Read by QxMD icon Read

Clinical workflow

L Sonnow, S Koennecker, R Luketina, T Werncke, J B Hinrichs, B C Meyer, F K Wacker, C von Falck
OBJECTIVES: The objective of this study was to compare the diagnostic performance of direct C-arm flat panel computed tomography arthrography (FPCT-A) with direct magnetic resonance arthrography (MR-A) of the wrist in patients with clinically suspected pathologies. METHODS: Forty-nine patients underwent tri-compartmental wrist arthrography. FPCT-A was acquired using a high-resolution acquisition mode, followed by a 3-T MR exam using a dedicated wrist coil. Image quality and artifacts of FPCT-A and MR-A were evaluated with regard to the depictability of anatomical structures...
December 14, 2018: European Radiology
Nicolae Done, Dennis H Oh, Martin A Weinstock, John D Whited, George L Jackson, Heather A King, Sara B Peracca, A Rani Elwy, Julia C Prentice
INTRODUCTION: Teledermatology has emerged as an important strategy to enhance access to high-quality skin care. VA Telederm is a provider-facing, web-based mobile app designed to integrate into the existing teledermatology workflow in the US Veterans Health Administration (VHA). In this study, we will conduct a systematic evaluation of VA Telederm on access outcomes in VHA facilities using a pragmatic trial guided by clinical and operational leaders. METHODS AND ANALYSIS: The study is a prospective, stepped-wedge cluster randomised trial with cross-sectional exposure and outcome measurement via retrospective database analysis of administrative records...
December 14, 2018: BMJ Open
Lucy Hutchinson, Bernhard Steiert, Antoine Soubret, Jonathan Wagg, Alex Phipps, Richard Peck, Jean-Eric Charoin, Benjamin Ribba
Recent advances in machine learning (ML) have led to enthusiasm about its use throughout the biopharmaceutical industry. ML methods can be applied to a wide range of problems and have the potential to revolutionize aspects of drug development. The incorporation of ML in modeling and simulation (M+S) has been eagerly anticipated and in this perspective we highlight examples where ML and M+S approaches can be integrated as complementary parts of a clinical pharmacology workflow. This article is protected by copyright...
December 14, 2018: CPT: Pharmacometrics & Systems Pharmacology
Zamzam Ahmed, Yogini Jani, Bryony Dean Franklin
BACKGROUND: A previous census of electronic prescribing (EP) systems in England showed that more than half of hospitals with EP reported more than one EP system within the same hospital. Our objectives were to describe the rationale for having multiple EP systems within a single hospital, and to explore perceptions of stakeholders about the advantages and disadvantages of multiple systems including any impact on patient safety. METHODS: Hospitals were selected from previous census respondents...
December 14, 2018: BMC Health Services Research
Elaine Zibrowski, Lisa Shepherd, Kamran Sedig, Richard Booth, Candace Gibson
BACKGROUND: The effectiveness of Lean Thinking as a quality improvement method for health care has been contested due, in part, to our limited contextual understanding of how it affects the working conditions and clinical workflow of nurses and physicians. Although there are some initial indications, arising from prevalence surveys and interviews, that Lean may intensify work performed within medical environments, the evidence base still requires detailed descriptions of the changes that were actually introduced to individuals' clinical workflow and how these changes impacted health care professionals...
December 13, 2018: JMIR Human Factors
K Wagner, B Springer, V P Pires, P M Keller
Molecular-based detection of bacterial pathogens directly from clinical specimens permits rapid initiation of effective antimicrobial treatment and adequate patient management. Broad-range polymerase chain reaction (PCR) amplification of the 16S rRNA gene (16S rDNA qPCR) is used in many diagnostic laboratories as a complement to cultural identification of bacterial pathogens. However, efforts for automation of 16S rDNA PCR workflows are needed in order to reduce turnaround times and to enhance reproducibility and standardization of the technique...
November 20, 2018: Diagnostic Microbiology and Infectious Disease
Niclas Skyttberg, Rong Chen, Sabine Koch
BACKGROUND: Emergency medicine is characterized by a high patient flow where timely decisions are essential. Clinical decision support systems have the potential to assist in such decisions but will be dependent on the data quality in electronic health records which often is inadequate. This study explores the effect of automated documentation of vital signs on data quality and workload. METHODS: An observational study of 200 vital sign measurements was performed to evaluate the effects of manual vs automatic documentation on data quality...
December 13, 2018: BMC Emergency Medicine
Meisam Faeghinejad, Periklis Proussaefs, Abdulaziz AlHelal, Jaime Lozada
The computer-assisted design/computer-assisted manufactured compound prosthesis involves designing and milling a cement-retained prosthesis over milled titanium bars. In the presented clinical case report, a diagnostic wax pattern was made to assess esthetics, contours, and occlusion. A total of eight maxillary root-form implants were restored by following the combined prosthesis design concept. The mandibular arch was restored with a screw-retained implant-supported zirconia fixed prosthesis. A milled polymethyl methacrylate (PMMA) maxillary interim prosthesis was fabricated to intraorally confirm the diagnostic wax pattern...
January 2019: International Journal of Periodontics & Restorative Dentistry
Carmen L Charlton, Esther Babady, Christine C Ginocchio, Todd F Hatchette, Robert C Jerris, Yan Li, Mike Loeffelholz, Yvette S McCarter, Melissa B Miller, Susan Novak-Weekley, Audrey N Schuetz, Yi-Wei Tang, Ray Widen, Steven J Drews
SUMMARYRespiratory viral infections are associated with a wide range of acute syndromes and infectious disease processes in children and adults worldwide. Many viruses are implicated in these infections, and these viruses are spread largely via respiratory means between humans but also occasionally from animals to humans. This article is an American Society for Microbiology (ASM)-sponsored Practical Guidance for Clinical Microbiology (PGCM) document identifying best practices for diagnosis and characterization of viruses that cause acute respiratory infections and replaces the most recent prior version of the ASM-sponsored Cumitech 21 document, Laboratory Diagnosis of Viral Respiratory Disease , published in 1986...
January 2019: Clinical Microbiology Reviews
Simon Hein, Martin Schönthaler, Rodrigo Suárez Ibarrola, Philippe-Fabian Müller, Dominik Schoeb, Arkadiusz Miernik
Flexible ureteroscopy (fURS) has become a success story in urology. Since its implementation into the treatment of urolithiasis, fURS has demonstrated excellent clinical performance and safety. In recent years, the spread of disposable ureteroscopes has shaped the field of endoscopic stone treatment. However, the primary advantage of these devices is that they improve the workflow in urology theatres (no sterilisation, no repair costs) and possibly minimise bacteria transfer in working channels rather than being a real technological "game changer"...
December 12, 2018: Aktuelle Urologie
Sema Murat, Ayhan Gürbüz, Kıvanç Kamburoğlu
This clinical report describes a digital workflow using an intraoral digital impression and cone beam computed tomography (CBCT) volumetric data to create a three-dimensional (3D) virtual model of the dentition, defect area, and soft and hard tissue of a patient who had undergone a hemimaxillectomy. Stereolithography (SLA) 3D printing technology was used to produce a resin mold, from which an obturator prosthesis was fabricated through a conventional technique.
2018: International Journal of Computerized Dentistry
M Sean Peach, Daniel M Trifiletti, Sunil W Dutta, James M Larner, David J Schlesinger, Jason P Sheehan
Background: Cone beam CT (CBCT) imaging has been integrated into the most recent version of the Leksell Gamma Knife for the primary purpose to facilitate fractionated therapy. Case description: This case study presents three patients where the CBCT system of the Gamma Knife Icon discovered potentially clinically significant frame shifts. In each case, patients were imaged with volumetric MR prior to stereotactic frame placement. Immediately following frame placement, diagnostic stereotactic CT imaging was acquired with a stereotactic indicator box attached to the frame...
2018: Journal of Radiosurgery and SBRT
Anjali V Desai, Virginia M Klimek, Kimberly Chow, Andrew S Epstein, Camila Bernal, Kelly Anderson, Molly Okpako, Robin Rawlins-Duell, Dana Kramer, Danielle Romano, Jessica I Goldberg, Judith E Nelson
BACKGROUND: Prior work to integrate early palliative care in oncology has focused on patients with advanced cancer and primarily on palliative care consultation. We developed this outpatient clinic initiative for newly diagnosed patients at any stage, emphasizing primary (nonspecialist) palliative care by oncology teams, with enhanced access to palliative care specialists. METHODS: We piloted the project in two medical oncology specialty clinics (for patients with myelodysplastic syndrome and GI cancer, respectively) to establish feasibility...
December 2018: Journal of Oncology Practice
Christopher L Guy, Elisabeth Weiss, Nuzhat Jan, Gary E Christensen, Geoffrey D Hugo
PURPOSE: To develop a quality control method to improve the accuracy of corresponding landmark sets used for deformable image registration evaluation in the lung parenchyma. METHODS: An iterative workflow was developed as a method for quality assurance of landmark sets. Starting with the initial landmark set for a given image pair, a landmark-based deformation was applied to one of the images. A difference image and a color overlay were generated using the deformed image and the other image of the pair...
December 11, 2018: Medical Physics
Miguel Fernández-García, David Rojo, Fernanda Rey-Stolle, Antonia García, Coral Barbas
A robust biomarker screening and validation is crucial for overcoming the current limits in the clinical management of infectious diseases. In this chapter, a general workflow for metabolomics is summarized. Subsequently, an overview of the major contributions of this omics science to the field of biomarkers of infectious diseases is discussed. Different approaches using a variety of analytical platforms can be distinguished to unveil the key metabolites for the diagnosis, prognosis, response to treatment and susceptibility for infectious diseases...
2018: Experientia. Supplementum
Jessica J Y Lee, Clara D M van Karnebeek, Wyeth W Wasserman
Objective: The clinical diagnosis of genetic disorders is undergoing transformation, driven by whole exome sequencing and whole genome sequencing (WES/WGS). However, such nucleotide-level resolution technologies create an interpretive challenge. Prior literature suggests that clinicians may employ characteristic cognitive processes during WES/WGS investigations to identify disruptions in genes causal for the observed disease. Based on cognitive ergonomics, we designed and evaluated a gene prioritization workflow that supported these cognitive processes...
December 7, 2018: Journal of the American Medical Informatics Association: JAMIA
Francesco Ferrini, Paolo Capparé, Raffaele Vinci, Enrico F Gherlone, Gianpaolo Sannino
Objectives: The aim of the study was to evaluate and compare digital and traditional prosthetic workflow for posterior maxillary restorations supported by an upright and a distally tilted implant at 3-year follow-up. Materials and Methods: Twenty-four patients were treated in the posterior maxilla with 24 immediately loaded axial and 24 distally tilted implants supporting 3-unit or 4-unit screw-retained prostheses. Three months after initial loading patients were randomly stratified into two groups: definitive traditional impressions were carried out in the control group, while digital impressions were performed in the test group...
2018: BioMed Research International
Hongmei Cao, Xin Zhou, Yong Zeng
There is an urgent need of sensitive bioanalytical platforms for sensitive and precise quantification of low-abundance microRNA targets in complex biological samples, including liquid biopsies of tumors. Many of current miRNA biosensing methods require laborious sample pretreatment procedures, including extraction of total RNA, which largely limits their biomedical and clinical applications. Herein we developed an integrated Microfluidic Exponential Rolling Circle Amplification (MERCA) platform for sensitive and specific detection of microRNAs directly in minimally processed samples...
January 15, 2019: Sensors and Actuators. B, Chemical
Jimmy Rodriguez Murillo, Magdalena Kuras, Melinda Rezeli, Tasso Milliotis, Lazaro Betancourt, Gyorgy Marko-Varga
To acquire a deeper understanding of malignant melanoma (MM), it is essential to study the proteome of patient tissues. In particular, phosphoproteomics of MM has become of significant importance because of the central role that phosphorylation plays in the development of MM. Investigating clinical samples, however, is an extremely challenging task as there is usually only very limited quantities of material available to perform targeted enrichment approaches. Here, an automated phosphopeptide enrichment protocol using the AssayMap Bravo platform was applied to MM tissues and assessed for performance...
2018: PloS One
Fausto Milletari, Johann Frei, Moustafa Aboulatta, Gerome Vivar, Seyed-Ahmad Ahmadi
BACKGROUND: Deep learning has been recently applied to a multitude of computer vision and medical image analysis problems. Although recent research efforts have improved the state of the art, most of the methods cannot be easily accessed, compared or used by other researchers or clinicians. Even if developers publish their code and pre-trained models on the internet, integration in stand-alone applications and existing workflows is often not straightforward, especially for clinical research partners...
December 5, 2018: IEEE Journal of Biomedical and Health Informatics
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"