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https://www.readbyqxmd.com/read/30109940/fourth-generation-antibiotic-gatifloxacin-encapsulated-by-microemulsions-structural-and-probing-dynamics
#1
Muhammad Faizan Nazar, Muhammad Yasir Siddique, Muhammad Atif Saleem, Muddassar Zafar, Faisal Nawaz, Muhammad Ashfaq, Asad Muhammad Khan, Hafiz Muhammad Abd Ur Rahman, Muhammad Tahir, Azwan Mat Lazim
To overcome the increased disease rate, utilizing of the versatile broad spectrum antibiotic drugs in controlled drug delivery systems has been a challenging and complex consignment. However, with the development of microemulsion (μE) based formulations, drugs can be effectively encapsulated and transferred to the target source. Herein, two biocompatible oil-in-water (o/w) μE formulations comprising clove oil/ tween 20/ ethylene glycol/ water (Formulation-A) and clove oil/ tween 20/ 1-butanol/ water (Formulation-B) were developed for encapsulating the gatifloxacin (GTF), a fourth-generation antibiotic...
August 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/30078011/pharmacological-signatures-of-the-exenatide-nanoparticles-complex-against-myocardial-ischemia-reperfusion-injury
#2
Yi Zhang, Ping Qian, Hong Zhou, Ruilin Shen, Bo Hu, Yajun Shen, Xiaofang Zhang, Xiaohua Shen, Guangtao Xu, Limin Jin
BACKGROUND/AIMS: Myocardial ischemia/reperfusion (I/R) injury (MI/RI) is a critical cause of death in patients with heart disease. However, the pharmaco-therapeutical outcome for MI/RI remains unsatisfactory. Innovative approaches for enhancing drug sensitivity and recovering myocardial function in MI/RI treatment are urgently needed. The purpose of this study was to evaluate the protective effects of exenatide-loaded poly(L-lysine)-poly(ethylene glycol)-poly(L-lysine) (PLL-PEG-PLL) nanoparticles (NPs) against MI/RI...
August 3, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/30077736/degradable-poly-ethylene-glycol-peg-based-hydrogels-for-spatiotemporal-control-of-sirna-nanoparticle-delivery
#3
Yuchen Wang, Sue Zhang, Danielle S W Benoit
Despite great therapeutic potential and development of a repertoire of delivery approaches addressing degradation and cellular uptake limitations, small interfering RNA (siRNA) exhibits poorly controlled tissue-specific localization. To overcome this hurdle, siRNA was complexed to nanoparticles (siRNA/NP) embedded within poly(ethylene glycol)-poly(lactic acid)-dimethacrylate (PEG-PLA-DM) hydrogels with the hypothesis that hydrolytic degradation of ester bonds within the PLA crosslinks would provide tunable, sustained siRNA/NP release...
August 2, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30073801/a-ph-mediated-electronic-wound-dressing-for-controlled-drug-delivery
#4
Gita Kiaee, Pooria Mostafalu, Mohamadmahdi Samandari, Sameer Sonkusale
Topical administration of drugs in a timely manner according to the physiological need at the wound site can enhance the healing rate of chronic wounds. Herein, an electronic wound dressing that enables active topical drug delivery in response to electrically induced pH change is demonstrated for potential treatment of chronic wounds. In this platform, the pH of the dressing is controlled using an electrical field. This allows precise electrical control over the temporal profile of pH-mediated drug release...
August 2, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30067755/production-of-methane-and-ethylene-from-plastic-in-the-environment
#5
Sarah-Jeanne Royer, Sara Ferrón, Samuel T Wilson, David M Karl
Mass production of plastics started nearly 70 years ago and the production rate is expected to double over the next two decades. While serving many applications because of their durability, stability and low cost, plastics have deleterious effects on the environment. Plastic is known to release a variety of chemicals during degradation, which has a negative impact on biota. Here, we show that the most commonly used plastics produce two greenhouse gases, methane and ethylene, when exposed to ambient solar radiation...
2018: PloS One
https://www.readbyqxmd.com/read/30032623/reductively-responsive-gel-capsules-prepared-using-a-water-soluble-zwitterionic-block-copolymer-emulsifier
#6
Hiroshi Nakaura, Akifumi Kawamura, Takashi Miyata
Utilizing the unique solubility of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), which is soluble in only water and alcohol, we synthesized a water-soluble block copolymer emulsifier composed of a hydrophilic PMPC block and an amphiphilic poly[oligo(ethylene glycol) methacrylate] (POEGMA) block via reversible addition-fragmentation chain transfer (RAFT) polymerization. Water-in-oil (W/O) emulsions were successfully formed in the presence of the resulting PMPC- b-POEGMA, which acted as a stabilizer of water droplets in a chloroform continuous phase because the PMPC and POEGMA blocks were distributed to the water and chloroform phases, respectively...
August 2, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/30023746/synthesis-self-assembly-and-drug-delivery-characteristics-of-poly-methyl-caprolactone-co-caprolactone-b-poly-ethylene-oxide-copolymers-with-variable-compositions-of-hydrophobic-blocks-combining-chemistry-and-microfluidic-processing-for-polymeric-nanomedicines
#7
Zheqi Xu, Changhai Lu, Carly Lindenberger, Yimeng Cao, Jeremy E Wulff, Matthew G Moffitt
The synthesis, characterization, and self-assembly of a series of biocompatible poly(methyl caprolactone- co -caprolactone)- b -poly(ethylene oxide) amphiphilic block copolymers with variable MCL contents in the hydrophobic block are described. Self-assembly gives rise to polymeric nanoparticles (PNPs) with hydrophobic cores that decrease in crystallinity as the MCL content increases, and their morphologies and sizes show nonmonotonic trends with MCL content. PNPs loaded with the anticancer drug paclitaxel (PAX) give rise to in vitro PAX release rates and MCF-7 GI50 (50% growth inhibition concentration) values that decrease as the MCL content increases...
August 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/30013340/codelivery-of-doxorubicin-and-jip1-sirna-with-novel-epha2-targeted-pegylated-cationic-nanoliposomes-to-overcome-osteosarcoma-multidrug-resistance
#8
Fateme Haghiralsadat, Ghasem Amoabediny, Samira Naderinezhad, Behrouz Zandieh-Doulabi, Tymour Forouzanfar, Marco N Helder
Purpose: Osteosarcoma (OS) mostly affects children and young adults, and has only a 20%-30% 5-year survival rate when metastasized. We aimed to create dual-targeted (extracellular against EphA2 and intracellular against JNK-interacting protein 1 [JIP1]), doxorubicin (DOX)-loaded liposomes to treat OS metastatic disease. Materials and methods: Cationic liposomes contained N -[1-(2,3-dioleoyloxy)propyl]- N , N , N -trimethylammonium methyl-sulfate (DOTAP), cholesterol, 1,2-dipalmitoyl- sn -glycero-3-phosphocholine (DPPC), and distearoyl-phosphatidylethanolamine-methyl-poly(ethylene glycol) (DSPE-mPEG) conjugate...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30011366/laser-induced-co-2-generation-from-gold-nanorod-containing-poly-propylene-carbonate-based-block-polymer-micelles-for-ultrasound-contrast-enhancement
#9
Jaewon Lee, Sung Duk Jo, Haejun Chung, Wooram Um, Rohith Chandrasekar, Yun Hwa Choi, Vladimir M Shalaev, You-Yeon Won
Poly(propylene carbonate) (PPC) decomposes at high temperature to release CO2 . This CO2 -generation temperature of PPC can be reduced down to less than 80 °C with the aid of a photoacid generator (PAG). In the present work, we demonstrate that using an additional helper component, surface plasmonic gold nanorods (GNRs), the PPC degradation reaction can also be initiated by infrared (IR) irradiation. For this purpose, a PPC-containing nanoparticle formulation was developed in which PPC-based amphiphilic block copolymers (BCPs), poly(poly(ethylene glycol) methacrylate- b-propylene carbonate- b-poly(ethylene glycol) methacrylate) (PPEGMA-PPC-PPEGMA), were self-assembled with GNRs and PAG molecules via solvent exchange...
August 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30005160/bioinspired-ph-and-temperature-responsive-injectable-adhesive-hydrogels-with-polyplexes-promotes-skin-wound-healing
#10
Thai Minh Duy Le, Huu Thuy Trang Duong, Thavasyappan Thambi, V H Giang Phan, Ji Hoon Jeong, Doo Sung Lee
Despite great potential, the delivery of genetic materials into cells or tissues of interest remains challenging owing to their susceptibility to nuclease degradation, lack of permeability to the cell membrane, and short in vivo half-life, which severely restrict their widespread use in therapeutics. To surmount these shortcomings, we developed a bioinspired in situ-forming pH- and temperature-sensitive injectable hydrogel depot that could control the delivery of DNA-bearing polyplexes for versatile biomedical applications...
July 27, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29966906/multi-functional-nanocarriers-based-on-iron-oxide-nanoparticles-conjugated-with-doxorubicin-poly-ethylene-glycol-and-folic-acid-as-theranostics-for-cancer-therapy
#11
S Rajkumar, M Prabaharan
Multi-functional nanocarriers based on iron oxide nanoparticles (IONPs) conjugated with doxorubicin (DOX), poly(ethylene glycol) (PEG), and folic acid (FA) (IO-MMA-DOX-PEG-OCH3 /FA) were prepared as theranostics for cancer therapy. Using mono-methyl adipate (MMA) as a linker, the anticancer drug, DOX, was conjugated on the surface of IONPs by acid-cleavable hydrazone bond. The average size of the IO-MMA-DOX-PEG-OCH3 /FA nanocarriers was determined as 14 and 40 nm by TEM and DLS, respectively. The saturation magnetization (Ms) and transverse relaxivity (r2 ) value of IO-MMA-DOX-PEG-OCH3 /FA nanocarriers were calculated as 28...
June 26, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29938314/role-of-poly-ethylene-oxide-in-copper-containing-composite-used-for-intrauterine-contraceptive-devices
#12
Huan Wang, Ying Tang, Xianping Xia, Yi Lu
Copper-containing composite is a cupric ions release system to prepare a novel copper intrauterine devices (Cu-IUDs), its biocompatibility and weight of the prepared composite Cu-IUDs are directly relevant to its such side-effects as pain and bleeding. To improve its biocompatibility and reduce its weight of such a composite Cu-IUDs, a copper-containing composite based on polymer alloy of poly(ethylene oxide) (PEO) and low-density polyethylene (LDPE) is developed. Here the role of its PEO in this novel cupric ions release system is reported...
June 25, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29936153/biodegradable-peg-poly-%C3%AF-pentadecalactone-co-p-dioxanone-nanoparticles-for-enhanced-and-sustained-drug-delivery-to-treat-brain-tumors
#13
Evan M Chen, Amanda R Quijano, Young-Eun Seo, Christopher Jackson, Alexander D Josowitz, Seth Noorbakhsh, Andrea Merlettini, Ranjini K Sundaram, Maria Letizia Focarete, Zhaozhong Jiang, Ranjit S Bindra, W Mark Saltzman
Intracranial delivery of therapeutic agents is limited by penetration beyond the blood-brain barrier (BBB) and rapid metabolism of the drugs that are delivered. Convection-enhanced delivery (CED) of drug-loaded nanoparticles (NPs) provides for local administration, control of distribution, and sustained drug release. While some investigators have shown that repeated CED procedures are possible, longer periods of sustained release could eliminate the need for repeated infusions, which would enhance safety and translatability of the approach...
September 2018: Biomaterials
https://www.readbyqxmd.com/read/29859042/parallel-online-determination-of-ethylene-release-rate-by-shaken-parsley-cell-cultures-using-a-modified-ramos-device
#14
Andreas Schulte, Jana Viola Schilling, Jannis Nolten, Anna Korona, Hannes Krömke, Jan-Bernd Vennekötter, Britta Schillheim, Matthias Wessling, Uwe Conrath, Jochen Büchs
BACKGROUND: Ethylene is an important plant hormone that controls many physiological processes in plants. Conventional methods for detecting ethylene include gas chromatographs or optical mid-infrared sensors, which are expensive and, in the case of gas chromatographs, are hardly suitable for automated parallelized online measurement. Electrochemical ethylene sensors are cheap but often suffer from poor resolution, baseline drifting, and target gas oxidation. Thus, measuring ethylene at extremely low levels is challenging...
June 1, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29801860/supramolecular-hydrogels-based-on-poly-ethylene-glycol-poly-lactic-acid-block-copolymer-micelles-and-%C3%AE-cyclodextrin-for-potential-injectable-drug-delivery-system
#15
Abishek Jung Poudel, Feng He, Lixia Huang, Lin Xiao, Guang Yang
A supramolecular hydrogel system was prepared by the host-guest interaction between the α-cyclodextrin (α-CD) and poly (ethylene glycol) (PEG) chains of the poly (ethylene glycol)-block-poly (lactic acid) (PEG-b-PLA) micelles. The formation of inclusion complex (IC) crystals between α-CD and the PEG chains of the micelles was verified by different techniques. Rheological studies indicated that the gelation kinetics and the mechanical strength of the hydrogels could be modulated by the α-CD concentration...
August 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29796552/the-role-of-hydrophobic-hydration-in-the-lcst-behaviour-of-poegma-300-by-all-atom-molecular-dynamics-simulations
#16
Eray Dalgakiran, Hasan Tatlipinar
The solubility and lower critical solution temperature (LCST) behaviour of poly(oligo(ethylene glycol)methyl ether methacrylate) (POEGMA300) in water were comprehensively investigated by all-atom molecular dynamics (MD) simulations for 5-, 20-, 50- and 75-mer homopolymers. According to various structural and dynamic properties, the water-solubility of POEGMA300 below the LCST is mainly provided by hydrophobic hydration around the side chain carbon atoms, which is achieved by cage-like water formations. The LCST phase transition occurs when these cage-like structures are disrupted by increasing the temperature above the LCST...
June 6, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29744441/inhibition-of-hela-cell-growth-by-doxorubicin-loaded-and-tuftsin-conjugated-arginate-peg-microparticles
#17
Tianmu Hu, Anwar Saeed Ahmed Qahtan, Lei Lei, Zhixin Lei, Dapeng Zhao, Hemin Nie
In order to improve the release pattern of chemotherapy drug and reduce the possibility of drug resistance, poly(ethylene glycol amine) (PEG)-modified alginate microparticles (ALG-PEG MPs) were developed then two different mechanisms were employed to load doxorubicin (Dox): 1) forming Dox/ALG-PEG complex by electrostatic attractions between unsaturated functional groups in Dox and ALG-PEG; 2) forming Dox-ALG-PEG complex through EDC-reaction between the amino and carboxyl groups in Dox and ALG, respectively...
March 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29719397/endogenous-ornithine-decarboxylase-polyamine-system-mediated-the-antagonist-role-of-insulin-peg-cmcs-preconditioning-against-heart-ischemia-reperfusion-injury-in-diabetes-mellitus
#18
Fei Tong, Suhuan Liu, Bing Yan, Xuejun Li, Shiwei Ruan, Shuyu Yang
Introduction: Insulin has shown antioxidation and cytoprotective effects to decrease heart ischemia/reperfusion injury (HI/RI) in diabetes mellitus (DM), but the role of insulin/poly(ethylene glycol)-carboxymethyl chitosan (PEG-CMCS) on HI/RI in DM is not known. This research explored whether insulin/PEG-CMCS revealed a protective effect on HI/RI in DM through ornithine decarboxylase (ODC)/polyamine systems. Materials and methods: Diabetes was induced via streptozotocin (STZ) in Sprague Dawley (SD) rats, which suffered from HI via blocking the left circumflex artery for 45 minutes, followed by 2 hours of reperfusion...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29719390/smart-polymeric-nanoparticles-with-ph-responsive-and-peg-detachable-properties-for-co-delivering-paclitaxel-and-survivin-sirna-to-enhance-antitumor-outcomes
#19
Mingji Jin, Guangming Jin, Lin Kang, Liqing Chen, Zhonggao Gao, Wei Huang
Background: The co-delivery of chemotherapeutic agents and small interfering RNA (siRNA) within one cargo can enhance the anticancer outcomes through its synergistic therapeutic effects. Materials and methods: We prepared smart polymeric nanoparticles (NPs) with pH-responsive and poly(ethylene glycol) (PEG)-detachable properties to systemically co-deliver paclitaxel (PTX) and siRNA against survivin gene for lung cancer therapy. The cationic polyethyleneimine-block-polylactic acid (PEI-PLA) was first synthesized and characterized, with good biocompatibility...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29696087/multifunctional-chitosan-magnetic-graphene-quantum-dot-nanocomposites-for-the-release-of-therapeutics-from-detachable-and-non-detachable-biodegradable-microneedle-arrays
#20
Richard Justin, Biqiong Chen
Biodegradable chitosan-magnetic graphene quantum dot (MGQD) nanocomposites were prepared and investigated for the release of small and large molecular weight (MWt) therapeutics from detachable and non-detachable biodegradable microneedle arrays. The presence of MGQDs in chitosan increased the electrical conductivity and biodegradation rate of chitosan while maintaining its mechanical properties. The detachable microneedle arrays were created by including a water-soluble ring of poly(ethylene glycol) (PEG) at the base of the microneedle, which enabled the rapid detachment of the microneedle shaft from the base...
June 6, 2018: Interface Focus
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