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Estrogen Receptor Myeloid derived suppressor cells Breast Cancer

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https://www.readbyqxmd.com/read/27996037/estrogen-induced-sdf-1%C3%AE-production-promotes-the-progression-of-er-negative-breast-cancer-via-the-accumulation-of-mdscs-in-the-tumor-microenvironment
#1
Liquan Ouyang, Weilong Chang, Bin Fang, Jieting Qin, Xincai Qu, Fanjun Cheng
Estrogen plays a role in the processes of tumorigenesis, metastasis, and drug resistance in estrogen receptor (ER)-positive breast cancer (BC). Whether estrogen contributes to ER-negative BC is unclear. Here, we aimed to investigate whether estrogen could stimulate the secretion of stromal-derived factor-1 (SDF-1α) by cancer-associated fibroblasts (CAFs) to promote the progression of ER-negative BC. We transplanted ER-negative BC cells into ovariectomized mice, which was followed by continuous injection of estrogen, and found that estrogen promoted the tumorigenesis of BC...
December 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/22760522/dipyridamole-prevents-triple-negative-breast-cancer-progression
#2
Daniela Spano, Jean-Claude Marshall, Natascia Marino, Daniela De Martino, Alessia Romano, Maria Nunzia Scoppettuolo, Anna Maria Bello, Valeria Di Dato, Luigi Navas, Gennaro De Vita, Chiara Medaglia, Patricia S Steeg, Massimo Zollo
Dipyridamole is a widely prescribed drug in ischemic disorders, and it is here investigated for potential clinical use as a new treatment for breast cancer. Xenograft mice bearing triple-negative breast cancer 4T1-Luc or MDA-MB-231T cells were generated. In these in vivo models, dipyridamole effects were investigated for primary tumor growth, metastasis formation, cell cycle, apoptosis, signaling pathways, immune cell infiltration, and serum inflammatory cytokines levels. Dipyridamole significantly reduced primary tumor growth and metastasis formation by intraperitoneal administration...
January 2013: Clinical & Experimental Metastasis
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