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lymphoedema treatment

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https://www.readbyqxmd.com/read/30295931/feasibility-study-of-combined-dynamic-imaging-and-lymphaticovenous-anastomosis-surgery-for-breast-cancer-related-lymphoedema
#1
A A Khan, I Hernan, J A Adamthwaite, K W D Ramsey
BACKGROUND: Breast cancer-related lymphoedema (BCRL) presents a significant healthcare burden and adversely affects quality of life of breast cancer survivors. A prospective feasibility study was performed on lymphaticovenous anastomosis (LVA) for the treatment of BCRL. METHODS: Patients with BCRL underwent near-infrared spectroscopy with indocyanine green lymphatic mapping to identify suitable lymphatic channels for LVA. End-to-end anastomoses to subdermal venules were performed and patients recommenced compression garment therapy (CGT) after surgery...
October 8, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/30293713/treatment-of-gynaecological-cancer-related-lower-limb-lymphoedema-with-liposuction
#2
Pauline McGee, David Alex Munnoch
OBJECTIVE: To evaluate outcomes in patients with gynaecological cancer related lymphoedema treated with liposuction. METHODS: A prospective analysis of 21 patients who underwent liposuction followed by compression therapy for chronic unilateral lower limb lymphoedema with up to 8 years follow up was performed. RESULTS: Duration of lymphoedema prior to liposuction ranged from 4 to 28 years (mean 15.2 years). The mean age at time of liposuction was 52 years (range 37-67)...
October 4, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30260281/chronic-oedema-and-the-older-person
#3
Garry Cooper-Stanton
Chronic oedema (CO) and lymphoedema (LO) are long-term conditions that can become more complicated or are more likely to develop with age. The ageing process can involve alterations in the structures that support the normal function of the lymphatic system or put it at greater risk of damage. The main three components (skin care, exercise and compression therapy) within the management of CO/LO can become more difficult to apply with age. This is because of reduced healing rates, decreased cardiovascular capacity and deterioration in vascular and arterial structures...
October 1, 2018: British Journal of Community Nursing
https://www.readbyqxmd.com/read/30260277/haddenham-star-cotton-improving-treatment-outcomes-in-maintaining-chronic-oedema
#4
Natalie Lee, Sue Lawrance
The aim of compression therapy is to apply pressure on the skin and underlying structures to counteract the force of gravity, supporting venous and lymphatic function, to prevent or minimise oedema in the affected tissues. Compression therapy to manage lymphoedema is supported by a plethora of research, as it helps to increase the velocity of flow and lymphatic contraction of the lymphatic collecting vessels. This encourages drainage to the route of the limb, which increases fluid drainage from the tissues into the lymphatics...
October 1, 2018: British Journal of Community Nursing
https://www.readbyqxmd.com/read/30196031/axillary-dissection-versus-no-axillary-dissection-in-patients-with-breast-cancer-and-sentinel-node-micrometastases-ibcsg-23-01-10-year-follow-up-of-a-randomised-controlled-phase-3-trial
#5
Viviana Galimberti, Bernard F Cole, Giuseppe Viale, Paolo Veronesi, Elisa Vicini, Mattia Intra, Giovanni Mazzarol, Samuele Massarut, Janez Zgajnar, Mario Taffurelli, David Littlejohn, Michael Knauer, Carlo Tondini, Angelo Di Leo, Marco Colleoni, Meredith M Regan, Alan S Coates, Richard D Gelber, Aron Goldhirsch
BACKGROUND: We previously reported the 5-year results of the phase 3 IBCSG 23-01 trial comparing disease-free survival in patients with breast cancer with one or more micrometastatic (≤2 mm) sentinel nodes randomly assigned to either axillary dissection or no axillary dissection. The results showed no difference in disease-free survival between the groups and showed non-inferiority of no axillary dissection relative to axillary dissection. The current analysis presents the results of the study after a median follow-up of 9·7 years (IQR 7·8-12·7)...
September 5, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30098774/a-mixed-methods-examination-of-distress-and-person-centred-experience-of-head-and-neck-lymphoedema
#6
Jodie L Nixon, Amanda E Pigott, Bena Cartmill, Jane Turner, Jennifer Fleming, Sandro V Porceddu
PURPOSE: This study aimed to examine the course and nature of distress and quality of life (QoL) during and after head and neck lymphoedema (HNL) treatment in people who developed HNL following treatment for head and neck cancer (HNC). METHODS: This study (n = 10) used a mixed method explanatory design to explore distress associated with HNL. Component 1 used a prospective repeated measures design to examine distress during a 22-week HNL program. Component 2 used a qualitative interview approach to understand the patient experience of distress after completion of HNL treatment...
August 2018: Oral Oncology
https://www.readbyqxmd.com/read/30057039/experiences-of-breast-cancer-related-lymphoedema-and-the-use-of-reflexology-for-managing-swelling-a-qualitative-study
#7
Judith Whatley, Rachael Street, Sally Kay
BACKGROUND AND PURPOSE: An estimated 1 in 5 women surviving breast cancer will go on to develop breast cancer related lymphoedema (BCRL). There is a gap in the literature capturing experiences of people living with BCRL who use complementary therapies. MATERIALS AND METHODS: Data were collected from 26 participants via a semi-structured interview. Questioning centred around their personal experiences of living with lymphoedema, and their use of reflexology lymphatic drainage...
August 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/30044023/patient-perceptions-of-living-with-head-and-neck-lymphoedema-and-the-impacts-to-swallowing-voice-and-speech-function
#8
Claire Jeans, Elizabeth C Ward, Bena Cartmill, Anne E Vertigan, Amanda E Pigott, Jodie L Nixon, Chris Wratten
Head and neck lymphoedema (HNL) is common following head and neck cancer (HNC) treatment, and may contribute to numerous physical, functional and psychological symptoms. However, its impact on swallowing, voice and speech is less well understood. The aim of this study was to use interpretive description to explore patient perceptions relating to the impact of HNL on swallowing, voice and speech. Twelve participants, >3 months post HNC treatment and experiencing some form of HNL, participated in individual, semi-structured interviews...
July 25, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/30009576/penile-lymphoedema-approach-to-investigation-and-management
#9
T N Shim, P R Doiron, N Francis, S Minhas, A Muneer, D Hawkins, M Dinneen, C B Bunker
BACKGROUND: Penile lymphoedema (with and without cellulitis) is a rare, often chronic, clinically heterogeneous entity with an uncertain pathogenesis and an important differential diagnosis. It creates significant physical and psychosexual morbidity, and presents considerable therapeutic challenges. The existing literature is limited. AIM: To describe and share our updated cumulative experience of a cohort of patients with penile lymphoedema. METHODS: This was a retrospective review of the case records of patients with chronic penile lymphoedema seen in two dedicated male genital dermatology clinics between January 2011 and July 2016...
July 15, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29980515/surgical-management-of-chronic-genital-lymphoedema
#10
Derek B Hennessey, Ned Kinnear, Justin Chee
A 44-year-old man with a spinal cord injury was referred to a specialist urology service with a 7-year history of significant genital swelling. His condition had eluded diagnosis and was refractory to all previous treatments. The considerable swelling both impacted his quality of life and prevented the patient from adequately managing his neurogenic bladder. He was diagnosed with chronic idiopathic genital lymphoedema and underwent total scrotectomy, wide penile skin excision and split skin graft to the penile shaft...
July 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29972671/compression-therapy-and-exercise-enhancing-outcomes
#11
Louise Rooney, Garry Cooper-Stanton, Jayne Cave-Senior
Compression therapy is the main method used within the treatment and management of lymphoedema and chronic oedema. The increasing prevalence of the condition, which has multiple causes, such as genetic factors, age and external factors, require the effective management of the condition, and to enhance the management methods used to contain the condition. The use of exercise alongside the mainstay method of treatment (compression therapy) has been an underutilised area. The application of a structured exercise programme in conjunction with multi-layer lymphoedema bandaging combined with an adjustable velcro wrap based systems led to a decrease in limb volume in one case study...
July 2, 2018: British Journal of Community Nursing
https://www.readbyqxmd.com/read/29956468/lipoedema-is-not-lymphoedema-a-review-of-current-literature
#12
Eran Shavit, Uwe Wollina, Afsaneh Alavi
Lipoedema is a rare painful disorder of the adipose tissue. It essentially affects females and is often misdiagnosed as lymphoedema or obesity. It is globally misdiagnosed or underdiagnosed, and the literature is lacking appropriate guidance to assist clinicians towards this diagnosis. However, the need to recognise this disorder as a unique entity has important implications to establish proper treatment and, therefore, its tremendous effect on patients. Early diagnosis and treatment can turn these patients' lives upside down...
June 29, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29938631/-surgical-treatment-for-lymphoedema
#13
Rikke Falsig Vestergaard, Alexander Andersen Juhl, Tine Engberg Damsgaard
Lymphoedema is a frequent condition after surgical treatment for breast cancer. Lymphoedema causes great discomfort for the patients and is primarily treated conservatively with compression garments and physical therapy. Recently, surgical interventions have gained popularity in the form of lympho-lymphatic anastomoses, lympho-venous anastomoses and autologous lymph node transplantation, either as stand-alone treatment or in combination with secondary breast reconstruction. In Denmark, lympho-venous anastomoses is currently the primary surgical treatment for lymphoedema...
June 18, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29906197/mobiderm-autofit-an-adjustable-sleeve-that-enables-patients-to-self-manage-lymphoedema
#14
Marie Todd, Charlotte Stubbs, Stacy Pugh
Lymphoedema can result in debilitating physical and psychosocial morbidity and when combined with other chronic comorbidity, often requires holistic, specialist management that encompasses all the complex and compounding problems. Self-care is an integral component of any treatment strategy, however, the patient must be fully prepared and ongoing support should be provided. Self-care consists of managing the symptoms of lymphoedema but should include other fundamental aspects of healthy living, for example, maintaining a healthy weight and activity levels...
April 1, 2018: British Journal of Community Nursing
https://www.readbyqxmd.com/read/29804748/first-successful-experimental-implantation-of-a-drainage-device-to-reduce-lymphoedema-in-a-rat-lymphoedema-model
#15
Valentina Triacca, Marco Pisano, Claudia Lessert, Benoit Petit, Karima Bouzourene, Aimable Nahimana, Marie-Catherine Vozenin, Nikolaos Stergiopulos, Melody A Swartz, Lucia Mazzolai
OBJECTIVE/BACKGROUND: Despite recent advances in pharmacological research and microsurgery, lymphoedema remains an incurable disease that deeply affects quality of life. There is an urgent need for innovative approaches to restore continuous lymph flow in affected tissues. To this end, the efficacy of a subcutaneously implanted draining device in reducing lymphoedema volume in a rat hindlimb lymphoedema model was tested. METHODS: A rat model of chronic lymphoedema was developed by surgical removal of popliteal and inguinal lymph nodes, followed by irradiation...
May 24, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29774284/rapid-integrated-clinical-survey-to-determine-prevalence-and-co-distribution-patterns-of-lymphatic-filariasis-and-onchocerciasis-in-a-loa-loa-co-endemic-area-the-angolan-experience
#16
Miguel Brito, Rossely Paulo, Pedro Van-Dunem, António Martins, Thomas R Unnasch, Robert J Novak, Benjamin Jacob, Michelle C Stanton, David H Molyneux, Louise A Kelly-Hope
The Republic of Angola is a priority country for onchocerciasis and lymphatic filariasis (LF) elimination, however, the co-distribution of the filarial parasite Loa loa (loiasis) is a significant impediment, due to the risk of severe adverse events (SAEs) associated with ivermectin used in mass drug administration (MDA) campaigns. Angola has a high risk loiasis zone identified in Bengo Province where alternative interventions may need to be implemented; however, the presence and geographical overlap of the three filarial infections/diseases are not well defined...
August 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29773516/lymphoedema-management-to-prevent-acute-dermatolymphangioadenitis-in-podoconiosis-in-northern-ethiopia-golbet-a-pragmatic-randomised-controlled-trial
#17
Henok Negussie, Meseret Molla, Moses Ngari, James A Berkley, Esther Kivaya, Patricia Njuguna, Greg Fegan, Abreham Tamiru, Abebe Kelemework, Trudie Lang, Melanie J Newport, Andy McKay, Fikre Enquoselassie, Gail Davey
BACKGROUND: Podoconiosis (also known as endemic, non-filarial elephantiasis) affects about 4 million subsistence farmers in tropical Africa. Poor awareness of the condition and inadequate evidence for the efficacy of treatment mean that no government in an endemic country yet offers lymphoedema management for patients with podoconiosis. Among patients with filarial lymphoedema, trials suggest that limb care is effective in reducing the most disabling sequelae: episodes of acute dermatolymphangioadenitis...
July 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29724903/natural-history-of-gata2-deficiency-in-a-survey-of-79-french-and-belgian-patients
#18
Jean Donadieu, Marie Lamant, Claire Fieschi, Flore Sicre de Fontbrune, Aurélie Caye, Marie Ouachee, Blandine Beaupain, Jacinta Bustamante, Hélène A Poirel, Bertrand Isidor, Eric Van Den Neste, Antoine Neel, Stanislas Nimubona, Fabienne Toutain, Vincent Barlogis, Nicolas Schleinitz, Thierry Leblanc, Pierre Rohrlich, Felipe Suarez, Dana Ranta, Wadih Abou Chahla, Bénédicte Bruno, Louis Terriou, Sylvie Francois, Bruno Lioure, Guido Ahle, Françoise Bachelerie, Claude Preudhomme, Eric Delabesse, Hélène Cave, Christine Bellanné-Chantelot, Marlène Pasquet
Heterozygous germline GATA2 mutations strongly predispose to leukemia, immunodeficiency, and/or lymphoedema. We describe a series of 79 patients (53 families) diagnosed since 2011, made up of all patients in France and Belgium, with a follow up of 2249 patients/years. Median age at first clinical symptoms was 18.6 years (range, 0-61 years). Severe infectious diseases (mycobacteria, fungus, and human papilloma virus) and hematologic malignancies were the most common first manifestations. The probability of remaining symptom-free was 8% at 40 years old...
August 2018: Haematologica
https://www.readbyqxmd.com/read/29704765/lymphatic-endothelial-progenitor-cells-origins-and-roles-in-lymphangiogenesis
#19
REVIEW
Jan Kazenwadel, Natasha L Harvey
How are lymphatic vessels built? What are the sources of progenitor cells employed to construct lymphatic vessels during embryogenesis and in pathological situations? Are lymphatic vessels in different tissues built the same way? These questions have been highly topical and actively debated in the field of lymphangiogenesis research for more than 100 years. While embryonic veins and cells of mesenchymal origin have been recognised as sources of embryonic lymphatic endothelial cells for many years, recent advances in technology have revealed the existence of additional sources of lymphatic endothelial cells important for embryonic lymphangiogenesis...
April 25, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29674402/cutaneous-lymphangitis-carcinomatosa-made-cervicofacial-oedema-intractable-in-a-patient-with-superior-vena-cava-syndrome
#20
Eriko Kashihara, Osamu Kanai, Misato Okamura, Tadashi Mio
Cutaneous lymphangitis carcinomatosa (CLC) is a rare form of cutaneous metastasis that causes lymphoedema and various eruptions. We report a case of lung cancer with CLC that caused both superior vena cava (SVC) stenosis and cervicofacial oedema, suggestive of SVC syndrome. A 64-year-old woman with lung adenocarcinoma presented with cervicofacial oedema and erythema, followed by severe dyspnoea 2 months after four cycles of carboplatin, pemetrexed and bevacizumab triplet therapy. Although chest CT indicated SVC stenosis, cervicofacial oedema remained despite treating the SVC stenosis via balloon dilation...
April 19, 2018: BMJ Case Reports
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