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Cord And Clamping

J Meléndez-Gallardo, A Eblen-Zajjur
Despite frequent clinical hyper- or hypothermia cases, the thermal-dependence of the endogenous pain modulation system at the spinal cord is not well understood. The spinal dorsal horn neuronal network responses during mechanical heterotopic noxious stimuli was evaluated at three different body temperatures (34, 37 or 40°C) by measurement of lumbar cord dorsum potentials activated by electrical stimulation of the ipsilateral sural nerve in adult thiopental anesthetized rats. A noxious clamp was applied randomly to the tail, right hind paw, right forepaw, muzzle, or left forepaw...
August 15, 2018: Journal of Integrative Neuroscience
X E Cheng, H Z Peng, X X Hu, X J Feng, L X Ma, C Y Jiang, T Liu
OBJECTIVE: To unravel the underlying mechanism of minocycline in formalin-induced inflammatory pain, and to investigate the effects of minocycline on synaptic transmission in substantia gela-tinosa (SG) neurons of rat spinal dorsal horn. METHODS: Behavioral and immunohistochemistry experiments: 30 male Sprague-Dawley (SD) rats (3-5 weeks old) were randomly assigned to control (n=8 rats), model (n=8 rats), saline treatment model (n=6 rats) and minocycline treatment model (n=8 rats) groups...
October 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Ana-Mari Gallo, Gabi Aliyev
OBJECTIVE: To adopt evidence-based recommendations to delay cord clamping in vigorous preterm neonates. DESIGN: Evidence-based practice change project with quantitative data. SETTING/LOCAL PROBLEM: Delayed cord clamping (DCC) was not a usual practice at the hospital where this project took place, despite research findings that show benefits of DCC for preterm neonates. PARTICIPANTS: Vigorous neonates born before 37 weeks completed gestation...
October 5, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
Valerie Greffeuille, Yves Kameli, Chhoun Chamnan, Mary Chea, Sok Daream, Pattanee Winichagoon, Chaniphun Butryee, Bach Mai Le, Tran Thi Lua, Siti Muslimatum, Airin Roshita, Sengchanh Kounnavong, Frank T Wieringa, Jacques Berger
BACKGROUND: Despite scientific evidence on the potential impact or importance of specific interventions to improve micronutrient status of vulnerable groups, political commitment and extensive support from national stakeholders is paramount to support introduction and implementation of these interventions at national level. In order to develop efficient nutritional strategies to improve the micronutrient status of children < 5 years of age and women of reproductive age that will be supported by a wide range of stakeholders, a better understanding of viewpoints on the nutrition politics and strategies is necessary...
October 5, 2018: Maternal and Child Health Journal
Irmak Vural, Hulya Ozdemir, Gulsen Teker, Tevfik Yoldemir, Hulya Bilgen, Eren Ozek
AIM: To compare the post-natal effects of delayed cord clamping (DCC) and early cord clamping (ECC) in term large-for-gestational age (LGA) infants. METHODS: This prospective randomised study included 51 term LGA infants. The umbilical cords of these infants were clamped at 15 s in group 1 (ECC group (n = 26)) and at 60 s in group 2 (DCC group (n = 25)). Data for Apgar scores, cord blood, pH and lactate values, second haematocrit, 24th bilirubin levels, duration of hospital stay and admission to the neonatal intensive care unit (NICU) were recorded...
October 4, 2018: Journal of Paediatrics and Child Health
Tao Xu, Qing Yue, Yan Wang, John Murray, Howard Sobel
OBJECTIVES: As a part of the process of implementing Early Essential Newborn Care (EENC) in China, which are evidence-based interventions recommended by the World Health Organization (WHO), we sought to understand whether current hospital policies are consistent with WHO-recommended standards and what factors influence their use. Data from the study will help inform policy changes needed to support the introduction of evidence-based childbirth and early newborn care practices effectively and to inform further scale up of EENC nationwide...
October 3, 2018: Global Health, Science and Practice
Stefano Ghirardello, Beatrice L Crippa, Valeria Cortesi, Elena Di Francesco, Dario Consonni, Lorenzo Colombo, Monica Fumagalli, Arjan B Te Pas, Fabio Mosca
Objective: To compare the effect of Delayed Cord Clamping (DCC) to Immediate Cord Clamping (ICC) on phototherapy treatment in a cohort of cesarean-delivered newborns with AB0-alloimmunization. Study Design: In a retrospective cohort study neonates with Gestational Age (GA) ≥ 35 weeks and diagnosed with AB0-alloimmunization before implementation of DCC (ICC group) were compared with neonates born after implementation (DCC group). The primary outcome was the need for phototherapy. Secondary outcomes included hospital stay, readmission rate, need for extra intravenous fluids, maximum bilirubin concentration, and hours of life at bilirubin peak...
2018: Frontiers in Pediatrics
Emma Brouwer, Ronny Knol, Alex S N Vernooij, Thomas van den Akker, Patricia E Vlasman, Frans J C M Klumper, Philip DeKoninck, Graeme R Polglase, Stuart B Hooper, Arjan B Te Pas
OBJECTIVE: Physiological-based cord clamping (PBCC) led to a more stable cardiovascular adaptation and better oxygenation in preterm lambs, but in preterm infants, this approach has been challenging. Our aim was to assess the feasibility of PBCC, including patterns of oxygen saturation (SpO2 ) and heart rate (HR) during stabilisation in preterm infants using a new purpose-built resuscitation table. DESIGN: Observational study. SETTING: Tertiary referral centre, Leiden University Medical Centre, The Netherlands...
October 3, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
Jeremy W Chopek, Filipe Nascimento, Marco Beato, Robert M Brownstone, Ying Zhang
Layering of neural circuits facilitates the separation of neurons with high spatial sensitivity from those that play integrative temporal roles. Although anatomical layers are readily identifiable in the brain, layering is not structurally obvious in the spinal cord. But computational studies of motor behaviors have led to the concept of layered processing in the spinal cord. It has been postulated that spinal V3 interneurons (INs) play multiple roles in locomotion, leading us to investigate whether they form layered microcircuits...
October 2, 2018: Cell Reports
Olivier Roca-Lapirot, Pascal Fossat, Sherie Ma, Karine Egron, Gabriella Trigilio, María-José López-González, João Covita, Rabia Bouali-Benazzouz, Alexandre Favereaux, Andrew L Gundlach, Marc Landry
Pain is associated with negative emotions such as anxiety, but the underlying neurocircuitry and modulators of the association of pain and anxiety remain unclear. The neuropeptide cholecystokinin (CCK) has both pro-nociceptive and anxiogenic properties, so we explored the role of CCK in anxiety and nociception in the central amygdala (CeA), a key area in control of emotions and descending pain pathways. Local infusion of CCK into the CeA of control rats increased anxiety, as measured in the light-dark box test, but had no effect on mechanical sensitivity...
September 26, 2018: Pain
Nisha Rana, Ashish Kc, Mats Målqvist, Kalpana Subedi, Ola Andersson
BACKGROUND: Delayed cord clamping (DCC) is associated with an improved iron status at 8 months, a reduction of anemia at 12 months, and an improved development at 4 years. Assessment of the development after DCC has not been performed earlier in a setting with a high prevalence of iron deficiency. OBJECTIVE: The aim of this paper was to investigate the effects of DCC compared to early cord clamping (ECC) on the development evaluated with the Ages and Stages Questionnaire (ASQ) at 12 months of age...
October 2, 2018: Neonatology
Alfonso Francisco Pantoja, Ann Ryan, Michelle Feinberg, Mark DeMarie, John Britton, Ellina Liptsen, Maggie Chen, Jordan Crow
The practice of delayed cord clamping (DCC) in premature infants has proven benefit to the neonate. In a community-based perinatal centre, the practice of DCC for more than 60 s for premature infants with gestational age of <35 weeks was identified to occur infrequently at 20% in 2013. The perinatology group in conjunction with nursery, labour and delivery, and obstetric staff sought to improve adherence to the best practice of DCC for premature infants. In an effort to achieve this goal, we developed an evidence-based clinical practice guideline, included key stakeholders in its development and provided timely feedback to delivery providers about DCC performance...
2018: BMJ open quality
Parisa Mokarami, Nana Wiberg, Karin Källén, Per Olofsson
Traditional validation of umbilical cord blood samples with positive veno-arterial (V-A) ΔpH and A-V ΔpCO2 values confirms the source of samples, where negative Δvalues represent mix-up of samples. To investigate whether this is true, the distributions of V-A ΔpO2 and A-V Δlactate were also explored and related to clinical characteristics. In addition, different cord blood sampling techniques were evaluated MATERIAL AND METHODS: Register study with cord blood acid-base and clinical data from 27 233 newborns...
September 26, 2018: Acta Obstetricia et Gynecologica Scandinavica
Melissa A Tadros, Ihssane Zouikr, Deborah M Hodgson, Robert J Callister
Previous studies have shown that neonatal exposure to a mild inflammatory challenge, such as lipopolysaccharide (LPS, Salmonella enteriditis ) results in altered pain behaviors later in life. To further characterize the impact of a neonatal immune challenge on pain processing, we examined the excitability of superficial dorsal horn (SDH) neurons following neonatal LPS exposure and subsequent responses to noxious stimulation at three time-points during early postnatal development. Wistar rats were injected with LPS (0...
2018: Frontiers in Neurology
R Douglas Wilson, Aaron B Caughey, Stephen L Wood, George A Macones, Ian J Wrench, Jeffrey Huang, Mikael Norman, Karin Pettersson, William J Fawcett, Medhat M Shalabi, Amy Metcalfe, Leah Gramlich, Gregg Nelson
OBJECTIVE: This ERAS Guideline for perioperative care in Cesarean Delivery (CD) will provide best practice, evidenced-based, recommendations for pre-operative, intra-operative, and post-operative phases with primarily, a maternal focus. The 'focused' pathway process for scheduled and unscheduled CD, for this ERAS CD guideline will consider, from 'decision to operate (starting with the 30 - 60 minutes prior to skin incision) to hospital discharge'. METHODS: The literature search (1966-2017) used Embase and PubMed to search medical subject headings including "Cesarean Section", "Cesarean Section", "Cesarean Section Delivery" and all pre- and intra-operative ERAS® items...
September 18, 2018: American Journal of Obstetrics and Gynecology
Kun Niu, Hui Liu, Ruo-Wen Chen, Qi-Wu Fang, Hui Wen, Su-Mei Guo, John P Williams, Jian-Xiong An
PURPOSE: Nausea and vomiting are common, undesirable symptoms during cesarean section. We conducted this study to assess the antiemetic properties of propofol for the prevention and immediate treatment of post-delivery nausea and vomiting during cesarean section under combined spinal-epidural anesthesia. METHODS: Eighty women undergoing elective cesarean delivery under combined spinal-epidural anesthesia were randomized to receive either propofol at a plasma concentration of 1000 ng/mL or normal saline immediately after clamping of the umbilical cord...
September 12, 2018: Journal of Anesthesia
Himanshu Popat, Claire Galea, Nicholas Evans, Barbara Lingwood, Paul B Colditz, Robert Halliday, David Osborn
BACKGROUND AND OBJECTIVE: The mechanism of reported benefits of delayed cord clamping (DCC) are unclear. We aimed to determine whether DCC compared to immediate cord clamping (ICC) in very preterm infants improves cerebral oxygenation in the first 24 h. STUDY DESIGN: This is a prospective study of a subset of infants at < 30 weeks of gestation who were randomised to DCC (≥60 s) or ICC (< 10 s) and required an indwelling arterial catheter. Regional cerebral oxygenation (rScO2), blood pressure, PI, and peripheral saturation were measured and cerebral fractional tissue oxygen extraction (cFTOE) calculated for the following 3 time intervals: 3-6, 6-12, and 12-28 h of age...
September 10, 2018: Neonatology
Katsuhiro Yamanaka, Mohamed Eldeiry, Muhammad Aftab, Thomas J Ryan, Joshua Mares, Xianzhong Meng, Michael J Weyant, Joseph C Cleveland, David A Fullerton, T Brett Reece
BACKGROUND: Paraplegia remains a devastating complication of thoracoabdominal aortic intervention. Metabolic stress induces expression of Beta Common Receptor subunit of erythropoietin (EPO) receptor (bcR) to exert a neuroprotective effect in spinal cord ischemia reperfusion injury (SCIR). Diazoxide (DZ) has been shown to induce ischemic tolerance. We previously reported that DZ upregulated bcR expression, and DZ enhanced the neuroprotective effects of EPO through the upregulation of bcR...
September 4, 2018: Annals of Thoracic Surgery
Raghavendra Rao, Reeta Bora
No abstract text is available yet for this article.
September 5, 2018: Journal of Pediatrics
Ridhimaa Jain, Ashish Jain, Veena Devgan, Jerin Sekhar
OBJECTIVE: To determine the effect of alternative positions (relative to placenta) of normal term neonates, prior to the recommended delayed cord clamping, on placental transfusion and short-term neonatal outcome. METHODS: Normal term neonates born vaginally were randomly assigned to be placed either on mother's abdomen (Group AL, n = 97) or 20 cm below the introitus (Group BL, n = 102) for 90 seconds after delivery. Subsequently the cord was clamped...
September 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
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