kanno, Atsushi Masamune, Tatsuhide Nabeshima, Seiji Hongo, Shin Miura, Tetsuya Takikawa, Shin Hamada, Kazuhiro Kikuta, Kiyoshi Kume, Masamichi Ueno, Tooru Shimosegawa
A 79-year-old woman was referred for pancreatic tail cancer with multiple liver metastases. The pancreatic tail tumor was diagnosed as acinar cell carcinoma (ACC) histologically by endoscopic ultrasound-guided fine-needle aspiration. Because of multiple liver metastases, S-1 chemotherapy was administered, resulting in a partial response to chemotherapy one year later. After approximately three years, liver atrophy and esophageal varices developed. We suspected S-1 as the cause of the liver cirrhosis. S-1 cessation minimized ascites and improved the esophageal varices...
August 10, 2018: Internal Medicine
Tomohiro Kamio, Seiji Kawano, Hideki Onishi, Yuka Obayashi, Atsushi Oyama, Kazuhiro Nouso, Keita Harada, Hiroyuki Okada, Hiroyasu Fujiwara, Yu Kanazawa
A 55-year-old man was admitted to our hospital because of massive gastrointestinal bleeding. He had a history of type B liver cirrhosis, multiple abdominal surgeries, and endoscopic treatment of esophageal varices. Colonoscopy was performed, but the source of bleeding could not be identified. Computed tomography during arterial portography (CTAP) demonstrated small intestinal varices and collateral veins from the superior mesenteric vein to the epigastric vein. We performed phlebosclerozation by directly puncturing the epigastric vein under the skin...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Kenshi Matsuno, Ryu Ishihara, Kentaro Nakagawa, Masayasu Ohmori, Hiroyoshi Iwagami, Shuntaro Inoue, Taro Iwatsubo, Hiroko Nakahira, Noriko Matsuura, Satoki Shichijyo, Akira Maekawa, Kanesaka Takashi, Sachiko Yamamoto, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Takashi Matsunaga
BACKGROUND AND AIM: Multiple Lugol-voiding lesions (LVLs) on Lugol chromoendoscopy can predict the development of metachronous multiple cancers in the esophagus and the head and neck region. However, Lugol chromoendoscopy sometimes causes adverse events such as chest pain and discomfort. We therefore investigated the endoscopic findings on narrow band imaging (NBI) or blue laser imaging (BLI) that correspond to the presence of multiple LVLs in patients with esophageal squamous cell carcinoma (ESCC)...
August 12, 2018: Journal of Gastroenterology and Hepatology
Sebastian H Doeltgen, Lakkari Rigney, Charles Cock, Taher Omari
BACKGROUND: Anodal transcranial direct current stimulation (tDCS) has demonstrated effects on corticobulbar excitability and swallowing function as assessed via clinical rating scales in stroke cohorts. Biomechanical effects of anodal tDCS on swallowing remain largely unexplored. We investigated how anodal tDCS applied over the floor of mouth (FOM) representation on the primary motor cortex affects swallowing biomechanics in healthy participants. METHODS: Anodal and sham tDCS were applied for 20 minutes at 1...
August 13, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Ingrid Marin, Noemi Caballero, Carlos Guarner-Argente, Jordi Serra
BACKGROUND: Patients with achalasia develop a well-defined obstructive pattern of pressure in response to a rapid drink challenge test (RDC). Our aim was to determine if successful treatment of achalasia can revert the obstructive pattern of pressure in response to the RDC, and if this simple test could be useful in the follow-up of patients with achalasia. METHODS: In 26 healthy controls and 103 patients with achalasia, pressure responses to a RDC were prospectively analysed using high resolution esophageal manometry in two consecutive protocols: (a) Development study: one RDC was performed in 20 healthy controls, 63 patients with nontreated achalasia, and 21 patients with previously treated achalasia; (b) Validation study: two RDC were performed before, and 8-12 weeks after treatment, in 19 patients with nontreated, newly diagnosed achalasia...
August 13, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Amanda B Muir, Joshua X Wang, Hiroshi Nakagawa
Eosinophilic esophagitis (EoE) is a food allergen-induced inflammatory disorder. EoE is increasingly recognized as a cause of swallowing dysfunction, food impaction and esophageal stricture. Inflammation of the esophageal mucosa involves immune cell infiltrate, reactive epithelial changes and fibroblast activation, culminating in robust tissue remodeling toward esophageal fibrosis characterized by excess collagen deposition in the subepithelial lamina propria. Fibrosis contributes to a unique mechanical property of the EoE-affected esophagus that is substantially stiffer than the normal esophagus...
August 12, 2018: Journal of Gastroenterology
Laís Braga Soares, Renata Buccheri, Renata Bacic Palhares, Amaro Nunes Duarte-Neto
Disseminated human cytomegalovirus (CMV) disease occurs mainly as a congenital infection and among immunocompromised hosts. Patients with acquired immunodeficiency syndrome (AIDS) are at increased risk for CMV infection, and the most prevalent clinical manifestation is retinitis, followed by colitis, esophagitis, pneumonitis, and encephalitis. CMV oophoritis is poorly described in the literature with some cases reported in patients with hematological or solid malignancies, bone marrow or solid organ transplantation, immunosuppressive therapy, and advanced AIDS cases...
July 2018: Autopsy & Case Reports
Michelle-Thao Lieu, Michael E Layoun, David Dai, Guy W Soo Hoo, Jaime Betancourt
Boerhaave syndrome, a rare yet frequently fatal diagnosis, is characterized by the spontaneous transmural rupture of the esophagus. The classic presentation of Boerhaave syndrome is characterized by Mackler's triad, consisting of chest pain, vomiting, and subcutaneous emphysema. However, Boerhaave syndrome rarely presents with all the features of Mackler's triad; instead, the common presentation of Boerhaave syndrome includes chest or epigastric pain, severe retching and vomiting, dyspnea, and shock. These symptoms are typically misdiagnosed as cardiogenic in origin...
2018: Respiratory Medicine Case Reports
Sepher Lalezari, Courtney R Hanak, Thomas Husted
Introduction: Hiatal hernia is rare after transhiatal esophagectomy occurring in less than 2% of patients [5]. Due to the rare incidence of hiatal hernias after transhiatal esophagectomy overlooking this differential in a symptomatic patient can be problematic. Patients can presents with recurrent pneumonia, complaints of reflux, and in the case presented small bowel obstructions. Surgery has been the mainstay of treatment for symptomatic hiatal hernias. This case report poses that nonoperative management is a viable treatment option for patients with complicated hiatal hernias after transhiatal esophagectomy...
September 2018: Annals of Medicine and Surgery
Wenyao Zhu, Yan Zhang, Li Kong, Yong Huang, Jinsong Zheng, Renben Wang, Minghuan Li, Jinming Yu
Purpose: To evaluate the capability of 18 F-fluorodeoxyglucose positron emission tomography/ computed tomography (18 F-FDG-PET/CT) to predict the clinical response of metastatic lymph node (mLN) to definitive chemoradiotherapy (dCRT) and guide personalized radiation dose in esophageal squamous cell carcinoma (ESCC) patients. Patients and methods: One hundred and forty-three mLNs from 59 patients with ESCC treated with dCRT and who had undergone a pretreatment 18 F-FDG-PET/CT scan were included in the study...
2018: OncoTargets and Therapy
Zhiyu Dong, Junwen Wang, Tingting Zhan, Shuchang Xu
Purpose: Esophageal adenocarcinoma (EAC) is the most common type of esophageal cancer in Western countries. It is usually detected at an advanced stage and has a poor prognosis. The aim of this study was to identify key genes and miRNAs in EAC. Methods: The mRNA microarray data sets GSE1420, GSE26886, and GSE92396 and miRNA data set GSE16456 were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs) were obtained using R software...
2018: OncoTargets and Therapy
Walter Alexander
We review key findings in the areas of prostate cancer, non-small-cell lung cancer, breast cancer, esophageal cancer, pancreatic cancer, leukemias, metastatic colon cancer, and one session on molecular profiling guidance of therapy.
August 2018: P & T: a Peer-reviewed Journal for Formulary Management
Hanan Alrammah, Sami Ghazal
Dynamic left ventricular outflow tract obstruction (LVOTO) can be hemodynamically significant and can adversely affect the heart and quality of life. It is caused by systolic anterior motion (SAM) of the anterior mitral valve into the LVOT. The mechanism underlying SAM has been an area of special interest. However, SAM occurrence in the absence of septal hypertrophy is exceedingly uncommon. Here we present a case of a young male patient who sought medical care with a complaint of exertional dyspnea, New York Heart Association functional Class 2-3, and was found to have SAM and severe LVOTO at rest without hypertrophic cardiomyopathy...
October 2018: Journal of the Saudi Heart Association
Noriyuki Hirahara, Yoshitsugu Tajima, Yusuke Fujii, Ryoji Hyakudomi, Tetsu Yamamoto, Kazunari Ishitobi, Takahito Taniura, Yasunari Kawabata
BACKGROUND: Red cell distribution width (RDW) is routinely assessed as part of the complete blood count (CBC) to gather information on the heterogeneity in the size of circulating erythrocytes. RDW is a more sensitive screening marker for anemia, inflammation, and nutritional deficiencies. The purpose of this study was to explore the prognostic value of RDW in esophageal squamous cell carcinoma (ESCC) patients. METHODS: We conducted a retrospective study of data from 148 ESCC consecutive patients who underwent potentially curative esophagectomy and analyzed the correlation of RDW with various clinicopathological factors...
October 2018: Journal of Surgical Research
Sarah B Cairo, George Ventro, Ellene Sandoval, David H Rothstein
BACKGROUND: The purpose of this study is to describe a cohort of pediatric patients undergoing cholecystectomy for biliary dyskinesia (BD) and characterize postoperative resource utilization. METHODS: Single-institution, retrospective chart review of pediatric patients after cholecystectomy for BD was done. Patient demographics and clinical characteristics as well as operative details and postoperative interventions were abstracted. Telephone follow-up was performed to identify persistent symptoms, characterize the patient experience, and quantify postoperative resource utilization...
October 2018: Journal of Surgical Research
Takashi Kojima, Kentaro Yamazaki, Ken Kato, Kei Muro, Hiroki Hara, Keisho Chin, Thomas Goddemeier, Stefan Kuffel, Morihiro Watanabe, Toshihiko Doi
Sym004 is a 1:1 mixture of two antibodies targeting non-overlapping epitopes of the epidermal growth factor receptor that antagonizes ligand binding and induces receptor downregulation. In preclinical models, it has superior antitumor activity to cetuximab and panitumumab. Japanese adults aged ≥20 years with an ECOG status of 0/1 and life expectancy ≥3 months were eligible. Patients in Part A (dose escalation) had refractory or recurrent late-stage solid tumors and received Sym004 6 mg/kg/week (n = 3), 9 mg/kg loading/6 mg/kg/week (n = 6), 12 mg/kg/week (n = 6), or 18 mg/kg biweekly (n=6)...
August 12, 2018: Cancer Science
Burhan Beger, Orhan Beger
BACKGROUND: Complications such as stricture, leakage, recurrent tracheoesophageal fistula and mucosal pouch are commonly seen in myotomy techniques used for long-gap esophageal atresia (LGEA) treatments. Therefore, we think that there is a clear need for other techniques which would enable us to create more robust and longer esophagus in such cases. In this study, we reviewed multiple V-myotomy (VM) technique and the differences of the said technique with Livaditis circular myotomy (LM) and Kimura spiral myotomy (KM) techniques using literature as an aid...
August 11, 2018: Esophagus: Official Journal of the Japan Esophageal Society
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