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https://www.readbyqxmd.com/read/30326152/diagnostic-accuracy-of-the-mcgill-thyroid-nodule-score-in-pediatric-patients
#1
Ana Creo, Fares Alahdab, Alaa Al Nofal, Kristen Thomas, Amy Kolbe, Siobhan Pittock
INTRODUCTION: Thyroid cancer is the most common pediatric endocrine cancer; accurate diagnosis and prompt management of pediatric thyroid nodules is critical. The McGill Thyroid Nodule Score (MTNS), based upon clinical, ultrasound (US), and cytology criteria has recently been modified and studied in a pilot pediatric group with good results. We aim to describe the diagnostic accuracy of the pediatric modified MTNS (PMTNS) in a large pediatric cohort. METHODS: We utilized an established retrospective cohort between 1996 and 2015 of 99 patients ≤ 21 years old with 131 thyroid nodules...
October 16, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/30325892/thrombosis-in-pediatric-malignancy-a-review-and-future-perspectives-with-focus-on-management
#2
Mohammadreza Bordbar, Mehran Karimi, Nader Shakibazad
: Venous thromboembolism (VTE) result in significant morbidity and mortality in children with cancer. The cause of VTE in children with cancer is multifactorial and includes genetic predisposition (thrombophilia), disease-related factors, and treatment-related factors including use of central venous catheter (CVC), surgery, and chemotherapy. This review aims to examine current knowledge regarding the incidence, risk factors, clinical manifestation, evaluation, prevention, and management of thromboembolic events in children with cancer...
November 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30325861/international-study-group-of-pediatric-pancreatitis-in-search-for-a-cure-cohort-study-design-and-rationale-for-insppire-2-from-the-consortium-for-the-study-of-chronic-pancreatitis-diabetes-and-pancreatic-cancer
#3
Aliye Uc, Emily R Perito, John F Pohl, Uzma Shah, Maisam Abu-El-Haija, Bradley Barth, Melena D Bellin, Kate M Ellery, Douglas S Fishman, Cheryl E Gariepy, Matthew J Giefer, Tanja Gonska, Melvin B Heyman, Ryan W Himes, Sohail Z Husain, Asim Maqbool, Maria R Mascarenhas, Brian A McFerron, Veronique D Morinville, Tom K Lin, Quin Y Liu, Jaimie D Nathan, Sue J Rhee, Chee Y Ooi, Zachary M Sellers, Sarah Jane Schwarzenberg, Jose Serrano, David M Troendle, Steven L Werlin, Michael Wilschanski, Yuhua Zheng, Ying Yuan, Mark E Lowe
We created the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE (INSPPIRE 2) cohort to study the risk factors, natural history, and outcomes of pediatric acute recurrent pancreatitis and chronic pancreatitis (CP). Patient and physician questionnaires collect information on demographics, clinical history, family and social history, and disease outcomes. Health-related quality of life, depression, and anxiety are measured using validated questionnaires. Information entered on paper questionnaires is transferred into a database managed by Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer's Coordinating and Data Management Center...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30324520/embryonic-stem-cell-models-of-human-brain-tumors
#4
Ludivine Coudière Morrison, Nazanin Tatari, Tamra E Werbowetski-Ogilvie
Utilization of human embryonic stem cells (hESCs) as a model system to study highly malignant pediatric cancers has led to significant insight into the molecular mechanisms governing tumor progression and has revealed novel therapeutic targets for these devastating diseases. Here, we describe a method for generating heterogeneous populations of neural precursors from both normal and neoplastic hESCs and the subsequent injection of neoplastic human embryonic neural cells (hENs) into intracerebellar or intracranial xenograft models...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30324284/taste-changes-in-children-with-cancer-and-hematopoietic-stem-cell-transplant-recipients
#5
Robyn Loves, Deborah Tomlinson, Christina Baggott, David Dix, Paul Gibson, Shannon Hyslop, Donna L Johnston, Andrea D Orsey, Carol Portwine, Victoria Price, Tal Schechter, Magimairajan Vanan, Susan Kuczynski, Brenda Spiegler, George A Tomlinson, L Lee Dupuis, Lillian Sung
BACKGROUND: Objectives were to describe bothersome self-reported changes in taste in pediatric oncology and hematopoietic stem cell (HSCT) patients and to identify patient and treatment-related factors associated with bothersome taste changes. METHODS: We prospectively enrolled children and adolescents with cancer or pediatric HSCT recipients 8-18 years of age from three groups: inpatients receiving cancer treatments; outpatients in maintenance therapy for acute lymphoblastic leukemia (ALL); and outpatients in survivorship...
October 15, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/30323696/impact-of-blinatumomab-on-patient-outcomes-in-relapsed-refractory-acute-lymphoblastic-leukemia-evidence-to-date
#6
REVIEW
Lindsey Hathaway, Jeremy Michael Sen, Michael Keng
Relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) is associated with a poor prognosis in both children and adults. Traditionally, there were limited options for salvage therapy, which consisted mostly of conventional chemotherapy. However, in the past 5 years, novel agents have changed our treatment strategies in this population. Blinatumomab, a bispecific CD19 directed CD3 T-cell engager, has shown to be effective in both minimal residual disease and R/R B-cell ALL. In R/R B-cell ALL, blinatumomab was associated with an improved median overall survival of 7...
2018: Patient related Outcome Measures
https://www.readbyqxmd.com/read/30322880/clinically-relevant-and-minimally-invasive-tumor-surveillance-of-pediatric-diffuse-midline-gliomas-using-patient-derived-liquid-biopsy
#7
Eshini Panditharatna, Lindsay B Kilburn, Mariam S Aboian, Madhuri Kambhampati, Heather Gordish-Dressman, Suresh N Magge, Nalin Gupta, John S Myseros, Eugene I Hwang, Cassie Kline, John R Crawford, Katherine E Warren, Soonmee Cha, Winnie S Liang, Michael E Berens, Roger J Packer, Adam C Resnick, Michael Prados, Sabine Mueller, Javad Nazarian
Purpose: Pediatric diffuse midline glioma (DMG) are highly malignant tumors with poor clinical outcomes. Over 70% of patients with DMG harbor the histone 3 p.K27M (H3K27M) mutation, which correlates with a poorer clinical outcome, and is also used as a criterion for enrollment in clinical trials. Because complete surgical resection of DMG is not an option, biopsy at presentation is feasible, but rebiopsy at time of progression is rare. While imaging and clinical-based disease monitoring is the standard of care, molecular-based longitudinal characterization of these tumors is almost nonexistent...
October 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30322830/long-term-dental-anomalies-after-pediatric-cancer-treatment-in-children
#8
Gülser Kılınç, Gülçin Bulut, Fahinur Ertuğrul, Hale Ören, Bengü Demirağ, Ayşe Demiral, Serap Aksoylar, Emine Serra Kamer, Hülya Ellidokuz, Nur Olgun
No abstract text is available yet for this article.
October 16, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/30321455/therapeutic-potency-of-oncolytic-virotherapy-induced-cancer-stem-cells-targeting-in-brain-tumors-current-status-and-perspectives
#9
REVIEW
Amirhossein Bahreyni, Elnaz Ghorbani, Hamid Fuji, Mikhail Ryzhikov, Majid Khazaei, Marjan Erfani, Amir Avan, Seyed M Hassanian, Kayhan Azadmanesh
Brain tumors are the most common form of solid tumors in children and is presently a serious therapeutic challenge worldwide. Traditional treatment with chemotherapy and radiotherapy was shown to be unsuccessful in targeting brain tumor cancer stem cells (CSCs), leading to recurrent, treatment-resistant secondary malignancies. Oncolytic virotherapy (OV) is an effective antitumor therapeutic strategy which offers a novel, targeted approach for eradicating pediatric brain tumor CSCs by utilizing mechanisms of cell killing that differ from conventional therapies...
October 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30320932/phosphorylation-of-srsf1-at-tyr-19-promotes-cell-proliferation-in-pediatric-acute-lymphoblastic-leukemia
#10
Liting Xu, Han Zhang, Mei Mei, Chaohao Du, Xiahe Huang, Jing Li, Yingchun Wang, Shilai Bao, Huyong Zheng
Serine/arginine-rich splicing factor 1 (SRSF1) has been linked to various human cancers including pediatric acute lymphoblastic leukemia (ALL). Our previous study has shown that SRSF1 potentially contributes to leukemogenesis, however its underlying mechanism remains unclear. In this study, leukemic cells were isolated from pediatric ALL bone marrow samples, followed by immune-precipitation assays and mass spectrum analysis specific to SRSF1. Subcellular localization of the SRSF1 protein and its mutants were analyzed by immunofluorescence staining...
October 15, 2018: Cancer Science
https://www.readbyqxmd.com/read/30319960/vestibulotoxicity-associated-with-platinum-based-chemotherapy-in-survivors-of-cancer-a-scoping-review
#11
Pattarawadee Prayuenyong, John A Taylor, Stephanie E Pearson, Rachel Gomez, Poulam M Patel, Deborah A Hall, Anand V Kasbekar, David M Baguley
Background: Cochleotoxicity following the treatment with platinum-based chemotherapy is well documented. The potential for vestibulotoxicity is still unclear. This scoping review examined the extent of current research literature, summarized research findings and identified research gaps regarding vestibular-related adverse effects associated with platinum-based chemotherapy in survivors of cancer. Methods: Inclusion criteria followed the PICO principles: Participants, adult, and pediatric cancer patients of any cancer type; Intervention, platinum-based chemotherapy (such as cisplatin, carboplatin, and oxaliplatin); Control, none or any; Outcomes, vestibular-related adverse effects...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30319400/metronomic-four-drug-regimen-has-anti-tumor-activity-in-pediatric-low-grade-glioma-the-results-of-a-phase-ii-clinical-trial
#12
Arnauld Verschuur, Marie-Amélie Heng-Maillard, Philippe Dory-Lautrec, Romain Truillet, Elisabeth Jouve, Pascal Chastagner, Pierre Leblond, Isabelle Aerts, Stéphane Honoré, Natasha Entz-Werle, Nicolas Sirvent, Jean-Claude Gentet, Nadège Corradini, Nicolas André
Background: Metronomic chemotherapy (MC) is defined as the frequent administration of chemotherapy at doses below the maximal tolerated dose and with no prolonged drug-free break. MC has shown its efficacy in adult tumor types such as breast and ovarian cancer and has to some extent been studied in pediatrics. Objective: To assess the anti-tumor activity and toxicity of a four-drug metronomic regimen in relapsing/refractory pediatric brain tumors (BT) with progression-free survival (PFS) after two cycles as primary endpoint...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30318786/development-of-pediatric-oncology-supportive-care-indicators-evaluation-of-febrile-neutropenia-care-in-the-north-of-the-netherlands
#13
Sanne Ten Berg, Erik A H Loeffen, Marianne D van de Wetering, Daniëlle H J Martens, Carla M van Ede, Leontien C M Kremer, Wim J E Tissing
INTRODUCTION: Febrile neutropenia (FN) is a common complication of the intensive treatment strategies used in pediatric oncology. By close adherence to high-quality guidelines, which can be evaluated by indicators, the burden of FN can potentially be reduced. OBJECTIVES: The aims of this study were tripartite-(1) to develop structure, process, and outcome indicators, (2) to evaluate the implementation of the Dutch Childhood Oncology Group (DCOG) guideline on FN, and (3) to produce baseline measures on local quality of FN care (in the north of the Netherlands)...
October 14, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30318385/a-systematic-review-of-interventions-to-reduce-psychological-distress-in-pediatric-patients-receiving-radiation-therapy
#14
REVIEW
Moira O'Connor, Georgia Kb Halkett
OBJECTIVE: Radiation therapy (RT) is a cornerstone for management of pediatric cancer. For younger patients, unintended radiation to critical organs is a concern and children need to remain immobile. Distress in children is common so many centres sedate pediatric patients. Children often are unable to remain still, due to anxiety. Interventions to reduce distress could also reduce sedation rates. The objectives of this systematic review were to: review the interventions used to address pediatric RT patients' distress and anxiety and assess their effectiveness...
September 29, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/30315888/career-expectations-and-preferences-of-urology-residency-applicants
#15
Julia Han, Andrew Rabley, Alex Vlasak, Shahab Bozorgmehri, Vincent Bird, Louis Moy
OBJECTIVE: To survey the characteristics, career goals, and practice preferences of current urology applicants. METHODS: An anonymous survey was emailed to applicants pursuing a residency position at the University of Florida for the 2017-2018 academic year Urology Match. The survey included questions on demographics, motivating factors to pursue urology, plans for fellowship training, and anticipated and desired practice patterns. RESULTS: 151 of 295 applicants completed the survey, mean age 26...
October 10, 2018: Urology
https://www.readbyqxmd.com/read/30315865/berberis-orthobotrys-a-promising-herbal-anti-tumorigenic-candidate-for-the-treatment-of-pediatric-alveolar-rhabdomyosarcoma
#16
Anna Adamus, Katharina Peer, Iftikhar Ali, Jan Lisec, Abiodun Falodun, Marcus Frank, Guido Seitz, Nadja Engel
ETHNOPHARMACOLOGICAL RELEVANCE: Berberis orthobotrys (BORM) is a medical plant with a long history in traditional usage for the treatment of wounds, cancer, gastrointestinal malady and several other diseases. Our previous studies identified the endemic Pakistani plant Berberis orthobotrys Bien. ex Aitch. as promising source for the treatment of breast cancer and osteosarcoma. AIM OF THE STUDY: The present study was aimed to evaluate the anti-cancer properties of 26 plant derived extracts and compounds including the methanolic root extract of Berberis orthobotrys (BORM) on pediatric alveolar rhabdomyosarcoma (RMA), which is known to develop drug resistance, metastatic invasion and potential tumor progression...
October 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30315686/unmet-supportive-care-needs-and-psychological-distress-among-parents-of-children-with-cancer-in-indonesia
#17
Yulanticha Diaz Ahwalia Aziza, Shan-Tair Wang, Mei-Chih Huang
OBJECTIVE: The aim of this study was to investigate the needs and associating factors, psychological distress of parents when taking care of children with cancer in Indonesia. METHODS: A cross-sectional study was conducted among 100 parents of children with cancer from the pediatric ward of two hospitals in Indonesia. The parents were assessed using the Indonesian version of the Supportive Care Needs Survey for Partner and Caregiver (unmet needs) and the Hospital Anxiety Depression Scale (psychological distress)...
October 13, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/30314663/cancer-prevention-education-for-providers-staff-parents-and-teens-improves-adolescent-human-papillomavirus-immunization-rates
#18
Manika Suryadevara, Cynthia A Bonville, Donald A Cibula, Joseph B Domachowske
OBJECTIVE: To develop a program to educate providers, office staff, patients, and parents on life-long cancer prevention strategies, including the use of human papillomavirus (HPV) vaccine to improve adolescent HPV vaccination rates. STUDY DESIGN: A 2-phase program was implemented at 6 pediatric practices across upstate New York. Phase 1 included provider and staff education regarding practice-specific vaccination challenges and discussion of the contents of a study-specific cancer-prevention booklet, which included HPV vaccine information...
October 9, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30314361/the-multiple-roles-of-peptidyl-prolyl-isomerases-in-brain-cancer
#19
REVIEW
Stefano Stifani
Peptidyl prolyl isomerases (PPIases) are broadly expressed enzymes that accelerate the cis - trans isomerization of proline peptide bonds. The most extensively studied PPIase family member is protein interacting with never in mitosis A1 (PIN1), which isomerizes phosphorylated serine/threonine⁻proline bonds. By catalyzing this specific cis - trans isomerization, PIN1 can alter the structure of its target proteins and modulate their activities in a number of different ways. Many proteins are targets of proline-directed phosphorylation and thus PIN1-mediated isomerization of proline bonds represents an important step in the regulation of a variety of cellular mechanisms...
October 11, 2018: Biomolecules
https://www.readbyqxmd.com/read/30312727/identification-of-smac-mimetics-as-novel-substrates-for-p-glycoprotein
#20
Manuela Hugle, Sebastian Czaplinski, Karoline Habermann, Meike Vogler, Simone Fulda
Multidrug resistance (MDR) in cancer patients undergoing chemotherapy is preventing effective treatment of multiple cancer types including pediatric tumors. Resistance to chemotherapeutic drugs in cancer cells is frequently associated with high expression of p-glycoprotein, a transporter in the plasma membrane that can mediate cellular drug export. Here, we generated pediatric cancer cells with acquired resistance to the chemotherapeutic drug vincristine (VCR). In these cells, acquired resistance is associated with increased expression of p-glycoprotein...
October 9, 2018: Cancer Letters
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