Emily Ferreira Dos Santos, Ângelo Antônio Oliveira Silva, Natália Erdens Maron Freitas, Leonardo Maia Leony, Ramona Tavares Daltro, Carlos Antônio de Souza Teles Santos, Maria da Conceição Chagas de Almeida, Fernando Luiz Vieira de Araújo, Paola Alejandra Fiorani Celedon, Marco Aurélio Krieger, Nilson Ivo Tonin Zanchin, Mitermayer Galvão Dos Reis, Fred Luciano Neves Santos
Chagas disease (CD) is among the top 10 causes of inability to blood donation. Blood donation centers screen for anti- Trypanosoma cruzi antibodies using highly sensitive immunoenzymatic (ELISA) or chemiluminescent methods, which can lead to false positive results. Since positive samples cannot be used, to avoid the loss of valuable blood donations, it is necessary to improve specificity without reducing the sensitivity of the tests used for blood screening. For this purpose, our group has developed four chimeric proteins (IBMP-8...
2022: Frontiers in Medicine