Yixiang Liao, Ruyi Wen, Shengwei Fu, Xiaofang Cheng, Shuancheng Ren, Minmin Lu, Ling Qian, Fenlan Luo, Yaling Wang, Qin Xiao, Xiao Wang, Hengying Ye, Xiaolong Zhang, Chenggang Jiang, Xin Li, Shiyin Li, Ruozhi Dang, Yingying Liu, Junjun Kang, Zhongxiang Yao, Jie Yan, Jiaxiang Xiong, Yanjiang Wang, Shengxi Wu, Xiaowei Chen, Yulong Li, Jianxia Xia, Zhian Hu, Chao He
The hypocretin (Hcrt) (also known as orexin) neuropeptidic wakefulness-promoting system is implicated in the regulation of spatial memory, but its specific role and mechanisms remain poorly understood. In this study, we revealed the innervation of the medial entorhinal cortex (MEC) by Hcrt neurons in mice. Using the genetically encoded G-protein-coupled receptor activation-based Hcrt sensor, we observed a significant increase in Hcrt levels in the MEC during novel object-place exploration. We identified the function of Hcrt at presynaptic glutamatergic terminals, where it recruits fast-spiking parvalbumin-positive neurons and promotes gamma oscillations...
November 1, 2023: Neuron