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https://www.readbyqxmd.com/read/30321641/peptide-functionalized-and-high-drug-loaded-novel-nanoparticles-as-dual-targeting-drug-delivery-system-for-modulated-and-controlled-release-of-paclitaxel-to-brain-glioma
#1
Primiano Pio Di Mauro
A dual-targeting drug delivery system for paclitaxel (PTX) was developed by functionalizing novel polyester-based nanoparticles (NPs) with peptides possessing special affinity for low-density lipoprotein receptor (LDLR), overcoming the limitations of the current chemotherapeutics, to transport drug from blood to brain, and then target glioma cells. Employing novel biodegradable block co-polymers (P and 2P), PTX loaded and peptide-functionalized nanoparticles were prepared by a modified nano-co-precipitation method, carried out in one step only without emulsifier, allowing to obtain spherical nanometric (<200 nm), monodisperse (PDI∼0...
October 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30295090/biodegradable-microsphere-hydrogel-ocular-drug-delivery-system-for-controlled-and-extended-release-of-bioactive-aflibercept-in-vitro
#2
Wenqiang Liu, Bao-Shiang Lee, William F Mieler, Jennifer J Kang-Mieler
PURPOSE: Current standard of care for neovascular eye diseases require repeated intravitreal bolus injections of anti-vascular endothelial growth factors (anti-VEGFs). The purpose of this study was to validate a degradable microsphere-thermoresponsive hydrogel drug delivery system (DDS) capable of releasing bioactive aflibercept in a controlled and extended manner for 6 months. MATERIALS AND METHODS: The DDS was fabricated by suspending aflibercept-loaded poly(lactic-co-glycolic acid) microspheres within a biodegradable poly(ethylene glycol)-co-(l-lactic acid) diacrylate/N-isopropylacrylamide (PEG-PLLA-DA/NIPAAm) thermoresponsive hydrogel...
October 7, 2018: Current Eye Research
https://www.readbyqxmd.com/read/30248847/effect-of-hydrolyzed-protein-based-mulching-coatings-on-the-soil-properties-and-productivity-in-a-tunnel-greenhouse-crop-system
#3
Luciana Sartore, Evelia Schettini, Laura de Palma, Gennaro Brunetti, Claudio Cocozza, Giuliano Vox
Polymeric protein-based biocomposites were used in this work as water dispersions to generate, in situ, biobased mulching coatings by spray technique, as alternative to low density polyethylene films for soil mulching. At the end of their lifetime, these biodegradable coatings degrade in soil thank to the microbial community that mineralizes them. Protein hydrolysates (PH) were derived from waste products of the leather industry, while poly(ethylene glycol) diglycidyl ether (PEG) and epoxidized soybean oil (ESO) were used to make the biodegradable spray coatings...
December 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30226512/phosphonium-hydrogels-for-controlled-release-of-ionic-cargo
#4
Tristan D Harrison, Paul J Ragogna, Elizabeth R Gillies
We describe the synthesis of three different phosphonium salts and their reaction with poly(ethylene glycol) dimethacrylate to create cationic hydrogels. The hydrogels were loaded with an anionic dye and an anionic anti-inflammatory drug through ionic interactions and compared with an analogous ammonium gel. The release rates of these anions depended on their structure and pKa values, as well as the pH and ionic strength of the release medium.
October 2, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/30184758/synthesis-and-characterization-of-paclitaxel-imprinted-microparticles-for-controlled-release-of-an-anticancer-drug
#5
Jianwei Bai, Yunan Zhang, Longqi Chen, Huijun Yan, Chunhong Zhang, Lijia Liu, Xiaodong Xu
In this study, novel molecularly imprinted polymer (MIP) microparticles containing methacryl polyhedral oligomeric silsesquioxane (M-POSS) were synthesized through the RAFT precipitation polymerization (RAFTPP) method using paclitaxel (PTX) as the templates. During the course of this investigation, methacrylic acid (MAA) was used as the functional monomer, while ethylene glycol dimethacrylate (EGDMA) was utilized as a cross-linker. The effects of different molar ratios of M-POSS on the microparticles were characterized...
November 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30179485/microfluidic-processing-approach-to-controlling-drug-delivery-properties-of-curcumin-loaded-block-copolymer-nanoparticles
#6
Ruyao Chen, Jeremy E Wulff, Matthew G Moffitt
We apply gas-liquid microfluidic reactors containing flow-variable, high-shear "hot spots" to produce curcumin-loaded polymer nanoparticles (CUR-PNPs) comprised of poly(caprolactone)- block-poly(ethylene oxide) (PCL- b-PEO) block copolymers at various flow rates and CUR loading ratios. CUR-PNPs prepared using the conventional nanoprecipitation method (bulk method) showed decreased encapsulation efficiency and increased drug precipitation as the loading ratio increased. However, CUR-PNPs prepared by microfluidic manufacturing showed both increased encapsulation efficiency and increased drug loading as either the flow rate or the loading ratio increased...
October 1, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/30171978/encapsulation-of-thermo-responsive-gel-in-ph-sensitive-polymersomes-as-dual-responsive-smart-carriers-for-controlled-release-of-doxorubicin
#7
Fatemeh Oroojalian, Maryam Babaei, Seyed Mohammad Taghdisi, Khalil Abnous, Mohammad Ramezani, Mona Alibolandi
In the current study, thermoresponsive poly(N-isopropylacrylamide)-doxorubicin (PNIPAM-DOX) hydrogel was synthesized and loaded into pH-responsive poly ethylene glycol)-2,4,6- trimethoxy benzylidene pentaerythritol carbonate (PEG-PTMBPEC) polymersomes in order to fabricate a smart thermo-pH stimuli responsive drug delivery system. Thermo-pH responsive polymersomal formulation of DOX revealed average size of 170 ± 11.2 nm. The prepared system was loaded with PNIPAM-DOX conjugate with encapsulation efficiency of 30...
October 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30152718/dual-growth-factor-incorporated-heparin-pluronic-hydrogel-gelatin-poly-tyramine-hydrogel
#8
Ae Ryang Jung, Yong Hyun Park, Seung Hwan Jeon, Ga Eun Kim, Mee Young Kim, Joo Young Son, U-Syn Ha, Sung Hoo Hong, Sae Woong Kim, Ki Dong Park, Ji Youl Lee
The number of cases of erectile dysfunction (ED) caused after radical prostatectomy (RP) prostate cancer (PCa) treatment is increasing steadily. Although various studies have been conducted for treatment of post-RP ED, there is still a need for more effective methods. A dual growth factor incorporated heparin-pluronic/gelatin-poly(ethylene glycol)-tyramine (HP/GPT) hydrogel, which consists of a bFGF-loaded HP hydrogel and NGF-loaded GPT hydrogel, can control dose and rate of growth factor release. In this study, we demonstrated that dual growth factor incorporated HP/GPT hydrogel could further improve erectile function in a rat model of bilateral cavernous nerve injury (BCNI)...
August 28, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/30145339/influence-of-polymer-composition-and-drug-loading-procedure-on-dual-drug-release-from-plga-peg-electrospun-fibers
#9
Jing Wang, Maike Windbergs
Poly(lactide-co-glycolide) (PLGA) has been widely investigated for fabricating electrospun fibers due to their biocompatibility, paired with the capacity for encapsulating different drugs. However, such scaffolds shrink and distort upon contact with biological media, which is undesired for local drug application. To address this issue, we fabricated composite fiber scaffolds with the combination of PLGA and poly(ethylene glycol) (PEG). Scaffold shrinkage could successfully be overcome, however, the release kinetics of the encapsulated drug was strongly dependent on the amount of PEG...
November 1, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30109940/fourth-generation-antibiotic-gatifloxacin-encapsulated-by-microemulsions-structural-and-probing-dynamics
#10
Muhammad Faizan Nazar, Muhammad Yasir Siddique, Muhammad Atif Saleem, Muddassar Zafar, Faisal Nawaz, Muhammad Ashfaq, Asad Muhammad Khan, Hafiz Muhammad Abd Ur Rahman, Muhammad Bilal Tahir, Azwan Mat Lazim
To overcome the increased disease rate, utilization of the versatile broad spectrum antibiotic drugs in controlled drug-delivery systems has been a challenging and complex consignment. However, with the development of microemulsion (μE)-based formulations, drugs can be effectively encapsulated and transferred to the target source. Herein, two biocompatible oil-in-water (o/w) μE formulations comprising clove oil/Tween 20/ethylene glycol/water (formulation A) and clove oil/Tween 20/1-butanol/water (formulation B) were developed for encapsulating the gatifloxacin (GTF), a fourth-generation antibiotic...
September 11, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/30078011/pharmacological-signatures-of-the-exenatide-nanoparticles-complex-against-myocardial-ischemia-reperfusion-injury
#11
Yi Zhang, Ping Qian, Hong Zhou, Ruilin Shen, Bo Hu, Yajun Shen, Xiaofang Zhang, Xiaohua Shen, Guangtao Xu, Limin Jin
BACKGROUND/AIMS: Myocardial ischemia/reperfusion (I/R) injury (MI/RI) is a critical cause of death in patients with heart disease. However, the pharmaco-therapeutical outcome for MI/RI remains unsatisfactory. Innovative approaches for enhancing drug sensitivity and recovering myocardial function in MI/RI treatment are urgently needed. The purpose of this study was to evaluate the protective effects of exenatide-loaded poly(L-lysine)-poly(ethylene glycol)-poly(L-lysine) (PLL-PEG-PLL) nanoparticles (NPs) against MI/RI...
2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/30077736/degradable-poly-ethylene-glycol-peg-based-hydrogels-for-spatiotemporal-control-of-sirna-nanoparticle-delivery
#12
Yuchen Wang, Sue Zhang, Danielle S W Benoit
Despite great therapeutic potential and development of a repertoire of delivery approaches addressing degradation and cellular uptake limitations, small interfering RNA (siRNA) exhibits poorly controlled tissue-specific localization. To overcome this hurdle, siRNA was complexed to nanoparticles (siRNA/NP) embedded within poly(ethylene glycol)-poly(lactic acid)-dimethacrylate (PEG-PLA-DM) hydrogels with the hypothesis that hydrolytic degradation of ester bonds within the PLA crosslinks would provide tunable, sustained siRNA/NP release...
October 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30073801/a-ph-mediated-electronic-wound-dressing-for-controlled-drug-delivery
#13
Gita Kiaee, Pooria Mostafalu, Mohamadmahdi Samandari, Sameer Sonkusale
Topical administration of drugs in a timely manner according to the physiological need at the wound site can enhance the healing rate of chronic wounds. Herein, an electronic wound dressing that enables active topical drug delivery in response to electrically induced pH change is demonstrated for potential treatment of chronic wounds. In this platform, the pH of the dressing is controlled using an electrical field. This allows precise electrical control over the temporal profile of pH-mediated drug release...
September 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30067755/production-of-methane-and-ethylene-from-plastic-in-the-environment
#14
Sarah-Jeanne Royer, Sara Ferrón, Samuel T Wilson, David M Karl
Mass production of plastics started nearly 70 years ago and the production rate is expected to double over the next two decades. While serving many applications because of their durability, stability and low cost, plastics have deleterious effects on the environment. Plastic is known to release a variety of chemicals during degradation, which has a negative impact on biota. Here, we show that the most commonly used plastics produce two greenhouse gases, methane and ethylene, when exposed to ambient solar radiation...
2018: PloS One
https://www.readbyqxmd.com/read/30032623/reductively-responsive-gel-capsules-prepared-using-a-water-soluble-zwitterionic-block-copolymer-emulsifier
#15
Hiroshi Nakaura, Akifumi Kawamura, Takashi Miyata
Utilizing the unique solubility of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), which is soluble in only water and alcohol, we synthesized a water-soluble block copolymer emulsifier composed of a hydrophilic PMPC block and an amphiphilic poly[oligo(ethylene glycol) methacrylate] (POEGMA) block via reversible addition-fragmentation chain transfer (RAFT) polymerization. Water-in-oil (W/O) emulsions were successfully formed in the presence of the resulting PMPC- b-POEGMA, which acted as a stabilizer of water droplets in a chloroform continuous phase because the PMPC and POEGMA blocks were distributed to the water and chloroform phases, respectively...
August 2, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/30023746/synthesis-self-assembly-and-drug-delivery-characteristics-of-poly-methyl-caprolactone-co-caprolactone-b-poly-ethylene-oxide-copolymers-with-variable-compositions-of-hydrophobic-blocks-combining-chemistry-and-microfluidic-processing-for-polymeric-nanomedicines
#16
Zheqi Xu, Changhai Lu, Carly Lindenberger, Yimeng Cao, Jeremy E Wulff, Matthew G Moffitt
The synthesis, characterization, and self-assembly of a series of biocompatible poly(methyl caprolactone- co -caprolactone)- b -poly(ethylene oxide) amphiphilic block copolymers with variable MCL contents in the hydrophobic block are described. Self-assembly gives rise to polymeric nanoparticles (PNPs) with hydrophobic cores that decrease in crystallinity as the MCL content increases, and their morphologies and sizes show nonmonotonic trends with MCL content. PNPs loaded with the anticancer drug paclitaxel (PAX) give rise to in vitro PAX release rates and MCF-7 GI50 (50% growth inhibition concentration) values that decrease as the MCL content increases...
August 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/30013340/codelivery-of-doxorubicin-and-jip1-sirna-with-novel-epha2-targeted-pegylated-cationic-nanoliposomes-to-overcome-osteosarcoma-multidrug-resistance
#17
Fateme Haghiralsadat, Ghasem Amoabediny, Samira Naderinezhad, Behrouz Zandieh-Doulabi, Tymour Forouzanfar, Marco N Helder
Purpose: Osteosarcoma (OS) mostly affects children and young adults, and has only a 20%-30% 5-year survival rate when metastasized. We aimed to create dual-targeted (extracellular against EphA2 and intracellular against JNK-interacting protein 1 [JIP1]), doxorubicin (DOX)-loaded liposomes to treat OS metastatic disease. Materials and methods: Cationic liposomes contained N -[1-(2,3-dioleoyloxy)propyl]- N , N , N -trimethylammonium methyl-sulfate (DOTAP), cholesterol, 1,2-dipalmitoyl- sn -glycero-3-phosphocholine (DPPC), and distearoyl-phosphatidylethanolamine-methyl-poly(ethylene glycol) (DSPE-mPEG) conjugate...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30011366/laser-induced-co-2-generation-from-gold-nanorod-containing-poly-propylene-carbonate-based-block-polymer-micelles-for-ultrasound-contrast-enhancement
#18
Jaewon Lee, Sung Duk Jo, Haejun Chung, Wooram Um, Rohith Chandrasekar, Yun Hwa Choi, Vladimir M Shalaev, You-Yeon Won
Poly(propylene carbonate) (PPC) decomposes at high temperature to release CO2 . This CO2 -generation temperature of PPC can be reduced down to less than 80 °C with the aid of a photoacid generator (PAG). In the present work, we demonstrate that using an additional helper component, surface plasmonic gold nanorods (GNRs), the PPC degradation reaction can also be initiated by infrared (IR) irradiation. For this purpose, a PPC-containing nanoparticle formulation was developed in which PPC-based amphiphilic block copolymers (BCPs), poly(poly(ethylene glycol) methacrylate- b-propylene carbonate- b-poly(ethylene glycol) methacrylate) (PPEGMA-PPC-PPEGMA), were self-assembled with GNRs and PAG molecules via solvent exchange...
August 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30005160/bioinspired-ph-and-temperature-responsive-injectable-adhesive-hydrogels-with-polyplexes-promotes-skin-wound-healing
#19
Thai Minh Duy Le, Huu Thuy Trang Duong, Thavasyappan Thambi, V H Giang Phan, Ji Hoon Jeong, Doo Sung Lee
Despite great potential, the delivery of genetic materials into cells or tissues of interest remains challenging owing to their susceptibility to nuclease degradation, lack of permeability to the cell membrane, and short in vivo half-life, which severely restrict their widespread use in therapeutics. To surmount these shortcomings, we developed a bioinspired in situ-forming pH- and temperature-sensitive injectable hydrogel depot that could control the delivery of DNA-bearing polyplexes for versatile biomedical applications...
August 13, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29966906/multi-functional-nanocarriers-based-on-iron-oxide-nanoparticles-conjugated-with-doxorubicin-poly-ethylene-glycol-and-folic-acid-as-theranostics-for-cancer-therapy
#20
S Rajkumar, M Prabaharan
Multi-functional nanocarriers based on iron oxide nanoparticles (IONPs) conjugated with doxorubicin (DOX), poly(ethylene glycol) (PEG), and folic acid (FA) (IO-MMA-DOX-PEG-OCH3 /FA) were prepared as theranostics for cancer therapy. Using mono-methyl adipate (MMA) as a linker, the anticancer drug, DOX, was conjugated on the surface of IONPs by acid-cleavable hydrazone bond. The average size of the IO-MMA-DOX-PEG-OCH3 /FA nanocarriers was determined as 14 and 40 nm by TEM and DLS, respectively. The saturation magnetization (Ms) and transverse relaxivity (r2 ) value of IO-MMA-DOX-PEG-OCH3 /FA nanocarriers were calculated as 28...
October 1, 2018: Colloids and Surfaces. B, Biointerfaces
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