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https://www.readbyqxmd.com/read/30109940/fourth-generation-antibiotic-gatifloxacin-encapsulated-by-microemulsions-structural-and-probing-dynamics
#1
Muhammad Faizan Nazar, Muhammad Yasir Siddique, Muhammad Atif Saleem, Muddassar Zafar, Faisal Nawaz, Muhammad Ashfaq, Asad Muhammad Khan, Hafiz Muhammad Abd Ur Rahman, Muhammad Tahir, Azwan Mat Lazim
To overcome the increased disease rate, utilizing of the versatile broad spectrum antibiotic drugs in controlled drug delivery systems has been a challenging and complex consignment. However, with the development of microemulsion (μE) based formulations, drugs can be effectively encapsulated and transferred to the target source. Herein, two biocompatible oil-in-water (o/w) μE formulations comprising clove oil/ tween 20/ ethylene glycol/ water (Formulation-A) and clove oil/ tween 20/ 1-butanol/ water (Formulation-B) were developed for encapsulating the gatifloxacin (GTF), a fourth-generation antibiotic...
August 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/30107882/ectopic-expression-of-fvwrky42-a-wrky-transcription-factor-from-the-diploid-woodland-strawberry-fragaria-vesca-enhances-resistance-to-powdery-mildew-improves-osmotic-stress-resistance-and-increases-abscisic-acid-sensitivity-in-arabidopsis
#2
Wei Wei, Meng-Yuan Cui, Yang Hu, Kuan Gao, Yin-Ge Xie, Ying Jiang, Jia-Yue Feng
WRKY transcription factors play a critical role in biotic and abiotic stress responses in plants, but very few WRKYs have been reported in strawberry plants. Here, a multiple stress-inducible gene, FvWRKY42, was isolated from the wild diploid woodland strawberry (accession Heilongjiang-3). FvWRKY42 expression was induced by treatment with powdery mildew, salt, drought, salicylic acid (SA), methyl jasmonate (MeJA), abscisic acid (ABA), and ethylene. The protein interaction network analysis showed that the FvWRKY42 protein interacts with various stress-related proteins...
October 2018: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/30103165/integrated-process-for-scalable-bioproduction-of-glycolic-acid-from-cell-catalysis-of-ethylene-glycol
#3
Xia Hua, Rou Cao, Xin Zhou, Yong Xu
Glycolic acid (GA) is presently booming as a versatile raw material in the fields of high-grade cosmetics, polymer degradable materials, and drug production. The biocatalysis of ethylene glycol (EG) to GA is promising, with environmentally friendly benefits, while the effective and straight bioproduction of GA qualified for polymer synthesis purity is a challenge. In this study, we combine whole cell catalysis step and acidification-purification step. A compressed oxygen supply in the sealed aerated stirred tank reaction (COS-SSTR) and a weak basic anion-exchange resins were integrated to develop an efficient process of GA bioproduction from EG...
August 7, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/30096996/alginate-poly-amidoamine-injectable-hybrid-hydrogel-for-cell-delivery
#4
S S Patil, K C Nune, Rdk Misra
A covalently cross-linked injectable hybrid hydrogel, namely, alginate/poly(amidoamine) (PAMAM), with the objective of cell delivery was innovatively designed and synthesized using tetra-amino-functional PAMAM dendrimer as the cross-linker. With the increase in percentage of PAMAM cross-linker, the pore size and swelling ratio of hydrogels were in the range of 57 ± 18 μm to 88 ± 25 μm and 110 ± 16 to 157 ± 20, respectively. The study of attachment and proliferation of MC3T3-E1 pre-osteoblasts using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay through indirect and direct contact methods indicated a continuous increase in metabolically active live cells with time, implying non-cytotoxicity of the synthesized hydrogel...
August 2018: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/30096728/chiral-separation-and-determination-of-amino-acid-enantiomers-in-fruit-juice-by-open-tubular-nano-liquid-chromatography
#5
Cemil Aydoğan
A novel chiral porous-layer stationary phase was developed for use in open-tubular nano liquid chromatography. The stationary phase was prepared by an in-situ polymerization of 3-chloro-2-hydroxypropylmethacrylate (HPMA-Cl) and ethylene dimethacrylate (EDMA). The reactive chloro groups at the surface of the porous stationary phase were reacted with β-Cyclodextrin (β-CD). The resulting morphology was characterized by using scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FT-IR)...
August 10, 2018: Chirality
https://www.readbyqxmd.com/read/30092137/oligo-ethylene-glycol-length-effect-of-water-soluble-ru-based-olefin-metathesis-catalysts-on-reactivity-and-removability
#6
Cheoljae Kim, Hoyong Chung
A study of reaction kinetics and removal efficiency of a family of ruthenium (Ru)-based olefin metathesis catalysts containing ethylene-glycol-oligomer-tethered N-heterocyclic carbene (NHC) ligands has been carried out, with a focus on variation of ethylene glycol oligomer length. The length of ethylene glycol oligomer was precisely defined by sequential addition of repeating units. Due to the dual solubility of ethylene glycol oligomer, the produced catalyst was highly soluble in both aqueous and organic solvents (dichloromethane)...
August 9, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/30082767/new-insight-for-surface-chemistries-in-ultra-thin-self-assembled-monolayers-modified-high-voltage-spinel-cathodes
#7
Dae-Wook Kim, Shuhei Uchida, Hiromasa Shiiba, Nobuyuki Zettsu, Katsuya Teshima
The electrochemical properties of the interface between the spinel LiNi0.5 Mn1.5 O4-δ (LNMO4-δ ) cathodes and ethylene carbonate-dimethyl carbonate (EC-DMC) electrolyte containing 1 M of LiPF6 have been investigated to achieve high-voltage durability of LNMO4-δ /graphite full cells. Coating the LNMO4-δ crystal surface by a fluoroalkylsilane self-assembled monolayer with a thickness below 2 nm resulted in a capacity retention of 94% after 100 cycles at a rate of 1 C and suppression of capacity fading for both the cathode and anode of the full cell...
August 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30078011/pharmacological-signatures-of-the-exenatide-nanoparticles-complex-against-myocardial-ischemia-reperfusion-injury
#8
Yi Zhang, Ping Qian, Hong Zhou, Ruilin Shen, Bo Hu, Yajun Shen, Xiaofang Zhang, Xiaohua Shen, Guangtao Xu, Limin Jin
BACKGROUND/AIMS: Myocardial ischemia/reperfusion (I/R) injury (MI/RI) is a critical cause of death in patients with heart disease. However, the pharmaco-therapeutical outcome for MI/RI remains unsatisfactory. Innovative approaches for enhancing drug sensitivity and recovering myocardial function in MI/RI treatment are urgently needed. The purpose of this study was to evaluate the protective effects of exenatide-loaded poly(L-lysine)-poly(ethylene glycol)-poly(L-lysine) (PLL-PEG-PLL) nanoparticles (NPs) against MI/RI...
August 3, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/30077736/degradable-poly-ethylene-glycol-peg-based-hydrogels-for-spatiotemporal-control-of-sirna-nanoparticle-delivery
#9
Yuchen Wang, Sue Zhang, Danielle S W Benoit
Despite great therapeutic potential and development of a repertoire of delivery approaches addressing degradation and cellular uptake limitations, small interfering RNA (siRNA) exhibits poorly controlled tissue-specific localization. To overcome this hurdle, siRNA was complexed to nanoparticles (siRNA/NP) embedded within poly(ethylene glycol)-poly(lactic acid)-dimethacrylate (PEG-PLA-DM) hydrogels with the hypothesis that hydrolytic degradation of ester bonds within the PLA crosslinks would provide tunable, sustained siRNA/NP release...
August 2, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30073801/a-ph-mediated-electronic-wound-dressing-for-controlled-drug-delivery
#10
Gita Kiaee, Pooria Mostafalu, Mohamadmahdi Samandari, Sameer Sonkusale
Topical administration of drugs in a timely manner according to the physiological need at the wound site can enhance the healing rate of chronic wounds. Herein, an electronic wound dressing that enables active topical drug delivery in response to electrically induced pH change is demonstrated for potential treatment of chronic wounds. In this platform, the pH of the dressing is controlled using an electrical field. This allows precise electrical control over the temporal profile of pH-mediated drug release...
August 2, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30073557/osrack1a-encodes-a-circadian-clock-regulated-wd40-protein-negatively-affect-salt-tolerance-in-rice
#11
Dongping Zhang, Yuzhu Wang, Jinyu Shen, Jianfeng Yin, Dahong Li, Yan Gao, Weifeng Xu, Jiansheng Liang
The receptor for activated C kinase 1 (RACK1) is a WD40 type protein that is involved in multiple signaling pathways and is conserved from prokaryotes to eukaryotes. Here we report that rice RACK1A (OsRACK1A) is regulated by circadian clocks and plays an important role in the salt stress response. OsRACK1A was found to follow a rhythmic expression profile under circadian conditions at both the transcription and the translation levels, although the expression was arrhythmic under salt stress. Analysis of plant survival rates, fresh weight, proline content, malondialdehyde, and chlorophyll showed that suppression of OsRACK1A enhanced tolerance to salt stress...
August 2, 2018: Rice
https://www.readbyqxmd.com/read/30067755/production-of-methane-and-ethylene-from-plastic-in-the-environment
#12
Sarah-Jeanne Royer, Sara Ferrón, Samuel T Wilson, David M Karl
Mass production of plastics started nearly 70 years ago and the production rate is expected to double over the next two decades. While serving many applications because of their durability, stability and low cost, plastics have deleterious effects on the environment. Plastic is known to release a variety of chemicals during degradation, which has a negative impact on biota. Here, we show that the most commonly used plastics produce two greenhouse gases, methane and ethylene, when exposed to ambient solar radiation...
2018: PloS One
https://www.readbyqxmd.com/read/30063262/binary-cooperative-prodrug-nanoparticles-improve-immunotherapy-by-synergistically-modulating-immune-tumor-microenvironment
#13
Bing Feng, Fangyuan Zhou, Bo Hou, Dangge Wang, Tingting Wang, Yuanlei Fu, Yuting Ma, Haijun Yu, Yaping Li
Checkpoint blockade immunotherapy is promising for clinical treatment of various malignant tumors. However, checkpoint blockade immunotherapy suffers from a low response rate due to insufficient tumor immunogenicity and the immunosuppressive tumor microenvironment (ITM). In this study, a tumor-microenvironment-activatable binary cooperative prodrug nanoparticle (BCPN) is rationally designed to improve immunotherapy by synergistically modulating the immune tumor microenvironment. BCPN is purely constructed from a tumor acidity and reduction dual-responsive oxaliplatin (OXA) prodrug for triggering immunogenic cell death (ICD) and eliciting antitumor immunity, and a reduction-activatable homodimer of NLG919 for inactivating indoleamine 2,3-dioxygenase 1, which is a key regulator for ITM...
July 31, 2018: Advanced Materials
https://www.readbyqxmd.com/read/30062344/layer-by-layer-assembled-multilayers-of-charged-polyurethane-and-graphene-oxide-platelets-for-flexible-and-stretchable-gas-barrier-films
#14
Min Ji Noh, Min Jun Oh, Jae Ho Choi, Jae Chul Yu, Woo-Jae Kim, Juhyun Park, Young-Wook Chang, Pil J Yoo
With the advent of the era of consumer-oriented displays and mobile devices, the importance of barrier film coatings for securing devices from oxygen or moisture penetration has become more salient. Recently developed approaches to generate gas barrier films in a combination of polyelectrolyte multilayer matrices and incorporated inorganic nanosheets have shown great potential in outperforming conventional gas barrier films. However, these films have the intrinsic drawback of vulnerability to brittleness and inability to stretch for flexible device applications...
July 31, 2018: Soft Matter
https://www.readbyqxmd.com/read/30059507/cryopreservation-of-human-mucosal-tissues
#15
Sean M Hughes, April L Ferre, Sarah E Yandura, Cory Shetler, Chris A R Baker, Fernanda Calienes, Claire N Levy, Rena D Astronomo, Zhiquan Shu, Gretchen M Lentz, Michael Fialkow, Anna C Kirby, M Juliana McElrath, Elizabeth Sinclair, Lisa C Rohan, Peter L Anderson, Barbara L Shacklett, Charlene S Dezzutti, Dayong Gao, Florian Hladik
BACKGROUND: Cryopreservation of leukocytes isolated from the cervicovaginal and colorectal mucosa is useful for the study of cellular immunity (see Hughes SM et al. PLOS ONE 2016). However, some questions about mucosal biology and sexually transmitted infections are better addressed with intact mucosal tissue, for which there is no standard cryopreservation protocol. METHODS AND FINDINGS: To find an optimal preservation protocol for mucosal tissues, we tested slow cooling (1°C/min) with 10% dimethylsulfoxide (designated "cryopreservation") and fast cooling (plunge in liquid nitrogen) with 20% dimethylsulfoxide and 20% ethylene glycol ("vitrification")...
2018: PloS One
https://www.readbyqxmd.com/read/30055345/mutualistic-fungus-phomopsis-liquidambari-increases-root-aerenchyma-formation-through-auxin-mediated-ethylene-accumulation-in-rice-oryza-sativa-l
#16
Li-Yan Hu, Dan Li, Kai Sun, Wei Cao, Wan-Qiu Fu, Wei Zhang, Chuan-Chao Dai
The fungal endophyte Phomopsis liquidambari can improve nitrification rates and alter the abundance and composition of ammonia-oxidizers in the soil rhizosphere of rice. Aerenchyma is related to oxygen transport efficiency and contributes to the enhanced rhizospheric nitrification under flooding conditions. However, whether and how P. liquidambari affects aerenchyma formation is largely unknown. We therefore conducted pot and hydroponic experiments to investigate the changes of aerenchyma area, ethylene and indole-3-acetic acid (IAA) levels in rice with or without P...
July 18, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/30055272/photopolymerizable-thiol-acrylate-maleiated-hyaluronic-acid-thiol-terminated-poly-ethylene-glycol-hydrogels-as-potential-in-situ-formable-scaffolds
#17
Can Zhang, Qi Dong, Kaili Liang, Ding Zhou, Hongjun Yang, Xin Liu, Weilin Xu, Yingshan Zhou, Pu Xiao
Despite their potential in various biomedical applications, photocrosslinkable hyaluronate hydrogels have often been limited by weak formation and unsatisfied mechanical strength which can be attributed to insufficient substitution of photoactive groups on the hyaluronate backbone and the oxygen inhibition effect. In this study, a new approach for the production of hyaluronic acid (MHA) with high acrylate group substitution (i.e. 2.27) is developed. It is based on the reaction of sodium hyaluronate and maleic anhydride in dimethyl sulfoxide, which has never been reported previously...
July 25, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30050008/high-capacity-and-high-efficiency-maple-tree-biomass-derived-hard-carbon-as-an-anode-material-for-sodium-ion-batteries
#18
Yuesheng Wang, Zimin Feng, Wen Zhu, Vincent Gariépy, Catherine Gagnon, Manon Provencher, Dharminder Laul, René Veillette, Michel L Trudeau, Abdelbast Guerfi, Karim Zaghib
Sodium-ion batteries (SIBs) are in the spotlight because of their potential use in large-scale energy storage devices due to the abundance and low cost of sodium-based materials. There are many SIB cathode materials under investigation but only a few candidate materials such as carbon, oxides and alloys were proposed as anodes. Among these anode materials, hard carbon shows promising performances with low operating potential and relatively high specific capacity. Unfortunately, its low initial coulombic efficiency and high cost limit its commercial applications...
July 26, 2018: Materials
https://www.readbyqxmd.com/read/30044519/tawrky51-promotes-lateral-root-formation-through-negatively-regulating-ethylene-biosynthesis-in-wheat-triticum-aestivum-l
#19
Zhaorong Hu, Rui Wang, Mei Zheng, Xingbei Liu, Fei Meng, Hualing Wu, Yingyin Yao, Mingming Xin, Huiru Peng, Zhongfu Ni, Qixin Sun
Common wheat (Triticum aestivum L.) is an important crop for staple food resources worldwide. Lateral root (LR) as the major component of root architecture affects water and nutrient uptake in wheat. The phytohormone ethylene is known to affect LR formation; however, the factor(s) modulating ethylene during this process have not yet been elucidated in wheat. Here, we identified a wheat TaWRKY51 as a key factor that functions in LR formation by modulating ethylene biosynthesis. Wheat TaWRKY51-RNAi lines and both homozygous mutants tawrky51-2a and tawrky51-2b produced less LR number compared with wild type and negative transgenic plants, whereas the TaWRKY51 overexpression (TaWRKY51-OE) lines had the opposite phenotype...
July 25, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/30042562/combined-postharvest-uv-c-and-1-methylcyclopropene-1-mcp-treatment-followed-by-storage-continuously-in-low-level-of-ethylene-atmosphere-improves-the-quality-of-tahitian-limes
#20
Penta Pristijono, Michael C Bowyer, Christopher J Scarlett, Quan V Vuong, Costas E Stathopoulos, John B Golding
The green Tahitian limes ( Citrus latifolia ) were exposed to 7.2 kJ m-2 UV-C and 0.5 μL L-1 1-methylcyclopropene (1-MCP) treatments both separately and in combination. After treatment, fruit were stored in ethylene free (i.e. air containing < 0.005 μL L-1 ) or 0.1 μL L-1 ethylene at 20 °C and 100% RH. The results showed that UV-C treatment delayed skin degreening and reduced endogenous ethylene production compared to untreated control fruit, however these effects reduced over the storage time...
July 2018: Journal of Food Science and Technology
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