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Serum Uric Acid And Preeclampsia

Jianming Peng, Wen Wang, Lei Zheng, Yanfei Guan, Guicheng Ye, Huichun Tong, Ying Wang, Qian Wang
Objective: To explore whether there was an increased secretion of cystatin C (Cys C) in twin pregnancy. Methods: Patients with a total of 281 singleton pregnancies (including 38 patients with preeclampsia) and 72 twin pregnancies, as well as 42 patients who were not pregnant, were included in this study. We tested levels of serum Cys C, creatinine, and uric acid, along with the estimated glomerular filtration rate (eGFR), in different groups. Results: The levels of serum Cys C in all 3 trimesters for women with twin pregnancy were much higher than those in the corresponding trimesters for women with singleton pregnancy...
December 4, 2018: Laboratory Medicine
Naina Kumar, Amit K Singh
OBJECTIVE: Assess the relationship between maternal serum uric acid and severity of Hypertensive disorders of pregnancy in a rural tertiary care centre. MATERIALS AND METHODS: Present study was conducted in Obstetrics and Gynaecology department of rural tertiary care centre of Northern India over seven months (October 2016-May 2017) on 110 women admitted with a Hypertensive disorder of pregnancy (Gestational hypertension, Pre-eclampsia, Eclampsia) at ≥34 weeks gestation...
November 12, 2018: Current Hypertension Reviews
Maryam Kasraeian, Nasrin Asadi, Homeira Vafaei, Tarlan Zamanpour, Hadi Raeisi Shahraki, Khadije Bazrafshan
Objectives: To determine serum biomarkers in detection of preeclampsia severity among pregnant women. Methods: Among 450 pregnant women with various severity of preeclampsia, serum biomarkers ofaspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), hemoglobin (Hb), platelet count (PLT), uric acid, direct bilirubin, total bilirubin, creatinine, and alkaline phosphatase were compared using area under the Receiver operating characteristic (ROC) curve and Area Under the Curve (AUC)...
July 2018: Pakistan Journal of Medical Sciences Quarterly
María C Álvarez-Cabrera, Edgar Barrientos-Galeana, Asyadette Barrera-García, Mauricio Osorio-Caballero, Jesús F Acevedo, Oscar Flores-Herrera, Néstor F Díaz, Anayansí Molina-Hernández, Guadalupe García-López, Héctor Flores-Herrera
The extracellular heat shock proteins (eHsp) family act as molecular chaperones regulating folding, transporting protein and are associated with immune modulation in different physiological and pathological processes. They have been localized in different gestational tissues and their concentration in amniotic fluid and serum has been determined. In the present study, we proposed to determine the concentration of eHsp-60, -70, IL-1β and TNFα in the serum of pregnant patients with 34 weeks of gestation with and without clinical evidences of preeclampsia (PE)...
November 2018: Journal of Cellular and Molecular Medicine
Olive P Khaliq, Tadashi Konoshita, Jagidesa Moodley, Thajasvarie Naicker
PURPOSE OF REVIEW: Because of the significant discrepancies on this topic, this review will focus on the role of uric acid in PE, uric acid as a predictor of preeclampsia and fetal growth retardation. We considered eligible review and original articles relevant to the research question. RECENT FINDINGS: Hypertensive disorders of pregnancy such as preeclampsia (PE) are a major cause of both maternal and fetal morbidity and mortality worldwide. Uric acid has been reported as a key factor contributing to the pathogenesis of PE...
July 10, 2018: Current Hypertension Reports
Li-Juan Sun, Gu-Feng Xu, Min Lv, Hao Zhou, He-Feng Huang, Qiong Luo
BACKGROUND: In clinical practice, abnormal biochemical changes often occur in women who eventually develop preeclampsia (PE). The study aims to investigate whether maternal serum biochemical markers in the early third trimester can predict PE and neonatal birth weight. STUDY DESIGN: A retrospective case-control study was performed on 287 women who subsequently developed PE (mild = 139; severe = 148) and 143 healthy women. Fasting venous blood samples of all gravidas were drawn for routine biochemical markers screening in the early third trimester (28...
June 19, 2018: Journal of Women's Health
Jarunee Leetheeragul, Dittakarn Boriboonhirunsarn, Kanit Reesukumal, Nusara Srisaimanee, Siriluck Horrasith, Tuangsit Wataganara
INTRODUCTION: There is little information on the effect of maternal characteristics and on-admission laboratory parameters to the therapeutic serum magnesium sulfate (MgSO4 ) levels in women with preeclampsia (PE). We sought to identify factors that may predict timely attainment of therapeutic serum magnesium levels after intravenous administration for seizure prophylaxis. MATERIALS AND METHODS: On-admission factors of 360 women with PE who received intravenous MgSO4 (4-g loading and 2-g/h maintenance) for seizure prophylaxis were retrospectively reviewed...
July 16, 2018: Journal of Maternal-fetal & Neonatal Medicine
Mohamed Rezk, Wael Gaber, Abdelhamid Shaheen, Ahmed Nofal, Mahmoud Emara, Awni Gamal, Hassan Badr
OBJECTIVE: To determine if second trimester mean platelet volume (MPV) and serum uric acid are reasonable predictors of preeclampsia (PE) or not, in patients at moderate and low risk. METHODS: This prospective study was conducted on 9522 women at low or moderate risk for developing PE who underwent dual measurements of MPV and serum uric acid at late first trimester (10-12 weeks) and at second trimester (18-20 weeks) and subsequently divided into two groups; PE group (n = 286) who later developed PE and non-PE group (n = 9236)...
August 2018: Hypertension in Pregnancy
Xiaodan Di, Hui Mai, Zheng Zheng, Kaimin Guo, Abraham N Morse, Huishu Liu
Eclampsia is a leading cause of maternal and fetal morbidity and mortality worldwide, and its pathogenesis remains elusive. Our objective was to investigate neuroimaging findings in women who developed neurologic symptoms in severe preeclampsia with or without eclampsia to further understand the relationship between neuroimaging findings and the pathogenesis of eclamptic seizures. This retrospective study included 79 women with severe preeclampsia/eclampsia who underwent brain MRI/CT examination between 2005 and 2017...
August 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Gbemisola E Osanyin, Kehinde S Okunade, Ayodeji Ayotunde Oluwole
BACKGROUND: Preeclampsia is a syndrome of unknown etiology characterized by hypertension, proteinuria, and/or organ dysfunction. CA125 is an antigenic determinant recognized by the murine monoclonal antibody OC125 quantified by radioimmunoassay. Its role in obstetrics is yet to be fully understood as most clinical trials advocating its uses are widely experimental in nature and unacknowledged. AIM: This study was done to assess the relationship between serum concentration of CA125 in normal pregnancies and those complicated with preeclampsia...
May 2018: Hypertension in Pregnancy
Maryam Asgharnia, Fariba Mirblouk, Soudabeh Kazemi, Davood Pourmarzi, Mina Mahdipour Keivani, Seyedeh Fatemeh Dalil Heirati
Background: Preeclampsia is associated with maternal and neonatal complications. It has been indicated that increased uric acid might have a predictive role on preeclampsia. Objective: We aimed to investigate the relationship between the level of uric acid with maternal and neonatal complications in women with preeclampsia. Materials and Methods: In this cross-sectional study, 160 singleton preeclamptic women at more than 28 wk gestational age were included...
September 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
Clara Barneo-Caragol, Eduardo Martínez-Morillo, Susana Rodríguez-González, Paloma Lequerica-Fernández, Ignacio Vega-Naredo, Francisco V Álvarez Menéndez
BACKGROUND: Preeclampsia (PE) is considered a specific vascular disease in which endothelial dysfunction may be the crucial factor of its pathogenesis. It has been suggested that strontium (Sr) may play a role in the pathophysiology of PE. Our group established in a previous study the serum levels of Sr in healthy pregnancies, and the main aim of the present study was to evaluate Sr concentrations and oxidative status in preeclamptic women. METHODS: The study population included women with early-onset PE (E-PE, n = 39), late-onset PE (L-PE, n = 67) and serial samples from a subset of preeclamptic women (PE-ss, n = 20)...
May 2018: Journal of Trace Elements in Medicine and Biology
K A Sudharshana Murthy, Ambarisha Bhandiwada, Shivani L Chandan, Surakshith L Gowda, G Sindhusree
Background: Prevalence of Gestational Diabetes Mellitus in India is increasing. In addition to performing physiological role in fetoplacental unit during pregnancy, cytokines also play pathophysiological role if expressed in abnormal amounts or sites. Objective: To estimate Proinflammatory Cytokines TNF-α, IL-6, IL-8 and anti-oxidants Glutathione Peroxidase (GTX), Superoxide dismutase (SOD), uric acid and Bilirubin levels in GDM and correlate with pregnancy outcome...
January 2018: Indian Journal of Endocrinology and Metabolism
Armando Alberto Moreno Santillan, Jesus Carlos Briones Garduño, Manuel Antonio Diaz de Leon Ponce
The relationship between hyperuricemia and hypertensive disorders is well established; however, until today, the role of uric acid in the clinical course of severe preeclampsia has not been elucidated. Some recent studies suggest that at the time of presentation, subjects with severe preeclampsia frequently have significantly elevated serum uric acid levels, and that the degree of elevation correlates with the severity of the maternal syndrome and fetal morbimortality. In this chapter, we present our workgroup experience...
2018: Contributions to Nephrology
Mamatha S Shetty, Amitha Ramesh, Prasanna Kumar Shetty, Priyanka Agumbe
Background and Objectives: Preeclampsia is a challenging disease of human pregnancy that affects the mother and her foetus. It is a common obstetric syndrome of undefined aetiology affecting 7-10% of pregnant women. This study aimed to investigate the total antioxidant capacity (TAC), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, malondialdehyde levels, uric acid, vitamin C, and vitamin E levels in serum and saliva of preeclamptic and normotensive pregnant women with and without periodontitis...
February 2018: Journal of Obstetrics and Gynaecology of India
Martin Risch, Mette-Triin Purde, Marc Baumann, Markus Mohaupt, Beatrice Mosimann, Harald Renz, Luigi Raio, Daniel Surbek, Lorenz Risch
Early biochemical identification of women at high risk for the development of pre-eclampsia (PE) is still unsatisfactory. Renal markers measured during the first trimester were analysed to predict later occurrence of PE. A nested case-control study was conducted within the prospective predictive markers for the diagnosis of preeclampsia study. Pregnant women were included at the end of the first trimester and followed up until birth. Controls were matched to PE cases. Renal markers [i.e. creatinine, cystatin C (CysC), β2 microglobulin (B2M), β-trace protein (BTP), glomerular filtration rate estimations (eGFR) of the aforementioned markers, uric acid (UA), urea, and serum uromodulin (sUMOD)] were compared to placental growth factor (PlGF), a marker known to predict PE later in pregnancy...
December 2017: Scandinavian Journal of Clinical and Laboratory Investigation
Langeza Saleh, Yvonne Vergouwe, Anton H van den Meiracker, Koen Verdonk, Henk Russcher, Henk A Bremer, Hans J Versendaal, Eric A P Steegers, A H Jan Danser, Willy Visser
To assess the incremental value of a single determination of the serum levels of sFlt-1 (soluble Fms-like tyrosine kinase 1) and PlGF (placental growth factor) or their ratio, without using cutoff values, for the prediction of maternal and fetal/neonatal complications and pregnancy prolongation, 620 women with suspected/confirmed preeclampsia, aged 18 to 48 years, were included in a prospective, multicenter, observational cohort study. Women had singleton pregnancies and a median pregnancy duration of 34 (range, 20-41) weeks...
November 2017: Hypertension
Apeksha Niraula, Madhab Lamsal, Nirmal Baral, Shankar Majhi, Seraj Ahmed Khan, Pritha Basnet, Kashyap Dahal
Preeclampsia is a devastating pregnancy-associated disorder characterized by the onset of hypertension, proteinuria, and edema with limited plausible pathophysiology known. Cystatin-C, a novel marker for the detection of renal impairment, is increased in preeclampsia at an early stage. This study was aimed to evaluate the diagnostic efficiency of Cystatin-C as an early marker of renal function in preeclampsia comparing it to the traditional renal markers. A hospital based comparative cross-sectional study was performed on 104 women (52 diagnosed cases of preeclampsia and 52 healthy pregnant women)...
2017: Journal of Biomarkers
Iftach Sagy, Amjad Abu Salman, Louise Kezerle, Offer Erez, Idan Yoel, Leonid Barski
BACKGROUND: Peri-partum cardiomyopathy (PPCM) is a clinical heart failure that usually develops during the final stage of pregnancy or the first months following delivery. High maternal serum uric acid concentrations have been previous associated with heart failure and preeclampsia. OBJECTIVES: 1) To explored the clinical characteristics of PPCM patients; and 2) to determine the association between maternal serum uric acid concentrations and PPCM. METHODS: This is a retrospective population based case control study...
September 2017: Heart & Lung: the Journal of Critical Care
Berna Aslan Cetin, Begum Aydogan Mathyk, Tayfur Cift, Abdullah Tuten, Berk Bulut, Nevin Yilmaz, Hakan Erenel, Hakan Ekmekci, Altay Gezer
AIM: The aim of this study is to investigate the maternal levels of collectrin in early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE). To assess the correlation between serum collectrin levels and blood pressure in humans. MATERIAL AND METHODS: This cross-sectional study was conducted including 79 pregnant women, 27 with normal pregnancy, 30 with EOPE and 22 with LOPE. Maternal serum levels of collectrin were measured by using enzyme-linked immunosorbent assay kits...
November 2018: Journal of Maternal-fetal & Neonatal Medicine
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