Pauraic McCarron, Malachy McCann, Michael Devereux, Kevin Kavanagh, Ciaran Skerry, Petros C Karakousis, Ana C Aor, Thaís P Mello, André L S Santos, Débora L Campos, Fernando R Pavan
Mycobacterium tuberculosis is the etiologic agent of tuberculosis. The demand for new chemotherapeutics with unique mechanisms of action to treat (multi)resistant strains is an urgent need. The objective of this work was to test the effect of manganese(II) and copper(II) phenanthroline/dicarboxylate complexes against M. tuberculosis . The water-soluble Mn(II) complexes, [Mn2 (oda)(phen)4 (H2 O)2 ][Mn2 (oda)(phen)4 (oda)2 ]·4H2 O ( 1 ) and {[Mn(3,6,9-tdda)(phen)2 ]·3H2 O·EtOH}n ( 3 ) (odaH2 = octanedioic acid, phen = 1,10-phenanthroline, tddaH2 = 3,6,9-trioxaundecanedioic acid), and water-insoluble complexes, [Mn(ph)(phen)(H2 O)2 ] ( 5 ), [Mn(ph)(phen)2 (H2 O)]·4H2 O ( 6 ), [Mn2 (isoph)2 (phen)3 ]·4H2 O ( 7 ), {[Mn(phen)2 (H2 O)2 ]}2 (isoph)2 (phen)·12H2 O ( 8 ) and [Mn(tereph)(phen)2 ]·5H2 O ( 9 ) (phH2 = phthalic acid, isophH2 = isophthalic acid, terephH2 = terephthalic acid), robustly inhibited the viability of M...
2018: Frontiers in Microbiology