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https://www.readbyqxmd.com/read/30517324/hepatic-retractor-in-an-ex-vivo-model1
#1
Delano Gurgel Silveira, Márcio Alencar Barreira, Luiz Gonzaga de Moura Junior, Charles Jean Gomes de Mesquita, Hermano Alexandre Lima Rocha, Gleydson Cesar de Oliveira Borges
PURPOSE: To discuss the use of models of hepatic retraction by laparoscopy, to present a new Hepatic Retractor (HR) and to evaluate its practicality, efficacy and safety in Esophageal Hiatus Exposure (EHE). METHODS: Experimental cross - sectional study with a quantitative character. It was carried out in the Laboratory of Health Training of Christus University Center. The sample consisted of 12 livers of adult pigs weighing between 30 and 45 kg. A circular-shaped HR, 5 cm diameter and deformable materials was developed with a polypropylene cloth, metallic guide wire, epidural needle plastic guide and nylon string...
November 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30516891/-gastric-cancer-management-and-multidisciplinary-treatment
#2
Mickael Chevallay, Minoa Jung, Philippe Morel, Stefan Mönig
Despite a decreasing incidence, gastric cancer remains a burden. Generally discovered at an advanced stage, survival improved with progress in perioperative treatment and surgical management. Preoperative staging is essential to accurately classify the tumor and introduce the appropriate treatment. Tumor location is particularly important because the treatment of tumors of the esophageal junction and the stomach is different. Minimally invasive techniques can probably reduce postoperative morbidity and help to put patients in the best possible conditions for adjuvant treatment...
December 5, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/30516869/high-cd169-expression-in-lymph-node-macrophages-predicts-a-favorable-clinical-course-in-patients-with-esophageal-cancer
#3
Hiroto Takeya, Takuya Shiota, Taisuke Yagi, Koji Ohnishi, Yoshifumi Baba, Yuko Miyasato, Yuki Kiyozumi, Naoya Yoshida, Motohiro Takeya, Hideo Baba, Yoshihiro Komohara
Recent findings indicate CD169-positive lymph node sinus macrophages (LySMs) in the regional lymph nodes (RLNs) play an important role in anti-cancer immunity. In the present study, we investigated the correlation between CD169 expression in RLNs and clinicopathologic factors. Higher CD169 expression in LySMs was significantly associated with longer cancer-specific survival (CSS). The density of tumor-infiltrating lymphocytes (TILs) in the cancer nest and CD169 expression on LySMs were positively associated in patients who underwent pretreatment...
December 5, 2018: Pathology International
https://www.readbyqxmd.com/read/30516569/identification-of-adenosquamous-carcinoma-as-a-rare-aggressive-her2-negative-subgroup-of-esophageal-gastroesophageal-junction-adenocarcinoma
#4
Zhaohui Jin, Marie Holubek, William R Sukov, Christopher A Sattler, Anne E Wiktor, Robert B Jenkins, Tsung-Teh Wu, Harry H Yoon
BACKGROUND: Our purpose was to evaluate the prognostic impact of pathologically confirmed esophageal adenosquamous carcinoma (ASC) and its association with HER2 status and clinicopathologic characteristics. METHODS: Among 796 patients with esophageal or gastroesophageal junction adenocarcinoma who underwent curative resection, surgical pathology reports were reviewed, and suspected ASC was confirmed utilizing p63 and CK5/6 immunostaining. HER2 status was determined using immunohistochemistry and fluorescence in situ hybridization...
December 3, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30516400/intestinal-metaplasia-at-the-gastroesophageal-junction-is-associated-with-gastroesophageal-reflux-but-not-with-helicobacter-pylori-infection
#5
Mats Hall, Jörgen Wenner, Peter Scherman, Stefan Öberg
OBJECTIVE: Studies of the etiology of intestinal metaplasia (IM) at a normal appearing gastroesophageal junction (GEJ) are conflicting as associations with both H. Pylori (HP) infection and gastroesophageal reflux has been reported. The aim of this study was to investigate whether IM at the GEJ is associated with gastroesophageal reflux or HP infection. MATERIAL AND METHODS: Fifty asymptomatic volunteers and 149 patients with reflux symptoms underwent endoscopy with biopsies obtained from the gastric antrum and the squamocolumnar junction (SCJ)...
December 5, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/30515890/snare-combined-with-endoclips-in-endoscopic-submucosal-dissection-with-mucosal-traction-for-gastroesophageal-neoplasia
#6
Qiang Zhang, Xiang Yao, Jian-Qun Cai, Bao-Hua Zhang, Zhen Wang
BACKGROUND AND AIMS: Mucosal traction as a "second hand" in endoscopic submucosal dissection (ESD) is very helpful for ESD operators. The efficacy of using a snare combined with endoclips to assist in ESD (SC-ESD) was evaluated whether it could achieve peroral external traction (PET) and internal traction (PIT) and real-time adjustment of mucosal traction position. This study aimed to preliminarily evaluate its feasibility. METHODS: A snare was fixed using endoclips to the incised mucosal flap that was intended for dissection...
December 4, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30515811/recent-advances-in-tmem16a-structure-function-and-disease
#7
REVIEW
Qiushuang Ji, Shuai Guo, Xuzhao Wang, Chunli Pang, Yong Zhan, Yafei Chen, Hailong An
TMEM16A (also known as anoctamin 1, ANO1) is the molecular basis of the calcium-activated chloride channels, with ten transmembrane segments. Recently, atomic structures of the transmembrane domains of mouse TMEM16A (mTMEM16A) were determined by single-particle electron cryomicroscopy. This gives us a solid ground to discuss the electrophysiological properties and functions of TMEM16A. TMEM16A is reported to be dually regulated by Ca2+ and voltage. In addition, the dysfunction of TMEM16A has been found to be involved in many diseases including cystic fibrosis, various cancers, hypertension, and gastrointestinal motility disorders...
December 4, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30515521/safety-and-tolerability-of-pharyngeal-high-resolution-manometry
#8
Molly A Knigge, Stevie Marvin, Susan L Thibeault
Purpose: Pharyngeal high-resolution manometry is an emerging practice for diagnosis of swallowing disorders in the upper aerodigestive tract. Advancement of a catheter through the upper esophageal sphincter may introduce safety considerations. There are no published studies of catheter placement complications, side effects, or tolerability. This study examines patient-reported side effects and tolerability of pharyngeal high-resolution manometry. Method: Data were collected prospectively from 133 adult patients who underwent pharyngeal high-resolution manometry for the 1st time...
December 4, 2018: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/30515332/video-capsule-endoscopy-in-the-assessment-of-portal-hypertensive-enteropathy
#9
Yasir Al-Azzawi, Lidia Spaho, Mohammed Mahmoud, Joan Kheder, Anne Foley, David Cave
Background: The features of the portal hypertension enteropathy (PHE) vary from mild mucosal changes to varices with or without bleeding. The prevalence and the development are not fully understood. Aim: Our aim is to examine the prevalence and the different manifestations of PHE using video capsule endoscopy (VCE). Methods: It is a single center retrospective study of patients with cirrhosis, who had VCE. Based on the published literature, we divided the PHE lesions into vascular lesions and mucosal lesions...
2018: International Journal of Hepatology
https://www.readbyqxmd.com/read/30514328/promoter-hypomethylation-mediated-upregulation-of-microrna-10b-3p-targets-foxo3-to-promote-the-progression-of-esophageal-squamous-cell-carcinoma-escc
#10
Yi-Fang Lu, Jia-Rui Yu, Zhao Yang, Guan-Xia Zhu, Peng Gao, Huan Wang, Si-Yuan Chen, Jie Zhang, Mei-Yue Liu, Yi Niu, Xiao-Mei Wei, Wei Wang, Feng-Jin Ye, Li-Xin Zhang, Yue Zhao, Guo-Gui Sun
BACKGROUND: Esophageal cancer is a high incident cancer worldwide with poor survival and limited therapeutic options. Alterations of microRNAs are common in cancers, and many of these micro RNAs are potential therapeutic and diagnostic targets to treat these cancers. miR-10b-3p located in chromosome region 2q31.1, and its expression is frequently increased in esophageal squamous cell carcinoma (ESCC). However, the biological functions, clinical significance and therapeutic implications of miR-10b-3p in ESCC remain unclear...
December 4, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/30514256/esophageal-cancer-with-severe-funnel-chest-treated-by-simultaneous-funnel-chest-surgery-and-thoracoscopic-esophagectomy-a-case-report
#11
Keiichiro Hatoyama, Yusuke Taniyama, Tadashi Sakurai, Chiaki Sato, Hiroshi Okamoto, Yu Onodera, Takashi Kamei
BACKGROUND: Funnel chest is the most common chest deformity, occurring in 0.06-0.3% of the general population. When it occurs concomitantly with esophageal cancer, it hinders intrathoracic surgery that is necessary for treatment. Although there are a few reports of esophagectomy performed in patients with funnel chest, simultaneous treatment of esophageal cancer and funnel chest with funnel chest surgery (Nuss method) and esophagectomy has not been reported. We report the first case of advanced esophageal cancer complicated by severe funnel chest that was treated using the Nuss method and radical thoracoscopic esophagectomy...
December 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30514238/use-of-over-the-counter-products-in-older-cardiovascular-patients-admitted-to-a-tertiary-care-center-in-usa
#12
Marwan Sheikh-Taha, Hani Dimassi
BACKGROUND: In recent years there has been a substantial increase in the use of over-the-counter (OTC) products around the world. While they are assumed to be safe by consumers, they can potentially lead to adverse effects and drug interactions particularly in older adults. METHODS: We assessed the patterns of OTC products used by older adults admitted to the cardiology service in a tertiary care medical center in the USA over a three month period. We conducted a retrospective chart review where older adults with cardiovascular diseases (CVD) who were taking at least one OTC product at home were included...
December 4, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/30511197/vitamin-d-and-gastrointestinal-cancers-a-narrative-review
#13
REVIEW
Hemant Goyal, Abhilash Perisetti, M Rubayat Rahman, Avi Levin, Giuseppe Lippi
Calcitriol (1,25(OH)2 D3 ) performs various activities throughout the body. Although low serum 25-hydroxyvitamin D [25(OH)D] levels are associated with several disease processes such as risk of fractures and falls, hypertension, cardiovascular disease, and diabetes mellitus, recent evidence attests that this important hormone also regulates several cellular pathways involved in cancer development and progression. Calcitriol modulates several genes controlling gut physiology and calcium homeostasis and also maintains the integrity of epithelial barriers, regulates the absorption of phosphate and calcium, and modulates host defense against pathogens and inflammatory response by interplaying with several types of secretory and immune cells...
December 3, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/30511093/the-role-and-prognostic-significance-of-aortopulmonary-anterior-mediastinal-and-tracheobronchial-lymph-nodes-in-esophageal-cancer-update-of-the-eighth-edition-tnm-staging-system-2018
#14
Wen-Ping Wang, Peng-Zhi Ni, Yu-Shang Yang, Song-Lin He, Wei-Peng Hu, Long-Qi Chen
BACKGROUND: The eighth edition of TNM staging for esophageal cancer will be implemented at 2018. The stations 5, 6, and 10 lymph nodes (LNs) have been omitted from the regional lymph node map for the new TNM staging. However, the role and prognostic significance of these LN stations were not clear. The purpose of this study was to investigate whether the revised nodal staging is appropriate and to verify the role, prognostic significance, and therapeutic value of these LNs in esophageal cancer...
December 3, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30510992/three-dimensional-organoids-reveal-therapy-resistance-of-esophageal-and-oropharyngeal-squamous-cell-carcinoma-cells
#15
Takashi Kijima, Hiroshi Nakagawa, Masataka Shimonosono, Prasanna M Chandramouleeswaran, Takeo Hara, Varun Sahu, Yuta Kasagi, Osamu Kikuchi, Koji Tanaka, Veronique Giroux, Amanda B Muir, Kelly A Whelan, Shinya Ohashi, Seiji Naganuma, Andres J Klein-Szanto, Yoshiaki Shinden, Ken Sasaki, Itaru Omoto, Yoshiaki Kita, Manabu Muto, Adam J Bass, J Alan Diehl, Gregory G Ginsberg, Yuichiro Doki, Masaki Mori, Yasuto Uchikado, Takaaki Arigami, Narayan G Avadhani, Devraj Basu, Anil K Rustgi, Shoji Natsugoe
Background & Aims: Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, three-dimensional (3D) organoids may be useful for functional characterization of cancer cells ex vivo . We investigated the feasibility and the utility of patient-derived 3D organoids of esophageal and oropharyngeal squamous cell carcinomas...
2019: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30510939/benefits-of-the-seattle-biopsy-protocol-in-the-diagnosis-of-barrett-s-esophagus-in-a-chinese-population
#16
Shou-Wu Lee, Han-Chung Lien, Chi-Sen Chang, Ming-Xian Lin, Chung-Hsin Chang, Chung-Wang Ko
AIM: To investigate the benefits of the Seattle protocol in the diagnosis of Chinese individuals with Barrett's esophagus. METHODS: Subjects enrolled were patients from one center with endoscopically-suspected esophageal metaplasia. These patients first received narrow-band imaging-targeted biopsy, and later, the Seattle protocol-guided biopsy, within a period from October 2012 to December 2014. Those cases without initial pathologic patterns of intestinal metaplasia (IM) and then appearance or loss of IM tissue were designated as Group A or B, respectively...
November 26, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/30510650/prevalence-and-association-of-human-papillomavirus-epstein-barr-virus-and-merkel-cell-polyomavirus-with-neoplastic-esophageal-lesions-in-northern-iran
#17
Yousef Yahyapour, Rabeae Rahmani, Majid Alipour, Ahad Alizadeh, Aynaz Khademian, Farzin Sadeghi
Background: Studies concerning on esophageal squamous cell carcinoma (ESCC) etiological factors have been done for several decades, however, results reported from various investigations were not consistent. The present investigation aimed to explore the presence of 3 oncogenic viruses, human papilloma virus (HPV), Epstein-Barr virus (EBV) and Merkel cell polyomavirus (MCPyV) in the neoplastic and non- neoplastic esophageal lesions collected from Mazandaran, a high risk area of Iran. Methods: In total, 168 esophageal specimens (100 with ESCC confirmed diagnosis and 68 without esophageal malignancy) were analyzed for HPV, EBV and MCPyV by Real Time PCR...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/30510377/timing-of-upper-gastrointestinal-endoscopy-does-not-influence-short-term-outcomes-in-patients-with-acute-variceal-bleeding
#18
Jeong-Ju Yoo, Young Chang, Eun Ju Cho, Ji Eun Moon, Sang Gyune Kim, Young Seok Kim, Yun Bin Lee, Jeong-Hoon Lee, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon
AIM: To examine the association between the timing of endoscopy and the short-term outcomes of acute variceal bleeding in cirrhotic patients. METHODS: This retrospective study included 274 consecutive patients admitted with acute esophageal variceal bleeding of two tertiary hospitals in Korea. We adjusted confounding factors using the Cox proportional hazards model and the inverse probability weighting (IPW) method. The primary outcome was the mortality of patients within 6 wk...
November 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30510209/complex-role-of-mir-130a-3p-and-mir-148a-3p-balance-on-drug-resistance-and-tumor-biology-in-esophageal-squamous-cell-carcinoma
#19
A K Eichelmann, C Matuszcak, K Lindner, J Haier, D J Hussey, R Hummel
miRNAs play a crucial role in cancer development and progression. However, results on the impact of miRNAs on drug sensitivity and tumor biology vary, and most studies to date focussed on either increasing or decreasing miRNA expression levels. Therefore, the current study investigated the role of different expression levels of miR-130a-3p and miR-148a-3p on drug resistance and tumor biology in four esophageal squamous cell carcinoma cell lines. Interestingly, up- and downregulation of both miRNAs significantly increased sensitivity towards chemotherapy...
December 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30509077/neoadjuvant-therapy-theoretical-biological-and-medical-consideration
#20
Evgeny N Imyanitov, Grigoriy A Yanus
Neoadjuvant therapy (NAT) is widely utilized in the routine management of cancer patients and various clinical trials for the treatment of breast, ovarian, rectal, esophageal, head and neck, lung, prostate and many other cancer types. There is a number of potential benefits of applying systemic treatment before the operation. NAT may significantly reduce the tumor burden thus allowing less traumatic surgery. NAT is often considered as personalized in vivo drug sensitivity test, as it allows rapid evaluation of tumor response to a given therapy and consequent adjustment of further treatment planning...
December 2018: Chinese Clinical Oncology
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