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Protein status

Q Ye, F Liu, X Wang, T Han, Y M Qi, F M Wang
Objective: To study the nutritional status and energy metabolic characteristics of patients with nonalcoholic fatty liver disease (NAFLD), and to provide evidence for clinical evaluation and intervention. Methods: A total of 359 NAFLD patients diagnosed on ultrasound from June 2015 to March 2017 were selected as study subjects and divided into mild, moderate to severe fatty liver disease group and 50 healthy subjects as control group. The changes of ICW, ECW, body fat, skeletal muscle, protein and visceral fat area (VFA) of patients and controls were analyzed by using body composition analyzer...
July 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Q P Wang, M F Gan, J W Zhang, S X Weng, L N Zhang
Objective: To study the clinicopathologic characteristics, immunophenotype and ALK gene alterations of gastrointestinal inflammatory myofibroblastic tumor. Methods: Clinical data, histological features and immunohistochemical results were analyzed in 7 cases of gastrointestinal inflammatory myofibroblastic tumor at Zhejiang Province Taizhou Hospital from January 2005 to December 2016. ALK gene status was investigated by ALK fluorescence in situ hybridization. Results: There were 4 female and 3 male patients...
October 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Vishwanatha K Rao, Gerardo Zavala, Abhijit Deb Roy, Richard E Mains, Betty A Eipper
The biosynthetic and endocytic pathways of secretory cells are characterized by progressive luminal acidification, a process which is crucial for posttranslational modifications and membrane trafficking. This progressive fall in luminal pH is mainly achieved by the vacuolar-type-H+ ATPase (V-ATPase). V-ATPases are large, evolutionarily ancient rotary proton pumps that consist of a peripheral V1 complex, which hydrolyzes ATP, and an integral membrane V0 complex, which transports protons from the cytosol into the lumen...
October 14, 2018: Journal of Cellular Physiology
Nirmaljeet Kaur, Prachi Gupta, Vikram Saini, Sandeep Sherawat, Sanjeev Gupta, Anita Dua, Vinod Kumar, Elisha Injeti, Ashwani Mittal
Skeletal muscle atrophy/wasting is associated with impaired protein metabolism in diverse physiological and pathophysiological conditions. Elevated levels of reactive oxygen species (ROS), disturbed redox status, and weakened antioxidant defense system are the major contributing factors toward atrophy. Regulation of protein metabolism by controlling ROS levels and its associated catabolic pathways may help in treating atrophy and related clinical conditions. Although cinnamaldehyde (CNA) enjoys the established status of antioxidant and its role in ROS management is reported, impact of CNA on skeletal muscle atrophy and related pathways is still unexplored...
October 14, 2018: Journal of Cellular Physiology
Yusuke Kono, Hiroaki Saito, Yuki Murakami, Yuji Shishido, Hirohiko Kuroda, Tomoyuki Matsunaga, Manabu Yamamoto, Yoji Fukumoto, Tomohiro Osaki, Keigo Ashida, Yoshiyuki Fujiwara
PURPOSE: Inflammation, together with immune and nutritional status, are associated with the progression of various cancer types. We evaluated the prognostic significance of the postoperative ratio (post-CLR) of the maximum C-reactive protein value (post-CRPMax ) to the minimum peripheral lymphocyte count (post-LCMin ) in patients with gastric cancer (GC). METHODS: The subjects of this retrospective study were 227 patients who underwent curative surgery for histopathologically diagnosed gastric adenocarcinoma...
October 13, 2018: Surgery Today
Qiong Wu, Hua Wang
OBJECTIVE: To investigate the spatiotemporal expression of cannabinoid receptor type 2 (CB2R) in the hippocampus of pilocarpine-induced status epilepticus rats hippocampus of pilocarpine-treated rats experiencing a status epilepticus (SE). METHODS: A total of 112 male Sprague-Dawley rats at three weeks of age, weighing 43 g-68.5 g, were used for this study. Rats were randomly divided into a control group (n = 16) and an epilepsy a SE group. The epilepsy SE group was further divided into 6 sub-groups (2 h, 1, 3, 7, 14, and 21 days after status epilepticus (SE))...
October 9, 2018: Epilepsy Research
Guoyuan Qi, Wanqiang Wu, Yashi Mi, Renjie Shi, Keyu Sun, Runnan Li, Xiao Liu, Xuebo Liu
Circadian rhythms are intimately linked to cellular redox status homeostasis via the regulation of mitochondrial function. Tea polyphenols (TP) are nutraceuticals that possess powerful antioxidant properties, especially ameliorating oxidative stress. The objective of this study was to investigate whether circadian clock is involved in the protection effect of TP on oxidative stress cell models. TP ameliorate H2 O2 -triggered relatively shallow daily oscillations and phase shift of circadian clock genes transcription and protein expression...
October 11, 2018: Food and Chemical Toxicology
Xiliang Du, Guowen Liu, Juan J Loor, Zhiyuan Fang, Ryan Bucktrout, Yuchen Yang, Qianqian Ye, Zhen Shi, Taiyu Shen, Xinghui Wang, Zhicheng Peng, Chenxu Zhao, Bin Lv, Dongmei Xing, Yiwei Zhu, Xiaobing Li, Xinwei Li
The ability of liver to respond to changes in nutrient availability is essential for the maintenance of metabolic homeostasis. Autophagy encompasses mechanisms of cell survival, including capturing, degrading, and recycling of intracellular proteins and organelles in lysosomes. During negative nutrient status, autophagy provides substrates to sustain cellular metabolism and hence, tissue function. Severe negative energy balance in dairy cows is associated with fatty liver. The aim of this study was to investigate the hepatic autophagy status in dairy cows with severe fatty liver and to determine associations with biomarkers of liver function and inflammation...
October 10, 2018: Journal of Dairy Science
M Khosravi, Y Rouzbehan, M Rezaei, J Rezaei
Total mixed rations containing corn silage (CS) or forage sorghum silage (SS) were fed to mid-lactation Holstein cows to determine the effects on feed intake, lactation performance, milk composition and fatty acid profile, nutrient digestibility, blood metabolites, rumen microbial N synthesis, and antioxidant status. The experiment was designed as a 2-period change-over (two 28-d periods) trial with 2 diets including CS diet or SS diet and 12 cows. Total replacement of CS with SS had no significant influence on dry matter intake...
October 10, 2018: Journal of Dairy Science
Alicja Piotrowska-Niczyporuk, Andrzej Bajguz, Elżbieta Zambrzycka-Szelewa, Monika Bralska
The effects of auxins (IAA, IBA, PAA) and cytokinins (tZ, Kin, DPU) on the growth, oxidative damage, level of antioxidants and the activity of antioxidant enzymes as well as the contents of proteins and photosynthetic pigments in green alga Acutodesmus obliquus were investigated under 100 μM lead (Pb) stress. Heavy metal induced oxidative damage as evidenced by a decrease in cell number and reduction in the contents of proteins and chlorophylls as a consequence of an increase in reactive oxygen species (ROS) formation and lipid peroxidation...
October 6, 2018: Plant Physiology and Biochemistry: PPB
Kristine Doney, Kerry McMillen, Laura Buono, H Joachim Deeg, Ted Gooley
This retrospective analysis of 2503 adult (≥20 years of age) allogeneic hematopoietic cell transplantation (HCT) recipients assessed the effect of body mass index (BMI) on transplant outcome. Median patient age was 51.7 years. Both nonmalignant and malignant diagnoses were included. Patients received either a myeloablative (52%) or reduced-intensity (48%) conditioning regimen. Donors were either related (42%) or unrelated (58%). Cord blood recipients were excluded. G-CSF mobilized peripheral blood cells were the stem cell source in 86% of transplants...
October 10, 2018: Biology of Blood and Marrow Transplantation
Johanna O Zeitz, Susanne Kaltenböck, Erika Most, Klaus Eder
This study investigated the hypothesis that dietary supplementation of L-methionine (L-Met) in weaned piglets in relation to DL-methionine (DL-Met) results in a higher antioxidant status and lower need for antioxidant enzyme activation in intestinal epithelium and body tissues, and improves gut morphology and gut barrier function as well as performance. A total of 99 early-weaned 21-day old piglets were allotted to six groups and fed a semi-synthetic wheat-barley-based basal diet supplemented with 0.067%, 0...
October 12, 2018: Journal of Animal Physiology and Animal Nutrition
Duc Ninh Nguyen, Thomas Thymann, Sandra K Goericke-Pesch, Shuqiang Ren, Wei Wei, Kerstin Skovgaard, Peter Damborg, Anders Brunse, Charlotte van Gorp, Boris W Kramer, Tim G Wolfs, Per T Sangild
Prenatal inflammation is a major risk for preterm birth and neonatal morbidity, but its effects on postnatal immunity and organ functions remain unclear. Using preterm pigs as a model for preterm infants, we investigated whether prenatal intra-amniotic (IA) inflammation modulates postnatal systemic immune status and organ functions. Preterm pigs exposed to IA lipopolysaccharide (LPS) for 3 days were compared with controls at birth and postnatal day 5 after formula feeding. IA LPS induced mild chorioamnionitis but extensive intra-amniotic inflammation...
October 4, 2018: American Journal of Pathology
Hyun-Soo Kim, Ji-Ye Kim, Yong Jae Lee, So Hee Kim, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Young Tae Kim
OBJECTIVE: To investigate the prognostic value of the expressions of programmed cell death ligand 1 (PD-L1) and immune checkpoint markers in residual tumors after neoadjuvant chemotherapy (NAC) for advanced high-grade serous ovarian cancer (HGSOC). METHODS: We collected pre- and post-NAC tumor samples from patients with advanced HGSOC between 2006 and 2017. Post-NAC tumor tissue samples were available for immunostaining from 131 patients. The expressions of PD-L1 and immune checkpoint markers were assessed by immunohistochemical staining and the status of tumor-infiltrating lymphocytes (TILs) was also evaluated...
October 9, 2018: Gynecologic Oncology
Qiyuan An, Wenkai Yan, Yi Zhao, Keqiang Yu
Rheumatoid arthritis (RA) is a high morbidity and disability disease with numerous inflammatory cells infiltrating in interstitial of articular cartilages and bones. As the most abundant inflammatory cells, neutrophil has been reported that their apoptosis changed gradually in the circumstance of RA. Apoptosis, one modality of programmed cell death (PCD), is closely associated with autophagy, which indicates neutrophil autophagy may also alter in RA. Flow cytometry, western blotting, immunohistochemistry, immunofluorescence, transmission electron microscope and multiplex antibody microarray were used to comparative investigate the status of neutrophil autophagy in patients with RA and in vitro...
October 9, 2018: International Immunopharmacology
Andrea Scirè, Maurizio Baldassarre, Fabio Tanfani, Jessica Capraro, Marcello Duranti, Alessio Scarafoni
Interaction with model phospholipid membranes of lupin seed γ-conglutin, a glycaemia-lowering protein from Lupinus albus seeds, has been studied by means of Fourier-Transform infrared spectroscopy at p2 H 7.0 and at p2 H 4.5. The protein maintains the same secondary structure both at p2 H 7.0 and at p2 H 4.5, but at p2 H 7.0 a higher 1 H/2 H exchange was observed, indicating a greater solvent accessibility. The difference in Tm and TD1/2 of the protein at the abovementioned p2 H's has been calculated around 20 °C...
October 9, 2018: Biochimica et biophysica acta. Proteins and proteomics
Rui Zhang, Margaret M Billingsley, Michael J Mitchell
The idea of developing therapeutic vaccines against cancer has been explored since the early discovery of tumor-specific antigens by Georg Klein in 1967. However, challenges including weak immunogenicity, systematic toxicity, and off-target effects of cancer vaccines remain as barriers to their broad clinical translation. The emerging field of biomaterials has led to advancements in many different biomedical applications, and it may also help cancer vaccines overcome the various aforementioned challenges. Here, we discuss the rational design and clinical status of several classes of cancer vaccines (i...
October 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Thiago Veiga Jardim, Miles D Witham, Shafika Abrahams-Gessel, F Xavier Gómez-Olivé, Stephen Tollman, Lisa Berkman, Thomas A Gaziano
OBJECTIVES: To characterize the cardiovascular disease (CVD) profile of individuals aged 80 and older in rural South Africa. DESIGN: First wave of population-based longitudinal cohort. SETTING: Agincourt subdistrict (Mpumalanga Province) in rural South Africa. PARTICIPANTS: Adults residents (N = 5,059). MEASUREMENTS: In-person interviews were conducted to obtain social, behavioral, economic, and clinical data...
October 12, 2018: Journal of the American Geriatrics Society
Xindi Yin, Dongxu Ming, Lili Bai, Fei Wu, Hu Liu, Yifan Chen, Linlin Sun, Yidong Wan, Philip Alfred Thacker, Guoyao Wu, Fenglai Wang
This study was conducted to explore the effect of graded levels of pyrroloquinoline quinone disodium (PQQ·Na2) on the performance and intestinal development of weaned pigs. A total of 216 pigs weaned at 28 d were assigned in a randomized complete block design to 6 diets containing 0, 1.5, 3.0, 4.5, 6.0, or 7.5 mg/kg PQQ·Na2 for 28 d. Performance, diarrhea incidence, intestinal morphology, redox status, cytokines, and the expression of tight junction proteins were determined. Pigs had increased ADG (linear, P < 0...
October 12, 2018: Journal of Animal Science
Dipendra Gautam, Bryan Johnson, Michelle Mac, Cary A Moody
The life cycle of HPV is tied to the differentiation status of its host cell, with productive replication, late gene expression and virion production restricted to the uppermost layers of the stratified epithelium. HPV DNA is histone-associated, exhibiting a chromatin structure similar to that of the host chromosome. Although HPV chromatin is subject to histone post-translational modifications, how the viral life cycle is epigenetically regulated is not well understood. SETD2 is a histone methyltransferase that places the trimethyl mark on H3K36 (H3K36me3), a mark of active transcription...
October 12, 2018: PLoS Pathogens
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