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Phytoestrogens and bone

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https://www.readbyqxmd.com/read/29543713/therapeutic-perspectives-of-8-prenylnaringenin-a-potent-phytoestrogen-from-hops
#1
REVIEW
Kateřina Štulíková, Marcel Karabín, Jakub Nešpor, Pavel Dostálek
Hop ( Humulus lupulus L.), as a key ingredient for beer brewing, is also a source of many biologically active molecules. A notable compound, 8-prenylnaringenin (8-PN), structurally belonging to the group of prenylated flavonoids, was shown to be a potent phytoestrogen, and thus, became the topic of active research. Here, we overview the pharmacological properties of 8-PN and its therapeutic opportunities. Due to its estrogenic effects, administration of 8-PN represents a novel therapeutic approach to the treatment of menopausal and post-menopausal symptoms that occur as a consequence of a progressive decline in hormone levels in women...
March 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29279718/-lannea-acida-a-rich-anacardiaceae-ethanol-extract-exhibits-estrogenic-effects-and-prevents-bone-loss-in-an-ovariectomized-rat-model-of-osteoporosis
#2
Mouchili Riepouo Oumarou, Stéphane Zingue, Berlise Yengwa Bakam, Sylvin Benjamin Ateba, Simplice Harquin Foyet, Fritz Teddy Tchaptchet Mbakop, Dieudonné Njamen
Phytoestrogens have been shown to prevent postmenopausal osteoporosis. Lannea acida is a medicinal plant traditionally used in Cameroon to treat infertility, gynaecological complaints, and rheumatism. These uses prompted us to evaluate estrogenic activity of Lannea acida bark ethanolic extract and its antiosteoporotic potential in ovariectomized Wistar rats. In vitro , the E-screen assay was used to assess the ability of L. acida extract to induce MCF-7 cells proliferation. In vivo , a 3-day uterotrophic assay and a 12-week oral treatment in ovariectomized adult rats were carried out to evaluate the ability of L...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29188893/therapeutic-role-of-punica-granatum-pomegranate-seed-oil-extract-on-bone-turnover-and-resorption-induced-in-ovariectomized-rats
#3
N Z Shaban, I M Talaat, F H Elrashidy, A Y Hegazy, A S Sultan
CONTEXT: Postmenopausal osteoporosis is mostly caused by increased bone remodeling resulting from estrogen deficiency. Hormone replacement therapy (HRT) is used to prevent osteoporosis, but it increases the risk for breast cancer, thromboembolism, strokes, and heart attacks. Pomegranate seed oil extract (SOE) is rich in phytoestrogen and antioxidant compounds. OBJECTIVES: To evaluate the therapeutic role of SOE against bone turnover, resorption and osteoporosis induced in ovariectomized rats as a postmenopausal model and comparing the results with those from Generic CycloProgynova drug (D)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29156930/benefits-of-soy-in-women-s-health
#4
Carmen Martín Salinas, Ana M López-Sobaler
A great interest has been developed last decades on the role of phytoestrogens as an alternative to hormone replacement therapy. In fact, numerous studies have shown the effects of soy isoflavones on climacteric symptomatology by significantly reducing the frequency and intensity of hot flashes, as well on cardiovascular health. The aim of this paper was to review the last studies, mainly randomized controlled trials, on the effect of isoflavones on climacteric symptoms and their impact on women's quality of life, as well as on other health markers...
October 15, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29098573/diet-and-exercise-a-match-made-in-bone
#5
REVIEW
Hubertine M E Willems, Ellen G H M van den Heuvel, Ruud J W Schoemaker, Jenneke Klein-Nulend, Astrid D Bakker
PURPOSE OF REVIEW: Multiple dietary components have the potential to positively affect bone mineral density in early life and reduce loss of bone mass with aging. In addition, regular weight-bearing physical activity has a strong positive effect on bone through activation of osteocyte signaling. We will explore possible synergistic effects of dietary components and mechanical stimuli for bone health by identifying dietary components that have the potential to alter the response of osteocytes to mechanical loading...
December 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29058779/the-combination-of-icariin-and-constrained-dynamic-loading-stimulation-attenuates-bone-loss-in-ovariectomy-induced-osteoporotic-mice
#6
Qiang-Song Wang, Gui-Fang Wang, Yu-Ren Lu, Yuan-Lu Cui, Hao Li, Rui-Xin Li, Xi-Zheng Zhang, Chun-Qiu Zhang, Tian-Jun Liu
Osteoporosis is a disease characterized by low bone mass and progressive destruction of bone microstructure, resulting in increasing the risk of fracture. Icariin (ICA) as a phytoestrogen shows osteogenic effects, and the mechanical stimulation has been demonstrated the improving effect on osteoporosis. The objective of this study was to investigate the effect of ICA in combination with constrained dynamic loading (CDL) stimulation on osteoporosis in ovariectomized (OVX) mice. The serum hormone levels, bone turnover markers, trabecular architecture, ulnar biomechanical properties, and the expression of osteoblast-related gene (alkaline phosphatase, ALP; osteocalcin, OCN; bone morphogenetic protein-2, BMP-2; Collagen I (α1), COL1; osteoprotegerin, OPG) and osteoclast-related genes (receptor activators of NF-κB ligand, RANKL; tartrate-resistant acid phosphatase, TRAP) were analyzed...
October 23, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29058054/long-term-high-dose-resveratrol-supplementation-reduces-bone-mass-and-fracture-strength-in-rats
#7
Marie Juul Ornstrup, Annemarie Brüel, Jesper Skovhus Thomsen, Torben Harsløf, Bente Lomholt Langdahl, Steen Bønløkke Pedersen
Resveratrol (RSV) is a natural polyphenolic compound. A recent study suggests a positive effect on BMD in men; however, the underlying changes in microstructure and strength remain unknown. We aimed to investigate the effects of RSV on the skeleton in hindlimb-immobilized and non-immobilized rats. Seventy-two female Wistar rats were divided into six groups. Two baseline (BSL) groups underwent short-term diet intervention for 4 weeks before sacrifice [phytoestrogen-deficient diet (PD) (BSL + PD) or RSV diet (600 mg/kg body weight/day) (BSL + RSV)]...
October 20, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28968518/beneficial-role-of-the-phytoestrogen-genistein-on-vascular-calcification
#8
Sabrina B Cepeda, Marisa J Sandoval, María B Rauschemberger, Virginia L Massheimer
Although soy phytoestrogen are proposed to prevent or improve postmenopausal vascular and bone diseases, the currently available data are controversial and unclear. In this study we evaluated the molecular and biochemical action of genistein on the cellular events involved in vascular calcification. Rat monocytes, aortic vascular cell and osteoblasts cultures in vitro exposed to Gen were employed. Gen down regulated the expression of cell adhesion molecules involved in stable leukocyte attachment. Using flow cytometry we found that the PE significantly diminished monocyte integrins CD11b, CD11c and CD18 expression either under basal and pro-inflammatory environment...
December 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28962172/psoralen-stimulates-osteoblast-proliferation-through-the-activation-of-nuclear-factor-%C3%AE%C2%BAb-mitogen-activated-protein-kinase-signaling
#9
Feimeng Li, Qihuo Li, Xiaoqing Huang, Yunting Wang, Chana Ge, Yong Qi, Wei Guo, Hongtao Sun
Osteoporosis is a systemic skeletal disease that leads to increased bone fragility and susceptibility to fracture. Approximately 50% of postmenopausal women develop osteoporosis as a result of postmenopausal estrogen deficiency. To reduce fractures related to osteoporosis in women, previous studies have focused on therapeutic strategies that aim to increase bone formation or decrease bone resorption. However, pharmacological agents that aim to improve bone fracture susceptibility exhibit side effects. Current studies are investigating natural alternatives that possess the benefits of selective estrogen receptor modulators (SERMs) without the adverse effects...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28899509/a-standardized-humulus-lupulus-l-ethanol-extract-partially-prevents-ovariectomy-induced-bone-loss-in-the-rat-without-induction-of-adverse-effects-in-the-uterus
#10
Annekathrin M Keiler, Janina Helle, Manuela I Bader, Tino Ehrhardt, Kristin Nestler, Georg Kretzschmar, Ricardo Bernhardt, Günter Vollmer, Dejan Nikolić, Judy L Bolton, Guido F Pauli, Shao-Nong Chen, Birgit M Dietz, Richard B van Breemen, Oliver Zierau
BACKGROUND: Hops (Humulus lupulus (L.)) dietary supplements are of interest as herbal remedies to alleviate menopausal symptoms, such as hot flushes, depression and anxiety. So far, the evidence regarding estrogenic and related properties of hops preparations has been considered insufficient for a market authorization for menopausal indications. PURPOSE: The study aims to investigate a chemically standardized hops extract regarding its safety in the uterus, as wells as its efficacy to prevent bone loss in the ovariectomized rat model...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28718749/glycinol-enhances-osteogenic-differentiation-and-attenuates-the-effects-of-age-on-mesenchymal-stem-cells
#11
Amy L Strong, Robert B Jones, Julie Glowacki, Stephen M Boue, Matthew E Burow, Bruce A Bunnell
AIM: Phytoestrogens, such as glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential. METHODS: The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). RESULTS: BMSCs isolated from older donors demonstrated reduced osteogenesis...
July 18, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28460884/enhanced-therapeutic-benefit-of-quercetin-loaded-phytosome-nanoparticles-in-ovariectomized-rats
#12
Abeer I Abd El-Fattah, Mohamed M Fathy, Zeinab Y Ali, Abd El-Rahman A El-Garawany, Ehsan K Mohamed
Quercetin, a dietary flavonol phytoestrogen, has many health benefits but it is poorly absorbed when administered orally. To improve its bioavailability, we prepared quercetin-loaded phytosome nanoparticles (QP) using the thin film hydration method. The prepared nano-formulations were characterized using different techniques. Transmission electron microscopy revealed the homogeneously spherical, well and uniformly dispersed, nano-sized nature of QP. Dynamic light scattering measurements of QP (70 ± 7.44 nm) also confirmed this...
June 1, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28412809/selective-estrogen-receptor-modulator-serm-like-activities-of-diarylheptanoid-a-phytoestrogen-from-curcuma-comosa-in-breast-cancer-cells-pre-osteoblast-cells-and-rat-uterine-tissues
#13
Natthakan Thongon, Nittaya Boonmuen, Kanoknetr Suksen, Patsorn Wichit, Arthit Chairoungdua, Patoomratana Tuchinda, Apichart Suksamrarn, Wipawee Winuthayanon, Pawinee Piyachaturawat
Diarylheptanoids from Curcuma comosa, of the Zingiberaceae family, exhibit diverse estrogenic activities. In this study we investigated the estrogenic activity of a major hydroxyl diarylheptanoid, 7-(3,4 -dihydroxyphenyl)-5-hydroxy-1-phenyl-(1E)-1-heptene (compound 092) isolated from C. comosa. The compound elicited different transcriptional activities of estrogen agonist at low concentrations (0.1-1 μM) and antagonist at high concentrations (10-50 μM) using luciferase reporter gene assay in HEK-293T cells...
May 3, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28325144/therapeutic-potential-and-outlook-of-alternative-medicine-for-osteoporosis
#14
Tao Wang, Qian Liu, William Tjhioe, Jinmin Zhao, Aiping Lu, Ge Zhang, Ren Xiang Tan, Mengyu Zhou, Jiake Xu, Hao Tian Feng
Osteoporosis, a bone disease resulting in the loss of bone density and microstructure quality, is often associated with fragility fractures, and the latter imposes a great burden on the patient and society. Although there are several different treatments available for osteoporosis such as hormone replacement therapy, bisphosphonates, Denosumab, and parathyroid hormone, some concerns have been raised regarding the inherent side effects of their long term use. It would be of great relevance to search for alternative natural compounds, which could complementarily overcome the limitations of the currently available therapy...
2017: Current Drug Targets
https://www.readbyqxmd.com/read/28314478/osteoinductive-effects-of-glyceollins-on-adult-mesenchymal-stromal-stem-cells-from-adipose-tissue-and-bone-marrow
#15
COMPARATIVE STUDY
Marjorie E Bateman, Amy L Strong, Ryan S Hunter, Melyssa R Bratton, Rajesh Komati, Jayalakshmi Sridhar, Kevin E Riley, Guangdi Wang, Daniel J Hayes, Stephen M Boue, Matthew E Burow, Bruce A Bunnell
BACKGROUND: While current therapies for osteoporosis focus on reducing bone resorption, the development of therapies to regenerate bone may also be beneficial. Promising anabolic therapy candidates include phytoestrogens, such as daidzein, which effectively induce osteogenesis of adipose-derived stromal cells (ASCs) and bone marrow stromal cells (BMSCs). PURPOSE: To investigate the effects of glyceollins, structural derivatives of daidzein, on osteogenesis of ASCs and BMSCs...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28183304/genistein-treatment-improves-fracture-resistance-in-obese-diabetic-mice
#16
Britton Odle, Nathan Dennison, Layla Al-Nakkash, Tom L Broderick, Jeffrey H Plochocki
BACKGROUND: Obese, type two diabetics are at an increased risk for fracturing their limb bones in comparison to the general population. Phytoestrogens like as the soy isoflavone genistein have been shown to protect against bone loss. In this study, we tested the effects of genistein treatment on femurs of ob/ob mice, a model for obesity and type two diabetes mellitus. METHODS: Twenty six-week-old female mice were divided into obese (ob/ob) control, obese genistein-treated, lean (ob/+) control, and lean genistein-treated groups (n = 5 each)...
January 9, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28125641/synergistic-action-of-genistein-and-calcitriol-in-immature-osteosarcoma-mg-63-cells-by-sgpl1-up-regulation
#17
Nadja Engel, Anna Adamus, Nicolas Schauer, Juliane Kühn, Barbara Nebe, Guido Seitz, Karin Kraft
BACKGROUND: Phytoestrogens such as genistein, the most prominent isoflavone from soy, show concentration-dependent anti-estrogenic or estrogenic effects. High genistein concentrations (>10 μM) also promote proliferation of bone cancer cells in vitro. On the other hand, the most active component of the vitamin D family, calcitriol, has been shown to be tumor protective in vitro and in vivo. The purpose of this study was to examine a putative synergism of genistein and calcitriol in two osteosarcoma cell lines MG-63 (early osteoblast), Saos-2 (mature osteoblast) and primary osteoblasts...
2017: PloS One
https://www.readbyqxmd.com/read/27917278/the-preventive-and-therapeutic-roles-of-phytoestrogen-%C3%AE-zearalanol-on-osteoporetic-rats-due-to-ovariectomization
#18
Shaochun Li, Weiwei Zhang, Fei Duan, Weihua Liu, Xiaofang Sun, Xuefeng Pan
OBJECTIVES: The aim of this study was to observe the influence of phytoestrogen α-Zearalanol on ovariectomy-induced postmenopausal osteoporosis in rats. MATERIALS AND METHODS: 40 SD female rats were randomly divided into four groups: Sham group, OVX group (ovariectomized and fed estrogen), α-Zearalanol group (ovariectomized and fed α-Zearalanol) and untreated group (ovariectomized). Three weeks later after surgery, α-Zearalanol and estradiol valerate were administered by oral gavage for 12 weeks to the α-Zearalanol group and the OVX group, respectively...
November 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27908549/noni-leaf-and-black-tea-enhance-bone-regeneration-in-estrogen-deficient-rats
#19
Nor Aijratul Asikin Mohd Shalan, Noordin M Mustapha, Suhaila Mohamed
OBJECTIVE: Black tea and Nonileaf are among the dietary compounds that can benefit patients with bone resorption disorders. Their bone regeneration effects and their mechanisms were studied in estrogen-deficient rats. METHODS: Noni leaves (three doses) and black tea water extracts were fed to ovariectomized rats for 4 mo, and their effects (analyzed via mechanical measurements, micro-computed tomography scan, and reverse transcriptase polymerase chain reaction mRNA) were compared with Remifemin (a commercial phytoestrogen product from black cohosh)...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27872812/anti-inflammatory-effects-of-the-essential-oils-of-ginger-zingiber-officinale-roscoe-in-experimental-rheumatoid-arthritis
#20
Janet L Funk, Jennifer B Frye, Janice N Oyarzo, Jianling Chen, Huaping Zhang, Barbara N Timmermann
Ginger and its extracts have been used traditionally as anti-inflammatory remedies, with a particular focus on the medicinal properties of its phenolic secondary metabolites, the gingerols. Consistent with these uses, potent anti-arthritic effects of gingerol-containing extracts were previously demonstrated by our laboratory using an experimental model of rheumatoid arthritis, streptococcal cell wall (SCW)-induced arthritis. In this study, anti-inflammatory effects of ginger's other secondary metabolites, the essential oils (GEO), which contain terpenes with reported phytoestrogenic activity, were assessed in female Lewis rats with SCW-induced arthritis...
July 2016: PharmaNutrition
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