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Protein status

Madeleine U Shalowitz, Christine Dunkel Schetter, Marianne M Hillemeier, Vernon M Chinchilli, Emma K Adam, Calvin J Hobel, Sharon Landesman Ramey, Maxine Reed Vance, Patricia O'Campo, John M Thorp, Teresa E Seeman, Tonse N K Raju
OBJECTIVE:  Allostatic load (AL) represents multisystem physiological "wear-and-tear" reflecting emerging chronic disease risk. We assessed AL during the first year postpartum in a diverse community sample with known health disparities. METHODS:  The Eunice Kennedy Shriver National Institute for Child Health and Human Development Community Child Health Network enrolled 2,448 predominantly low-income African-American, Latina, and White women immediately after delivery of liveborn infants at ≥20 weeks' gestation, following them over time with interviews, clinical measures, and biomarkers...
December 14, 2018: American Journal of Perinatology
Manzar Alam, Tanushree Kashyap, Prajna Mishra, Aditya K Panda, Siddavaram Nagini, Rajakishore Mishra
BACKGROUND: Bax, a proapoptotic protein but its regulation during oral cancer progression and resistance remains elusive. METHODS: A total of 127 samples including adjacent normal, primary tumor, and resistance to chemoradiation therapy (RCRT) samples from oral squamous cell carcinoma (OSCC) patients were used. The status of Bax was analyzed at DNA/mRNA/protein levels and the results were correlated with p53 and Akt expression in tissue samples/cisplatin-resistant oral tongue SCC (SCC9/SCC4-CisR) cell line...
December 14, 2018: Head & Neck
Manal S Fawzy, Mona G Elgazzaz, Ahmed Ibrahim, Mohammad H Hussein, Motaz S Khashana, Eman A Toraih
Several studies have investigated the association of Group-specific Component (GC) gene, also known as vitamin D binding protein (VDBP), and various respiratory disorder susceptibility with conflicting results. In this sense, we aimed to investigate whether rs7041 and rs4588 variants confer susceptibility to bronchial asthma in a sample of an Egyptian population and to elucidate by in silico analysis the structural and functional impact of these variants. GC polymorphisms rs7041 and rs4588 were genotyped in 192 Egyptian children and adolescents (96 with asthma and 96 healthy controls) by TaqMan single nucleotide polymorphism genotyping assay...
December 12, 2018: Scandinavian Journal of Immunology
Robert P Ostrowski, John H Zhang
The objectives of this present work were to review recent developments on the role of hypoxia-inducible factor (HIF) in the survival of cells under normoxic versus hypoxic and inflammatory brain conditions. The dual nature of HIF effects appears well established, based on the accumulated evidence of HIF playing both the role of adaptive factor and mediator of cell demise. Cellular HIF responses depend on pathophysiological conditions, developmental phase, comorbidities, and administered medications. In addition, HIF-1α and HIF-2α actions may vary in the same tissues...
December 12, 2018: Journal of Neuroscience Research
Ning Ding, Sam A Miller, Sudha S Savant, Heather M O'Hagan
At sites of chronic inflammation epithelial cells undergo aberrant DNA methylation that contributes to tumorigenesis. Inflammation is associated with an increase in reactive oxygen species (ROS) that cause oxidative DNA damage, which has also been linked to epigenetic alterations. We previously demonstrated that in response to ROS, mismatch repair (MMR) proteins MSH2 and MSH6 recruit epigenetic silencing proteins DNA methyltransferase 1 (DNMT1) and Polycomb repressive complex 2 (PRC2) members to sites of DNA damage, resulting in transcriptional repression of tumor suppressor genes (TSGs)...
December 11, 2018: Environmental and Molecular Mutagenesis
Katarzyna Skonieczna, Arkadiusz Jawień, Andrzej Marszałek, Tomasz Grzybowski
BACKGROUND: p53 is a tumour suppressor protein that is involved in many cancer-related processes. Growing evidence suggests that p53 also plays an important role in mtDNA maintenance. Somatic mitogenome mutations are frequently observed in colorectal cancer cells. Thus, it was important to verify whether somatic mtDNA changes are associated with TP53 mutational status. METHODS: Here, we analysed the TP53 gene in 67 colorectal cancer patients, for whom mitogenome haplotypes were previously described...
December 10, 2018: Journal of Gene Medicine
Tilman Müller, Anastasia Z Kalea, Alonso Marquez, Ivy Hsieh, Syed Haque, Minghao Ye, Jan Wysocki, Michael Bader, Daniel Batlle
The bioactive peptides of the apelinergic system and its receptor APJ have been shown to play a protective role in experimental cardiovascular and diabetic kidney disease (DKD). Mechanisms of this renoprotective effect remain to be elucidated. In this study, we examined the localization of APJ within the normal kidney and its kidney expression in the db/db model of DKD. The effect of hyperglycemia and angiotensin II on APJ was examined in cultured podocytes. In the glomerulus, APJ colocalized with podocyte but not endothelial cell markers...
December 2018: Physiological Reports
Aleksandra Klisic, Nebojsa Kavaric, Bojko Bjelakovic, Elvir Zvrko, Ivan Soldatovic, Jelena Kotur-Stevuljevic
OBJECTIVE: Better than simple anthropometric parameters, the visceral adiposity index (VAI) has recently been proposed as a predictor of cardiometabolic risk in adults. However, there are conflicting results on the associations of these parameters in children and adolescents. Therefore, we aimed to estimate this potential relationship between VAI, anthropometric parameters (i.e., body mass index [BMI], waist circumference [WC], and waist-to-height ratio [WHtR], respectively), and inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) levels in a cohort of adolescent girls...
December 2018: Puerto Rico Health Sciences Journal
Arezki Chekaoui, Karima Lahmar, Houda Belguendouz, Fettoum Mazari, Malika Terahi, Djenette Hakem, Pierre Youinou, Chafia Touil-Boukoffa
Behçet's disease is a multisystem disease. It stands at the crossroad between the autoimmunity and auto-inflammatory disorders. In this study, we sought to address a relationship that might exist between interleukin-1β (IL-1β) and the oxidants/antioxidants markers in Behçet's patients. Behçet's disease patients (n = 78: active stage, n = 28; inactive stage, n = 50) and 41 healthy controls have been included in our study. In this context, we investigated the plasma levels of IL-1β and the nitrosative/oxidative markers: nitric oxide (NO), advanced oxidative protein products (AOPP) and fatty acids peroxidation-malondialdehyde (MDA)...
September 1, 2018: European Cytokine Network
Shuang Ma, Wan-Lin Zhang, Bruce D Leckey, Hong-Tao Xu, Lian-He Yang, Endi Wang
BACKGROUND: Disabled-2 (Dab2) is known as a tumor suppressor as well as a Wnt pathway inhibitor. We previously reported that Dab2 was down-regulated due to gene promoter hypermethylation in lung cancer. Here, we aim to study if X-ray irradiation can induce de-methylation of the Dab2 gene and subsequently up-regulate its expression, and also to attempt to suppress the malignant biological behavior of and enhance the radiosensitivity in lung cancer cells with hypermethylation of the Dab2 gene...
December 14, 2018: Journal of Experimental & Clinical Cancer Research: CR
Jinlan Gao, Chenyang Zhao, Qi Liu, Xiaoyu Hou, Sen Li, Xuesha Xing, Chunhua Yang, Yang Luo
BACKGROUND: Gastric cancer is one of the most common malignant tumors. Cyclin G2 has been shown to be associated with the development of multiple types of tumors, but its underlying mechanisms in gastric tumors is not well-understood. The aim of this study is to investigate the role and the underlying mechanisms of cyclin G2 on Wnt/β-catenin signaling in gastric cancer. METHODS: Real-time PCR, immunohistochemistry and in silico assay were used to determine the expression of cyclin G2 in gastric cancer...
December 14, 2018: Journal of Experimental & Clinical Cancer Research: CR
Sardar H Ijaz, Shakeel M Jamal, Rehan Qayyum
Background The hormones of the hypophysis-thyroid axis (HTA), thyroid stimulating hormone (TSH), and thyroid hormones, L-thyroxine (T4) and 3, 3', 5-L-triiodothyronine (T3), modulate the metabolism, differentiation, and proliferation of almost every cell in the body. Several studies have examined the effect of HTA hormones on platelet count and mean platelet volume (MPV), but have reported inconsistent results. Our aim was to examine the association between HTA hormones and platelet count and MPV in a large cohort of the adult population of the United States...
October 8, 2018: Curēus
Wen-Jing Ding, Yi Yang, Zi-Xing Chen, Yuan-Yuan Wang, Wan-Li Dong, Jian-Nong Cen, Xiao-Fei Qi, Feng Jiang, Su-Ning Chen
Previous studies on the pathogenesis of myelodysplastic syndrome (MDS) have identified multiple associated gene mutations, including mutations of tetmethylcytosinedioxygenase 2, isocitrate dehydrogenase [NADP(+)] 1 cytosolic, isocitrate dehydrogenase [NADP(+)] 2 mitochondrial and additional sex combs like 1 transcriptional regulator, all of which may be considered epigenetic regulators. Furthermore, mutations of RAS type GTPase family genes have been identified in 10-15% patients with MDS. The authors' previous study on the gene expression profile of cluster of differentiation 34+ cells using microarray analysis identified elevated expression of RAP1GTPase activating protein 1 (Rap1GAP) in patients with MDS compared with that in non-malignant blood diseases (NM) control group...
December 2018: Oncology Letters
Ana Roguljic, Gulio Spagnoli, Antonio Juretic, Bozena Sarcevic, Marija Banovic, Lidija Beketic Oreskovic
Cancer/testis antigens (CTAs) are a large family of tumor-associated antigens expressed in human tumors of different histological origin, but not in normal tissues, with the exception of the testes and placenta. Numerous immunohistochemical studies have reported associations between CTA expression and a negative estrogen receptor (ER) status in breast tumors, and demonstrated that CTAs are frequently expressed in tumors with higher nuclear grade. The expression of CTAs has not been studied as extensively in ductal carcinoma in situ (DCIS) as it has been in invasive breast cancer...
December 2018: Oncology Letters
Sandra Meršaková, Veronika Holubeková, Marián Grendár, Jozef Višňovský, Marcela Ňachajová, Michal Kalman, Erik Kúdela, Pavol Žúbor, Tibor Bielik, Zora Lasabová, Ján Danko
Cervical cancer (CC) is the second most common type of cancer affecting the female population. The development of CC takes several years, and involves a precancerous stage known as cervical intraepithelial neoplasia (CIN). A key factor in the development of disease is the human papillomavirus (HPV) infection, which initiates carcinogenesis. Furthermore, CC is also impacted by epigenetic changes such as DNA methylation, which causes activation or exclusion of certain genes, and the hypermethylation of cytosines in promoters, thereby switching off previously active genes...
December 2018: Oncology Letters
Dong-Yue Wen, Jia-Cheng Huang, Jie-Yu Wang, Wen-Ya Pan, Jiang-Hui Zeng, Yu-Yan Pang, Hong Yang
In order to determine the diagnostic efficacy of microRNA (miR)-122-5p and to identify the potential molecular signaling pathways underlying the function of miR-122-5p in hepatocellular carcinoma (HCC), the expression profiles of data collected from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and literature databases were analyzed, along with any associations between clinicopathological characteristics and the diagnostic value of miR-122-5p in HCC. The intersection of 12 online prediction databases and differentially expressed genes from TCGA and GEO were utilized in order to select the prospective target genes of miR-122-5p in HCC...
December 2018: Oncology Letters
Mark Z Kos, Jubao Duan, Alan R Sanders, Lucy Blondell, Eugene I Drigalenko, Melanie A Carless, Pablo V Gejman, Harald H H Göring
The dopaminergic hypothesis of schizophrenia (SZ) postulates that positive symptoms of SZ, in particular psychosis, are due to disturbed neurotransmission via the dopamine (DA) receptor D2 (DRD2). However, DA is a reactive molecule that yields various oxidative species, and thus has important non-receptor-mediated effects, with empirical evidence of cellular toxicity and neurodegeneration. Here we examine non-receptor-mediated effects of DA on gene co-expression networks and its potential role in SZ pathology...
December 13, 2018: Translational Psychiatry
Aya Aly A El-Shazly, Alaliaa M Sallam, Mohamed H El-Hefnawy, Hala O El-Mesallamy
AIMS: Diabetic nephropathy (DN) that progress to end stage renal failure is a serious health problem. Autophagy is involved in DN pathogenesis. Finding renal prognostic biomarkers can help in the future renal status prevision. Therefore, the aim of current study was to evaluate and correlate circulating levels of autophagy regulator protein Unc-51-like kinase 1 (ULK-1) with the widely expressed receptor in mammalian kidney; epidermal growth factor receptor (EGFR); and the key functional podocyte protein podocin (PDCN)...
November 22, 2018: Journal of Diabetes and its Complications
Ali Taravati, Fatemeh Tohidi
Preeclampsia is a hypertensive disorder in pregnant women, which can be the leading cause of maternal and neonatal death or premature birth. Although the cause of preeclampsia is still not clear, local or systemic oxidative stress may explain the pathological features associated with this complication. However, it is not clear whether oxidative stress is the cause or the result of preeclampsia. For this purpose, the present meta-analysis was intended to evaluate the oxidant and antioxidant status in women with preeclampsia...
December 2018: Taiwanese Journal of Obstetrics & Gynecology
Pepijn W Kooij, Bryn M Dentinger, David A Donoso, Jonathan Z Shik, Ester Gaya
Leaf-cutting ants are often considered agricultural pests, but they can also benefit local people and serve important roles in ecosystems. Throughout their distribution, winged reproductive queens of leaf-cutting ants in the genus Atta Fabricius, 1804 are consumed as a protein-rich food source and sometimes used for medical purposes. Little is known, however, about the species identity of collected ants and the accuracy of identification when ants are sold, ambiguities that may impact the conservation status of Atta species as well as the nutritional value that they provide to consumers...
December 12, 2018: Insects
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