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https://www.readbyqxmd.com/read/30529658/can-drug-release-rate-from-implants-be-tailored-using-poly-urethane-mixtures
#1
Michael B Lowinger, Yongchao Su, Xingyu Lu, Robert O Williams, Feng Zhang
Hydrophobic and hydrophilic thermoplastic poly(urethane) (TPU) mixtures offer the opportunity to tune water swelling capacity and diffusion rate for drugs exhibiting broadly different properties. We sought to (1) assess the range of drug diffusion rates achieved by varying hydrophilic-to-hydrophobic TPU ratio relative to varying ethylene vinyl acetate (EVA) crystallinity; (2) investigate the effect of mixture ratio on permeability of emtricitabine; and (3) investigate the impact of the extrusion process on mixing of the two TPUs and the resulting impact on drug diffusion...
December 6, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30529294/hydroxycamptothecin-nanoparticles-based-on-poly-oligo-ethylene-glycol-architecture-effects-of-nanocarriers-on-antitumor-efficacy
#2
Yifei Guo, Ting Wang, Hanhong Qiu, Meihua Han, Zhengqi Dong, Xiangtao Wang, Yanhong Wang
Nanoparticles decorated with hydrophilic PEG chains had been emerged as effective drug delivery system due to their biocompatibility and biodegradability, while, the influence of their architecture on antitumor efficacy remained challenging. In this study, the linear poly(ethylene glycol) (PEG45 ), brush oligo(triethylene glycol) (TEG10 ), and oligo(ethylene glycol) dendron (G2), which showed the similar molar mass but different architecture, were utilized as nanocarriers to prepare 10-hydroxycamptothecin (HCPT) nanoparticles...
December 5, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/30509181/preharvest-application-of-ethephon-and-postharvest-uv-b-radiation-improve-quality-traits-of-beetroot-beta-vulgaris-l-ssp-vulgaris-as-source-of-colourant
#3
Gregorio Barba-Espin, Stephan Glied-Olsen, Tsaneta Dzhanfezova, Bjarne Joernsgaard, Henrik Lütken, Renate Müller
BACKGROUND: Betanins have become excellent replacers for artificial red-purple food colourants. Red beet (Beta vulgaris L. spp. vulgaris) known as beetroot, is a rich source of betalains, which major forms are betanin (red to purple) and vulgaxanthin (yellow). Betalains and phenolic compounds are secondary metabolites, accumulation of which is often triggered by elicitors during plant stress responses. In the present study, pre-harvest applications of ethephon (an ethylene-releasing compound) and postharvest UV-B radiation were tested as elicitors of betalains and phenolic compounds in two beetroot cultivars...
December 3, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/30497010/immunofunctional-photodegradable-poly-ethylene-glycol-hydrogel-surfaces-for-the-capture-and-release-of-rare-cells
#4
Paige J LeValley, Mark W Tibbitt, Ben Noren, Prathamesh Kharkar, April M Kloxin, Kristi S Anseth, Mehmet Toner, John Oakey
Circulating tumor cells (CTCs) play a central role in cancer metastasis and represent a rich source of data for cancer prognostics and therapeutic guidance. Reliable CTC recovery from whole blood therefore promises a less invasive and more sensitive approach to cancer diagnosis and progression tracking. CTCs, however, are exceedingly rare in whole blood, making their quantitative recovery challenging. Several techniques capable of isolating these rare cells have been introduced and validated, yet most suffer from low CTC purity or viability, both of which are essential to develop a clinically viable CTC isolation platform...
November 20, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30479928/development-of-biocompatible-ha-hydrogels-embedded-with-a-new-synthetic-peptide-promoting-cellular-migration-for-advanced-wound-care-management
#5
Sun Young Wang, Hyosuk Kim, Gijung Kwak, Hong Yeol Yoon, Sung Duk Jo, Ji Eun Lee, Daeho Cho, Ick Chan Kwon, Sun Hwa Kim
In the past few years, there have been many efforts underway to develop effective wound healing treatments for traumatic injuries. In particular, wound-healing peptides (WHPs) and peptide-grafted dressings hold great promise for novel therapeutic strategies for wound management. This study reports a topical formulation of a new synthetic WHP (REGRT, REG) embedded in a hyaluronic acid (HA)-based hydrogel dressing for the enhancement of acute excisional wound repair. The copper-free click chemistry is utilized to form biocompatible HA hydrogels by cross-linking dibenzocyclooctyl-functionalized HA with 4-arm poly(ethylene glycol) (PEG) azide...
November 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/30477300/microfluidic-manufacturing-of-sn-38-loaded-polymer-nanoparticles-with-shear-processing-control-of-drug-delivery-properties
#6
Yi-Meng Cao, Lisa K Silverman, Changhai Lu, Rebecca Hof, Jeremy E Wulff, Matthew G Moffitt
Two-phase gas-liquid microfluidic reactors provide shear processing control of SN-38-loaded polymer nanoparticles (SN-38-PNPs). We prepare SN-38-PNPs from the block copolymer poly(methyl caprolactone-co-caprolactone)-block-poly(ethylene oxides) (P(MCL-co-CL)-b-PEO) using bulk and microfluidic methods and at different drug-to-polymer loading ratios and on-chip flow rates. We show that as the microfluidic flow rate (Q) increases, encapsulation efficiency and drug loading increase and release half times increase...
November 26, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/30362476/acid-active-supramolecular-anticancer-nanoparticles-based-on-cyclodextrin-polyrotaxanes-damaging-both-mitochondria-and-nuclei-of-tumor-cells
#7
Shuang Bai, Xiaoli Zhang, Xiaoqian Ma, Jiucun Chen, Qiubing Chen, Xiaoxiao Shi, Meili Hou, Peng Xue, Yuejun Kang, Zhigang Xu
As a supramolecular macrocyclic polymer, cyclodextrin (CD) polyrotaxanes (PRs) have many advantages for developing nanomedicines, such as stable chemical composition, abundant functionalized hydroxyl groups, moving across biological barriers, adjustable nanoparticle size and good biocompatibility. Herein, we synthesized a class of acid-active therapeutic nanoparticles comprising a α-CD-based PR polymeric prodrug of PRs-poly(doxorubicin)-co-poly[(ethylene glycol) methyl ether methacrylate] (PR-PDOX-co-POEGMA, denoted as PRMO@DOX) to reduce drug leakage and selectively deliver drugs into tumor cells, aiming to achieve maximal treatment efficacy of supramolecular therapeutics...
November 20, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/30360105/cascade-cytosol-delivery-of-dual-sensitive-micelle-tailored-vaccine-for-enhancing-cancer-immunotherapy
#8
Dandan Jiang, Weiwei Mu, Xiuping Pang, Yongjun Liu, Na Zhang, Yunmei Song, Sanjay Garg
Enhancing cytosol delivery of exogenous antigens in antigen presenting cells can improve cross-presentation and CD8+ T cell-mediated immune response. The antigen cytosol delivery speed, which has great importance on the rate of MHC class I molecules (MHC I) antigen presentation pathway and cytotoxic T lymphocytes (CTLs) induction, has not been well studied. We hypothesized that micelle-tailored vaccine with multiple cascaded lysosomal responsive capabilities could accelerate lysosomal escape and enhance cancer immunotherapy...
October 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30321641/peptide-functionalized-and-high-drug-loaded-novel-nanoparticles-as-dual-targeting-drug-delivery-system-for-modulated-and-controlled-release-of-paclitaxel-to-brain-glioma
#9
Primiano Pio Di Mauro, Anna Cascante, Pau Brugada Vilà, Vanessa Gómez-Vallejo, Jordi Llop, Salvador Borrós
A dual-targeting drug delivery system for paclitaxel (PTX) was developed by functionalizing novel polyester-based nanoparticles (NPs) with peptides possessing special affinity for low-density lipoprotein receptor (LDLR), overcoming the limitations of the current chemotherapeutics, to transport drug from blood to brain, and then target glioma cells. Employing novel biodegradable block co-polymers (P and 2P), PTX loaded and peptide-functionalized nanoparticles were prepared by a modified nano-co-precipitation method, carried out in one step only without emulsifier, allowing to obtain spherical nanometric (<200 nm), monodisperse (PDI ∼ 0...
October 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30295090/biodegradable-microsphere-hydrogel-ocular-drug-delivery-system-for-controlled-and-extended-release-of-bioactive-aflibercept-in-vitro
#10
Wenqiang Liu, Bao-Shiang Lee, William F Mieler, Jennifer J Kang-Mieler
PURPOSE: Current standard of care for neovascular eye diseases require repeated intravitreal bolus injections of anti-vascular endothelial growth factors (anti-VEGFs). The purpose of this study was to validate a degradable microsphere-thermoresponsive hydrogel drug delivery system (DDS) capable of releasing bioactive aflibercept in a controlled and extended manner for 6 months. MATERIALS AND METHODS: The DDS was fabricated by suspending aflibercept-loaded poly(lactic-co-glycolic acid) microspheres within a biodegradable poly(ethylene glycol)-co-(l-lactic acid) diacrylate/N-isopropylacrylamide (PEG-PLLA-DA/NIPAAm) thermoresponsive hydrogel...
October 7, 2018: Current Eye Research
https://www.readbyqxmd.com/read/30248847/effect-of-hydrolyzed-protein-based-mulching-coatings-on-the-soil-properties-and-productivity-in-a-tunnel-greenhouse-crop-system
#11
Luciana Sartore, Evelia Schettini, Laura de Palma, Gennaro Brunetti, Claudio Cocozza, Giuliano Vox
Polymeric protein-based biocomposites were used in this work as water dispersions to generate, in situ, biobased mulching coatings by spray technique, as alternative to low density polyethylene films for soil mulching. At the end of their lifetime, these biodegradable coatings degrade in soil thank to the microbial community that mineralizes them. Protein hydrolysates (PH) were derived from waste products of the leather industry, while poly(ethylene glycol) diglycidyl ether (PEG) and epoxidized soybean oil (ESO) were used to make the biodegradable spray coatings...
December 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30226512/phosphonium-hydrogels-for-controlled-release-of-ionic-cargo
#12
Tristan D Harrison, Paul J Ragogna, Elizabeth R Gillies
We describe the synthesis of three different phosphonium salts and their reaction with poly(ethylene glycol) dimethacrylate to create cationic hydrogels. The hydrogels were loaded with an anionic dye and an anionic anti-inflammatory drug through ionic interactions and compared with an analogous ammonium gel. The release rates of these anions depended on their structure and pKa values, as well as the pH and ionic strength of the release medium.
October 2, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/30184758/synthesis-and-characterization-of-paclitaxel-imprinted-microparticles-for-controlled-release-of-an-anticancer-drug
#13
Jianwei Bai, Yunan Zhang, Longqi Chen, Huijun Yan, Chunhong Zhang, Lijia Liu, Xiaodong Xu
In this study, novel molecularly imprinted polymer (MIP) microparticles containing methacryl polyhedral oligomeric silsesquioxane (M-POSS) were synthesized through the RAFT precipitation polymerization (RAFTPP) method using paclitaxel (PTX) as the templates. During the course of this investigation, methacrylic acid (MAA) was used as the functional monomer, while ethylene glycol dimethacrylate (EGDMA) was utilized as a cross-linker. The effects of different molar ratios of M-POSS on the microparticles were characterized...
November 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30179485/microfluidic-processing-approach-to-controlling-drug-delivery-properties-of-curcumin-loaded-block-copolymer-nanoparticles
#14
Ruyao Chen, Jeremy E Wulff, Matthew G Moffitt
We apply gas-liquid microfluidic reactors containing flow-variable, high-shear "hot spots" to produce curcumin-loaded polymer nanoparticles (CUR-PNPs) comprised of poly(caprolactone)- block-poly(ethylene oxide) (PCL- b-PEO) block copolymers at various flow rates and CUR loading ratios. CUR-PNPs prepared using the conventional nanoprecipitation method (bulk method) showed decreased encapsulation efficiency and increased drug precipitation as the loading ratio increased. However, CUR-PNPs prepared by microfluidic manufacturing showed both increased encapsulation efficiency and increased drug loading as either the flow rate or the loading ratio increased...
October 1, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/30171978/encapsulation-of-thermo-responsive-gel-in-ph-sensitive-polymersomes-as-dual-responsive-smart-carriers-for-controlled-release-of-doxorubicin
#15
Fatemeh Oroojalian, Maryam Babaei, Seyed Mohammad Taghdisi, Khalil Abnous, Mohammad Ramezani, Mona Alibolandi
In the current study, thermoresponsive poly(N-isopropylacrylamide)-doxorubicin (PNIPAM-DOX) hydrogel was synthesized and loaded into pH-responsive poly ethylene glycol)-2,4,6- trimethoxy benzylidene pentaerythritol carbonate (PEG-PTMBPEC) polymersomes in order to fabricate a smart thermo-pH stimuli responsive drug delivery system. Thermo-pH responsive polymersomal formulation of DOX revealed average size of 170 ± 11.2 nm. The prepared system was loaded with PNIPAM-DOX conjugate with encapsulation efficiency of 30...
October 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30152718/therapeutic-effect-of-controlled-release-of-dual-growth-factor-using-heparin-pluronic-hydrogel-gelatin-poly-ethylene-glycol-tyramine-hydrogel-system-in-a-rat-model-of-cavernous-nerve-injury
#16
Ae Ryang Jung, Yong Hyun Park, Seung Hwan Jeon, Ga Eun Kim, Mee Young Kim, Joo Young Son, U-Syn Ha, Sung-Hoo Hong, Sae Woong Kim, Ki Dong Park, Ji Youl Lee
The number of cases of erectile dysfunction (ED) caused after radical prostatectomy (RP) prostate cancer treatment is increasing steadily. Although various studies have been conducted for treatment of post-RP ED, there is still a need for more effective methods. A dual growth factor incorporated heparin-pluronic/gelatin-poly(ethylene glycol)-tyramine (HP/GPT) hydrogel, which consists of a basic fibroblast growth factor (bFGF)-loaded HP hydrogel and nerve growth factor (NGF)-loaded GPT hydrogel, can control dose and rate of growth factor release...
October 29, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/30145339/influence-of-polymer-composition-and-drug-loading-procedure-on-dual-drug-release-from-plga-peg-electrospun-fibers
#17
Jing Wang, Maike Windbergs
Poly(lactide-co-glycolide) (PLGA) has been widely investigated for fabricating electrospun fibers due to their biocompatibility, paired with the capacity for encapsulating different drugs. However, such scaffolds shrink and distort upon contact with biological media, which is undesired for local drug application. To address this issue, we fabricated composite fiber scaffolds with the combination of PLGA and poly(ethylene glycol) (PEG). Scaffold shrinkage could successfully be overcome, however, the release kinetics of the encapsulated drug was strongly dependent on the amount of PEG...
November 1, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30109940/fourth-generation-antibiotic-gatifloxacin-encapsulated-by-microemulsions-structural-and-probing-dynamics
#18
Muhammad Faizan Nazar, Muhammad Yasir Siddique, Muhammad Atif Saleem, Muddassar Zafar, Faisal Nawaz, Muhammad Ashfaq, Asad Muhammad Khan, Hafiz Muhammad Abd Ur Rahman, Muhammad Bilal Tahir, Azwan Mat Lazim
To overcome the increased disease rate, utilization of the versatile broad spectrum antibiotic drugs in controlled drug-delivery systems has been a challenging and complex consignment. However, with the development of microemulsion (μE)-based formulations, drugs can be effectively encapsulated and transferred to the target source. Herein, two biocompatible oil-in-water (o/w) μE formulations comprising clove oil/Tween 20/ethylene glycol/water (formulation A) and clove oil/Tween 20/1-butanol/water (formulation B) were developed for encapsulating the gatifloxacin (GTF), a fourth-generation antibiotic...
September 11, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/30078011/pharmacological-signatures-of-the-exenatide-nanoparticles-complex-against-myocardial-ischemia-reperfusion-injury
#19
Yi Zhang, Ping Qian, Hong Zhou, Ruilin Shen, Bo Hu, Yajun Shen, Xiaofang Zhang, Xiaohua Shen, Guangtao Xu, Limin Jin
BACKGROUND/AIMS: Myocardial ischemia/reperfusion (I/R) injury (MI/RI) is a critical cause of death in patients with heart disease. However, the pharmaco-therapeutical outcome for MI/RI remains unsatisfactory. Innovative approaches for enhancing drug sensitivity and recovering myocardial function in MI/RI treatment are urgently needed. The purpose of this study was to evaluate the protective effects of exenatide-loaded poly(L-lysine)-poly(ethylene glycol)-poly(L-lysine) (PLL-PEG-PLL) nanoparticles (NPs) against MI/RI...
2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/30077736/degradable-poly-ethylene-glycol-peg-based-hydrogels-for-spatiotemporal-control-of-sirna-nanoparticle-delivery
#20
Yuchen Wang, Sue Zhang, Danielle S W Benoit
Despite great therapeutic potential and development of a repertoire of delivery approaches addressing degradation and cellular uptake limitations, small interfering RNA (siRNA) exhibits poorly controlled tissue-specific localization. To overcome this hurdle, siRNA was complexed to nanoparticles (siRNA/NP) embedded within poly(ethylene glycol)-poly(lactic acid)-dimethacrylate (PEG-PLA-DM) hydrogels with the hypothesis that hydrolytic degradation of ester bonds within the PLA crosslinks would provide tunable, sustained siRNA/NP release...
October 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
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