keyword
https://read.qxmd.com/read/38536949/combination-nano-delivery-systems-remodel-the-immunosuppressive-tumor-microenvironment-for-metastatic-triple-negative-breast-cancer-therapy
#1
JOURNAL ARTICLE
Liya Bai, Hui Liu, Ran You, Xiaoyu Jiang, Tao Zhang, Yunan Li, Tianhe Shan, Zhanyin Qian, Yinsong Wang, Yuanyuan Liu, Chunyu Li
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer for which effective therapies are lacking. Targeted remodeling of the immunosuppressive tumor microenvironment (TME) and activation of the body's immune system to fight tumors with well-designed nanoparticles have emerged as pivotal breakthroughs in tumor treatment. To simultaneously remodel the immunosuppressive TME and trigger immune responses, we designed two potential therapeutic nanodelivery systems to inhibit TNBC. First, the bromodomain-containing protein 4 (BRD4) inhibitor JQ1 and the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CXB) were coloaded into chondroitin sulfate (CS) to obtain CS@JQ1/CXB nanoparticles (NPs)...
March 27, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38536591/circ_0020460-drives-tumorigenesis-in-cervical-cancer-through-mir-485-3p-sponging
#2
JOURNAL ARTICLE
Kun Yan, Chunyan Hu, Yali Cheng, Lingzhi Zheng, Baojin Zeng, Sujun Zhao, Chen Liu
Deregulation of circular RNAs (circRNAs) is widely recognized in cancer progression. Our study aims to investigate the role of circ_0020460 in the development of cervical cancer (CC) and its potential mechanism of action. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assays were used to detect the expression levels of circ_0020460, miR-485-3p and C-X-C motif chemokine ligand 1 (CXCL1). The roles of circ_0020460 on cell proliferation, cell migration, cell invasion, cell apoptosis, and angiogenesis were investigated using cell counting kit-8 (CCK-8) and Ethynyl deoxyuridine (Edu) assay, wound healing assay, transwell assay, flow cytometry assay, and tube formation assay, respectively...
March 27, 2024: Discover. Oncology
https://read.qxmd.com/read/38536567/mir-374a-b-5p-suppresses-cell-growth-in-papillary-thyroid-carcinoma-through-blocking-exosomal-anxa1-induced-macrophage-m2-polarization
#3
JOURNAL ARTICLE
Sanbao Liu
Papillary thyroid carcinoma (PTC), comprising 85% of all thyroid cancers, is an epithelial malignancy. The potential for malignant transformation in normal cells by thyroid cancer cells via exosomal Annexin A1 (ANXA1) delivery is investigated in this study. Our aim is to determine the impact of PTC cells on macrophage polarization through exosomal ANXA1 secretion and its implications for tumor progression. Exosomes in PTC cells were examined using transmission electron microscopy, exosome labeling, and nanoparticle tracking analysis...
March 27, 2024: Biochemical Genetics
https://read.qxmd.com/read/38536483/cacna2d1-regulates-the-progression-and-influences-the-microenvironment-of-colon-cancer
#4
JOURNAL ARTICLE
Hiroyuki Inoue, Atsushi Shiozaki, Toshiyuki Kosuga, Hiroki Shimizu, Michihiro Kudou, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Yoshiaki Kuriu, Takeshi Kubota, Hitoshi Fujiwara, Yukiko Morinaga, Eiichi Konishi, Eigo Otsuji
BACKGROUND: Calcium voltage-gated channel auxiliary subunit alpha 2/delta 1 (CACNA2D1), a gene encoding a voltage-gated calcium channel, has been reported as an oncogene in several cancers. However, its role in colon cancer (CC) remains unclear. This study aimed to investigate the function of CACNA2D1 and its effect on the microenvironment in CC. METHODS: Immunohistochemistry (IHC) analysis was performed on samples collected from 200 patients with CC who underwent curative colectomy...
March 27, 2024: Journal of Gastroenterology
https://read.qxmd.com/read/38536085/the-cryo-em-structure-of-ask1-reveals-an-asymmetric-architecture-allosterically-modulated-by-trx1
#5
JOURNAL ARTICLE
Karolina Honzejkova, Dalibor Kosek, Veronika Obsilova, Tomas Obsil
Apoptosis signal-regulating kinase 1 (ASK1) is a crucial stress sensor, directing cells toward apoptosis, differentiation, and senescence via the p38 and JNK signaling pathways. ASK1 dysregulation has been associated with cancer and inflammatory, cardiovascular, and neurodegenerative diseases, among others. However, our limited knowledge of the underlying structural mechanism of ASK1 regulation hampers our ability to target this member of the MAP3K protein family towards developing therapeutic interventions for these disorders...
March 27, 2024: ELife
https://read.qxmd.com/read/38535786/bee-venom-composition-and-anticancer-properties
#6
REVIEW
Goran Gajski, Elina Leonova, Nikolajs Sjakste
Among the various natural compounds used in alternative and Oriental medicine, toxins isolated from different organisms have had their application for many years, and Apis mellifera venom has been studied the most extensively. Numerous studies dealing with the positive assets of bee venom (BV) indicated its beneficial properties. The usage of bee products to prevent the occurrence of diseases and for their treatment is often referred to as apitherapy and is based mainly on the experience of the traditional system of medical practice in diverse ethnic communities...
February 29, 2024: Toxins
https://read.qxmd.com/read/38535455/marine-derived-anticancer-agents-targeting-apoptotic-pathways-exploring-the-depths-for-novel-cancer-therapies
#7
REVIEW
Doralyn S Dalisay, Chuckcris P Tenebro, Edna M Sabido, Angelica Faith L Suarez, Melissa June V Paderog, Rikka Reyes-Salarda, Jonel P Saludes
Extensive research has been conducted on the isolation and study of bioactive compounds derived from marine sources. Several natural products have demonstrated potential as inducers of apoptosis and are currently under investigation in clinical trials. These marine-derived compounds selectively interact with extrinsic and intrinsic apoptotic pathways using a variety of molecular mechanisms, resulting in cell shrinkage, chromatin condensation, cytoplasmic blebs, apoptotic bodies, and phagocytosis by adjacent parenchymal cells, neoplastic cells, or macrophages...
February 28, 2024: Marine Drugs
https://read.qxmd.com/read/38535442/natural-products-derived-from-marine-sponges-with-antitumor-potential-against-lung-cancer-a-systematic-review
#8
REVIEW
Alba Ortigosa-Palomo, Francisco QuiƱonero, Raul Ortiz, Francisco Sarabia, Jose Prados, ConsolaciĆ³n Melguizo
Non-small-cell lung cancer (NSCLC), the most commonly diagnosed cancer and the leading cause of cancer-related death worldwide, has been extensively investigated in the last decade in terms of developing new therapeutic options that increase patient survival. In this context, marine animals are a source of new, interesting bioactive molecules that have been applied to the treatment of different types of cancer. Many efforts have been made to search for new therapeutic strategies to improve the prognosis of lung cancer patients, including new bioactive compounds and cytotoxic drugs from marine sponges...
February 23, 2024: Marine Drugs
https://read.qxmd.com/read/38535120/triple-silencing-of-hsp27-cflip-and-clu-genes-promotes-the-sensitivity-of-doxazosin-induced-apoptosis-in-pc-3-prostate-cancer-cells
#9
JOURNAL ARTICLE
Jeong Man Cho, Sojung Sun, Eunji Im, Hyunwon Yang, Tag Keun Yoo
Background: This study investigated how the expression of heat shock protein 27 (HSP27), cellular FLICE-like inhibitory protein (cFLIP), and clusterin (CLU) affects the progression of cancer cells and their susceptibility to doxazosin-induced apoptosis. By silencing each of these genes individually, their effect on prostate cancer cell viability after doxazosin treatment was investigated. Methods: PC-3 prostate cancer cells were cultured and then subjected to gene silencing using siRNA targeting HSP27, cFLIP, and CLU, either individually, in pairs, or all together...
February 21, 2024: Medicines (Basel, Switzerland)
https://read.qxmd.com/read/38534770/the-combination-of-oolonghomobisflavan-b-and-diallyl-disulfide-induces-apoptotic-cell-death-via-67-kda-laminin-receptor-cyclic-guanosine-monophosphate-in-acute-myeloid-leukemia-cells
#10
JOURNAL ARTICLE
Jaehoon Bae, Su-Jin Park
Diallyl disulfide (DADS) is a well-known principal functional component derived from garlic ( Allium sativum ) that has various health benefits. Previously, we identified a 67-kDa laminin receptor, a receptor for oolong tea polyphenol oolonghomobisflavan B (OHBFB). However, its molecular mechanisms still remain to be elucidated. Here, we show that DADS synergistically enhanced the effect of the oolong tea polyphenol oolonghomobisflavan B (OHBFB), which induces apoptosis in acute myeloid leukemia (AML) cancer cells without affecting normal human peripheral blood mononuclear cells (PBMCs)...
March 14, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534746/mitochondrial-dysfunction-a-key-player-in-brain-aging-and-diseases
#11
REVIEW
Sydney Bartman, Giuseppe Coppotelli, Jaime M Ross
Mitochondria are thought to have become incorporated within the eukaryotic cell approximately 2 billion years ago and play a role in a variety of cellular processes, such as energy production, calcium buffering and homeostasis, steroid synthesis, cell growth, and apoptosis, as well as inflammation and ROS production. Considering that mitochondria are involved in a multitude of cellular processes, mitochondrial dysfunction has been shown to play a role within several age-related diseases, including cancers, diabetes (type 2), and neurodegenerative diseases, although the underlying mechanisms are not entirely understood...
March 2, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534371/protac-mediated-dual-degradation-of-bcl-xl-and-bcl-2-is-a-highly-effective-therapeutic-strategy-in-small-cell-lung-cancer
#12
JOURNAL ARTICLE
Sajid Khan, Lin Cao, Janet Wiegand, Peiyi Zhang, Maria Zajac-Kaye, Frederic J Kaye, Guangrong Zheng, Daohong Zhou
BCL-xL and BCL-2 are validated therapeutic targets in small-cell lung cancer (SCLC). Targeting these proteins with navitoclax (formerly ABT263, a dual BCL-xL/2 inhibitor) induces dose-limiting thrombocytopenia through on-target BCL-xL inhibition in platelets. Therefore, platelet toxicity poses a barrier in advancing the clinical translation of navitoclax. We have developed a strategy to selectively target BCL-xL in tumors, while sparing platelets, by utilizing proteolysis-targeting chimeras (PROTACs) that hijack the cellular ubiquitin proteasome system for target ubiquitination and subsequent degradation...
March 17, 2024: Cells
https://read.qxmd.com/read/38534365/tnf-related-apoptosis-inducing-ligand-non-apoptotic-signalling
#13
REVIEW
Abderrahmane Guerrache, Olivier Micheau
TNF-related apoptosis-inducing ligand (TRAIL or Apo2 or TNFSF10) belongs to the TNF superfamily. When bound to its agonistic receptors, TRAIL can induce apoptosis in tumour cells, while sparing healthy cells. Over the last three decades, this tumour selectivity has prompted many studies aiming at evaluating the anti-tumoral potential of TRAIL or its derivatives. Although most of these attempts have failed, so far, novel formulations are still being evaluated. However, emerging evidence indicates that TRAIL can also trigger a non-canonical signal transduction pathway that is likely to be detrimental for its use in oncology...
March 16, 2024: Cells
https://read.qxmd.com/read/38534315/cisplatin-and-starvation-differently-sensitize-autophagy-in-renal-carcinoma-a-potential-therapeutic-pathway-to-target-variegated-drugs-resistant-cancerous-cells
#14
JOURNAL ARTICLE
Ankita Dutta, Subarna Thakur, Debasish Kumar Dey, Anoop Kumar
Cisplatin, a powerful chemotherapy medication, has long been a cornerstone in the fight against cancer due to chemotherapeutic failure. The mechanism of cisplatin resistance/failure is a multifaceted and complex issue that consists mainly of apoptosis inhibition through autophagy sensitization. Currently, researchers are exploring ways to regulate autophagy in order to tip the balance in favor of effective chemotherapy. Based on this notion, the current study primarily identifies the differentially expressed genes (DEGs) in cisplatin-treated autophagic ACHN cells through the Illumina Hi-seq platform...
March 7, 2024: Cells
https://read.qxmd.com/read/38534178/a-novel-inhibitor-of-poly-adp-r-ibose-polymerase-1-inhibits-proliferation-of-a-brca-deficient-breast-cancer-cell-line-via-the-dna-d-amage-a-ctivated-cgas-sting-pathway
#15
JOURNAL ARTICLE
Yonglong Jin, Lijie Wang, Chengxue Jin, Na Zhang, Shosei Shimizu, Wenjing Xiao, Chuanlong Guo, Xiguang Liu, Hongzong Si
Loss-of-function mutations in the Breast Cancer Susceptibility Gene (BRCA1 and BRCA2) are often detected in patients with breast cancer. Poly(ADP-ribose) polymerase-1 (PARP1) plays a key role in the repair of DNA strand breaks, and PARP inhibitors have been shown to induce highly selective killing of BRCA1/2-deficient tumor cells, a mechanism termed synthetic lethality. In our previous study, a novel PARP1 inhibitor─( E )-2-(2,3-dibromo-4,5-dimethoxybenzylidene)- N -(4-fluorophenyl) hydrazine-1-carbothioamide (4F-DDC)─was synthesized, which significantly inhibited PARP1 activity with an IC50 value of 82 ± 9 nM...
March 27, 2024: Chemical Research in Toxicology
https://read.qxmd.com/read/38534030/fep-based-nanotheranostic-platform-for-enhanced-phototherapy-ferroptosis-chemodynamic-therapy
#16
JOURNAL ARTICLE
Na An, Shuanglong Tang, Yuwei Wang, Jing Luan, Ying Shi, Minghui Gao, Chongshen Guo
Ferroptosis is an iron-dependent and lipid peroxides (LPO)-overloaded programmed damage cell death, induced by glutathione (GSH) depletion and glutathione peroxide 4 (GPX4) inactivation. However, the inadequacy of endogenous iron and reactive oxygen species (ROS) restricts the efficacy of ferroptosis. To overcome this obstacle, a near-infrared photo-responsive FeP@PEG NPs is fabricated. Exogenous iron pool can enhance the effect of ferroptosis via the depletion of GSH and further regulate GPX4 inactivation...
March 27, 2024: Small
https://read.qxmd.com/read/38533806/improved-effectiveness-of-x-pdt-against-human-triple-negative-breast-cancer-cells-through-the-use-of-liposomes-co-loaded-with-protoporphyrin-ix-and-perfluorooctyl-bromide
#17
JOURNAL ARTICLE
Biyao Yang, Rui Sang, Yi Li, Ewa M Goldys, Wei Deng
In this study, we utilized X-ray-induced photodynamic therapy (X-PDT) against triple-negative breast cancer (TNBC) cells. To achieve this, we developed a liposome delivery system that co-loaded protoporphyrin IX (PPIX) and perfluorooctyl bromide (PFOB) in a rational manner. Low-dose X-ray at 2 Gy was employed to activate PPIX for the generation of reactive oxygen species (ROS), and the co-loading of PFOB provided additional oxygen to enhance ROS production. The resulting highly toxic ROS effectively induced cell death in TNBC...
March 27, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38533693/effects-of-electromagnetic-pulses-exosomes-inhibition-and-their-coaction-on-a549-cells
#18
JOURNAL ARTICLE
Qian Zhang, Qingxia Hou, Guangzhou An
Mounting literature indicates that electromagnetic pulses (EMP) is the promising modality to treat cancers with advantages such as noninvasiveness and few side-effects, but its appropriate parameters and underlying mechanisms such as its influence on tumor-derived exosomes (TDEs) are largely unknown. This study aimed to elucidate effects of EMP, exosome inhibition and their coaction on A549 lung adenocarcinoma cells. A549 cells were randomly divided into control group, GW4869 group treated by 20 μM GW4869, vehicle group treated by dimethyl sulfoxide, EMP group treated by EMP exposure, and EMPG group treated by EMP exposure combined with 20 μM GW4869...
March 27, 2024: Bioelectromagnetics
https://read.qxmd.com/read/38533528/silencing-of-circ_0088036-inhibits-growth-and-invasion-of-lung-adenocarcinoma-through-mir-203-sp1-axis
#19
JOURNAL ARTICLE
Xiuhua Liu, Yan Feng, Linna Wang, Lei Shi, Kunxiang Ji, Nan Hu, Yang Du, Mingyang Liu, Man Wang
Lung cancer is the leading cause of cancer-related deaths worldwide. Circular RNA (circRNA) circ_0088036 is a recently discovered circRNA known for its roles in rheumatoid arthritis. The study aimed to study the function of circ_0088036 in lung adenocarcinoma (LUAD). Circ_0088036 expressions were analyzed in the Gene Expression Omnibus (GEO) database. The relationship between circ_0088036 expressions and clinicopathological data of LUAD was assessed. The messenger RNA and protein levels were analyzed by quantitative real-time polymerase chain reaction and Western blot...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38533461/the-postbiotic-sodium-butyrate-synergizes-the-antiproliferative-effects-of-dexamethasone-against-the-ags-gastric-adenocarcinoma-cells
#20
JOURNAL ARTICLE
Radwa A Eladwy, Muhammad A Alsherbiny, Dennis Chang, Mohamed Fares, Chun-Guang Li, Deep Jyoti Bhuyan
A growing body of literature underlines the fundamental role of gut microbiota in the occurrence, treatment, and prognosis of cancer. In particular, the activity of gut microbial metabolites (also known as postbiotics) against different cancer types has been recently reported in several studies. However, their in-depth molecular mechanisms of action and potential interactions with standard chemotherapeutic drugs remain to be fully understood. This research investigates the antiproliferative activities of postbiotics- short-chain fatty acid (SCFA) salts, specifically magnesium acetate (MgA), sodium propionate (NaP), and sodium butyrate (NaB), against the AGS gastric adenocarcinoma cells...
2024: Frontiers in Nutrition
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