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Reverse triggering

Vikas Sharma, Unnikrishnan Puthumana, Pirudhan Karak, Apurba Lal Koner
An efficient method for visible light-triggered generation of radical from mono and dinitro-substituted Perylenediimide (PDI) derivatives is developed. UV-Vis.-NIR and EPR measurements were carried out to confirm the formation of radical. Most importantly, these radical anions were remarkably stable for several months. Subsequently, the reversible nature of anions was validated by both chemical and spectroelectrochemical methods for the application in electrochromic materials.
August 15, 2018: Journal of Organic Chemistry
Guillaume Collet, Timothée Lathion, Céline Besnard, Claude Piguet, Stéphane Petoud
We have designed a rigid photocleavable dianthracene-based ligand that reacts with ytterbium as coordination metal ion for the creation of a class of tridimensional light-degradable metal-organic framework (MOF). We demonstrated that we can obtain a high level of control on the disassembly of the MOF formed with this ligand which can be triggered either through light irradiation or temperature increase. The reversible 4π-4π photodimerization is the intrinsic chemical mechanism ruling the ligand and MOF cleavage...
August 15, 2018: Journal of the American Chemical Society
Xiongjun Wang, Wencheng Zhu, Peng Chang, Hongyu Wu, Haoping Liu, Jiangye Chen
Phenotypic plasticity is common in development. Candida albicans , a polymorphic fungal pathogen of humans, possesses the unique ability to achieve rapid and reversible cell fate between unicellular form (yeast) and multicellular form (hypha) in response to environmental cues. The NuA4 histone acetyltransferase activity and Hda1 histone deacetylase activity have been reported to be required for hyphal initiation and maintenance. However, how Hda1 and NuA4 regulate hyphal elongation is not clear. NuA4 histone acetyltransferase and SWR1 chromatin remodeling complexes are conserved from yeast to human, which may have merged together to form a larger TIP60 complex since the origin of metazoan...
2018: Cell Discovery
Fujun Li, Liubin Wang, Youxuan Ni, Kaixiang Lei, Huanhuan Dong, Sen Tian
Sodium-ion batteries (SIBs) have attracted significant research interest in large-scale electric energy storage. However, anodes with good rate capability and long cycle life are still lacking. Here, a three-dimensional (3D) porous Sn on Cu foil (Sn/Cu) is prepared by tuning the redox potential of Cu+/Cu with a ligand of thiourea to trigger the replacement reaction between Cu and Sn2+. The as-synthesized Sn/Cu is featured as an integrated porous electrode and can be directly applied as an advanced freestanding electrode for SIBs...
August 14, 2018: ChemSusChem
Sven Tobisch
A detailed computational probe of the rare earth metal-mediated intramolecular amidination of aminoalkenes with nitriles by an archetypical [Y{N(SiMe3)2}3] precatalyst is presented. The mechanistic picture derived from smooth energy profiles, acquired by employing a reliable computational protocol applied to a realistic catalyst model, conforms to available experimental data that includes a significant primary KIE. Sequential Y-N silylamide aminolysis transforms the precatalyst into a multitude of silylamide/amide compounds, of which the bis-amine coordinated [Y{N(SiMe3)2}(NRR')2] is the most abundant, capable of promoting cycloamidination...
August 14, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Hui Xiong, Jiang Ni, Zhijie Jiang, Fengchun Tian, Jianping Zhou, Jing Yao
Drug efflux induced by multidrug resistance (MDR) overexpression, as well as secondary drug resistance caused by subtoxic drug microenvironments as a result of inefficient drug release of nanoscopic drug carriers in tumor cells, are major bottlenecks for chemotherapy. In order to overcome these limitations, we have devised a synergism-based polymer supramolecular nanoassembly (LH) by combining hyaluronic acid (HA) modified curcumin (HA-CUR) with a pH-sensitive low molecular weight heparin (LMWH) derivative modified doxorubicin (L-DOX)...
August 14, 2018: Biomaterials Science
Swapnil Varhade, Zahid M Bhat, Ravikumar Thimmappa, Mruthyunjayachari C Devendrachari, Alagar R Kottaichamy, Manu Gautam, Shahid P Shafi, Yogesh Kalegowda, Musthafa Ottakam Thotiyl
Hydrazine is a pollutant with high hydrogen content, offering tremendous possibilities in a direct hydrazine fuel cell (DHFC) as it can be converted into electricity via benign end products. Due to the inner sphere nature of half-cell chemistries, hydrazine cross over triggers parasitic chemistry at the Pt-based air cathode of a state-of-the-art DHFC, overly complicating the already sluggish electrode kinetics at the positive electrode. Here, we illustrate that by altering the interfacial chemistry of the catholyte from inner sphere to outer sphere, the parasitic chemistry can be dissociated from the redox chemistry of the electron acceptor and the hybrid fuel cell can be driven by simple carbon-based cathodes...
August 14, 2018: Physical Chemistry Chemical Physics: PCCP
Tobias Eckrich, Kerstin Blum, Ivan Milenkovic, Jutta Engel
Before the onset of hearing, which occurs around postnatal day 12 (P12) in mice, inner hair cells (IHCs) of the immature cochlea generate sound-independent Ca2+ action potentials (APs), which stimulate the auditory pathway and guide maturation of neuronal circuits. During these early postnatal days, intercellular propagating Ca2+ waves elicited by ATP-induced ATP release are found in inner supporting cells (ISCs). It is debated whether IHCs are able to fire Ca2+ APs independently or require a trigger by an ISC Ca2+ wave...
2018: Frontiers in Molecular Neuroscience
Michaeline L Hebron, Monica Javidnia, Charbel E-H Moussa
Tau hyperphosphorylation is a critical factor in neurodegenerative diseases, including dementia and Parkinsonism. Existing animal models of tauopathies express tau in neurons within the forebrain and do not often show tau accumulation in the brainstem and astrocytes. This study aims to understand the effects of differential regional expression of tau on neurotransmitter balance in the brain. To obtain an animal model that expresses tau in the brainstem, we bred hemizygous mice that express P301L tau (TauP301L) and detected hyper-phosphorylated tau (p-tau) predominantly in the hippocampus, cortex, brainstem and thalamus...
August 15, 2018: Journal of the Neurological Sciences
Britto Sandanaraj, Mohan Reddy, Pavankumar Bhandari, Sugam Kumar, Vinod Aswal
Self-assembly of proteins into higher order super-structures is ubiquitous in biological systems. Genetic methods comprising both computational and rational design strategies are emerging as powerful methods for design of synthetic protein complexes with high accuracy and fidelity. Although useful, most of the reported protein complexes lack dynamic behavior that may limit their potential applications. On the contrary, protein engineering using chemical strategiesoffers excellent possibilities for the design of protein complexes with stimuli-responsive functions and adaptive behavior...
August 12, 2018: Chemistry: a European Journal
Alicia Martinez-Lopez, Marta Martin-Fernandez, Sofija Buta, Baek Kim, Dusan Bogunovic, Felipe Diaz-Griffero
Germline mutations in the human SAMHD1 gene cause the development of Aicardi-Goutières Syndrome (AGS), with a dominant feature being increased systemic type I interferon(IFN) production. Here we tested the state of type I IFN induction and response to, in SAMHD1 knockout (KO) human monocytic cells. SAMHD1 KO cells exhibited spontaneous transcription and translation of IFN-β and subsequent interferon-stimulated genes (ISGs) as compared to parental wild-type cells. This elevation of IFN-β and ISGs was abrogated via inhibition of the TBK1-IRF3 pathway in the SAMHD1 KO cells...
August 8, 2018: Molecular Immunology
Wei Liu, Yanhua Wu, Feng Yu, Wenxue Hu, Xiaowu Fang, Wenke Hao
AIM: This study was purposed to figure out the contribution of Numb-induced Notch signaling to the development of diabetic nephropathy (DN). METHODS: Two hundred and twenty six DN patients were included, and human glomerular endothelial cells (RGEC) were cultured. MSCV-Numb-IRES-GFP, MSCV-Notch1-IRES-GFP and MSCV-Hes1-IRES-GFP were transfected to construct the recombinant retroviral vectors. RESULT: The over-expressed Numb and Notch1, as well as the under-expressed Hes-1 were correlated with the undesirable prognosis of DN patients (P < 0...
July 10, 2018: Journal of Diabetes and its Complications
Yu-Huei Liu, Yui-Ping Weng, Hsin-Ying Tsai, Chao-Jung Chen, Der-Yen Lee, Ching-Liang Hsieh, Yang-Chang Wu, Jung-Yaw Lin
BACKGROUND: Pancreatic cancer (PC) remains the leading cause of cancer mortality, with limited therapeutic targets, and alterations in endoplasmic reticulum (ER)-related proteostasis may be a potential target for therapy. The root bark of Paeonia suffruticosa has been shown to inhibit cancer growth and metastasis, although its impact on PC is unknown. PURPOSE: To ascertain the anti-cancer effects of P. suffruticosa on oncogenic functions of PC and determine the detailed molecular mechanisms...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Julie K Bray, Gabriel S Chiu, Leslie K McNeil, Morgan L Moon, Robyn Wall, Albert E Towers, Gregory G Freund
Background: Reducing caloric intake is a proven intervention for mitigating and modulating morbidities associated with overnutrition. Caloric restriction is difficult to affect clinically, therefore, dietary interventions that ameliorate the adverse consequences of overnutrition in the presence of a high-calorie diet would be of value. Methods: Mice were fed an obesogenic diet containing 60% fat + 10% cellulose (HFC), or a control diet containing 10% fat + 10% cellulose (LFC) for 12 wks...
2018: Nutrition & Metabolism
Aditi Chandra, Swapan Senapati, Sudipta Roy, Gobinda Chatterjee, Raghunath Chatterjee
BACKGROUND: Psoriasis is a chronic inflammatory autoimmune skin disorder. Several studies suggested psoriasis to be a complex multifactorial disease, but the exact triggering factor is yet to be determined. Evidences suggest that in addition to genetic factors, epigenetic reprogramming is also involved in psoriasis development. Major histopathological features, like increased proliferation and abnormal differentiation of keratinocytes, and immune cell infiltrations are characteristic marks of psoriatic skin lesions...
August 9, 2018: Clinical Epigenetics
Fasil Abebe, Treshaun Sutton, Pierce Perkins, Roosevelt Shaw
Two new rhodamine derivative L1 and L2 bearing 2-methoxy-1-naphthaldehyde and 5-bromo-3-methoxy salicylaldehyde units were designed and synthesized using microwave-assisted organic synthesis and utilized towards sequential fluorescence detection of aluminum ion (Al3+ ) and azide (N3 - ) in aqueous acetonitrile solution. Aluminum ion (Al3+ ) triggers the formation of highly fluorescent ring-open spirolactam. The fluorescence and colorimetric response of the L1 -Al3+ and L2 -Al3+ complexes were quenched by the addition of N3 - , which extracting the Al3+ from the complexes and turn-off the sensors, confirming that the recognition process is reversible...
August 8, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
Mohammed Zacky Ariffin, Khairunisa Mohamad Ibrahim, Andy Thiam-Huat Lee, Rui Zhi Lee, Shou Yu Poon, Hwai Kit Thong, Eugene Hern Choon Liu, Chian-Ming Low, Sanjay Khanna
The present study explored the role of the medial septal region (MS) in experimental neuropathic pain. For the first time, we found that the MS sustains nociceptive behaviors in rodent models of neuropathic pain, especially in the chronic constriction injury (CCI) model and the paclitaxel model of chemotherapy-induced neuropathic pain. For example, inactivation of the MS with intraseptal muscimol (2 μg/μl, 0.5 μl), a GABA mimetic, reversed peripheral hypersensitivity (PH) in the CCI model and induced place preference in a conditioned place preference task, a surrogate measure of spontaneous nociception...
August 8, 2018: Scientific Reports
Yujie Ke, Shancheng Wang, Guowei Liu, Ming Li, Timothy J White, Yi Long
The reversible, ultrafast, and multistimuli responsive phase transition of vanadium dioxide (VO2 ) makes it an intriguing "smart" material. Its crystallographic transition from the monoclinic to tetragonal phases can be triggered by diverse stimuli including optical, thermal, electrical, electrochemical, mechanical, or magnetic perturbations. Consequently, the development of high-performance smart devices based on VO2 grows rapidly. This review systematically summarizes VO2 -based emerging technologies by classifying different stimuli (inputs) with their corresponding responses (outputs) including consideration of the mechanisms at play...
August 7, 2018: Small
Tiejun Hou, Shanyong Li, Guangwei Zhang, Yan Li
Periodontitis can exert a severe impact on the life of patients, and the use of stem cell therapy for this disease is promising. The inflammatory response consequent to periodontitis can promote stem cell proliferation. Activated inflammation triggers inhibitory cytokine secretion, thus reducing inflammation subsequent to stem cell activation. High‑fluence low‑power laser irradiation (HF‑LPLI) has the ability to regulate stem cell function through its effect on inflammation. Thus, the aim of the present study was to examine whether HF‑LPLI is able to activate stem cells to promote regeneration in periodontitis by promoting inflammation resolution, as well as to evaluate the underlying mechanism of action if an effect is observed...
October 2018: International Journal of Molecular Medicine
Wen-Xiang Cao, Ting Li, Zheng-Hai Tang, Le-Le Zhang, Zhao-Yu Wang, Xia Guo, Min-Xia Su, Xiuping Chen, Jin-Jian Lu
The pseudokinase mixed lineage kinase domain-like protein (MLKL) is a core effector of necroptosis, and its function in necroptosis is widely studied. However, the function of MLKL in apoptosis remains unclear. In the present study, the role of MLKL in chelerythrine (CHE)-promoted apoptosis was studied. A special band of MLKL (i.e., *MLKL) was observed after treatment with CHE. MLKL and *MLKL were accumulated in the nucleus upon treatment with CHE and MLKL silencing reversed the CHE-induced apoptosis. Blockade of CHE-triggered reactive oxygen species (ROS) generation or inhibition of CHE-activated protein kinase-like endoplasmic reticulum kinase (PERK)-eukaryotic initiation factor 2 α subunit (eIF2α) pathway reversed the apoptosis...
August 6, 2018: Apoptosis: An International Journal on Programmed Cell Death
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