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Cord And Clamping

M Mansour, J Degheili, I Khalifeh, H Tamim, R F Jaafar, Y El-Hout
BACKGROUND: Testicular torsion is a surgical emergency mainly affecting adolescent boys, with a relatively high rate of missed torsion and testicular loss secondary to delay in prompt diagnosis and surgical intervention. With ischemic reperfusion injury as its underlying culprit, testicular torsion may respond favorably to remote ischemic conditioning (RIC) where a non-privileged site (e.g. limb) is concurrently rendered ischemic to divert the cascade of reperfusion injury from the privileged organ (e...
September 24, 2018: Journal of Pediatric Urology
Katsuhiro Yamanaka, Mohamed Eldeiry, Muhammad Aftab, Thomas J Ryan, Xianzhong Meng, Michael J Weyant, David A Fullerton, Thomas Brett Reece
BACKGROUND: Paraplegia remains a significant complication of thoracoabdominal aortic intervention. We previously reported that diazoxide (DZ), enhances the neuroprotective efficacy of erythropoietin (EPO). We hypothesized that DZ and EPO combined treatment attenuates spinal cord ischemic injury through upregulation of nerve growth factor (NGF). METHODS: DZ (pretreatment) was given to adult male C57/BL6 mice by oral gavage and EPO (before surgery) was intraperitoneally injected 32 h after administration of DZ...
January 2019: Journal of Surgical Research
Anup C Katheria
This is a review of umbilical cord milking, a controversial technique where the umbilical cord is squeezed several times before it is clamped an cut. While not physiological or natural for newborns, the question lies as to whether it is useful in certain circumstances, namely the depressed newborn. Here we review the literature and discuss why it could be considered as an alternative for the current practice of delayed cord clamping.
2018: Frontiers in Pediatrics
Chayatat Ruangkit, Sommart Bumrungphuet, Panyu Panburana, Anant Khositseth, Pracha Nuntnarumit
BACKGROUND: Delayed cord clamping (DCC) improves placental transfusion and increases blood volume in preterm infants when compared with immediate cord clamping (ICC). However, evidence to support DCC in multiple-birth preterm infants is still lacking. OBJECTIVE: To compare the outcomes of ICC versus DCC in preterm infants of multiple births. STUDY DESIGN: Women with a multiple pregnancy, including twins and triplets with a gestational age of 28-36 weeks, were randomized to receive ICC (23 women and 50 infants) or DCC for 30-60 s (24 and 51 infants)...
November 27, 2018: Neonatology
Anubhuti Rana, Krishna Agarwal, Siddarth Ramji, Gauri Gandhi, Latika Sahu
Objective: There is concern regarding the safety of delayed cord clamping (DCC) in babies born at less than 34 weeks' gestation. Therefore, the primary objective of this study was to compare the rates of hyperbilirubinemia and polycythemia during initial 7 days in infants born at less than 34 weeks' gestation and randomized to receive DCC by 120 seconds or early cord clamping (ECC) within less than 30 seconds. Methods: One hundred pregnant women were randomly subjected to DCC or ECC at the time of birth in a tertiary referral hospital setting...
November 2018: Obstetrics & Gynecology Science
Judith S Mercer, Debra A Erickson-Owens, Sean C L Deoni, Douglas C Dean, Jennifer Collins, Ashley B Parker, Meijia Wang, Sarah Joelson, Emily N Mercer, James F Padbury
OBJECTIVE: To evaluate whether placental transfusion influences brain myelination at 4 months of age. STUDY DESIGN: A partially blinded, randomized controlled trial was conducted at a level III maternity hospital in the US. Seventy-three healthy term pregnant women and their singleton fetuses were randomized to either delayed umbilical cord clamping (DCC, >5 minutes) or immediate clamping (ICC, <20 seconds). At 4 months of age, blood was drawn for ferritin levels...
December 2018: Journal of Pediatrics
Chong Wang, Ting Yu, Tsugumi Fujita, Eiichi Kumamoto
BACKGROUND: Transient receptor potential ankyrin-1 (TRPA1) channels expressed in the central terminal of dorsal root ganglion neurons in the spinal substantia gelatinosa (SG) play a role in modulating nociceptive transmission. Although plant-derived compounds exhibiting antinociception (such as eugenol, carvacrol and thymol) activate TRPA1 channels to enhance spontaneous excitatory transmission while hyperpolarizing membranes in SG neurons without TRPA1 activation, specific chemical moieties involved in synaptic modulation are unknown...
September 7, 2018: Pharmacological Reports: PR
Pavel Adamek, Mario Heles, Jiri Palecek
Paclitaxel chemotherapy treatment often leads to neuropathic pain resistant to available analgesic treatments. Recently spinal Toll-like receptor 4 (TLR4) and the transient receptor potential cation channel subfamily V member 1 (TRPV1) were identified to be involved in the pro-nociceptive effect of paclitaxel. The aim of this study was to investigate the role of phosphatidylinositol 3-kinase (PI3K) and serine/threonine kinases in this process, with the use of their antagonists (wortmannin, LY-294002 and staurosporine)...
November 21, 2018: Neuropharmacology
Karen M Frank
Advances made in the last several decades in the care of the fetus and newborn have had a significant impact on morbidity and mortality. Delayed umbilical cord clamping in the preterm newborn results in fewer transfusions for anemia, decreased intraventricular hemorrhage, and decreased necrotizing enterocolitis. Because of advances made in fetal ultrasound diagnosis and technological advances, fetal surgeries to treat congenital diaphragmatic hernia, myelomeningocele, twin-to-twin transfusion syndrome, fetal lower urinary tract obstructions, amniotic band syndrome, and congenital cystic adenoid malformation or congenital pulmonary airway malformations have improved the quality of life and survival for these patients...
December 2018: Critical Care Nursing Clinics of North America
Dan Liu, Lingli Zhang, Chuan Zhang, Min Chen, Li Zhang, Jinke Li, Guanjian Liu
BACKGROUND: Varied regimens of penicillin antibiotics were given to women for preventing infection after cesarean section, but there is no study compares the effectiveness and safety of them. METHODS: We searched MEDLINE, Embase, CENTRAL, CNKI, Wanfang, VIP, and CBM Database, and contacted experts in the field and searched reference lists of retrieved studies. We included randomized controlled trials comparing different regimens of penicillin antibiotics given to women after cesarean section...
November 2018: Medicine (Baltimore)
Alessandra Lio, Claudia Aurilia, Valerie Zahra, Timothy J Moss, Domenic A LaRosa, Stuart B Hooper, Andrew W Gill, Martin Kluckow, Ilias Nitsos, Giovanni Vento, Graeme R Polglase
Background: Delaying umbilical cord clamping until after aeration of the lung (physiological-based cord clamping; PBCC) maintains cardiac output and oxygenation in preterm lambs at birth, however, its efficacy after intrauterine inflammation is not known. Given the high incidence of chorioamnionitis in preterm infants, we investigated whether PBCC conferred any benefits compared to immediate cord clamping (ICC) in preterm lambs exposed antenatally to 7 days of intrauterine inflammation. Methods: Ultrasound guided intraamniotic injection of 20 mg Lipopolysaccharide (from E...
2018: Frontiers in Pediatrics
Musa Silahli, Enes Duman, Zeynel Gokmen, Erzat Toprak, Mahmut Gokdemir, Ayse Ecevit
OBJECTIVE: To compare the effect of umbilical cord milking and early cord clamping on thymic size, and neonatal mortality and morbidity in preterm infants. METHODS: This single-center, prospective, double-blind, randomised controlled study was conducted at Baskent University, Konya Education and Research Centre, Konya, Turkey, between October 2015 and April 2016. Pregnant women who delivered before 32 weeks of gestation were randomised to receive umbilical cord milking (group 1) or early cord clamping (group 2)...
November 2018: JPMA. the Journal of the Pakistan Medical Association
Francesca Viaroli, Po-Yin Cheung, Megan O'Reilly, Graeme R Polglase, Gerhard Pichler, Georg M Schmölzer
Cerebrovascular injury is one of the major detrimental consequences of preterm birth. Recent studies have focused their attention on factors that contribute to the development of brain lesions immediately after birth. Among those factors, hypothermia and lower cerebral oxygen saturation during delivery room resuscitation and high tidal volumes delivered during respiratory support are associated with increased risk of severe neurologic injury. In preterm infants, knowledge about causes and prevention of brain injury must be applied before and at birth...
2018: Frontiers in Pediatrics
Jing Wu, Sicong Peng, Linghui Xiao, Xiaoe Cheng, Haixia Kuang, Mengye Zhu, Daying Zhang, Changyu Jiang, Tao Liu
Spinal lamina II (substantia gelatinosa, SG) neurons integrate nociceptive information from the primary afferents and are classified according to electrophysiological (tonic firing, delayed firing, single spike, initial burst, phasic firing, gap firing and reluctant firing) or morphological (islet, central, vertical, radial and unclassified) criteria. T-type calcium (Cav3) channels play an essential role in the central mechanism of pathological pain, but the electrophysiological properties and the cell-type specific distribution of T-type channels in SG neurons have not been fully elucidated...
2018: Frontiers in Cellular Neuroscience
Tadakazu Abe, Wataru Taniguchi, Naoko Nishio, Terumasa Nakatsuka, Munehito Yoshida, Hiroshi Yamada
BACKGROUND: Baclofen is a lipophilic γ-aminobutyric acid (GABA) derivative that exhibits strong intrinsic activity and a high affinity for GABAB receptors. Intrathecal baclofen therapy has been used as an antispasticity and muscle relaxant drug in the clinical treatment of patients with severe spasticity. However, the cellular mechanisms of the antispasticity effects of baclofen on the ventral horn neurons of the spinal cord are unknown. OBJECTIVE: We examined the action of baclofen on excitatory synaptic transmission in ventral horn neurons in the rat spinal cord by whole-cell patch-clamp recordings...
January 2, 2019: Neuroreport
Marco Garofalo, Alessandro Colella, Paolo Sadini, Lorenzo Bianchi, Giacomo Saraceni, Eugenio Brunocilla, Giorgio Gentile, Fulvio Colombo
INTRODUCTION: Self-inflicted orchidectomy and auto-castration, also known as "Eshmun complex" is a rare phenomenon. The aim of our study it to present the management of a patient who performed a self orchiectomy and propose a non-systematic review of literature about self-orchiectomy. MATERIAL AND METHOD: A 27-years old male Patient with psychiatric disorder was admitted to our ward to have been cutted his scrotum with scissors and cut away his left testicle causing active bleeding from the left spermatic artery...
September 30, 2018: Archivio Italiano di Urologia, Andrologia
Kıymet Yeşilçiçek Çalik, Özlem Karabulutlu, Canan Yavuz
BACKGROUND: Interventions can be lifesaving when properly implemented but can also put the lives of both mother and child at risk by disrupting normal physiological childbirth when used indiscriminately without indications. Therefore, this study was performed to investigate the effect of frequent interventions during labor on maternal satisfaction and to provide evidence-based recommendations for labor management decisions. METHODS: The study was performed in descriptive design in a state hospital in Kars, Turkey with 351 pregnant women who were recruited from the delivery ward...
October 24, 2018: BMC Pregnancy and Childbirth
Nicolas Chiriboga, Josef Cortez, Adriana Pena-Ariet, Kartikeya Makker, Carmen Smotherman, Shiva Gautam, Allison Blair Trikardos, Holly Knight, Mark Yeoman, Erin Burnett, Alexandra Beier, Inbal Cohen, Mark L Hudak
OBJECTIVE: Our specific, measurable, attainable, relevant, and time-limited (SMART) aim was to reduce the incidence of severe intracranial hemorrhage (ICH) among preterm infants born <30 weeks' gestation from a baseline of 24% (January 2012-December 2013) to a long-term average of 11% by December 2015. STUDY DESIGN: We instituted an ICH bundle consisting of elements of the "golden hour" (delayed cord clamping, optimized cardiopulmonary resuscitation, improved thermoregulation) and provision of cluster care in the neonatal intensive care unit (NICU)...
October 22, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Enisha Sarin, Nigel Livesley
OBJECTIVE: To compare the impact of quality improvement (QI) approaches and other health system factors (level of health facility, cadre of staff conducting the delivery, years of experience of staff conducting the delivery, and time of day) on the quality of six elements of delivery and postpartum/postnatal care. DESIGN: Cross-sectional study using external observers. SETTING: 12 public health facilities in 6 states in India during November 2014...
September 15, 2018: Indian Pediatrics
Nejada Dingu, Ronald Deumens, Giuliano Taccola
Locomotor patterns are mainly modulated by afferent feedback, but its actual contribution to spinal network activity during continuous passive limb training is still unexplored. To unveil this issue, we devised a robotic in vitro setup (Bipedal Induced Kinetic Exercise, BIKE) to induce passive pedaling, while simultaneously recording low-noise ventral and dorsal root (VR and DR) potentials in isolated neonatal rat spinal cords with hindlimbs attached. As a result, BIKE evoked rhythmic afferent volleys from DRs, reminiscent of pedaling speed...
December 1, 2018: Neuroscience
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