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https://www.readbyqxmd.com/read/30338202/poxylated-dendrimer-based-nano-in-micro-dry-powder-formulations-for-inhalation-chemotherapy
#1
Rita B Restani, Rita F Pires, Anna Tolmatcheva, Rita Cabral, Pedro V Baptista, Alexandra R Fernandes, Teresa Casimiro, Vasco D B Bonifácio, Ana Aguiar-Ricardo
POxylated polyurea dendrimer (PUREG4 OOx48 )-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2 -assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4 OOx48 nanoparticles were much more cytotoxic than the free drug...
October 2018: ChemistryOpen
https://www.readbyqxmd.com/read/30337872/antidiabetic-biguanides-radiosensitize-hypoxic-colorectal-cancer-cells-through-a-decrease-in-oxygen-consumption
#2
Sven de Mey, Heng Jiang, Cyril Corbet, Hui Wang, Inès Dufait, Kalun Law, Estelle Bastien, Valeri Verovski, Thierry Gevaert, Olivier Feron, Mark De Ridder
Background and Purpose: The anti-diabetic biguanide drugs metformin and phenformin exhibit antitumor activity in various models. However, their radiomodulatory effect under hypoxic conditions, particularly for phenformin, is largely unknown. This study therefore examines whether metformin and phenformin as mitochondrial complex I blockades could overcome hypoxic radioresistance through inhibition of oxygen consumption. Materials and Methods: A panel of colorectal cancer cells (HCT116, DLD-1, HT29, SW480, and CT26) was exposed to metformin or phenformin for 16 h at indicated concentrations...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30335803/effect-of-elevated-co2-and-spectral-quality-on-whole-plant-gas-exchange-patterns-in-tomatoes
#3
Jason Lanoue, Evangelos D Leonardos, Shalin Khosla, Xiuming Hao, Bernard Grodzinski
In controlled environment plant production facilities, elevating either light or CO2 levels generally has led to increased biomass and yield due to enhanced canopy photosynthesis. Today, advancements in light-emitting diodes (LEDs) have made this technology a viable option for both supplementary lighting in greenhouses and a sole lighting source in controlled environment chambers. Our study used tomato plants grown under both ambient CO2 (AC) and elevated CO2 (EC) conditions then exposed them to various CO2 and lighting treatments during both whole plant and leaf level measurements...
2018: PloS One
https://www.readbyqxmd.com/read/30333809/formation-of-proton-motive-force-under-low-aeration-alkaline-conditions-in-alkaliphilic-bacteria
#4
REVIEW
Toshihide Matsuno, Toshitaka Goto, Shinichi Ogami, Hajime Morimoto, Koji Yamazaki, Norio Inoue, Hidetoshi Matsuyama, Kazuaki Yoshimune, Isao Yumoto
In Mitchell's chemiosmotic theory, a proton (H+ ) motive force across the membrane (Δp), generated by the respiratory chain, drives F1 Fo -ATPase for ATP production in various organisms. The bulk-base chemiosmotic theory cannot account for ATP production in alkaliphilic bacteria. However, alkaliphiles thrive in environments with a H+ concentrations that are one-thousandth (ca. pH 10) the concentration required by neutralophiles. This situation is similar to the production of electricity by hydroelectric turbines under conditions of very limited water...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30333638/evaluation-of-1-methylcyclopropene-1-mcp-treatment-combined-with-nano-packaging-on-quality-of-pleurotus-eryngii
#5
Fangxu Xu, Yefei Liu, Xiufeng Shan, Shenghou Wang
The aim of the present study was to investigate the effect of 1-methylcyclopropene (1-MCP) combined with nano-packaging on quality of pleurotus eryngii stored at 4 ± 1 °C for 12 days. Texture, respiration rate, soluble protein, soluble sugar, weight loss, soluble solid, malondialdehyde (MDA) content, polyphenol oxidase (PPO), superoxide dismutase (SOD) and catalase (CAT) activity of treated pleurotus eryngii were determined. The results suggested that 1-MCP treatment combined with nano-packaging reduce respiration rate, weight loss and MDA content, delayed the decrease of soluble protein content, and maintained soluble sugar and soluble solid content of treated pleurotus eryngii during the storage at 4 ± 1 °C compared with the untreated samples...
November 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/30329208/influence-of-heterologous-transplant-of-dna-lacking-mitochondria-from-entamoeba-histolytica-on-proliferation-of-entamoeba-invadens
#6
Makoto Kazama, Kazuhiro Yoshida, Sanae Ogiwara, Takashi Makiuchi, Hiroshi Tachibana
In mitochondria, compatibility of proteins encoded in mitochondrial DNA and nuclear DNA is essential for normal function of the organelle. Incompatibility between mitochondrial and nuclear DNA can lead to dysfunctional respiration, mitochondrial diseases and lethal problems, which suggests that the presence of heterologous mitochondria is unfavorable. In a previous study, we established a transplant method for DNA-lacking mitochondria (mitosomes) in the anaerobic protozoan Entamoeba histolytica. In this study, interspecies transplant of mitosomes from E...
October 17, 2018: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/30327662/phenotyping-for-nitrogen-use-efficiency-rice-genotypes-differ-in-n-responsive-germination-oxygen-consumption-seed-urease-activities-root-growth-crop-duration-and-yield-at-low-n
#7
Narendra Sharma, Vimlendu Bhushan Sinha, Neha Gupta, Soumya Rajpal, Surekha Kuchi, Vetury Sitaramam, Rajender Parsad, Nandula Raghuram
The biological improvement of fertilizer nitrogen use efficiency (NUE) is hampered by the poor characterization of the phenotype and genotype for crop N response and NUE. In an attempt to identify phenotypic traits for N-response and NUE in the earliest stages of plant growth, we analyzed the N-responsive germination, respiration, urease activities, and root/shoot growth of 21 Indica genotypes of rice ( Oryza sativa var. indica ). We found that N delays germination from 0 to 12 h in a genotype-dependent and source-dependent manner, especially with urea and nitrate...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/30327288/design-rationale-and-performance-evaluation-of-the-wavelet-health-wristband-benchtop-validation-of-a-wrist-worn-physiological-signal-recorder
#8
Onur Dur, Colleen Rhoades, Man Suen Ng, Ragwa Elsayed, Reinier van Mourik, Maulik D Majmudar
BACKGROUND: Wearable and connected health devices along with the recent advances in mobile and cloud computing provide a continuous, convenient-to-patient, and scalable way to collect personal health data remotely. The Wavelet Health platform and the Wavelet wristband have been developed to capture multiple physiological signals and to derive biometrics from these signals, including resting heart rate (HR), heart rate variability (HRV), and respiration rate (RR). OBJECTIVE: This study aimed to evaluate the accuracy of the biometric estimates and signal quality of the wristband...
October 16, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/30326665/itraq-based-proteomic-analysis-of-ogura-cms-cabbage-and-its-maintainer-line
#9
Fengqing Han, Xiaoli Zhang, Limei Yang, Mu Zhuang, Yangyong Zhang, Zhansheng Li, Zhiyuan Fang, Honghao Lv
Ogura cytoplasmic male sterility (CMS) contributes considerably to hybrid seed production in Brassica crops. To detect the key protein species and pathways involved in Ogura-CMS, we analysed the proteome of the cabbage Ogura-CMS line CMS01-20 and its corresponding maintainer line F01-20 using the isobaric tags for the relative and absolute quantitation (iTRAQ) approach. In total, 162 differential abundance protein species (DAPs) were identified between the two lines, of which 92 were down-accumulated and 70 were up-accumulated in CMS01-20...
October 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30325941/effect-of-straw-return-on-soil-respiration-and-nee-of-paddy-fields-under-water-saving-irrigation
#10
Shihong Yang, Yanan Xiao, Junzeng Xu, Xiaoyin Liu
Straw return (SR) and rice water-saving irrigation (WSI) affect the greenhouse gas emission of paddy fields. However, studies on CO2 exchange between paddy fields and the atmosphere with joint regulation of SR and WSI are few. We conducted a two-year field experiment to investigate the effects of SR on soil respiration and net ecosystem exchange of CO2 (NEE) in paddy fields under controlled irrigation (CI), which is a typical WSI technique. The rice yields, irrigation water use efficiency, seasonal variations in soil respiration, NEE, and soil organic carbon content were measured...
2018: PloS One
https://www.readbyqxmd.com/read/30325116/the-stress-levels-of-parents-of-premature-infants-and-related-factors-in-nenoatal-intensive-care-units
#11
Burcu Çekin, Türkan Turan
Çekin B, Turan T. The stress levels of parents of premature infants and related factors in Nenoatal Intensive Care Units. Turk J Pediatr 2018; 60: 117-125. The aim of this study is to determine the stress levels of parents whose premature baby are hospitalized in the neonatal intensive care unit (NICU) and to determine the factors affecting their stress. The study sample included 101 parents of premature babies in the NICU of a university hospital. Interviews were conducted with the parents. Additionally, the Parental Stress Scale: Neonatal Intensive Care Unit (PSS:NICU) was administered...
2018: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/30323966/targeting-pdk4-inhibits-breast-cancer-metabolism
#12
Maheedhara R Guda, Swapna Asuthkar, Collin M Labak, Andrew J Tsung, Ilya Alexandrov, Malcolm J Mackenzie, Durbaka Vr Prasad, Kiran K Velpula
Dysregulated metabolism in the form of aerobic glycolysis occurs in many cancers including breast carcinoma. Here, we report PDK4 (pyruvate dehydrogenase kinase 4) as key enzyme implicated in the control of glucose metabolism and mitochondrial respiration is relatively highly expressed in breast cancers, and its expression correlates with poor patient outcomes. Silencing of PDK4 and ectopic expression of miR-211 attenuates PDK4 expression in breast cancer cells. Interestingly, low miR-211 expression is significantly associated with shorter overall survival and reveals an inverse correlation between expression of miR-211 and PDK4...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30320748/saccharomyces-cerevisiae-exponential-growth-kinetics-in-batch-culture-to-analyze-respiratory-and-fermentative-metabolism
#13
Ivanna Karina Olivares-Marin, Juan Carlos González-Hernández, Carlos Regalado-Gonzalez, Luis Alberto Madrigal-Perez
Saccharomyces cerevisiae cells in the exponential phase sustain their growth by producing ATP through fermentation and/or mitochondrial respiration. The fermentable carbon concentration mainly governs how the yeast cells generate ATP; thus, the variation in fermentable carbohydrate levels drives the energetic metabolism of S. cerevisiae. This paper describes a high-throughput method based on exponential yeast growth to estimate the effects of concentration changes and nature of the carbon source on respiratory and fermentative metabolism...
September 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30319446/association-between-phase-coupling-of-respiratory-sinus-arrhythmia-and-slow-wave-brain-activity-during-sleep
#14
Kyuichi Niizeki, Tadashi Saitoh
Phase coupling of respiratory sinus arrhythmia (RSA) has been proposed to be an alternative measure for evaluating autonomic nervous system (ANS) activity. The aim of this study was to analyze how phase coupling of RSA is altered during sleep, in order to explore whether this measure is a predictor of slow wave sleep (SWS). Overnight electroencephalograms (EEG), electrocardiograms (ECG), and breathing using inductance plethysmography were recorded from 30 healthy volunteers (six females, age range 21-64, 31...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30317874/do-older-patients-with-acute-or-subacute-subdural-hematoma-benefit-from-surgery
#15
Sander Bus, Dagmar Verbaan, Bertjan J Kerklaan, Marieke E S Sprengers, William P Vandertop, Jan Stam, Gerrit J Bouma, Pepijn van den Munckhof
PURPOSE: According to the international guidelines, acute subdural hematomas (aSDH) with a thickness of >10 mm, or causing a midline shift of >5 mm, should be surgically evacuated. However, high mortality rates in older patients resulted in ongoing controversy whether elderly patients benefit from surgery. We identified predictors of outcome in a single-centre cohort of elderly patients undergoing surgical evacuation of aSDH or subacute subdural hematoma (saSDH). MATERIALS AND METHODS: This retrospective study included all patients aged ≥65 years undergoing surgical evacuation of aSDH/saSDH from 2000 to 2015...
October 13, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/30317048/resting-parasympathetic-dysfunction-predicts-prosocial-helping-deficits-in-behavioral-variant-frontotemporal-dementia
#16
Virginia E Sturm, Isabel J Sible, Samir Datta, Alice Y Hua, David C Perry, Joel H Kramer, Bruce L Miller, William W Seeley, Howard J Rosen
In the behavioral variant of frontotemporal dementia (bvFTD), left-lateralized salience network dysfunction reduces basal activity in the parasympathetic nervous system, a branch of the autonomic nervous system that reduces arousal and fosters empathy and prosociality. Here we examined whether resting parasympathetic deficits in bvFTD related to diminished prosocial behavior. Eighty participants [30 with bvFTD, 25 with Alzheimer's disease (AD), and 25 healthy controls] completed a "helping task" in which we quantified participants' spontaneous reactions to an experimenter who struggled to find a lost key...
September 20, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/30309956/the-engineering-of-the-giant-dragonflies-of-the-permian-revised-body-mass-power-air-supply-thermoregulation-and-the-role-of-air-density
#17
REVIEW
Alan E R Cannell
An engineering examination of allometric and analogical data on the flight of giant Permian insects (Protodonata, Meganeura or griffinflies) indicates that previous estimates of the body mass of these insects are too low and that the largest of these insects (wingspan of 70 cm or more) would have had a mass of 100-150 g, several times greater than previously thought. Here, the power needed to generate lift and fly at the speeds typical of modern large dragonflies is examined together with the metabolic rate and subsequent heat generated by the thoracic muscles...
October 11, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/30308844/effectiveness-of-commercial-face-masks-to-reduce-personal-pm-exposure
#18
A Pacitto, F Amato, A Salmatonidis, T Moreno, A Alastuey, C Reche, G Buonanno, C Benito, X Querol
Cycling and walking are promoted as means of transportation which can contribute to the reduction of traffic pollution in urban areas. However, cyclists and pedestrians may be exposed to high concentrations of air pollutants due to their proximity to vehicle emissions. Commercial face mask respirators are widely used, in both developing and developed countries, as an individual protective measure against particle pollution. However scientific data on the efficacy of face mask respirators in reducing airborne particle exposure is limited...
February 10, 2019: Science of the Total Environment
https://www.readbyqxmd.com/read/30303249/nitrous-oxide-effluxes-from-plants-as-a-potentially-important-source-to-the-atmosphere
#19
Katharina Lenhart, Thomas Behrendt, Steffen Greiner, Jörg Steinkamp, Reinhard Well, Anette Giesemann, Frank Keppler
The global budget for nitrous oxide (N2 O), an important greenhouse gas and probably dominant ozone-depleting substance emitted in the 21st century, is far from being fully understood. Cycling of N2 O in terrestrial ecosystems has traditionally exclusively focused on gas exchange between the soil surface (nitrification-denitrification processes) and the atmosphere. Terrestrial vegetation has not been considered in the global budget so far, even though plants are known to release N2 O. Here, we report the N2 O emission rates of 32 plant species from 22 different families measured under controlled laboratory conditions...
October 10, 2018: New Phytologist
https://www.readbyqxmd.com/read/30302026/carbon-stocks-and-accumulation-rates-in-red-sea-seagrass-meadows
#20
Oscar Serrano, Hanan Almahasheer, Carlos M Duarte, Xabier Irigoien
Seagrasses play an important role in climate change mitigation and adaptation, acting as natural CO2 sinks and buffering the impacts of rising sea level. However, global estimates of organic carbon (Corg ) stocks, accumulation rates and seafloor elevation rates in seagrasses are limited to a few regions, thus potentially biasing global estimates. Here we assessed the extent of soil Corg stocks and accumulation rates in seagrass meadows (Thalassia hemprichii, Enhalus acoroides, Halophila stipulacea, Thalassodendrum ciliatum and Halodule uninervis) from Saudi Arabia...
October 9, 2018: Scientific Reports
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