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https://www.readbyqxmd.com/read/29719585/interleukin-gene-polymorphisms-in-chinese-han-population-with-breast-cancer-a-case-control-study
#1
Xiaoxiao Zuo, Miao Li, Ya Yang, Tiansong Liang, Hongyao Yang, Xinhan Zhao, Daoke Yang
Cytokines are known as important regulators of the cancer involved in inflammatory and immunological responses. This fact and plethora of gene polymorphism data prompted us to investigate IL1 gene polymorphisms in breast cancer (BC) patients. Totally, 530 patients with BC and 628 healthy control women were studied. The genetic polymorphisms for IL1 were analyzed by Massarray Sequencing method. Three single nucleotide polymorphisms (SNPs) identified in IL1B, IL1R1 gene are thought to influence breast cancer risk...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29615400/neth2pan-a-computational-tool-to-guide-mhc-peptide-prediction-on-murine-tumors
#2
Christa I DeVette, Massimo Andreatta, Wilfried Bardet, Steven J Cate, Vanessa I Jurtz, Kenneth W Jackson, Alana L Welm, Morten Nielsen, William H Hildebrand
With the advancement of personalized cancer immunotherapies, new tools are needed to identify tumor antigens and evaluate T-cell responses in model systems, specifically those that exhibit clinically relevant tumor progression. Key transgenic mouse models of breast cancer are generated and maintained on the FVB genetic background, and one such model is the mouse mammary tumor virus-polyomavirus middle T antigen (MMTV-PyMT) mouse-an immunocompetent transgenic mouse that exhibits spontaneous mammary tumor development and metastasis with high penetrance...
June 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29339440/repurposing-tin-mesoporphyrin-as-an-immune-checkpoint-inhibitor-shows-therapeutic-efficacy-in-preclinical-models-of-cancer
#3
Tamara Muliaditan, James W Opzoomer, Jonathan Caron, Mary Okesola, Paris Kosti, Sharanpreet Lall, Mieke Van Hemelrijck, Francesco Dazzi, Andrew Tutt, Anita Grigoriadis, Cheryl E Gillett, Stephen F Madden, Joy M Burchell, Shahram Kordasti, Sandra S Diebold, James F Spicer, James N Arnold
Purpose: Unprecedented clinical outcomes have been achieved in a variety of cancers by targeting immune checkpoint molecules. This preclinical study investigates heme oxygenase-1 (HO-1), an immunosuppressive enzyme that is expressed in a wide variety of cancers, as a potential immune checkpoint target in the context of a chemotherapy-elicited antitumor immune response. We evaluate repurposing tin mesoporphyrin (SnMP), which has demonstrated safety and efficacy targeting hepatic HO in the clinic for the treatment of hyperbilirubinemia, as an immune checkpoint blockade therapy for the treatment of cancer...
April 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29047186/il-1rn-gene-polymorphisms-are-associated-with-breast-cancer-risk-in-a-chinese-han-population
#4
Tianbo Jin, Wei Cao, Xiaoxiao Zuo, Miao Li, Ya Yang, Tiansong Liang, Hongyao Yang, Xinhan Zhao, Daoke Yang
BACKGROUND: The interleukins (ILs) are a large family of endogenous cytokines that are crucial in the regulation of inflammation and immunological responses. The IL-1 receptor antagonist (IL-1RN) has been found to be associated with risk breast cancer (BC) in Korean and Indian women. However, little information is found about the polymorphisms of IL-1RN in Chinese Han BC patients. METHODS: We investigated the association between single-nucleotide polymorphisms (SNPs) in IL-1RN and BC risk in a case-control study that included 530 BC cases and 628 healthy controls...
December 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28920955/mir-25-93-mediates-hypoxia-induced-immunosuppression-by-repressing-cgas
#5
Min-Zu Wu, Wei-Chung Cheng, Su-Feng Chen, Shin Nieh, Carolyn O'Connor, Chia-Lin Liu, Wen-Wei Tsai, Cheng-Jang Wu, Lorena Martin, Yaoh-Shiang Lin, Kou-Juey Wu, Li-Fan Lu, Juan Carlos Izpisua Belmonte
The mechanisms by which hypoxic tumours evade immunological pressure and anti-tumour immunity remain elusive. Here, we report that two hypoxia-responsive microRNAs, miR-25 and miR-93, are important for establishing an immunosuppressive tumour microenvironment by downregulating expression of the DNA sensor cGAS. Mechanistically, miR-25/93 targets NCOA3, an epigenetic factor that maintains basal levels of cGAS expression, leading to repression of cGAS during hypoxia. This allows hypoxic tumour cells to escape immunological responses induced by damage-associated molecular pattern molecules, specifically the release of mitochondrial DNA...
October 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28626727/mast-cell-infiltration-in-human-brain-metastases-modulates-the-microenvironment-and-contributes-to-the-metastatic-potential
#6
Ananya Roy, Sylwia Libard, Holger Weishaupt, Ida Gustavsson, Lene Uhrbom, Göran Hesselager, Fredrik J Swartling, Fredrik Pontén, Irina Alafuzoff, Elena Tchougounova
Metastatic brain tumors continue to be a clinical problem, despite new therapeutic advances in cancer treatment. Brain metastases (BMs) are among the most common mass lesions in the brain that are resistant to chemotherapies, have a very poor prognosis, and currently lack any efficient diagnostic tests. Predictions estimate that about 40% of lung and breast cancer patients will develop BM. Despite this, very little is known about the immunological and genetic aberrations that drive tumorigenesis in BM. In this study, we demonstrate the infiltration of mast cells (MCs) in a large cohort of human BM samples with different tissues of origin for primary cancer...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28008921/reprogramming-the-immunological-microenvironment-through-radiation-and-targeting-axl
#7
Todd A Aguilera, Marjan Rafat, Laura Castellini, Hussein Shehade, Mihalis S Kariolis, Angela Bik-Yu Hui, Henning Stehr, Rie von Eyben, Dadi Jiang, Lesley G Ellies, Albert C Koong, Maximilian Diehn, Erinn B Rankin, Edward E Graves, Amato J Giaccia
Increasing evidence suggests that ionizing radiation therapy (RT) in combination with checkpoint immunotherapy is highly effective in treating a subset of cancers. To better understand the limited responses to this combination we analysed the genetic, microenvironmental, and immune factors in tumours derived from a transgenic breast cancer model. We identified two tumours with similar growth characteristics but different RT responses primarily due to an antitumour immune response. The combination of RT and checkpoint immunotherapy resulted in cures in the responsive but not the unresponsive tumours...
December 23, 2016: Nature Communications
https://www.readbyqxmd.com/read/27869438/immunology-update-biologics
#8
REVIEW
S Paul Starr
Biologics are substances made from a living organism or its products. These include genes, proteins (eg, antibodies, receptors, enzymes, inhibitors), recombinant proteins, and fusion proteins. Biologics often are produced using recombinant DNA technology. For example, monoclonal antibodies are produced by inserting human genes into immortalized cell cultures, which then produce the gene product (ie, an antibody) in large quantity. Another approach is to fuse genetic material from nonhuman sources (eg, mice) with human genetic material...
November 2016: FP Essentials
https://www.readbyqxmd.com/read/27699256/claudin-low-bladder-tumors-are-immune-infiltrated-and-actively-immune-suppressed
#9
Jordan Kardos, Shengjie Chai, Lisle E Mose, Sara R Selitsky, Bhavani Krishnan, Ryoichi Saito, Michael D Iglesia, Matthew I Milowsky, Joel S Parker, William Y Kim, Benjamin G Vincent
We report the discovery of a claudin-low molecular subtype of high-grade bladder cancer that shares characteristics with the homonymous subtype of breast cancer. Claudin-low bladder tumors were enriched for multiple genetic features including increased rates of RB1 , EP300 , and NCOR1 mutations; increased frequency of EGFR amplification; decreased rates of FGFR3 , ELF3 , and KDM6A mutations; and decreased frequency of PPARG amplification. While claudin-low tumors showed the highest expression of immune gene signatures, they also demonstrated gene expression patterns consistent with those observed in active immunosuppression...
March 17, 2016: JCI Insight
https://www.readbyqxmd.com/read/27677113/synchronous-male-breast-and-colon-cancer-presenting-with-ileus-a-case-report
#10
Aziz Ari, Cihad Tatar, Kenan Buyukasik, Ozgur Segmen, Coskun Cakir, Soykan Arikan
INTRODUCTION: Cancer developing from more than one origin is called multiple primary cancer (MPC) and is a rare situation. In this article, we report a case presenting to the Emergency Clinic with symptoms of ileus who was diagnosed with synchronous colon and breast cancer. PRESENTATION OF CASE: A 57year old male patient presented to the Emergency Clinic with abdominal pain, vomiting, constipation and lack of flatulence. The patient was taken to the operating room for emergency surgery with the diagnosis of intestinal obstruction...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27583028/strategies-to-modulate-the-immune-system-in-breast-cancer-checkpoint-inhibitors-and-beyond
#11
REVIEW
Cristina Migali, Monica Milano, Dario Trapani, Carmen Criscitiello, Angela Esposito, Marzia Locatelli, Ida Minchella, Giuseppe Curigliano
Is breast cancer (BC) immunogenic? Many data suggest that it is. Many observations demonstrated the prognostic role of tumor-infiltrating lymphocytes (TILs) in triple negative (TN) and human epidermal growth factor receptor 2 (HER-2)-positive BC. TNBCs are poorly differentiated tumors with high genetic instability and very high heterogeneity. This heterogeneity enhances the 'danger signals' and select clone variants that could be more antigenic or, in other words, that could more strongly stimulate a host immune antitumor response...
September 2016: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/27196778/genomic-and-immunological-tumor-profiling-identifies-targetable-pathways-and-extensive-cd8-pdl1-immune-infiltration-in-inflammatory-breast-cancer-tumors
#12
Christopher A Hamm, Diarmuid Moran, Kakuturu Rao, Patricia B Trusk, Karen Pry, Mark Sausen, Siân Jones, Victor E Velculescu, Massimo Cristofanilli, Sarah Bacus
Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer that remains poorly understood at the molecular level. Comprehensive tumor profiling was performed to understand clinically actionable alterations in IBC. Targeted next-generation sequencing (NGS) and IHC were performed to identify activated pathways in IBC tumor tissues. siRNA studies examined the impact of IBC genomic variants in cellular models. IBC tumor tissues were further characterized for immune infiltration and immune checkpoint expression by IHC...
July 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27146558/clinical-implementation-of-novel-targeted-therapeutics-in-advanced-breast-cancer
#13
REVIEW
Mary D Chamberlin, Erica B Bernhardt, Todd W Miller
The majority of advanced breast cancers have genetic alterations that are potentially targetable with drugs. Through initiatives such as The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC), data can be mined to provide context for next-generation sequencing (NGS) results in the landscape of advanced breast cancer. Therapies for targets other than estrogen receptor alpha (ER) and HER2, such as cyclin-dependent kinases CDK4 and CDK6, were recently approved based on efficacy in patient subpopulations, but no predictive biomarkers have been found, leaving clinicians to continue a trial-and-error approach with each patient...
November 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27072698/clients-and-oncogenic-roles-of-molecular-chaperone-gp96-grp94
#14
REVIEW
Ephraim A Ansa-Addo, Jessica Thaxton, Feng Hong, Bill X Wu, Yongliang Zhang, Caroline W Fugle, Alessandra Metelli, Brian Riesenberg, Katelyn Williams, Daniel T Gewirth, Gabriela Chiosis, Bei Liu, Zihai Li
As an endoplasmic reticulum heat shock protein (HSP) 90 paralogue, glycoprotein (gp) 96 possesses immunological properties by chaperoning antigenic peptides for activation of T cells. Genetic studies in the last decade have unveiled that gp96 is also an essential master chaperone for multiple receptors and secreting proteins including Toll-like receptors (TLRs), integrins, the Wnt coreceptor, Low Density Lipoprotein Receptor-Related Protein 6 (LRP6), the latent TGFβ docking receptor, Glycoprotein A Repetitions Predominant (GARP), Glycoprotein (GP) Ib and insulin-like growth factors (IGF)...
2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/26929386/using-lessons-from-breast-cervical-and-colorectal-cancer-screening-to-inform-the-development-of-lung-cancer-screening-programs
#15
Katrina Armstrong, Jane J Kim, Ethan A Halm, Rachel M Ballard, Mitchell D Schnall
Multiple advisory groups now recommend that high-risk smokers be screened for lung cancer by low-dose computed tomography. Given that the development of lung cancer screening programs will face many of the same issues that have challenged other cancer screening programs, the National Cancer Institute-funded Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) consortium was used to identify lessons learned from the implementation of breast, cervical, and colorectal cancer screening that should inform the introduction of lung cancer screening...
May 1, 2016: Cancer
https://www.readbyqxmd.com/read/26927668/thymic-stromal-lymphopoietin-blocks-early-stages-of-breast-carcinogenesis
#16
Shadmehr Demehri, Trevor J Cunningham, Sindhu Manivasagam, Kenneth H Ngo, Sara Moradi Tuchayi, Rasika Reddy, Melissa A Meyers, David G DeNardo, Wayne M Yokoyama
Advances in the field of cancer immunology, including studies on tumor-infiltrating CD8+ cytotoxic T lymphocytes (CTLs), have led to new immunotherapeutics with proven efficacy against late-stage cancers. However, the antitumor potential of the immune system in targeting early-stage cancers remains uncertain. Here, we demonstrated that both genetic and chemical induction of thymic stromal lymphopoietin (TSLP) at a distant site leads to robust antitumor immunity against spontaneous breast carcinogenesis in mice...
April 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/26889659/novel-strategies-for-molecular-targeting-to-cancer
#17
REVIEW
Jun-Ping Liu
This editorial draws attention to the work published by CEPP in 2014-2015 on mechanisms underlying cancer drug resistance, invasion and metastasis. Genetic, genomic and immunological changes in platinum drug resistance and new drug candidates for cancer metastasis are highlighted. Attention is paid to the Epimedium plant drug icariin in glioblastoma invasion, the plant Avicennia marina bioactive compound Naphtho[1,2-b]furan-4,5-dione in breast cancer metastasis, the PI3K inhibitor BEZ235 in colon cancer stem cells, the histone methyltransferase EZH1 inhibitor GSK343 in cervical cancer, and vitamin D3 in prostate cancer...
March 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/26719528/stat3-establishes-an-immunosuppressive-microenvironment-during-the-early-stages-of-breast-carcinogenesis-to-promote-tumor-growth-and-metastasis
#18
Laura M Jones, Miranda L Broz, Jill J Ranger, John Ozcelik, Ryuhjin Ahn, Dongmei Zuo, Josie Ursini-Siegel, Michael T Hallett, Matthew Krummel, William J Muller
Immunosurveillance constitutes the first step of cancer immunoediting in which developing malignant lesions are eliminated by antitumorigenic immune cells. However, the mechanisms by which neoplastic cells induce an immunosuppressive state to evade the immune response are still unclear. The transcription factor STAT3 has been implicated in breast carcinogenesis and tumor immunosuppression in advanced disease, but its involvement in early disease development has not been established. Here, we genetically ablated Stat3 in the tumor epithelia of the inducible PyVmT mammary tumor model and found that Stat3-deficient mice recapitulated the three phases of immunoediting: elimination, equilibrium, and escape...
March 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/26711978/-associations-between-tox3-rs3803662-polymorphisms-and-immunological-markers-of-breast-cancer
#19
Qi Chen, Yaning He, Chaojun Liu, Hui Liu, Xianfu Sun, Yingbo Shao, Tao Huang, Bin Xu
OBJECTIVE: TOX3 gene was considered to be breast cancer susceptibility gene in the European population and East Asian populations. This study was aimed to investigate the relevance of TOX3 gene rs3803662 single nucleotide polymorphisms and sporadic breast cancer susceptibility among the Han Nationality in Henan Province. METHODS: A case-control study was performed among 253 patients with sporadic breast cancer and 343 control subjects in Henan Province. The SNP rs3803662 in TOX3 was genotyped by imLDR technique...
September 8, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26488882/involvement-of-membrane-blebbing-in-immunological-disorders-and-cancer
#20
REVIEW
Maitham A Khajah, Yunus A Luqmani
Cellular blebbing is a unique form of dynamic protrusion emanating from the plasma membrane which can be either apoptotic or nonapoptotic in nature. Blebs have been observed in a wide variety of cell types and in response to multiple mechanical and chemical stimuli. They have been linked to various physiological and pathological processes including tumor motility and invasion, as well as to various immunological disorders. They can form and retract extremely rapidly in seconds or minutes, or slowly over hours or days...
2016: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
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