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Hwa Reung Lee, Joong Hyun Park, Sang Won Han, Jong Sam Baik
OBJECTIVE: Cognitive impairment is one of the nonmotor symptoms in Parkinson's disease (PD), and olfactory dysfunction is used as a marker to detect premotor stages of PD. Serum uric acid (sUA) levels have been found to be a risk factor for PD. Our objective in this study was to examine whether sUA levels are associated with cognitive changes and olfactory dysfunction in early de novo PD patients. METHODS: The study participants included 196 de novo PD patients...
September 2018: Journal of Movement Disorders
Chenia Caldeira Martinez, Tássia Tonon, Tatiéle Nalin, Lilia Farret Refosco, Carolina Fischinger Moura de Souza, Ida Vanessa Doederlein Schwartz
Hepatic glycogen storage diseases (GSDs) are inborn errors of metabolism whose dietary treatment involves uncooked cornstarch administration and restriction of simple carbohydrate intake. The prevalence of feeding difficulties (FDs) and orofacial myofunctional disorders (OMDs) in these patients is unknown. OBJECTIVE: To ascertain the prevalence of FDs and OMDs in GSD. METHODS: This was a cross-sectional, prospective study of 36 patients (19 males; median age, 12...
September 22, 2018: JIMD Reports
G Magliulo, M De Vincentiis, G Iannella, A Ciofalo, B Pasquariello, A Manno, D Angeletti, A Polimeni
The sense of smell has a high impact on the quality of life. The aim of the present study was to investigate olfactory dysfunction in patients with obstructive sleep apnoea syndrome (OSAS) and correlate the severity of disease with olfactory dysfunction. The relationships between nasal obstruction, nasal mucociliary cleareance and olfactory tests were also evaluated. Sixty patients with a diagnosis of OSAS were enrolled and underwent olfactory function evaluation. In all patients olfactory performance was tested with the Sniffin' Sticks method...
August 2018: Acta Otorhinolaryngologica Italica
Gerold Besser, David T Liu, Bertold Renner, Thomas Hummel, Christian A Mueller
OBJECTIVES: Therapeutic options in olfactory dysfunction (OD) are limited. Numerous studies have shown impact of OD on quality of life. Lately, various studies support benefits of olfactory training, but therapy-refractory cases leave doctors and patients locked in a stalemate. An olfactory implant (OI), in analogy to the widely successful cochlear implant, still seems far away from realization. The present study sought to evaluate the demand of OI in patients with OD. METHODS: Sixty-one patients (28 females and 33 males, mean age/standard deviation 54...
August 25, 2018: Laryngoscope
Clemens Heiser, Bernhard Haller, Maximilian Sohn, Benedikt Hofauer, Andreas Knopf, Tobias Mühling, Jessica Freiherr, Martin Bender, Maximilian Tiller, Anna Schmidt, Wolfgang Schepp, Felix Gundling
INTRODUCTION AND AIM: Olfactory functions are altered to a variable degree by chronic liver disease. Few studies including only small populations of patients emphasized the possibility of hepatic encephalopathy (HE) influencing olfactory nervous tasks. So far, no study has explicitly focused on olfactory function depending on the severity of HE as assessed by objective diagnostic procedures. Thus we performed a study using the "Sniffin' Sticks" test system, critical flicker-fusion frequency (CFF) and clinical West Haven criteria...
August 24, 2018: Annals of Hepatology
Ji Eun Kim, Eungseok Oh, Jinse Park, Jinyoung Youn, Ji Sun Kim, Wooyoung Jang
The purpose of our study was to investigate the association between olfactory function in Parkinson's disease (PD) and serum vitamin D status. Thirty-nine patients with de novo PD were enrolled in this study. Olfactory function was assessed by an odor identification test, as a part of the KVSS (Korean version of sniffin' sticks) II test. All patients were also assessed with the NMSS (Non-Motor Symptoms Scale for PD) to check the subjective change in ability to smell. Vitamin D status was determined by measuring the level of serum 25-hydroxyvitamin D3 (25-OHD3)...
November 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Carlos Henrique Ferreira Camargo, Vinícius Aguiar Jobbins, Rafael Arthur Serpa, Frederico Antônio Berbetz, Jivago Szpoganicz Sabatini, Hélio Afonso Ghizoni Teive
OBJECTIVE: The aim of this study was to compare the cognitive deficits and olfaction in PD patients. PATIENTS AND METHODS: In all, 42 PD patients and 38 controls were selected. All the individuals in both groups underwent cognitive assessment with the SCOPA-Cog neuropsychological battery and Mini-Mental State Examination (MMSE) and olfactory assessment with the Sniffin' Sticks Screening 12 Test. Parkinson's disease dementia (PDD) was diagnosed using the International Parkinson and Movement Disorder Society (MDS) criteria...
October 2018: Clinical Neurology and Neurosurgery
Pengfei Han, Nicole Winkler, Cornelia Hummel, Antje Hähner, Johannes Gerber, Thomas Hummel
Traumatic brain injury (TBI) as a major public health problem may lead to olfactory dysfunction. However, little is known about brain responses to odors in TBI olfactory loss patients. Nineteen healthy controls and forty TBI olfactory dysfunctional patients (19 with hyposmia and 21 with anosmia) underwent a functional magnetic resonance imaging scan when two odors (peach and coffee) were presented intranasally using a computerized olfactometer. Olfactory performance was measured using the "Sniffin' Sticks" test...
August 14, 2018: Journal of Neurology
Kimia G Ganjaei, Zachary M Soler, Kristina A Storck, Nicholas R Rowan, Florence A Othieno, Rodney J Schlosser
Background Retronasal olfaction is important in flavor detection and enjoyment. The ability to identify specific individual retronasal odors may play a role in quality of life for patients with chronic rhinosinusitis (CRS). Objective To identify patterns and improve understanding of retronasal identification of individual odors in CRS patients. Methods Patients diagnosed with CRS underwent retronasal and orthonasal (Sniffin' Sticks) olfactory testing and taste testing (taste strips). Retronasal identification was tested with presentation of flavored powders on the posterior tongue...
September 2018: American Journal of Rhinology & Allergy
Woo Ri Choi, Hyeon-Yeong Jeong, Ji Heui Kim
BACKGROUND: The Questionnaire of Olfactory Disorders (QOD) is a self-report questionnaire that provides subjective information about olfactory dysfunction. The QOD is widely used in clinical practice because of its high level of reliability and efficacy in Western countries. In this study we evaluated the reliability and validity of the Korean version of the QOD. METHODS: A total of 213 patients with subjective olfactory dysfunction completed 2 different surveys (the QOD and the 36-item Short-Form Health Survey [SF-36])...
July 24, 2018: International Forum of Allergy & Rhinology
L Y Yao, Y C Guo, X J Zhan, J Liu, Z F Sun, X Gao, Y Li, Y X Wei
Objective: To investigate the white matter integrity in patients with olfactory dysfunction using diffusion tensor imaging (DTI). Methods: Twenty-one patients with olfactory dysfunction and sixteen age, sex and level of education matched normal subjects were recruited in this study. Sniffin' Sticks olfactory test was performed to evaluate the olfactory function of all subjects. We acquired diffusion tensor images with a echo planar imaging (EPI) sequence from all subjects on a 3T scanner. The fractional anisotropy (FA) images were performed using DTI-studio, and bilateral piriform cortex, orbitofrontal cortex, hippocampus and insula cortex adjacent white matter as well as capsula interna were delineated from the FA images as the region of interest associated with olfactory (ROI(awo)) manually...
July 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Swaantje Casjens, Beate Pesch, Christoph van Thriel, Wolfgang Zschiesche, Thomas Behrens, Tobias Weiss, Dirk Pallapies, Marina Arendt, Nico Dragano, Susanne Moebus, Karl-Heinz Jöckel, Thomas Brüning
Lead (Pb) is a recognized neurotoxin. Pb2+ can interfere with divalent metal transporters and ion channels and may thus affect other brain metals and cation signaling in neurons. Thereby, cognitive and sensory functions can be impaired. Whereas cognitive effects are well described less is known about olfaction and motor functions in the general population at currently lower exposure levels. The objective of this study was to evaluate the influence of Pb in blood (PbB) on odor identification and fine motor skills within the framework of the Heinz Nixdorf Recall Study (HNRS), a prospective cohort study among an elderly German population...
July 23, 2018: Neurotoxicology
Axel Muttray, Jan Gosepath, Florian Schmall, Jürgen Brieger, Otfried Mayer-Popken, Michael Melia, Stephan Letzel
INTRODUCTION: Ozone is a ubiquitous and irritant gas. We questioned whether an acute exposure to 0.2 ppm ozone impaired olfactory functioning. METHODS: Healthy, normosmic subjects were exposed according to a parallel group design either to 0.2 ppm ozone (n = 15) or to sham (n = 13) in an exposure chamber for two hours. Possible irritating effects were assessed by questionnaire (range 0-5). The detection threshold of n-butanol was measured with the Sniffin' Sticks test before and after exposure...
November 2018: Environmental Research
Nicholas R Rowan, Zachary M Soler, Florence Othieno, Kristina A Storck, Timothy L Smith, Rodney J Schlosser
BACKGROUND: Genetic variation of the bitter taste receptor T2R38 has been associated with recalcitrant chronic rhinosinusitis (CRS). Specific T2R38 polymorphisms, correlating with bitter taste sensitivity to phenylthiocarbamide (PTC), have been identified as an independent risk factor for surgical intervention in CRS patients without polyps; however, the exact role of PTC tasting ability in clinical practice remains unknown. In this investigation we characterize PTC taste sensitivity in a tertiary care rhinology practice with pertinent clinical measures of disease and quality of life (QOL)...
September 2018: International Forum of Allergy & Rhinology
Mariana Moscovich, Renato Puppi Munhoz, Adriana Moro, Salmo Raskin, Karen McFarland, Tetsuo Ashizawa, Helio A G Teive, Laura Silveira-Moriyama
Although the main clinical manifestations of spinocerebellar ataxias (SCAs) result from damage of the cerebellum, other systems may also be involved. Olfactory deficits have been reported in other types of ataxias, especially in SCA3; however, there are no studies on olfactory deficits in SCA type 10 (SCA10). To analyze olfactory function of SCA10 patients compared with that of SCA3, Parkinson's, and healthy controls. Olfactory identification was tested in three groups of 30 patients (SCA10, SCA3, and Parkinson's disease (PD)) and 44 healthy controls using the Sniffin' Sticks (SS16) test...
June 19, 2018: Cerebellum
Xiacan Chen, Jiajun Xu, Bin Li, Wanjun Guo, Jun Zhang, Junmei Hu
BACKGROUND: A body of studies has focused on the olfactory impairment among people with schizophrenia. The effect of sex on this relationship has attracted the attention of researchers. These issues have not been studied much in Chinese schizophrenia patients. METHODS: We conducted a case-control study of 110 first-episode antipsychotic medicine naïve schizophrenia patients aged 18-35 years and 110 controls, matched by age and sex. Odour threshold, discrimination and identification were assessed by the "Sniffin' Sticks" test...
June 18, 2018: BMC Psychiatry
L Y Yao, Y C Guo, X J Zhan, Z F Sun, S Q Wu, Y X Wei
Objective: To investigate the brain volume alterations in patients with hyposmia using voxel-based morphometry (VBM) and to correlate these alterations with the degree and duration of hyposmia. Methods: Forty patients with hyposmia from Department of Otorhinolaryngology Head and Neck Surgery, Beijing Anzhen Hospital since 2013 to 2016 and forty age and sex matched normal subjects were recruited in this study. Sniffin' Sticks olfactory test was performed to evaluate the olfactory function of all subjects. We acquired T1-weighted magnetic resonance images from all subject on a 3T scanner...
June 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Martin Kronenbuerger, Patrizia Belenghi, Justus Ilgner, Jessica Freiherr, Thomas Hummel, Irene Neuner
Tourette syndrome is a chronic tic disorder characterized by motor and vocal tics. Comorbidities such as attention deficit hyperactivity disorder and obsessive compulsive disorder can be found. The overlap between neuroanatomical regions and neurotransmitter systems in the olfactory system and the pathophysiology of Tourette syndrome let us hypothesize altered olfactory performance in Tourette syndrome. The main objective of this study was to systematically assess olfactory functioning in subjects with Tourette syndrome and to compare it to healthy controls...
2018: PloS One
Jessica de Nijs, Julia H Meijer, Lieuwe de Haan, Carin J Meijer, Richard Bruggeman, Neeltje E M van Haren, René S Kahn, Wiepke Cahn
Schizophrenia patients have difficulties identifying odors, possibly a marker of cognitive and social impairment. This study investigated olfactory identification (OI) differences between patients and controls, related to cognitive and social functioning in childhood and adolescence, to present state cognition and to present state social cognition. 132 schizophrenia patients and 128 healthy controls were assessed on OI performance with the Sniffin' Sticks task. Multiple regression analyses were conducted investigating OI in association with cognitive and social functioning measures in childhood/adolescence and in association with IQ, memory, processing speed, attention, executive functioning, face recognition, emotion recognition and theory of mind...
August 2018: Psychiatry Research
Carla Masala, Paolo Solla, A Liscia, G Defazio, L Saba, A Cannas, A Cavazzana, T Hummel, A Haehner
Although Parkinson's disease (PD) is usually considered as a movement disorder, it is strongly associated with non-motor symptoms (NMS), including smell and taste dysfunctions, cognitive impairment, apathy, fatigue, and autonomic dysregulation. Olfactory deficit is considered the most common NMS in PD preceding the motor symptoms for years. The aim of this study was to investigate olfactory function, cognitive impairment, apathy, and fatigue in patients with PD in comparison with healthy controls, and subsequently to analyse the correlations between these NMS and motor symptoms severity in subjects with PD...
August 2018: Journal of Neurology
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