Bei Qian, Ao Shen, Shixing Huang, Hongpeng Shi, Qiang Long, Yiming Zhong, Zhaoxi Qi, Xiaojun He, Yecen Zhang, Wangxi Hai, Xinming Wang, Yanna Cui, Ziheng Chen, Huixia Xuan, Qiang Zhao, Zhengwei You, Xiaofeng Ye
Myocardial infarction (MI) is a major cause of mortality worldwide. The major limitation of regenerative therapy for MI is poor cardiac retention of therapeutics, which results from an inefficient vascular network and poor targeting ability. In this study, a two-layer intrinsically magnetic epicardial patch (MagPatch) prepared by 3D printing with biocompatible materials like poly (glycerol sebacate) (PGS) is designed, poly (ε-caprolactone) (PCL), and NdFeB. The two-layer structure ensured that the MagPatch multifariously utilized the magnetic force for rapid vascular reconstruction and targeted drug delivery...
November 14, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)