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Woo Ri Choi, Hyeon-Yeong Jeong, Ji Heui Kim
BACKGROUND: The Questionnaire of Olfactory Disorders (QOD) is a self-report questionnaire that provides subjective information about olfactory dysfunction. The QOD is widely used in clinical practice because of its high level of reliability and efficacy in Western countries. In this study we evaluated the reliability and validity of the Korean version of the QOD. METHODS: A total of 213 patients with subjective olfactory dysfunction completed 2 different surveys (the QOD and the 36-item Short-Form Health Survey [SF-36])...
July 24, 2018: International Forum of Allergy & Rhinology
L Y Yao, Y C Guo, X J Zhan, J Liu, Z F Sun, X Gao, Y Li, Y X Wei
Objective: To investigate the white matter integrity in patients with olfactory dysfunction using diffusion tensor imaging (DTI). Methods: Twenty-one patients with olfactory dysfunction and sixteen age, sex and level of education matched normal subjects were recruited in this study. Sniffin' Sticks olfactory test was performed to evaluate the olfactory function of all subjects. We acquired diffusion tensor images with a echo planar imaging (EPI) sequence from all subjects on a 3T scanner. The fractional anisotropy (FA) images were performed using DTI-studio, and bilateral piriform cortex, orbitofrontal cortex, hippocampus and insula cortex adjacent white matter as well as capsula interna were delineated from the FA images as the region of interest associated with olfactory (ROI(awo)) manually...
July 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Swaantje Casjens, Beate Pesch, Christoph van Thriel, Wolfgang Zschiesche, Thomas Behrens, Tobias Weiss, Dirk Pallapies, Marina Arendt, Nico Dragano, Susanne Moebus, Karl-Heinz Jöckel, Thomas Brüning
Lead (Pb) is a recognized neurotoxin. Pb2+ can interfere with divalent metal transporters and ion channels and may thus affect other brain metals and cation signaling in neurons. Thereby, cognitive and sensory functions can be impaired. Whereas cognitive effects are well described less is known about olfaction and motor functions in the general population at currently lower exposure levels. The objective of this study was to evaluate the influence of Pb in blood (PbB) on odor identification and fine motor skills within the framework of the Heinz Nixdorf Recall Study (HNRS), a prospective cohort study among an elderly German population...
July 23, 2018: Neurotoxicology
Axel Muttray, Jan Gosepath, Florian Schmall, Jürgen Brieger, Otfried Mayer-Popken, Michael Melia, Stephan Letzel
INTRODUCTION: Ozone is a ubiquitous and irritant gas. We questioned whether an acute exposure to 0.2 ppm ozone impaired olfactory functioning. METHODS: Healthy, normosmic subjects were exposed according to a parallel group design either to 0.2 ppm ozone (n = 15) or to sham (n = 13) in an exposure chamber for two hours. Possible irritating effects were assessed by questionnaire (range 0-5). The detection threshold of n-butanol was measured with the Sniffin' Sticks test before and after exposure...
July 5, 2018: Environmental Research
Nicholas R Rowan, Zachary M Soler, Florence Othieno, Kristina A Storck, Timothy L Smith, Rodney J Schlosser
BACKGROUND: Genetic variation of the bitter taste receptor T2R38 has been associated with recalcitrant chronic rhinosinusitis (CRS). Specific T2R38 polymorphisms, correlating with bitter taste sensitivity to phenylthiocarbamide (PTC), have been identified as an independent risk factor for surgical intervention in CRS patients without polyps; however, the exact role of PTC tasting ability in clinical practice remains unknown. In this investigation we characterize PTC taste sensitivity in a tertiary care rhinology practice with pertinent clinical measures of disease and quality of life (QOL)...
July 4, 2018: International Forum of Allergy & Rhinology
Mariana Moscovich, Renato Puppi Munhoz, Adriana Moro, Salmo Raskin, Karen McFarland, Tetsuo Ashizawa, Helio A G Teive, Laura Silveira-Moriyama
Although the main clinical manifestations of spinocerebellar ataxias (SCAs) result from damage of the cerebellum, other systems may also be involved. Olfactory deficits have been reported in other types of ataxias, especially in SCA3; however, there are no studies on olfactory deficits in SCA type 10 (SCA10). To analyze olfactory function of SCA10 patients compared with that of SCA3, Parkinson's, and healthy controls. Olfactory identification was tested in three groups of 30 patients (SCA10, SCA3, and Parkinson's disease (PD)) and 44 healthy controls using the Sniffin' Sticks (SS16) test...
June 19, 2018: Cerebellum
Xiacan Chen, Jiajun Xu, Bin Li, Wanjun Guo, Jun Zhang, Junmei Hu
BACKGROUND: A body of studies has focused on the olfactory impairment among people with schizophrenia. The effect of sex on this relationship has attracted the attention of researchers. These issues have not been studied much in Chinese schizophrenia patients. METHODS: We conducted a case-control study of 110 first-episode antipsychotic medicine naïve schizophrenia patients aged 18-35 years and 110 controls, matched by age and sex. Odour threshold, discrimination and identification were assessed by the "Sniffin' Sticks" test...
June 18, 2018: BMC Psychiatry
L Y Yao, Y C Guo, X J Zhan, Z F Sun, S Q Wu, Y X Wei
Objective: To investigate the brain volume alterations in patients with hyposmia using voxel-based morphometry (VBM) and to correlate these alterations with the degree and duration of hyposmia. Methods: Forty patients with hyposmia from Department of Otorhinolaryngology Head and Neck Surgery, Beijing Anzhen Hospital since 2013 to 2016 and forty age and sex matched normal subjects were recruited in this study. Sniffin' Sticks olfactory test was performed to evaluate the olfactory function of all subjects. We acquired T1-weighted magnetic resonance images from all subject on a 3T scanner...
June 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Martin Kronenbuerger, Patrizia Belenghi, Justus Ilgner, Jessica Freiherr, Thomas Hummel, Irene Neuner
Tourette syndrome is a chronic tic disorder characterized by motor and vocal tics. Comorbidities such as attention deficit hyperactivity disorder and obsessive compulsive disorder can be found. The overlap between neuroanatomical regions and neurotransmitter systems in the olfactory system and the pathophysiology of Tourette syndrome let us hypothesize altered olfactory performance in Tourette syndrome. The main objective of this study was to systematically assess olfactory functioning in subjects with Tourette syndrome and to compare it to healthy controls...
2018: PloS One
Jessica de Nijs, Julia H Meijer, Lieuwe de Haan, Carin J Meijer, Richard Bruggeman, Neeltje E M van Haren, René S Kahn, Wiepke Cahn
Schizophrenia patients have difficulties identifying odors, possibly a marker of cognitive and social impairment. This study investigated olfactory identification (OI) differences between patients and controls, related to cognitive and social functioning in childhood and adolescence, to present state cognition and to present state social cognition. 132 schizophrenia patients and 128 healthy controls were assessed on OI performance with the Sniffin' Sticks task. Multiple regression analyses were conducted investigating OI in association with cognitive and social functioning measures in childhood/adolescence and in association with IQ, memory, processing speed, attention, executive functioning, face recognition, emotion recognition and theory of mind...
August 2018: Psychiatry Research
Carla Masala, Paolo Solla, A Liscia, G Defazio, L Saba, A Cannas, A Cavazzana, T Hummel, A Haehner
Although Parkinson's disease (PD) is usually considered as a movement disorder, it is strongly associated with non-motor symptoms (NMS), including smell and taste dysfunctions, cognitive impairment, apathy, fatigue, and autonomic dysregulation. Olfactory deficit is considered the most common NMS in PD preceding the motor symptoms for years. The aim of this study was to investigate olfactory function, cognitive impairment, apathy, and fatigue in patients with PD in comparison with healthy controls, and subsequently to analyse the correlations between these NMS and motor symptoms severity in subjects with PD...
August 2018: Journal of Neurology
Y F Liu, L Y Yao, Y C Guo, Q Q Wang, Y X Wei
Objective: To analyze the clinical features and recovery rate of post-traumatic olfactory dysfunction (PTOD) in Chinese adults in a case control follow-up study. Method: The clinical data of 202 patients who were diagnosed with olfactory dysfunction between January 2015 and December 2016 and followed up for 14 to 473 days were analyzed in this retrospective study. The patients were divided into those with PTODs (PTOD group) and those without PTODs (non-PTOD group). The two groups were compared with regard to age (years), sex, olfactory function (Sniffin' sticks), gustatory function (triple drop method), chemosensory evoked potentials, and magnetic resonance imaging (MRI) characteristics of olfactory pathways...
November 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Y C Guo, L Y Yao, Y X Wei
Objective: To observe the effect of ginkgo biloba extraction combined with glucocorticoids on postviral olfactory dysfunction. Method: Forty-two patients were diagnosed as postviral olfactory dysfunction. All patients underwent olfactory test, including T&T test and Sniffin Sticks test before and after treatment. The treatment lasted up to 3 months based on effectiveness. The results of olfactory test were recorded every month. Result: Twenty patients received the treatment with prednisone acetate. T&T test showed that the effective and improvement rate of the treatment with prednisone acetate were 25...
October 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Gabriel Bsteh, Harald Hegen, Felix Ladstätter, Klaus Berek, Matthias Amprosi, Sebastian Wurth, Michael Auer, Franziska Di Pauli, Florian Deisenhammer, Andreas Lutterotti, Thomas Berger
BACKGROUND: Impairment of olfactory threshold is a feature of early and active relapsing remitting multiple sclerosis (RRMS). It predicts inflammatory disease activity and was reported to be transient. However, the timing of onset and resolve of olfactory threshold impairment remains unclear. OBJECTIVE: To prospectively assess the development of olfactory threshold in acute MS relapse over time in comparison to stable MS patients. METHODS: In a prospective observational design, we measured olfactory threshold by performing the Sniffin' Sticks test (minimum score 0, maximum score 16 reflecting optimal olfactory function) at baseline and after 4, 12 and 24 weeks...
July 2018: Multiple Sclerosis and related Disorders
Jia Liu, Jayant M Pinto, Ling Yang, Linyin Yao, Xutao Miao, Yongxiang Wei
BACKGROUND: Idiopathic olfactory loss (IOL) accounts for a sizable fraction of olfactory dysfunction, but very little is known about its etiology and electrophysiological changes in the olfactory pathway. METHODS: We analyzed the physiology of IOL using chemosensory event-related potentials (ERPs) (olfactory and trigeminal: oERP and tERP) and olfactory pathway magnetic resonance imaging (MRI) measured in adult patients with IOL and healthy controls. Subjective olfactory function was measured by Toyota and Takagi (T&T) olfactometry and Sniffin' Sticks (SS)...
May 21, 2018: International Forum of Allergy & Rhinology
Mette Bratt, Toril Skandsen, Thomas Hummel, Kent G Moen, Anne Vik, Ståle Nordgård, Anne-S Helvik
OBJECTIVE: To assess the frequency and factors associated with posttraumatic olfactory dysfunction, including anosmia, in a follow-up of patients with moderate and severe traumatic brain injury (TBI). METHODS: The setting was a cross-sectional study of patients that were consecutively included in the Trondheim TBI database, comprising injury-related variables. Eligible participants 18-65 years were contacted 9-104 months post trauma and asked olfactory-related questions...
2018: Brain Injury: [BI]
Tine Nielsen, Martin Bang Jensen, Egon Stenager, Andreas Dammann Andersen
INTRODUCTION: The diagnosis of Parkinson's disease (PD) is typically based on the presence of motor symptoms, but in the early phase of the disease, the diagnostic process can be challenging. Examination of non-motor symptoms in patients suspected of PD has gained growing attention. Olfactory tests have shown promising results as ancillary diagnostic tests. The aim of this study was to investigate how olfactory tests may be used clinically in diagnostic process in PD. METHODS: A systematic search was conducted in PubMed for relevant literature on 8 March 2017...
May 2018: Danish Medical Journal
Milena Marek, Susanne Linnepe, Christine Klein, Thomas Hummel, Sebastian Paus
INTRODUCTION: Olfactory dysfunction has been established as a frequent non-motor symptom in neurodegenerative and movement disorders such as Parkinson's disease, Alzheimer's disease, and hereditary ataxias. To expand knowledge of non-motor symptoms in dystonia, and to test for a potential endophenotype, we examined olfactory function in cervical dystonia (CD). METHODS: In patients with CD, and neurologically healthy controls, olfactory function was examined by "Sniffin' Sticks", a test of nasal chemosensory function based on pen-like odor dispensing devices...
April 25, 2018: Parkinsonism & related Disorders
Johanna Bendas, Thomas Hummel, Ilona Croy
The olfactory system contributes significantly to human social behavior and especially to mate choice and empathic functioning. In this context, previous research examining individuals with impaired olfactory function indicated an influence of the sense of smell on different aspects of sexuality. However, the applied samples, methods, and results are diverse and an involvement of confounding factors, such as breathing problems, depression or social insecurity cannot be ruled out. The present study examined the potential correlation between odor threshold in healthy participants and their sexual desire, sexual experience, and sexual performance...
May 2, 2018: Archives of Sexual Behavior
Guowei Chen, Hongguang Pan, Lan Li, Jumei Wang, Delun Zhang, Zebin Wu
Young children with olfactory disturbance are sometimes encountered in ENT clinics. We investigated the clinical applicability of olfactory testing to the pediatric population in China.One hundred and ninety-three healthy children aged 6 to 17 years were enrolled. All participants were asked for demographic information (age, sex, body mass index [BMI], and rating of olfactory function) in a structured questionnaire and underwent olfactory testing including T&T Olfactometer (T&T), odor discrimination (OD), and odor identification (OI) tests of Sniffin' Sticks...
April 2018: Medicine (Baltimore)
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