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https://www.readbyqxmd.com/read/30516761/a-novel-cck2-gastrin-receptor-localizing-radiolabeled-peptide-probe-for-personalized-diagnosis-and-therapy-of-patients-with-progressive-or-metastatic-medullary-thyroid-carcinoma-gran-t-mtc-a-multicenter-phase-i-study
#1
Paola Anna Erba, Helmut Maecke, Renata Mikołajczak, Clemens Decristoforo, Katja Zaletel, Theodosia Maina-Nock, Petra Kolenc Peitl, Piotr Garnuszek, Alida Froberg, Georg Goebel, Marion de Jong, Agata Jabrocka-Hybel, Mark Konijnenberg, Irena Virgolini, Berthold Nock, Wioletta Lenda-Tracz, Dariusz Pawlak, Christine Rangger, Małgorzata Trofimiuk-Müldner, Anna Sowa-Staszczak, Monika Tomaszuk, Elisabeth von Guggenberg, Lorenza Scarpa, Alicja Hubalewska-Dydejczyk
No abstract text is available yet for this article.
December 5, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/30482582/persistent-disease-and-recurrence-in-medullary-thyroid-carcinoma-a-case-series
#2
Ana Alicia Tejera Hernández, María Isabel Gutiérrez Giner, Juan Carlos Rocca Cárdenas, Fructuoso Rodríguez Rodríguez, Juan Ramón Hernández Hernández
No abstract text is available yet for this article.
October 25, 2018: Cirugía Española
https://www.readbyqxmd.com/read/30478244/revised-american-thyroid-association-guidelines-for-the-management-of-medullary-thyroid-carcinoma
#3
(no author information available yet)
No abstract text is available yet for this article.
November 26, 2018: Pediatrics
https://www.readbyqxmd.com/read/30464902/understanding-malignancies-of-the-thyroid-gland-institutional-experience
#4
Jaimanti Bakshi, Sourabha Kumar Patro, Navjot Kaur, Naresh Kumar Panda, Grace Budhiraja
To study the epidemiological, pathological characters and determine survival in patients diagnosed of having thyroid gland malignancies. Retrospective chart review of patients having thyroid gland malignancies, which were managed by the two senior authors at our tertiary care institute from January 2000 to December 2006, were performed and evaluated in terms of various clinical, operative and histological parameters. Patients in which follow up of at least 10 years are available were included in the study...
December 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/30462353/plasmacytoma-of-thyroid-clinically-and-morphologically-mimicking-primary-thyroid-carcinoma
#5
Debasis Gochhait, Ramkumar Govindarajalou, Rakhee Kar, Vidhyalakshmi Rangarajan, Priyadarshini Dehuri, Biswajit Dubashi
Plasma cell neoplasms may have a spectrum of clinical presentation ranging from asymptomatic proliferation to single/multiple mass lesions in medullary/ extramedullary sites. Extramedullary plasmacytoma (EMP) is a rare tumor of the soft tissue without theinvolvement of bone marrow which most commonly affects the head and neck region and may precede multiple myeloma (MM) (1). Thyroid can rarely be a site for EMP or may be infiltrated by systemic multiple myeloma. These patients are predominantly males and are usually well beyond middle age...
November 21, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/30461619/medullary-thyroid-carcinoma-with-breast-metastasis-two-case-reports
#6
REVIEW
Kexin Meng, Wanyuan Chen, Wei Tian, Kewang Sun, Hailong Chen
RATIONALE: Medullary thyroid carcinoma (MTC) is an aggressive subtype of thyroid cancer with frequent hematogenous metastasis. While its metastasis is usually observed in the lung, liver, or bone, it rarely migrates to the breast. PATIENT CONCERNS: Here we report 2 cases with a complaint of breast lump after initial treatment of MTC. DIAGNOSES: In both patients, the MTC characteristics of breast nodules were confirmed by pathologic analysis of biopsy specimens...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30456051/gross-total-resection-of-a-jugular-foramen-thyroid-medullary-metastasis-via-a-transjugular-transsigmoid-approach
#7
Ilhan Aydin, Sima Sayyahmelli, Mark Pyle, Mustafa K Baskaya
Surgical resection of jugular foramen tumors poses a significant challenge to skull base surgeons with the selection of an appropriate surgical approach, a matter of some debate. Jugular foramen metastatic tumors may mimic paragangliomas, and in some selected cases surgical resection is needed. In this video, we demonstrate the microsurgical gross total resection of a jugular foramen tumor via a postauricular trans-jugular trans-sigmoid approach. The patient is a 61-year-old man with a 7-year history of medullary thyroid cancer, who underwent three neck operations and radiation to the neck...
December 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/30454940/the-use-of-post-ablation-stimulated-thyroglobulin-in-predicting-clinical-outcomes-in-differentiated-thyroid-carcinoma-what-cut-off-values-should-we-use
#8
K C W Wong, T Y Ng, K S Yu, J S S Kwok, K C A Chan, J J S Suen, S F Leung, A T C Chan
AIMS: Recently published international guidelines recommended using the stimulated thyroglobulin (sTg) post-radioactive iodine (RAI) ablation, in conjunction with tumour stage, as a risk stratification factor. The choice of cut-off values for sTg, namely 1 and 10 ng/ml, was, however, largely based on the functional sensitivities of the assays used, with relatively few published data addressing the prognostic impact of alternative cut-off values. Our study aims to provide data on the prognostic value of sTg at different levels of sensitivities and specificities...
November 16, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30450128/calcitonin-measurement-in-fine-needle-aspirate-washout-fluid-by-electrochemiluminescence-immunoassay-for-thyroid-tumors
#9
Minoru Kihara, Mitsuyoshi Hirokawa, Takumi Kudo, Toshitetsu Hayashi, Masatoshi Yamamoto, Hiroo Masuoka, Takuya Higashiyama, Mitsuhiro Fukushima, Yasuhiro Ito, Akihiro Miya, Akira Miyauchi
Purpose: For the differential diagnosis of medullary thyroid carcinoma (MTC) on thyroid nodules, ultrasound-guided fine-needle aspiration cytology is a useful and safe procedure, but its diagnostic accuracy is not high enough. As an ancillary method to accurately diagnose MTC, the calcitonin in fine-needle aspirate washout fluid (FNA-Ct) is used. However, no data are available about cut-off values of FNA-Ct using the currently available electrochemiluminescence immunoassay (ECLIA). Methods: We investigated 180 thyroid nodules in 141 patients...
2018: Thyroid Research
https://www.readbyqxmd.com/read/30429678/calcium-stimulated-calcitonin-the-new-standard-in-the-diagnosis-of-thyroid-c-cell-disease-clinically-relevant-gender-specific-cut-off-levels-for-an-old-test
#10
Martin B Niederle, Christian Scheuba, Alois Gessl, Shuren Li, Oskar Koperek, Christian Bieglmayer, Philipp Riss, Andreas Selberherr, Bruno Niederle
Introduction: Pentagastrin (Pg) stimulated calcitonin (sCT) was used to enhance accuracy in medullary thyroid cancer (MTC) diagnosis. As it is now unavailable, calcium (Ca) has been recommended as an alternative. The aim of this study was to define gender-specific cut-off values to predict MTC in patients with elevated basal CT (bCT) following Pg-sCT and Ca-sCT stimulation and to compare the time courses of CT release during stimulation. Materials and methods: The stimulation tests were applied in 62 consecutive patients with thyroid nodules...
October 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/30424779/pathological-characteristics-and-genetic-features-of-melanin-producing-medullary-thyroid-carcinoma
#11
Changsong Wang, Tian Yun, Zhicheng Wang, Nianlong Meng, Naijun Fan, Xuexia Lv, Fulin Li
OBJECTIVE: To study the clinicopathological characteristics and genetic features of melanin-producing medullary thyroid carcinoma (MP-MTC). METHODS: The immunophenotype of MP-MTC was studied using the immunohistochemical method, and its genetic features were assayed using an amplification refractory mutation system or PCR method. RESULTS: A 71-year-old man presented with a slowly growing 5-cm mass on the left side of the neck for approximately two months...
November 13, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/30415874/characterization-of-somatostatin-receptors-sstrs-expression-and-antiproliferative-effect-of-somatostatin-analogues-in-aggressive-thyroid-cancers
#12
Danilea M Carmona Matos, Samuel Jang, Baraa Hijaz, Alex W Chang, Ricardo V Lloyd, Herbert Chen, Renata Jaskula-Sztul
BACKGROUND: Certain human carcinomas have demonstrated a distinct expression of somatostatin receptors. Data on somatostatin receptor expression in follicular thyroid cancer and anaplastic thyroid cancer has been limited and conflicting. This study seeks to characterize somatostatin receptor expression in follicular thyroid cancer and anaplastic thyroid cancer and to assess the effects of somatostatin analogues. METHODS: Anaplastic thyroid cancer (Hth7 and 8505C) and follicular thyroid cancer (FTC-236) (Sigma-Aldrich, St...
November 8, 2018: Surgery
https://www.readbyqxmd.com/read/30415778/study-on-the-degradation-rule-of-calcitonin-in-vitro-in-patients-with-medullary-thyroid-carcinoma
#13
Guoping Ou, Qiaolun Chen, Wanli Liu, Xiaohui Li, Shulin Chen, Xingping Wu, Hao Chen
BACKGROUND: It was found that calcitonin in vitro can degrade rapidly whether in refrigeration or at room temperature, which increases the difficulty of accurate detecting of calcitonin greatly. This study was designed to solve this problem. METHODS: Serum samples with increased calcitonin from patients with medullary thyroid carcinoma were collected and divided into refrigeration and room temperature group. Analyze the degradation rule of calcitonin in the two groups according to the time of blood draw (T0), the time of sample detection (Tx), and the concentration (y) measured at Tx...
December 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30402314/a-case-of-lenvatinib-induced-focal-segmental-glomerulosclerosis-fsgs-in-metastatic-medullary-thyroid-cancer
#14
Kathryn Fleming, James McGuinness, David Kipgen, Hilary Glen, Pavlina Spiliopoulou
We describe a case of lenvatinib (E7080) associated focal segmental glomerulosclerosis (FSGS) encountered during the treatment of metastatic medullary thyroid cancer. Proteinuria is a relatively common side effect of VEGF-targeted treatments and can occasionally result in treatment discontinuation. Here, we describe a patient who developed secondary FSGS necessitating discontinuation of treatment at first but who was subsequently rechallenged with anti-VEGF-targeted treatment without recurrence of proteinuria...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/30396922/cystathione-%C3%AE-synthase-is-increased-in-thyroid-malignancies
#15
Elba A Turbat-Herrera, Matthew J Kilpatrick, Jie Chen, Andrew T Meram, James Cotelingam, Ghali Ghali, Christopher G Kevil, Domenico Coppola, Rodney E Shackelford
BACKGROUND: Cystathione β-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2 S) and cystathione, via the trans-sulfuration pathway. CBS protein expression levels are increased in several different human malignancies, with increased protein expression correlating with parameters such as tumor stage, anaplasia, metastases, and chemotherapy resistance. MATERIALS AND METHODS: This study employed tissue microarrays to examine CBS expression in benign thyroid tissue, thyroid oncocytomas, thyroid follicular adenomas, and in follicular, papillary, anaplastic, and medullary thyroid carcinomas...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30383218/primary-adrenal-insufficiency-during-lenvatinib-or-vandetanib-and-improvement-of-fatigue-after-cortisone-acetate-therapy
#16
Carla Colombo, Simone De Leo, Marta Di Stefano, Guia Vannucchi, Luca Persani, Laura Fugazzola
Context: Two tyrosine kinase inhibitors (TKIs), Lenvatinib and Vandetanib, are frequently used for the treatment of advanced radioiodine refractory differentiated thyroid cancer (RAI-R DTC) and medullary thyroid cancer (MTC), respectively. Fatigue is a frequent adverse event during treatment with these and other tyrosine-kinase inhibitors, and a common cause of drug discontinuation or dose reduction. Cases description: We evaluated the basal and stimulated adrenal function in 12 patients with advanced RAI-R DTC and MTC treated with Lenvatinib or Vandetanib, respectively...
October 31, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30374431/bilateral-medullary-thyroid-carcinoma-in-a-3-year-old-female-patient-with-multiple-endocrine-neoplasia-2a-syndrome-undergoing-prophylactic-thyroidectomy-should-current-guidelines-be-revised
#17
Abbas Al-Kurd, David J Gross, David Zangen, Karine Atlan, Haggi Mazeh, Simona Grozinsky-Glasberg
Background: Multiple endocrine neoplasia (MEN) 2A is an autosomal dominant disorder that results from a mutation in the RET proto-oncogene on chromosome 10. Almost all of the affected patients develop medullary thyroid carcinoma (MTC). The American Thyroid Association recommends prophylactic thyroidectomy in MEN 2A pediatric patients, with the age of the recommended thyroidectomy varying according to the codon mutation present. Objectives: This report questions the reliability of the currently placed guidelines and whether the age threshold for prophylactic thyroidectomy in patients with known codon 634 mutations should be lowered, in parallel with an earlier evaluation of calcitonin levels in the serum...
October 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/30370813/clear-cell-variant-of-a-follicular-thyroid-tumor-with-uncertain-malignant-potential-a-case-report
#18
C Christofer Juhlin, Robert Bränström, Ivan Shabo, Anders Höög
Follicular neoplasms of the thyroid gland are most often characterized by follicular-patterned thyrocytes with a neutrally stained cytoplasm, while a minority of cases present with oncocytic differentiation (Hürthle cell tumors). Exceedingly rare variants with a clear cell phenotype have also been reported, both as clear cell follicular thyroid adenomas (ccFTAs) and clear cell follicular carcinomas (ccFTCs). We present a patient with a 30-mm lesion in the thyroid isthmus in which the preoperative cytology proposed a follicular tumor...
October 29, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30366876/prophylactic-thyroidectomy-in-multiple-endocrine-neoplasia-2-men2-patients-with-the-c634y-mutation-a-long-term-follow-up-in-a-large-single-center-cohort
#19
Beatriz Febrero, José Manuel Rodríguez, Antonio Ríos, Pedro Segura, Belén Pérez-Sánchez, Nuria Torregrosa, Antonio Miguel Hernández, Pascual Parrilla
BACKGROUND: Medullary thyroid carcinoma (MTC) is the main cause of death in multiple endocrine neoplasia 2A (MEN2A) patients. It is therefore important to treat this disease at an early stage. The mutation in codon 634 is considered to be associated with an aggressive clinical course, whereas the C634Y mutation may result in a more indolent course. Prophylactic thyroidectomy is performed before thyroid disease occurs. However, controversy surrounds this disease regarding levels of calcitonin (Ct) and age...
October 17, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30358622/68ga-dotatoc-pet-ct-in-thyroid-metastases-of-lung-carcinoid
#20
Lucia Leccisotti, Margherita Lorusso, Elisa Giannetta, Andrea M Isidori, Vittoria Rufini
We report the case of a 43-year-old man with a history of lung carcinoid and a recent detection of thyroid nodules by ultrasound. The cytological analysis raised the suspicion of medullary thyroid carcinoma; however, calcitonin and carcinoembryonic antigen levels were in reference range. Considering the previous diagnosis of lung carcinoid, the patient underwent whole-body Ga-DOTATOC PET/CT. The images showed focal radiopharmaceutical uptake in both thyroid lobes. After thyroidectomy, the histology and immunohistochemistry (negative for calcitonin and positive for chromogranin A) confirmed the neuroendocrine origin of the thyroid nodules, possibly referable to previous lung carcinoid...
October 23, 2018: Clinical Nuclear Medicine
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