Sarah Stanley, Kavya Devarakonda, Richard O'Connor, Maria Jimenez-Gonzalez, Alexandra Alvarsson, Rollie Hampton, Diego Espinoza, Rosemary Li, Abigail Shtekler, Kaetlyn Conner, Mitchell Bayne, Darline Garibay, Jessie Martin, Vanessa Lehmann, Liheng Wang, Paul Kenny
Behavioral adaptations to environmental threats are crucial for survival and necessitate rapid deployment of energy reserves. The amygdala coordinates behavioral adaptations to threats, but little is known about its involvement in underpinning metabolic adaptations. Here, we show that acute stress activates medial amygdala (MeA) neurons that innervate the ventromedial hypothalamus (MeAVMH neurons), which precipitates hyperglycemia and hypophagia. The glycemic actions of MeAVMH neurons occur independent of adrenal or pancreatic glucoregulatory hormones...
March 29, 2024: Research Square