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Urology cancer

S B Imamverdiev, E D Gasymov, E N Efendiyev
AIM: To analyze features of kidney cancer diagnosis aimed at determination of invasion grade and suitable surgical approach. MATERIAL AND METHODS: The study was carried out at the clinical bases of Urology Department of the Azerbaijan Medical University. There were 170 patients with kidney cancer for the period 2006-2016 (93 (54.7%) men and 77 (45.3%) women aged 15-82 years (mean 61.7 years)). All patients underwent transabdominal ultrasound, 84 (49.4%) - CT (contrast-enhanced procedure in 63 of them), 23 patients - MRI...
2018: Khirurgiia
Ersan Arda, Basri Cakiroglu, Esra Akdeniz, Hakan Akdere, Ilkan Yuksel, Aykut Bugra Senturk
OBJECTIVE: To evaluate ultrasonically determined bladder wall thickness (BWT) and prostatic calcification presence, in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and to correlate the findings with patient characteristics and the UPOINT classification system. MATERIAL AND METHODS: Between January 2008 and December 2017 data of 1294 patients diagnosed with chronic prostatitis, in a single urology clinic, meeting a number of selective inclusion/exclusion criterias, were retrospectively analyzed...
December 4, 2018: Urology
Jan F M Verbeek, Chris H Bangma, Charlotte F Kweldam, Theodorus H van der Kwast, Intan P Kümmerlin, Geert J L H van Leenders, Monique J Roobol
INTRODUCTION: The use of risk calculators predicting clinically significant prostate cancer (csCaP) on biopsy reduces unnecessary biopsies and overdiagnosis of indolent disease compared to a Prostate Specific Antigen (PSA) strategy. Updating these tools using more specific outcome measures and contemporary predictors could potentially lead to further reductions. Our objective was to assess clinical impact of the 4 kallikrein (4K) score, the Rotterdam Prostate Cancer Risk Calculator (RPCRC), and the combination of both for predicting csCaP based on the latest International Society of Urological Pathology grading system and cribriform growth pattern...
December 6, 2018: Urologic Oncology
Long Chen, Wei-Na Zhang, Sheng-Miao Zhang, Yuan Gao, Tian-Hong Zhang, Ping Zhang
Introduction: During the last 3 decades, the standard treatment for stage Ia2-Ib1 cervical cancer has been Piver-Rutledge class II or III radical hysterectomy. However, this surgery is associated with a high rate of urologic morbidity. Aim: To determine the efficacy of class I radical hysterectomy compared with class III radical hysterectomy in terms of morbidity, overall survival, and patterns of relapse in patients with Ia2-Ib1 cervical cancer undergoing primary surgery...
December 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
Luca Villa, Paolo Capogrosso, Umberto Capitanio, Alberto Martini, Alberto Briganti, Andrea Salonia, Francesco Montorsi
INTRODUCTION: Silodosin determines smooth muscle relaxation in bladder and prostate tissues, increases bladder blood flow in conditions of chronic bladder ischemia and regulates the activity of transcriptional factors responsible for stromal growth and prostate hyperplasia. Phase III trials have already demonstrated the efficacy and safety of silodosin in the treatment of patients bothered by lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). OBJECTIVE: We aimed to describe the rationality for the use of silodosin and to summarize the current literature on the use of Silodosin for the treatment of LUTS...
December 6, 2018: Advances in Therapy
Amit L Jain, Abhinav Sidana, Mahir Maruf, Dordaneh Sugano, Brian Calio, Bradford J Wood, Peter A Pinto
INTRODUCTION AND OBJECTIVE: Focal therapy (FT) for localized prostate cancer (CaP) has been shown to have encouraging short-term oncological outcomes, excellent preservation of functional outcomes and is increasing in popularity in urologic community. We aim to evaluate the preferences and practice trends among urologists regarding this treatment strategy. METHODS: A 20 item online questionnaire was designed to collect information on urologists' views and use of FT...
December 3, 2018: Urologic Oncology
Rafaela Azevedo Abrantes de Oliveira, Márcia Maria Fontão Zago
PURPOSE: to describe the meanings that patients attribute to the term cancer survivor and to analyze the identities assumed by them according to their experience with the disease. METHODS: qualitative study with a narrative method, theoretical framework of the medical anthropology and identity concept. The study included 14 participants, men and women, diagnosed with urologic cancer. The semi-structured interviews were performed at the individual's home, after confirming participation...
November 29, 2018: Revista Latino-americana de Enfermagem
Teppei Okamoto, Shingo Hatakeyama, Shintaro Narita, Masahiro Takahashi, Toshihiko Sakurai, Sadafumi Kawamura, Senji Hoshi, Masanori Ishida, Toshiaki Kawaguchi, Shigeto Ishidoya, Jiro Shimoda, Hiromi Sato, Koji Mitsuzuka, Tatsuo Tochigi, Norihiko Tsuchiya, Yoichi Arai, Tomonori Habuchi, Chikara Ohyama
PURPOSE: To investigate the association between the Geriatric Nutritional Risk Index (GNRI) and prognosis of patients with metastatic hormone-naïve prostate cancer (mHNPC) and to design the optimal risk score predicting for prognosis. METHODS: We retrospectively reviewed data from the Michinoku Japan Urological Cancer Study Group database, containing information about 656 patients with mHNPC who initially received androgen-deprivation therapy between 2005 and 2017...
December 4, 2018: World Journal of Urology
Hongying Huang, Sergei R Guma, Jonathan Melamed, Ming Zhou, Peng Lee, Fang-Ming Deng
BACKGROUND: Prostate specific antigen (PSA), prostate specific membrane antigen (PSMA), and NKX3.1 are sensitive and prostate-specific markers frequently used for the diagnosis of metastatic prostate cancer (mPCa). International Society of Urological Pathology recommends use of PSA as the initial immunohistochemical (IHC) marker to identify PCa. If the tumor is equivocal/weak/negative for PSA, then P501S and NKX3.1 stains are suggested. However, no specific studies have attempted to compare the staining sensitivity of these markers post specimen decalcification of bone specimens...
2018: American Journal of Clinical and Experimental Urology
M Augugliaro, G Marvaso, D Ciardo, D Zerini, G Riva, E Rondi, S Vigorito, S Comi, O De Cobelli, R Orecchia, B Alicja Jereczek-Fossa
The aim of our study was to retrospectively report on radiotherapy (RT) in the oligometastastic recurrence of bladder cancer. Thirteen patients treated for low-volume metastatic transitional cell urinary bladder carcinoma (TCC) were reviewed. The primary endpoint was to evaluate the safety and efficacy of RT, proposed as an alternative to systemic treatment and/or to defer the start of a systemic therapy. Inclusion criteria for our retrospective study were as follows: patients that received RT (without other local/systemic therapy) for oligometastatic TCC with lymph node, bone, lung lesions or local recurrence...
September 4, 2018: Neoplasma
Eik Dybboe Bjerre, Klaus Brasso, Anders Bojer Jørgensen, Thomas Hindborg Petersen, Alexandra Röthlin Eriksen, Anders Tolver, Jesper Frank Christensen, Mads Hvid Poulsen, Søren Sørensen Madsen, Peter Busch Østergren, Michael Borre, Peter Krustrup, Christoffer Johansen, Mikael Rørth, Julie Midtgaard
BACKGROUND: Physical activity has been shown to mitigate the unwanted psychological and physiological side effects of prostate cancer treatments, but sustainable exercise possibilities are limited. OBJECTIVE: Our objective was to examine whether football in a real-world setting (i.e., local football clubs) was safe and feasible in practice and could improve quality of life, mitigate decline in muscle mass and bone density, and increase fat mass in patients with prostate cancer...
December 1, 2018: Sports Medicine
Mariano Martini
Enrico Bottini (Stradella, Pavia, 7 September 1835 - Porto Maurizio, Sanremo, 11 March 1903) was a multifaceted surgeon, who left a strong mark in modern surgery, not only Italian but worldwide. A pupil of Porta and Ribeti, as well as the distinguished French surgeon and anatomist Charles-Marie-Édouard Chassaignac, he has dedicated himself throughout his career to various areas of medicine, ranging from bacteriology and anti-sepsis (use of a derivative of phenic acid) to urological surgery (the so-called "endo-urethral galva-cauterization", also called Bottini's operation, or Perineal incision according to Bottini)...
December 2018: Acta Medico-historica Adriatica: AMHA
Thomas Höfner
INTRODUCTION:  Prostate cancer is the most common urological tumour disease in men. In the localized tumour stage in combination with radiotherapy and especially in advanced metastastic disease, classical androgen deprivation remains an essential therapy. During the last 10 years, our knowledge of the cardiovascular risk of this therapy has rapidly increased. MATERIAL AND METHODS:  This non-systematic review highlights the current data on cardiovascular risk in the use of androgen deprivation therapy in prostate cancer...
November 28, 2018: Aktuelle Urologie
Turgay Turan, Berrin Güçlüer, Özgür Efiloğlu, Furkan Şendoğan, Ramazan Gökhan Atış, Turhan Çaşkurlu, Asıf Yıldırım
OBJECTIVE: To investigate the factors to predict Gleason score upgrading (GSU) of patients with prostate cancer who were evaluated by using the International Society for Urological Pathology (ISUP) 2014 Gleason grading system. MATERIAL AND METHODS: Between January 2008 and December 2015, we retrospectively investigated patients who had undergone radical prostatectomy and followed up in the uro-oncology outpatient clinic. The pathologic specimens of the patients were evaluated based on the ISUP 2014 classification system...
August 17, 2018: Turkish Journal of Urology
Claire G Waltman, Tom A T Marcelissen, Joep G H van Roermund
BACKGROUND: Prostate biopsy, an invasive examination, is the gold standard for diagnosing prostate cancer (PCa). There is a need for a novel noninvasive diagnostic tool that achieves a significantly high pretest probability for PCa, reducing unnecessary biopsy numbers. Recent studies have shown that volatile organic compounds (VOCs) in exhaled breath can be used to detect different types of cancers via training of an artificial neural network (ANN). OBJECTIVE: To determine whether exhaled-breath analysis using a handheld electronic nose device can be used to discriminate between VOC patterns between PCa patients and healthy individuals...
November 24, 2018: European Urology Focus
Lars Egevad, Meagan Judge, Brett Delahunt, Peter A Humphrey, Glen Kristiansen, Jon Oxley, Krishan Rasiah, Hiroyuki Takahashi, Kiril Trpkov, Murali Varma, Thomas M Wheeler, Ming Zhou, John R Srigley, James G Kench
The International Collaboration on Cancer Reporting (ICCR) is a project which issues datasets and guidelines for international standardisation of cancer reporting. This review summarises the required and recommended elements of the datasets for prostate core needle biopsies and transurethral resection (TURP) and enucleation specimens of the prostate. To obtain as much information as possible from needle biopsies there should be only one core in each specimen jar with the exception of saturation biopsies. The gross description of the specimens should include core lengths of needle biopsies and weight of resection specimens...
November 23, 2018: Pathology
Brigid M Smith, Francesca E Duncan, Lauren Ataman, Kristin Smith, Gwendolyn P Quinn, R Jeffrey Chang, Courtney Finlayson, Kyle Orwig, Hanna Valli-Pulaski, Molly B Moravek, Mary B Zelinski, H Irene Su, Wendy Vitek, James F Smith, Jacqueline S Jeruss, Clarisa Gracia, Christos Coutifaris, Divya Shah, Leena Nahata, Veronica Gomez-Lobo, Leslie Coker Appiah, Robert E Brannigan, Valerie Gillis, William Gradishar, Asma Javed, Alice S Rhoton-Vlasak, Laxmi A Kondapalli, Evelyn Neuber, Jill P Ginsberg, Charles H Muller, Jennifer Hirshfeld-Cytron, William H Kutteh, Steven R Lindheim, Brooke Cherven, Lillian R Meacham, Pooja Rao, Lilibeth Torno, Leonard S Sender, Susan T Vadaparampil, Jodi L Skiles, Tara Schafer-Kalkhoff, Oliva J Frias, Julia Byrne, Lynn M Westphal, Danny J Schust, James L Klosky, Kate A McCracken, Alison Ting, Zaraq Khan, Candace Granberg, Barbara Lockart, Bert Scoccia, Monica M Laronda, Jennifer E Mersereau, Courtney Marsh, Mary E Pavone, Teresa K Woodruff
Once unimaginable, fertility management is now a nationally established part of cancer care in institutions, from academic centers to community hospitals to private practices. Over the last two decades, advances in medicine and reproductive science have made it possible for men, women and children to be connected with an oncofertility specialist or offered fertility preservation soon after a cancer diagnosis. The Oncofertility Consortium's National Physicians Cooperative is a large-scale effort to engage physicians across disciplines - oncology, urology, obstetrics and gynecology, reproductive endocrinology, and behavioral health - in clinical and research activities to enable significant progress in providing fertility preservation options to children and adults...
November 26, 2018: Future Oncology
Carl A Olsson, Hugh J Lavery, Kamlesh K Yadav, Ann E Anderson, Deepak Kapoor
We report changes in the histopathology of prostate cancer diagnosed in a large urology group practice after the final United States Preventive Services Task Force (USPSTF) Grade D recommendation against prostate-specific antigen screening. All prostate biopsies performed from 2011 through 2015 in a large urology group practice were retrospectively reviewed; 2012 was excluded as a transition year. The changes in biopsy data in years following the USPSTF decision (2013-2015) were then compared with baseline (2011)...
2018: Reviews in Urology
Viktor Soukup, Otakar Čapoun, Daniel Cohen, Virginia Hernández, Maximilian Burger, Eva Compérat, Paolo Gontero, Thomas Lam, A Hugh Mostafid, Joan Palou, Bas W G van Rhijn, Morgan Rouprêt, Shahrokh F Shariat, Richard Sylvester, Yuhong Yuan, Richard Zigeuner, Marek Babjuk
CONTEXT: This review focuses on the most widely used risk stratification and prediction tools for non-muscle-invasive bladder cancer (NMIBC). OBJECTIVE: To assess the clinical use and relevance of risk stratification and prediction tools to enhance clinical decision making and counselling of patients with NMIBC. EVIDENCE ACQUISITION: The most frequent, currently used risk stratification tools and prognostic models for NMIBC patients were identified by the members of the European Association of Urology (EAU) Guidelines Panel on NMIBC...
November 20, 2018: European Urology Focus
Olivier Rouvière, Philippe Puech, Raphaële Renard-Penna, Michel Claudon, Catherine Roy, Florence Mège-Lechevallier, Myriam Decaussin-Petrucci, Marine Dubreuil-Chambardel, Laurent Magaud, Laurent Remontet, Alain Ruffion, Marc Colombel, Sébastien Crouzet, Anne-Marie Schott, Laurent Lemaitre, Muriel Rabilloud, Nicolas Grenier
BACKGROUND: Whether multiparametric MRI improves the detection of clinically significant prostate cancer and avoids the need for systematic biopsy in biopsy-naive patients remains controversial. We aimed to investigate whether using this approach before biopsy would improve detection of clinically significant prostate cancer in biopsy-naive patients. METHODS: In this prospective, multicentre, paired diagnostic study, done at 16 centres in France, we enrolled patients aged 18-75 years with prostate-specific antigen concentrations of 20 ng/mL or less, and with stage T2c or lower prostate cancer...
November 20, 2018: Lancet Oncology
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