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https://www.readbyqxmd.com/read/30112841/long-term-risk-of-cardiovascular-mortality-in-lymphoma-survivors-a-systematic-review-and-meta-analysis
#1
REVIEW
Devon J Boyne, Alexis T Mickle, Darren R Brenner, Christine M Friedenreich, Winson Y Cheung, Karen L Tang, Todd A Wilson, Diane L Lorenzetti, Matthew T James, Paul E Ronksley, Doreen M Rabi
Cardiovascular disease has been identified as one of the late complications of cancer therapy. The purpose of this study was to quantify the long-term risk of cardiovascular mortality among lymphoma survivors relative to that of the general population. A systematic review and meta-analysis were conducted. Articles were identified in November 2016 by searching EMBASE, MEDLINE, and CINAHL databases. Observational studies were included if they assessed cardiovascular mortality in patients with lymphoma who survived for at least 5 years from time of diagnosis or if they had a median follow-up of 10 years...
August 15, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30112804/effect-of-a-statistical-outlier-in-potency-bioassays
#2
Perceval Sondag, Lingmin Zeng, Binbing Yu, Réjane Rousseau, Bruno Boulanger, Harry Yang, Steven Novick
The USP<1032> guidelines recommend the screening of bioassay data for outliers prior to performing a relative potency (RP) analysis. The guidelines, however, do not offer advice on the size or type of outlier that should be removed prior to model fitting and calculation of RP. Computer simulation was used to investigate the consequences of ignoring the USP<1032> guidance to remove outliers. For biotherapeutics and vaccines, outliers in potency data may result in the false acceptance/rejection of a bad/good lot of drug product...
August 15, 2018: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/30111880/resistive-switching-in-nano-structures
#3
V G Karpov, D Niraula
Solid state memory and switching devices aimed at replacing the flash memory technology operate by switching from the high to low resistance when conductive filaments are created in response to the electric pulse. The filaments are identified with either structurally different protrusions or purely electronic conductive pathways. The former can appear via the field induced nucleation (FIN), while the latter do not require phase transformations and are attributed to certain types of temperature and bias dependent conductivity...
August 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30111811/sex-differences-in-the-hypothalamic-pituitary-adrenal-axis-response-to-stress-an-important-role-for-gonadal-hormones
#4
REVIEW
Ashley L Heck, Robert J Handa
The hypothalamic-pituitary-adrenal (HPA) axis, a neuroendocrine network that controls hormonal responses to internal and external challenges in an organism's environment, exhibits strikingly sex-biased activity. In adult female rodents, acute HPA function following a stressor is markedly greater than it is in males, and this difference has largely been attributed to modulation by the gonadal hormones testosterone and estradiol. These gonadal hormones are produced by the hypothalamic-pituitary-gonadal (HPG) axis and have been shown to determine sex differences in adult HPA function after acute stress via their activational and organizational effects...
August 1, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30111704/enhancement-of-electrical-characteristics-and-stability-of-amorphous-si-sn-o-thin-film-transistors-with-sio-x-passivation-layer
#5
Xianzhe Liu, Weijing Wu, Weifeng Chen, Honglong Ning, Xiaochen Zhang, Weijian Yuan, Mei Xiong, Xiaofeng Wang, Rihui Yao, Junbiao Peng
In this research, a passivated methodology was proposed for achieving good electrical characteristics for back-channel-etch (BCE) typed amorphous Si-Sn-O thin film transistors (a-STO TFTs). This methodology implied that the thermal annealing (i.e., pre-annealing) should be carried out before deposition of a SiOx passivation layer. The pre-annealing played an important role in affecting device performance, which did get rid of the contamination of the lithography process. Simultaneously, the acceptor-like sub-gap density of states (DOS) of devices was extracted for further understanding the reason for improving device performance...
August 15, 2018: Materials
https://www.readbyqxmd.com/read/30110919/a-novel-sensitive-cell-based-immunoenzymatic-assay-for-palytoxin-quantitation-in-mussels
#6
Marco Pelin, Silvio Sosa, Valentina Brovedani, Laura Fusco, Mark Poli, Aurelia Tubaro
The marine algal toxin palytoxin (PLTX) and its analogues are some of the most toxic marine compounds. Their accumulation in edible marine organisms and entrance into the food chain represent their main concerns for human health. Indeed, several fatal human poisonings attributed to these compounds have been recorded in tropical and subtropical areas. Due to the increasing occurrence of PLTX in temperate areas such as the Mediterranean Sea, the European Food Safety Authority (EFSA) has suggested a maximum limit of 30 µg PLTX/kg in shellfish meat, and has recommended the development of rapid, specific, and sensitive methods for detection and quantitation of PLTX in seafood...
August 14, 2018: Toxins
https://www.readbyqxmd.com/read/30109053/flexible-decision-making-in-grooming-partner-choice-in-sooty-mangabeys-and-chimpanzees
#7
Alexander Mielke, Anna Preis, Liran Samuni, Jan F Gogarten, Roman M Wittig, Catherine Crockford
Living in permanent social groups forces animals to make decisions about when, how and with whom to interact, requiring decisions to be made that integrate multiple sources of information. Changing social environments can influence this decision-making process by constraining choice or altering the likelihood of a positive outcome. Here, we conceptualized grooming as a choice situation where an individual chooses one of a number of potential partners. Studying two wild populations of sympatric primate species, sooty mangabeys ( Cercocebus atys atys ) and western chimpanzees ( Pan troglodytes verus ), we tested what properties of potential partners influenced grooming decisions, including their relative value based on available alternatives and the social relationships of potential partners with bystanders who could observe the outcome of the decision...
July 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/30105443/evaluation-of-supplemental-samples-in-longitudinal-research-with-non-normal-missing-data
#8
Jessica A M Mazen, Xin Tong, Laura K Taylor
Missing data is a commonly encountered problem in longitudinal research. Methodological articles provide advice on ways to handle missing data at the analysis stage, however, there is less guidance for researchers who wish to use supplemental samples (i.e., the addition of new participants to the original sample after missing data appear at the second or later measurement occasions) to handle attrition. The purpose of this study is to evaluate the effects of using supplemental samples when analyzing longitudinal data that are non-normally distributed...
August 13, 2018: Behavior Research Methods
https://www.readbyqxmd.com/read/30097201/a-comparative-perspective-on-lateral-biases-and-social-behavior
#9
Gillian S Forrester, Brenda K Todd
Cerebral lateralization and associated motor behaviors were historically thought to be characteristics unique to humans. Today, it is clear that these features are present and visible in other animal species. These shared attributes of brain and behavior suggest inheritance from a distant common ancestor. Population-level motor biases are likely to reflect an early evolutionary division of primary survival functions of the brain's left and right hemispheres. In modern humans, these features may provide a foundational platform for the development of higher cognitive functions, inextricably cementing the ties between the evolution and development of cognition...
2018: Progress in Brain Research
https://www.readbyqxmd.com/read/30096079/smoothing-effect-in-vital-sign-recordings-fact-or-fiction-a-retrospective-cohort-analysis-of-manual-and-continuous-vital-sign-measurements-to-assess-data-smoothing-in-postoperative-care
#10
Hamish R Tomlinson, Marco A F Pimentel, Stephen Gerry, David A Clifton, Lionel Tarassenko, Peter J Watkinson
BACKGROUND: Data smoothing of vital signs has been reported in the anesthesia literature, suggesting that clinical staff are biased toward measurements of normal physiology. However, these findings may be partially explained by clinicians interpolating spurious values from noisy signals and by the undersampling of physiological changes by infrequent manual observations. We explored the phenomenon of data smoothing using a method robust to these effects in a large postoperative dataset including respiratory rate, heart rate, and oxygen saturation (SpO2)...
August 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/30095888/a-dual-band-multilayer-inse-self-powered-photodetector-with-high-performance-induced-by-surface-plasmon-resonance-and-asymmetric-schottky-junction
#11
Mingjin Dai, Hongyu Chen, Rui Feng, Wei Feng, Yunxia Hu, Huihui Yang, Guangbo Liu, Xiaoshuang Chen, Jia Zhang, Cheng-Yan Xu, PingAn Hu
A dual-band self-powered photodetector (SPPD) with high sensitivity is realized by a facile combination of InSe Schottky diode and Au plasmonic nanoparticle (NP) arrays. Comparing with pristine InSe devices, InSe/Au photodetectors possess an additional capability of photodetection in visible to near-infrared (NIR) region. This intriguing phenomenon is attributed to the wavelength selective enhancement of pristine responsivities by hybridized quadrupole plasmons resonance of Au NPs. It is worth pointing out that the maximum of enhancement ratio in responsivity reaches up to ~1200% at wavelength of 685 nm...
August 10, 2018: ACS Nano
https://www.readbyqxmd.com/read/30092234/estimate-of-hepatocellular-carcinoma-s-incidence-in-patients-with-alcoholic-cirrhosis
#12
Nathalie Ganne-Carrié, Cendrine Chaffaut, Valérie Bourcier, Isabelle Archambeaud, Jean-Marc Perarnau, Frédéric Oberti, Dominique Roulot, Christophe Moreno, Alexandre Louvet, Thông Dao, Romain Moirand, Odile Goria, Eric Nguyen-Khac, Nicolas Carbonell, Térésa Antonini, Stanislas Pol, Victor de Ledinghen, Violaine Ozenne, Jean Henrion, Jean-Marie Péron, Albert Tran, Gabriel Perlemuter, Xavier Amiot, Jean-Pierre Zarski, Michel Beaugrand, Sylvie Chevret
BACKGROUND AND AIMS: The CIRRAL cohort aimed to assess the burden of complications in patients with alcoholic cirrhosis, particularly the occurrence of hepatocellular carcinoma (HCC). PATIENTS: With biopsy-proven compensated alcoholic cirrhosis were included then prospectively followed. The main end point was the incidence of HCC. Secondary outcomes were incidence of hepatic focal lesions, overall survival (OS), liver-related mortality and event-free survival (EFS)...
August 6, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30089371/mode-specific-dynamics-in-bond-selective-reaction-o-3-p-hod-%C3%A2-o-h-od-o-d-oh
#13
Rui Zheng, Yongfa Zhu, Hongwei Song
Taking advantage of bond selectivity and mode specificity has long been realized to control the outcome of chemical reactions. The mode-specific dynamics in the bond selective abstraction reaction O'(3 P) + HOD are investigated using a full-dimensional time-dependent quantum wave packet method. Integral cross sections and product branching ratios from several low-lying vibrational states of the reactant HOD are calculated on an accurate global potential energy surface describing the lowest triplet state of the HOOH system...
August 7, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/30088324/simple-fabrication-of-sno-2-quantum-dot-modified-tio-2-nanorod-arrays-with-high-photoelectrocatalytic-activity-for-overall-water-splitting
#14
Yingguang Zhang, Qun Lin, Na Tong, Zizhong Zhang, Huaqiang Zhuang, Xiaoyan Zhang, Wang Ying, Hongwen Zhang, Xuxu Wang
Photoelectrochemical (PEC) water splitting has been demonstrated as a promising way to acquire clean hydrogen energy. However, the efficiency has been limited by the high recombination rate of photogenerated electron-hole pairs. Herein, we provided a simple approach to construct a novel SnO2 quantum dots (QDs) modified TiO2 nanorod arrays (NAs) by the calcination of SnCl2 -adsorbed TiO2 NAs. The photocurrent density of SnO2 QDs/TiO2 NAs exhibits about 5 times higher than that of parent TiO2 NAs at a bias of 0...
August 8, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/30084022/comparative-efficacy-of-stem-cells-and-secretome-in-articular-cartilage-regeneration-a-systematic-review-and-meta-analysis
#15
REVIEW
Suleiman Alhaji Muhammad, Norshariza Nordin, Muhammad Zulfadli Mehat, Sharida Fakurazi
Articular cartilage defect remains the most challenging joint disease due to limited intrinsic healing capacity of the cartilage that most often progresses to osteoarthritis. In recent years, stem cell therapy has evolved as therapeutic strategies for articular cartilage regeneration. However, a number of studies have shown that therapeutic efficacy of stem cell transplantation is attributed to multiple secreted factors that modulate the surrounding milieu to evoke reparative processes. This systematic review and meta-analysis aim to evaluate and compare the therapeutic efficacy of stem cell and secretome in articular cartilage regeneration in animal models...
August 6, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/30083838/target-distractor-congruency-sequential-effects-in-a-temporal-flanker-task
#16
Miriam Tomat, Mike Wendt, Aquiles Luna-Rodriguez, Michael Sprengel, Thomas Jacobsen
The Congruency Sequence Effect (CSE) denotes the common finding that distractor-target Congruency Effects are reduced after incongruent compared to after congruent trials. Although the CSE is widely attributed to attentional adjustment (i.e., increasing or decreasing the bias in attentional weights regarding processing the target or distractor), unequivocal evidence for this assumption is missing. To investigate the CSE and attentional adjustment we used a temporal flanker task and intermixed a "temporal search task", in which a target stimulus occurred randomly at one of two temporal positions, corresponding to the temporal positions of the target and the distractor occurrence in the temporal flanker task...
August 6, 2018: Psychological Research
https://www.readbyqxmd.com/read/30081340/meta-analysis-of-perinatal-factors-associated-with-epilepsy-in-tropical-countries
#17
REVIEW
Marc Harris Dassi Tchoupa Revegue, Benoit Marin, Euloge Ibinga, Farid Boumediene, Pierre-Marie Preux, Edgard Brice Ngoungou
Most people with epilepsy live in tropical countries. Perinatal factors seem to play a significant role in the occurrence of epilepsy. Available data provide different and sometimes contradictory conclusions on the role and the burden of these factors. The aim of our study was to evaluate the effect of these perinatal factors on the development of epilepsy in tropical countries. The main databases were screened, regardless the language, for all eligible studies published up to March 2017. Exposures were perinatal factors whilst the disease was epilepsy...
July 18, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/30076214/accounting-for-taste-a-multi-attribute-neurocomputational-model-explains-the-neural-dynamics-of-choices-for-self-and-others
#18
Alison Harris, John A Clithero, Cendri A Hutcherson
How do we make choices for others with different preferences from our own? Although neuroimaging studies implicate similar circuits in representing preferences for oneself and others, some models propose that additional corrective mechanisms come online when choices for others diverge from one's own preferences. Here we used event-related potentials (ERP) in humans, in combination with computational modeling, to examine how social information is integrated in the time leading up to choices for oneself and others...
August 3, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/30075057/diagnostic-tests-for-autism-spectrum-disorder-asd-in-preschool-children
#19
REVIEW
Melinda Randall, Kristine J Egberts, Aarti Samtani, Rob Jpm Scholten, Lotty Hooft, Nuala Livingstone, Katy Sterling-Levis, Susan Woolfenden, Katrina Williams
BACKGROUND: Autism spectrum disorder (ASD) is a behaviourally diagnosed condition. It is defined by impairments in social communication or the presence of restricted or repetitive behaviours, or both. Diagnosis is made according to existing classification systems. In recent years, especially following publication of the Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5; APA 2013), children are given the diagnosis of ASD, rather than subclassifications of the spectrum such as autistic disorder, Asperger syndrome, or pervasive developmental disorder - not otherwise specified...
July 24, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30074550/headaches-due-to-low-and-high-intracranial-pressure
#20
Deborah I Friedman
PURPOSE OF REVIEW: Headache disorders attributed to low and high intracranial pressure are commonly encountered in specialty headache practices and may occur more frequently than realized. While the headaches resulting from intracranial pressure disorders have what are conventionally thought of as defining characteristics, a substantial minority of patients do not manifest the "typical" features. Moreover, patients with intracranial pressure disorders may also have a preexisting primary headache disorder...
August 2018: Continuum: Lifelong Learning in Neurology
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