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https://www.readbyqxmd.com/read/30333957/an-ex-vivo-tissue-culture-model-for-the-assessment-of-individualized-drug-responses-in-prostate-and-bladder-cancer
#1
Arjanneke F van de Merbel, Geertje van der Horst, Maaike H van der Mark, Janneke I M van Uhm, Erik J van Gennep, Peter Kloen, Lijkele Beimers, Rob C M Pelger, Gabri van der Pluijm
Urological malignancies, including prostate and bladder carcinoma, represent a major clinical problem due to the frequent occurrence of therapy resistance and the formation of incurable distant metastases. As a result, there is an urgent need for versatile and predictive disease models for the assessment of the individualized drug response in urological malignancies. Compound testing on ex vivo cultured patient-derived tumor tissues could represent a promising approach. In this study, we have optimized an ex vivo culture system of explanted human prostate and bladder tumors derived from clinical specimens and human cancer cell lines xenografted in mice...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30325065/dataset-for-the-reporting-of-carcinoma-of-renal-tubular-origin-recommendations-from-the-international-collaboration-on-cancer-reporting-iccr
#2
REVIEW
B Delahunt, J R Srigley, M J Judge, M B Amin, A Billis, P Camparo, A J Evans, S Fleming, D Griffiths, A Lopez-Beltran, G Martignoni, H Moch, J N Nacey, M Zhou
AIMS: The International Collaboration on Cancer Reporting (ICCR) has provided detailed datasets based upon the published reporting protocols of the Royal College of Pathologists, The Royal College of Pathologists of Australasia and the College of American Pathologists. METHODS AND RESULTS: The dataset for carcinomas of renal tubular origin treated by nephrectomy was developed to provide a minimum structured reporting template suitable for international use and incorporated recommendations from the 2012 Vancouver Consensus Conference of the International Society of Urological Pathology and the fourth edition of the World Health Organization Bluebook on tumours of the urinary and male genital systems published in 2016...
October 16, 2018: Histopathology
https://www.readbyqxmd.com/read/30324096/reduced-sensitivity-of-multiparametric-mri-for-clinically-significant-prostate-cancer-in-men-under-the-age-of-50
#3
Ilan Gielchinsky, Matthijs J Scheltema, Thomas Cusick, John Chang, Ron Shnier, Daniel Moses, Warick Delprado, Quoc Nguyen, Carlo Yuen, Anne-Maree Haynes, Phillip D Stricker
Introduction: Three percent of all new diagnosed prostate cancer (PC) patients are under the age of 50. Multiparametric MRI (mpMRI) is considered as increasingly powerful tool for decision-making in diagnosis of PC and in some active surveillance protocols. Since prostate architecture changes with age, we evaluated the sensitivity of mpMRI to detect clinically significant PC in patients under the age of 50 compared to pair-matched older patients. Methods: Data from a prospective collected and ethics approved database were retrospectively analyzed...
2018: Research and Reports in Urology
https://www.readbyqxmd.com/read/30322726/prostate-cancer-in-transgender-women
#4
REVIEW
Matthew D Ingham, Richard J Lee, Dhara MacDermed, Aria F Olumi
INTRODUCTION: As the transgender patient population continues to increase, urologists and other providers who treat genitourinary malignancies will increasingly encounter cases of prostate cancer in transgender women. Little exists in the current literature to help summarize the challenges and opportunities which face this unique patient population. Similarly, little exists to provide guidance on how we may best diagnose, manage, and follow transgender women diagnosed with prostate cancer...
October 12, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/30318331/askmusic-leveraging-a-clinical-registry-to-develop-a-new-machine-learning-model-to-inform-patients-of-prostate-cancer-treatments-chosen-by-similar-men
#5
Gregory B Auffenberg, Khurshid R Ghani, Shreyas Ramani, Etiowo Usoro, Brian Denton, Craig Rogers, Benjamin Stockton, David C Miller, Karandeep Singh
BACKGROUND: Clinical registries provide physicians with a means for making data-driven decisions but few opportunities exist for patients to interact with registry data to help make decisions. OBJECTIVE: We sought to develop a web-based system that uses a prostate cancer (CaP) registry to provide newly diagnosed men with a platform to view predicted treatment decisions based on patients with similar characteristics. DESIGN, SETTING, AND PARTICIPANTS: The Michigan Urological Surgery Improvement Collaborative (MUSIC) is a quality improvement consortium of urology practices that maintains a prospective registry of men with CaP...
October 11, 2018: European Urology
https://www.readbyqxmd.com/read/30318330/intensive-imaging-based-follow-up-of-surgically-treated-localised-renal-cell-carcinoma-does-not-improve-post-recurrence-survival-results-from-a-european-multicentre-database-recur
#6
Saeed Dabestani, Christian Beisland, Grant D Stewart, Karim Bensalah, Eirikur Gudmundsson, Thomas B Lam, William Gietzmann, Paimaun Zakikhani, Lorenzo Marconi, Sergio Fernandéz-Pello, Serenella Monagas, Samuel Paul Williams, Christian Torbrand, Thomas Powles, Erik Van Werkhoven, Richard Meijer, Alessandro Volpe, Michael Staehler, Börje Ljungberg, Axel Bex
The optimal follow-up (FU) strategy for patients treated for localised renal cell carcinoma (RCC) remains unclear. Using the RECUR database, we studied imaging intensity utilised in contemporary FU to evaluate its association with outcome after detection of disease recurrence. Consecutive patients with nonmetastatic RCC (n=1612) treated with curative intent at 12 institutes across eight European countries between 2006 and 2011 were included. Recurrence occurred in 336 patients. Cross-sectional (computed tomography, magnetic resonance imaging) and conventional (chest X-ray, ultrasound) methods were used in 47% and 53%, respectively...
October 11, 2018: European Urology
https://www.readbyqxmd.com/read/30316671/-venous-thromboembolism-and-urological-cancer-epidemiology-and-therapeutically-management
#7
M Felber, F Rozet, S Droupy, V Misraï, D M Smadja, M Rouprêt
INTRODUCTION: Active cancer is a risk factor in the occurrence of venous thromboembolism (VTE). This is the second cause of death for these patients. In onco-urology, some cancers are associated with an increased risk of VTE. The aim of this study was to propose a focus of epidemiology and VTE therapy management. MATERIAL AND METHODS: A systematic analysis of the PubMed® database was performed through the PRISMA methodology using the followings keywords : "neoplasm", "venous thromboembolism", "prophylaxis", "pulmonary embolism", "urology"...
October 10, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/30315888/career-expectations-and-preferences-of-urology-residency-applicants
#8
Julia Han, Andrew Rabley, Alex Vlasak, Shahab Bozorgmehri, Vincent Bird, Louis Moy
OBJECTIVE: To survey the characteristics, career goals, and practice preferences of current urology applicants. METHODS: An anonymous survey was emailed to applicants pursuing a residency position at the University of Florida for the 2017-2018 academic year Urology Match. The survey included questions on demographics, motivating factors to pursue urology, plans for fellowship training, and anticipated and desired practice patterns. RESULTS: 151 of 295 applicants completed the survey, mean age 26...
October 10, 2018: Urology
https://www.readbyqxmd.com/read/30303589/the-anatomy-of-urination-what-every-physician-should-know
#9
REVIEW
Elroy Patrick Weledji, Divine Eyongeta, Eleanour Ngounou
INTRODUCTION: Normal voiding needs a coordinated, sustained bladder contraction of adequate size and duration. It requires a decrease in resistance of the bladder neck and urethra and no obstruction. Voiding problems can arise from abnormal storage of urine or problems with urinary control. The aim of this article was to review the functional anatomy and physiology of urinary control and micturition and the pathophysiology of urinary control problems. MATERIALS AND METHODS: The Medline (PubMed) database, Cochrane Library, and Science Citation Index were searched electronically to identify original published studies on bladder anatomy, function and urinary control...
October 10, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/30301700/current-controversies-and-developments-on-the-role-of-lymphadenectomy-for-penile-cancer
#10
REVIEW
Mounsif Azizi, Juan Chipollini, Charles C Peyton, Salim K Cheriyan, Philippe E Spiess
Penile squamous cell carcinoma is a rare cancer in men. The main prognosticators of survival for penile cancer patients remain the presence and the extent of lymph node metastasis. While radical inguinal lymphadenectomy has been the cornerstone of regional lymph node management for many years, it is still associated with significant morbidity and psychological distress. Recent developments in penile squamous cell carcinoma management have been met with some controversy in the urologic oncology community. Herein, we review the current controversies and developments on the role of inguinal lymphadenectomy for penile cancer...
October 6, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/30301698/focal-therapy-in-localised-prostate-cancer-real-world-urological-perspective-explored-in-a-cross-sectional-european-survey
#11
Giancarlo Marra, Guillaume Ploussard, Piet Ost, Pieter J L De Visschere, Alberto Briganti, Giorgio Gandaglia, Derya Tilki, Christian I Surcel, Igor Tsaur, Roderick C N Van Den Bergh, Alexander Kretschmer, Hendrik Borgmann, Paolo Gontero, Hashim U Ahmed, Massimo Valerio
INTRODUCTION: The urological community's opinion over focal therapy (FT) for prostate cancer (PCa) has never been assessed. Our aim was to investigate the current opinion on FT in the European urological community. METHODS: A 25-item questionnaire was devised according to the Cherries checklist and distributed through SurveyMonkey using a web link from November 2016 to October 2017. After a pilot validation (n = 40 urologists), the survey was sent through EAU and 9 other national European urological societies mailing list...
October 6, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/30293946/current-use-of-three-dimensional-model-technology-in-urology-a-road-map-for-personalised-surgical-planning
#12
REVIEW
Francesco Porpiglia, Daniele Amparore, Enrico Checcucci, Riccardo Autorino, Matteo Manfredi, Giada Iannizzi, Cristian Fiori
CONTEXT: Despite the current era of "precision surgery", an unmet need for an optimal surgical planning and navigation still remains for most genitourinary malignancies. In this setting, the 3D virtual reconstruction of 2D cross-sectional imaging has been increasingly adopted to facilitate the surgeon in better understanding the surgical anatomy. OBJECTIVE: To provide a short overview of the most recent evidences on the current applications of 3D virtual and printed reconstructions in urologic surgery...
October 4, 2018: European Urology Focus
https://www.readbyqxmd.com/read/30293231/consensus-on-management-of-castration-resistant-prostate-cancer-on-behalf-of-the-urological-tumours-working-group-uroncor-of-the-spanish-society-of-radiation-oncology
#13
A Gómez-Caamaño, C González-San Segundo, I Henríquez, X Maldonado, A Zapatero
BACKGROUND: The knowledge in the field of castration-resistant prostate cancer (CRPC) is developing rapidly, with emerging new therapies and advances in imaging. Nonetheless, in multiple areas there is still a lack of or very limited evidence, and clear guidance from clinicians regarding optimal strategy is required. METHODS: A modified Delphi method, with 116 relevant questions divided into 7 different CRPC management topics, was used to develop a consensus statement by the URONCOR group...
October 6, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/30290985/-place-of-partial-nephrectomy-assisted-by-robot-review-of-the-literature-at-the-time-of-a-request-for-a-specific-nomenclature
#14
G Poinas, J-A Long, X Rébillard, J-L Descotes
INTRODUCTION: Robot-assisted surgery is practiced more and more frequently in urology. Besides its place in prostatectomy for cancer, it also concerns partial nephrectomy (NP), in the treatment of renal tumors. The objective of this review is to compare the robot-assisted approach with laparoscopic or open approaches in partial nephrectomy in terms of functional or oncological outcomes and per- and postoperative complications. MATERIAL AND METHODS: A systematic review of the literature published from 2009 was carried out on PubMed...
October 2, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/30289332/treatment-recommendations-for-urological-symptoms-in-cancer-patients-clinical-guidelines-from-the-japanese-society-for-palliative-medicine
#15
Tomoyasu Tsushima, Takafumi Miura, Takahiko Hachiya, Ichiro Nakamura, Toyoko Yamato, Takeshi Kishida, Yoshinori Tanaka, Shin Irie, Norio Meguro, Takashi Kawahara, Nobuhisa Nakajima
BACKGROUND: Urological symptoms such as gross hematuria, lower and upper urinary tract symptoms, and bladder pain are common in and distressing for patients with advanced cancer. Although palliation of urological symptoms is important to improve the quality of life of cancer patients and their families and caregivers, clinical guidelines for managing urological symptoms in patients with cancer have not been published. METHODS: Following the formal guideline development process, the Japanese Society for Palliative Medicine (JSPM) developed comprehensive clinical guidelines for the management of urological symptoms in patients with cancer...
October 5, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/30287277/what-do-the-guidelines-say-for-metastatic-prostate-cancer-starting-androgen-deprivation-therapy-national-comprehensive-cancer-network-european-society-for-medical-oncology-and-european-association-of-urology-recommendations
#16
REVIEW
Evan Y Yu, Silke Gillessen, Nicolas Mottet
Clinical trial data forms the foundation of how we treat men with metastatic prostate cancer who are initiating therapy. However, clinical trial data does not answer everything; hence, good clinical practice, pragmatism, and occasionally extrapolation drives how we manage these patients. Fortunately, multiple international guideline committees meet regularly and offer clinical guidance. In this mini-review, we focus on the United States National Comprehensive Cancer Network, European Society for Medical Oncology, and European Association of Urology (EAU) recommendations for the initial treatment of metastatic prostate cancer...
October 1, 2018: European Urology Focus
https://www.readbyqxmd.com/read/30286577/virtual-reality-and-simulation-for-progressive-treatments-in-urology
#17
Alaric Hamacher, Taeg Keun Whangbo, Su Jin Kim, Kyung Jin Chung
In urology technologies and surgical practices are constantly evolving and virtual reality (VR) simulation has become a significant supplement to existing urology methods in the training curricula of urologists. However, new developments in urology also require training and simulation for a wider application. In order to achieve this VR and simulation could play a central role. The purpose of this article is a review of the principal applications for VR and simulation in the field of urology education and to demonstrate the potential for the propagation of new progressive treatments...
September 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/30281004/cystectomy-for-benign-disease-readmission-morbidity-and-complications
#18
Scott G Erpelding, Adam Dugan, Sudhir Isharwal, Stephen Strup, Andrew James, Shubham Gupta
INTRODUCTION: We sought to elucidate outcomes and risks associated with cystectomy and urinary diversion for benign urological conditions compared to malignant conditions. MATERIALS AND METHODS: We identified patients who underwent cystectomy and urinary diversion for benign and malignant diseases through the American College of Surgeons National Surgery Quality Improvement Program database for the period 2007-2015. Patients were selected for inclusion based upon their current procedure terminology and International Classification of Disease, Ninth revision codes...
October 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/30280090/the-role-of-immunohistochemical-analysis-as-a-tool-for-the-diagnosis-prognostic-evaluation-and-treatment-of-prostate-cancer-a-systematic-review-of-the-literature
#19
Arie Carneiro, Álan Roger Gomes Barbosa, Lucas Seiti Takemura, Paulo Priante Kayano, Natasha Kouvaleski Saviano Moran, Carolina Ko Chen, Marcelo Langer Wroclawski, Gustavo Caserta Lemos, Isabela Werneck da Cunha, Marcos Takeo Obara, Marcos Tobias-Machado, Adam G Sowalsky, Bianca Bianco
Background: Prostate cancer (PCa) is a heterogeneous disease that lends itself toward numerous therapeutic options depending on its risk stratification. One of the greatest challenges in PCa urologic practice is to select patients who should be referred for biopsy and, for those patients who are diagnosed with cancer, to differentiate between patients with indolent disease from those with an unfavorable prognosis and, to determine ideal patient management and avoid unnecessary interventions. Accordingly, there is a growing body of literature reporting immunohistochemical studies with the objective of determining a prostate cancer prognosis...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30273380/meta-analysis-of-the-association-between-the-inflammatory-potential-of-diet-and-urologic-cancer-risk
#20
Dong-Liang Lu, Zheng-Ju Ren, Qin Zhang, Peng-Wei Ren, Bo Yang, Liang-Ren Liu, Qiang Dong
BACKGROUND: The inflammatory potential of diet has been shown to have an association with the risk of several cancer types, but the evidence is inconsistent regarding the related risk of urologic cancer (UC). Therefore, we conducted the present meta-analysis to investigate the association between the inflammatory potential of diet and UC. METHODS: PubMed, Embase and Web of Science were searched up to July 31, 2018. Two reviewers independently selected the studies and extracted the data...
2018: PloS One
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