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electrical stimulation for wound healing

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https://www.readbyqxmd.com/read/30287745/a-disposable-photovoltaic-patch-controlling-cellular-microenvironment-for-wound-healing
#1
Hyeon-Ki Jang, Jin Young Oh, Gun-Jae Jeong, Tae-Jin Lee, Gwang-Bum Im, Ju-Ro Lee, Jeong-Kee Yoon, Dong-Ik Kim, Byung-Soo Kim, Suk Ho Bhang, Tae Il Lee
Electrical stimulation (ES) is known to affect the wound healing process by modulating skin cell behaviors. However, the conventional clinical devices that can generate ES for promoting wound healing require patient hospitalization due to large-scale of the extracorporeal devices. Herein, we introduce a disposable photovoltaic patch that can be applied to skin wound sites to control cellular microenvironment for promoting wound healing by generating ES. In vitro experiment results show that exogenous ES could enhance cell migration, proliferation, expression of extracellular matrix proteins, and myoblast differentiation of fibroblasts which are critical for wound healing...
October 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30286887/editorial-commentary-every-cloud-has-a-silver-lining%C3%A2-but-silver-may-not-be-the-currency-of-choice-the-bioelectric-silver-zinc-dressing-requires-additional-investigation
#2
EDITORIAL
Craig R Bottoni
The use of silver in various forms has been advocated for its antibacterial properties for centuries, because its toxicity to human cells is considerably lower than its toxicity to bacteria. The Greek historian Herodotus recounted how the king of Persia, before going to war, among his provisions included boiled water stored in flagons of silver, ostensibly to mitigate the risk of foodborne infections in his troops. Additionally, recent studies support the use of silver to generate an electrical stimulation for promotion of wound healing...
October 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/30263873/human-adipose-derived-stem-cell-conditioned-media-and-exosomes-containing-malat1-promote-human-dermal-fibroblast-migration-and-ischemic-wound-healing
#3
Denise R Cooper, Chunyan Wang, Rehka Patel, Andrea Trujillo, Niketa A Patel, Jamie Prather, Lisa J Gould, Mack H Wu
Objective: Chronically ill patients heal recalcitrant ulcerative wounds more slowly. Human adipose-derived stem cells (hADSCs) play an important role in tissue regeneration and exosomes secreted by hADSC contribute to their paracrine signaling. In addition to cytokines, lipids and growth factors, hADSC secrete mRNA, miRNA, and long noncoding (lnc) RNA into exosomes. In this study we examined the role of lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), an abundant lncRNA in exosomes from conditioned media (CM), on cell migration and ischemic wound healing...
September 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/30234576/effectiveness-of-transcutaneous-electrical-nerve-stimulation-energy-in-older-adults-a-pilot-clinical-trial
#4
Sara García-Pérez, Ma Carmen García-Ríos, José Manuel Pérez-Mármol, Rosa María Tapia-Haro, Manuel Albornoz-Cabello, Marie Carmen Valenza, María Encarnación Aguilar-Ferrándiz
OBJECTIVE: To evaluate the effectiveness of a transcutaneous electric nerve stimulation (TENS) device typically used for pain suppression (analgesia) during pressure injury (PI) healing, peripheral vascularization, and secondary pain in older adults with chronic PIs and cognitive impairment. DESIGN AND SETTING: This pilot clinical trial followed patients from 6 nursing homes. PATIENTS AND INTERVENTION: Twenty-two patients with PIs in the distal third of their lower limbs (7 men, 15 women) were included in this study...
October 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/30044714/electric-field-induced-migration-and-intercellular-stress-alignment-in-a-collective-epithelial-monolayer
#5
Youngbin Cho, Minjeong Son, Hyuntae Jeong, Jennifer H Shin
During wound healing, cells migrate with electrotactic bias as a collective entity. Unlike the case of the electric field (EF)-induced single-cell migration, the sensitivity of electrotactic response of the monolayer depends primarily on the integrity of the cell-cell junctions. Although there exist biochemical clues on how cells sense the EF, a well-defined physical portrait to illustrate how collective cells respond to directional EF remains elusive. Here, we developed an EF stimulating system integrated with a hydrogel-based traction measurement platform to quantify the EF-induced changes in cellular tractions, from which the complete in-plane intercellular stress tensor can be calculated...
September 15, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29977178/the-effect-of-pulsed-electric-field-on-expression-of-ecm-proteins-collagen-elastin-and-mmp1-in-human-dermal-fibroblasts
#6
Elise B Nguyen, Jeremy Wishner, Katarzyna Slowinska
Electrical stimulation of tissues has many uses in pain management, antibacterial treatment, and wound healing. The electric field stimulates epidermal migration and increases fibroblast cell proliferation. Here we show the effects of electrical field (EF) stimulation of human dermal fibroblasts (HDF) on the expression of collagen, elastin, and collagenase (MMP1; matrix metalloproteinase 1). The effects of EF stimulation are evaluated in terms of changes in cell morphology and extracellular matrix (ECM) protein expression, defined as intracellular concentration of collagen, elastin, and MMP1...
March 1, 2018: Journal of Electroanalytical Chemistry
https://www.readbyqxmd.com/read/29950908/percutaneous-direct-current-stimulation-a-new-electroceutical-solution-for-severe-neurological-pain-and-soft-tissue-injuries
#7
Albrecht Molsberger, Colin D McCaig
There is a high medical need to improve the effectiveness of the treatment of pain and traumatic soft tissue injuries. In this context, electrostimulating devices have been used with only sporadic success. There is also much evidence of endogenous electrical signals that play key roles in regulating the development and regeneration of many tissues. Transepithelial potential gradients are one source of the direct current (DC) electrical signals that stimulate and guide the migration of inflammatory cells, epithelial cells, fibroblasts and mesenchymal stem cells to achieve effective wound healing...
2018: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29923902/changes-in-s100-proteins-identified-in-healthy-skin-following-electrical-stimulation-relevance-for-wound-healing
#8
Chloe Lallyett, Ching-Yan Chloé Yeung, Rie Harboe Nielson, Leo A H Zeef, David Chapman-Jones, Michael Kjaer, Karl E Kadler
OBJECTIVE: Targeted electrical energy applied to wounds has been shown to improve wound-healing rates. However, the mechanisms are poorly understood. The aim of this study was to identify genes that are responsive to electrical stimulation (ES) in healthy subjects with undamaged skin. METHODS: To achieve this objective, study authors used a small, noninvasive ES medical device to deliver a continuous, specific, set sequence of electrical energy impulses over a 48-hour period to the skin of healthy volunteers and compared resultant gene expression by microarray analysis...
July 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29806124/a-fully-biodegradable-battery-for-self-powered-transient-implants
#9
Xueying Huang, Dan Wang, Zhangyi Yuan, Wensheng Xie, Yixin Wu, Rongfeng Li, Yu Zhao, Deng Luo, Liang Cen, Binbin Chen, Hui Wu, Hangxun Xu, Xing Sheng, Milin Zhang, Lingyun Zhao, Lan Yin
Biodegradable transient devices represent an emerging type of electronics that could play an essential role in medical therapeutic/diagnostic processes, such as wound healing and tissue regeneration. The associated biodegradable power sources, however, remain as a major challenge toward future clinical applications, as the demonstrated electrical stimulation and sensing functions are limited by wired external power or wireless energy harvesters via near-field coupling. Here, materials' strategies and fabrication schemes that enable a high-performance fully biodegradable magnesium-molybdenum trioxide battery as an alternative approach for an in vivo on-board power supply are reported...
July 2018: Small
https://www.readbyqxmd.com/read/29738296/microcurrent-as-an-adjunct-therapy-to-accelerate-chronic-wound-healing-and-reduce-patient-pain
#10
Harikrishna K R Nair
OBJECTIVE: The primary aim is to assess the efficacy of microcurrent, a form of electrical stimulation, as an adjunct therapy in accelerating healing in chronic wounds by reducing wound size and pain level. The secondary aim is to assess the qualitative changes in these parameters: inflammatory symptoms, vasodilation, sleep quality, gait and frequency of bowel movement. METHOD: Eligible patients with chronic wounds were enrolled between March and June 2016, from the Wound Care Unit, Hospital Kuala Lumpur in this consecutive case series...
May 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29684268/conducting-polymers-for-tissue-engineering
#11
Baolin Guo, Peter X Ma
Electrically conducting polymers such as polyaniline, polypyrrole, polythiophene, and their derivatives (mainly aniline oligomer and poly(3,4-ethylenedioxythiophene)) with good biocompatibility find wide applications in biomedical fields including bioactuators, biosensors, neural implants, drug delivery systems, and tissue engineering scaffolds. This review focuses on these conductive polymers for tissue engineering applications. Conductive polymers exhibit promising conductivity as bioactive scaffolds for tissue regeneration, and their conductive nature allows cells or tissue cultured on them to be stimulated by electrical signals...
June 11, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29570061/high-voltage-multiphasic-nanosecond-pulses-to-modulate-cellular-responses
#12
Hollie A Ryan, Shinji Hirakawa, Enbo Yang, Chunrong Zhou, Shu Xiao
Nanosecond electric pulses are an effective power source in plasma medicine and biological stimulation, in which biophysical responses are governed by peak power and not energy. While uniphasic nanosecond pulse generators are widely available, the recent discovery that biological effects can be uniquely modulated by reversing the polarity of nanosecond duration pulses calls for the development of a multimodal pulse generator. This paper describes a method to generate nanosecond multiphasic pulses for biomedical use, and specifically demonstrates its ability to cancel or enhance cell swelling and blebbing...
April 2018: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/29528124/from-the-basic-science-of-biological-effects-of-ultrashort-electrical-pulses-to-medical-therapies
#13
REVIEW
Karl H Schoenbach
This article is based on my presentation at the D'Arsonval Ceremony at the Joint Annual Meeting of the Bioelectromagnetics Society and the European BioElectromagnetics Association in Hangzhou, China, in June of 2017. It describes the pathway from the first studies on the effects of intense, nanosecond pulses on biological cells to the development of medical therapies based on these effects. The motivation for the initial studies of the effects of high voltage, nanosecond pulses on mammalian cells was based on a simple electrical circuit model, which predicted that such pulses allow us to affect not just the plasma membrane but also the subcellular structures...
May 2018: Bioelectromagnetics
https://www.readbyqxmd.com/read/29481324/a-randomized-controlled-clinical-study-to-assess-the-effect-of-anodal-and-cathodal-electrical-stimulation-on-periwound-skin-blood-flow-and-pressure-ulcer-size-reduction-in-persons-with-neurological-injuries
#14
Anna Polak, Cezary Kucio, Luther C Kloth, Malgorzata Paczula, Ewa Hordynska, Tomasz Ickowicz, Edward Blaszczak, Ewa Kucio, Krystian Oleszczyk, Krzysztof Ficek, Andrzej Franek
The use of electrical stimulation (ES) should be considered for treating nonhealing pressure ulcers (PUs), but optimal ES wound treatment protocols have yet to be established. A randomized, controlled, double-blind clinical study was conducted to evaluate the effects of cathodal and anodal high-voltage monophasic pulsed current (HVMPC) on periwound skin blood flow (PSBF) and size reduction of Stage 2 to Stage 4 PUs of at least 4 weeks' duration. Persons >18 years of age, hospitalized with neurological injuries, at high risk for PU development (Norton scale <14 points; Waterlow scale >15 points), and with at least 1 Stage 2 to Stage 4 PU were eligible to participate in the study...
February 2018: Ostomy/wound Management
https://www.readbyqxmd.com/read/29402577/high-voltage-electric-stimulation-of-the-donor-site-of-skin-grafts-accelerates-the-healing-process-a-randomized-blinded-clinical-trial
#15
Rosana C Gomes, Elaine C O Guirro, Adriana C Gonçalves, Jayme A Farina Junior, Luiz O Murta Junior, Rinaldo R J Guirro
INTRODUCTION: Severe burns benefit from skin grafting, and grafting surgery is of great importance in the treatment of these injuries. As a result, there is formation of an additional wound at the donor site, which is painful and susceptible to infection. However, the therapeutic approach to these problems at donor sites for skin grafting is insufficiently explored in the literature. AIM: To evaluate electrical stimulation of the donor sites of burn patients treated by grafting surgery...
May 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29343055/genetically-encoded-circuit-for-remote-regulation-of-cell-migration-by-magnetic-fields
#16
Abdullah A Mosabbir, Kevin Truong
Magnetoreception can be generally defined as the ability to transduce the effects of a magnetic field into a cellular response. Magnetic stimulation at the cellular level is particularly attractive due to its ability for deep penetration and minimal invasiveness, allowing remote regulation of engineered biological processes. Previously, a magnetic-responsive genetic circuit was engineered using the transient receptor potential vanilloid 1 (TRPV1) and the iron containing ferritin protein (i.e., the TF circuit)...
February 16, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29262296/electroactive-biomaterials-vehicles-for-controlled-delivery-of-therapeutic-agents-for-drug-delivery-and-tissue-regeneration
#17
REVIEW
Biranche Tandon, Adrián Magaz, Richard Balint, Jonny J Blaker, Sarah H Cartmell
Electrical stimulation for delivery of biochemical agents such as genes, proteins and RNA molecules amongst others, holds great potential for controlled therapeutic delivery and in promoting tissue regeneration. Electroactive biomaterials have the capability of delivering these agents in a localized, controlled, responsive and efficient manner. These systems have also been combined for the delivery of both physical and biochemical cues and can be programmed to achieve enhanced effects on healing by establishing control over the microenvironment...
April 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29140840/high-voltage-electrical-stimulation-versus-ultrasound-in-the-treatment-of-pressure-ulcers
#18
Pinar Bora Karsli, Eda Gurcay, Ozgur Zeliha Karaahmet, Aytul Cakci
OBJECTIVE: The aim of this study was to assess and compare the efficacy of high-voltage electrical stimulation (HVES) with ultrasound (US) in treating Stage II through Stage IV pressure ulcers (PrUs)* of hospitalized patients. DESIGN: This study was designed as a prospective, controlled trial in which patients were randomly assigned to 2 groups. PARTICIPANTS AND SETTINGS: A total of 27 patients (22 male, 5 female) hospitalized for neurologic rehabilitation in the Clinic of Physical Medicine and Rehabilitation with Stage II through Stage IV PrUs were included in this study...
December 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29131756/combined-use-of-modulated-ultrasound-and-electric-current-stimulation-for-diabetic-foot-ulcers-a-case-series
#19
T O'Connor, Z Moore, D Patton, P Wilson, C Gillen, M Hughes, A Reilly
OBJECTIVE: Diabetic foot ulcers (DFUs) are a significant challenge in wound care practice. Our aim was to evaluate the combined use of of two therapies, ultrasound and electrostimulation, in the treatment of DFUs. METHOD: This study employed a prospective, non-comparative, case series design, undertaken in a podiatry-led diabetic foot clinic, in an acute hospital setting, in an urban location in Ireland. We recruited patinets with hard-to-heal DFUs who were treated twice a week with combined modulated ultrasound and electric current stimulation...
November 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29052946/hierarchical-evaluation-of-electrical-stimulation-protocols-for-chronic-wound-healing-an-effect-size-meta-analysis
#20
REVIEW
Charles Khouri, Sylvain Kotzki, Matthieu Roustit, Sophie Blaise, Francois Gueyffier, Jean-Luc Cracowski
Electrical stimulation (ES) has been tested for decades to improve chronic wound healing. However, uncertainty remains on the magnitude of the efficacy and on the best applicable protocol. We conducted an effect size meta-analysis to assess the overall efficacy of ES on wound healing, to compare the efficacy of the different modalities of electrical stimulation, and to determine whether efficacy differs depending on the wound etiology, size, and age of the chronic wound. Twenty-nine randomized clinical trials with 1,510 patients and 1,753 ulcers were selected...
September 2017: Wound Repair and Regeneration
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