Quhan Cheng, Linli Zhang, Jingai Zhang, Xin Zhou, Boyu Wu, Dezheng Wang, Tingting Wei, Muhammad Shafiq, Shengbin Li, Dengke Zhi, Yong Guan, Kai Wang, Deling Kong
There is a great clinical need for regenerating the urinary tissue. Native urethra and ureter have bidirectional aligned smooth muscle cells (SMCs) layers, which plays a pivotal role for micturition and transport the urine and inhibit reflux. Up to now, urinary scaffolds have not been designed to induce the native-mimicking aligned arrangement of SMCs. In this study, we engineered a tubular decellularized extracellular matrix (dECM) with an intact internal layer and bidirectional aligned microchannels in the tubular wall, which was realized by the subcutaneous implantation of a template, followed by the removal of the template, and decellularization...
August 28, 2023: Advanced Healthcare Materials