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Izabella Thaís Silva, Jennifer Munkert, Elke Nolte, Naira Fernanda Zanchett Schneider, Sayonarah Carvalho Rocha, Ana Carolina Pacheco Ramos, Wolfgang Kreis, Fernão Castro Braga, Rodrigo Maia de Pádua, Alex G Taranto, Vanessa Cortes, Leandro Augusto Barbosa, Sven Wach, Helge Taubert, Cláudia Maria Oliveira Simões
Cardiac glycosides (CGs) are natural compounds used to treat congestive heart failure. They have garnered attention as a potential cancer treatment option, especially because they bind to Na+ /K+ -ATPase as a target and activate intracellular signaling pathways leading to a variety of cellular responses. In this study we evaluated AMANTADIG, a semisynthetic cardenolide derivative, for its cytotoxic activity in two human androgen-insensitive prostate carcinoma cell lines, and the potential synergistic effects with docetaxel...
August 11, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Inge M G J Bronckers, Maartje J van Geel, Peter C M van de Kerkhof, Elke M G J de Jong, Marieke M B Seyger
BACKGROUND: Psoriasis can have a substantial impact on health-related quality of life(HRQoL), life course and work productivity. Young adulthood is a critical, sensitive period of development that includes major life changing decisions. The impact of psoriasis on this vulnerable population is yet unknown. OBJECTIVES: To assess QoL, life course and work productivity in young adults with psoriasis and identify characteristics influencing these patient-reported outcomes(PRO)...
August 13, 2018: Journal of Dermatological Treatment
Minkyo Lee, Min-Goo Seo, Seung-Hun Lee, In-Ohk Ouh, Young-Hoan Kim, Joong-Kew Kim, Youn-Kyoung Goo, Man-Hee Rhee, Tae-Hwan Kim, Oh-Deog Kwon, Dongmi Kwak
The purpose of this study was to assess tick-borne pathogenic infections in 42 wild Korean water deer (KWD) and 26 farmed elk in the Gyeongbuk and Gangwon Provinces of Korea. Among the 42 wild KWD tested, the eighteen (42.9%) and five (11.9%) samples tested positive for Anaplasma phagocytophilum and A. bovis, respectively, by PCR and DNA sequencing. All positive samples were only from wild KWD. All samples were negative for other tick-borne pathogens tested. Detected 16S rRNA sequences of A. phagocytophilum and A...
August 10, 2018: Journal of Veterinary Medical Science
Peter J H Jones, Maryam Shamloo, Dylan S MacKay, Todd C Rideout, Semone B Myrie, Jogchum Plat, Jean-Baptiste Roullet, David J Baer, Kara L Calkins, Harry R Davis, P Barton Duell, Henry Ginsberg, Helena Gylling, David Jenkins, Dieter Lütjohann, Mohammad Moghadasian, Robert A Moreau, David Mymin, Richard E Ostlund, Rouyanne T Ras, Javier Ochoa Reparaz, Elke A Trautwein, Stephen Turley, Tim Vanmierlo, Oliver Weingärtner
Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples...
August 7, 2018: Nutrition Reviews
Bettina Böttcher, Elke R Gizewski, Christian Siedentopf, Ruth Steiger, Michael Verius, David Riedl, Anja Ischebeck, Julia Schmid, Ludwig Wildt, Sigrid Elsenbruch
BACKGROUND: Chronic pelvic pain, in particular dysmenorrhea, is a significant yet unresolved healthcare problem in gynecology. As interoceptive sensitivity and underlying neural mechanisms remain incompletely understood, this functional magnetic resonance imaging (fMRI) study assessed behavioral and neural responses to visceral stimuli in primary dysmenorrhea (PMD). METHODS: Women with PMD (N=19) without psychological comorbidity and healthy women (N=20) were compared with respect to visceral sensory and pain thresholds, and to neural responses to individually-calibrated mildly-painful and painful rectal distensions implemented during scanning...
August 11, 2018: European Journal of Pain: EJP
Christian Perez-Shibayama, Cristina Gil-Cruz, Hung-Wei Cheng, Lucas Onder, Andrea Printz, Urs Mörbe, Mario Novkovic, Conglei Li, Constantino Lopez-Macias, Matthew B Buechler, Shannon J Turley, Matthias Mack, Charlotte Soneson, Mark D Robinson, Elke Scandella, Jennifer Gommerman, Burkhard Ludewig
Immune protection of the body cavities depends on the swift activation of innate and adaptive immune responses in nonclassical secondary lymphoid organs known as fat-associated lymphoid clusters (FALCs). Compared with classical secondary lymphoid organs such as lymph nodes and Peyer's patches, FALCs develop along distinct differentiation trajectories and display a reduced structural complexity. Although it is well established that fibroblastic reticular cells (FRCs) are an integral component of the immune-stimulating infrastructure of classical secondary lymphoid organs, the role of FRCs in FALC-dependent peritoneal immunity remains unclear...
August 10, 2018: Science Immunology
Katrin Richter, Christian Koch, Alexander Perniss, Philipp M Wolf, Elke K H Schweda, Sven Wichmann, Sigrid Wilker, Ilona Magel, Michael Sander, J Michael McIntosh, Winfried Padberg, Veronika Grau
Phosphocholine-modified bacterial cell wall components are virulence factors enabling immune evasion and permanent colonization of the mammalian host, by mechanisms that are poorly understood. Recently, we demonstrated that free phosphocholine (PC) and PC-modified lipooligosaccharides (PC-LOS) from Haemophilus influenzae , an opportunistic pathogen of the upper and lower airways, function as unconventional nicotinic agonists and efficiently inhibit the ATP-induced release of monocytic IL-1β. We hypothesize that H...
August 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Pieter-Jan Coenraads, Werner Aberer, Antonio Cristaudo, Thomas Diepgen, Catherine Holden, Lukas Koch, Marie-Louise Schuttelaar, Elke Weisshaar, Anne Fuchs, Kordula Schlotmann, Carsten Goebel, Brunhilde Blömeke, Maya Krasteva
BACKGROUND: Contact dermatitis to hair dyes remains a health concern. Regulations in many countries require consumer self-testing for hair dyes, but no standardized procedure exists. OBJECTIVE: The aim of this study was to develop a self-test protocol for an allergy alert test (AAT) that can elicit a self-noticeable alert signal in p-phenylenediamine (PPD)-allergic consumers. METHODS: Simulating consumer use conditions (open application after mixing with a developer for 45 minutes), PPD-positive hair dye-allergic subjects and PPD-negative control subjects were tested on the forearm and behind the ear with experimental products containing 0...
August 9, 2018: Dermatitis
Patrick Leuthold, Matthias Schwab, Ute Hofmann, Stefan Winter, Steffen Rausch, Michael N Pollak, Jörg Hennenlotter, Jens Bedke, Elke Schaeffeler, Mathias Haag
Tissue analysis represents a powerful tool for the investigation of disease pathophysiology. However, the heterogeneous nature of tissue samples, in particular of neoplastic, may affect the outcome of such analysis and hence obscure interpretation of results. Thus comprehensive isolation and extraction of transcripts and metabolites from an identical tissue specimen would minimize variations and enable the economic use of biopsy material which is usually available in limited amounts. Here we demonstrate a fast and simple protocol for combined transcriptomics and metabolomics analysis in homogenates prepared from one single tissue sample...
August 9, 2018: Journal of Proteome Research
Annette Klein, Elke Zimmermann, Ute Radespiel, Frank Schaarschmidt, Andrea Springer, Christina Strube
BACKGROUND: Ectoparasitic infections are of particular interest for endangered wildlife, as ectoparasites are potential vectors for inter- and intraspecific pathogen transmission and may be indicators to assess the health status of endangered populations. Here, ectoparasite dynamics in sympatric populations of two Malagasy mouse lemur species, Microcebus murinus and M. ravelobensis, were investigated over an 11-month period. Furthermore, the animals' body mass was determined as an indicator of body condition, reflecting seasonal and environmental challenges...
August 8, 2018: Parasites & Vectors
Stefan Monecke, Peter Slickers, Darius Gawlik, Elke Müller, Annett Reissig, Antje Ruppelt-Lorz, Patrick E Akpaka, Dirk Bandt, Michele Bes, Samar S Boswihi, David C Coleman, Geoffrey W Coombs, Olivia S Dorneanu, Vladimir V Gostev, Margaret Ip, Bushra Jamil, Lutz Jatzwauk, Marco Narvaez, Rashida Roberts, Abiola Senok, Anna C Shore, Sergey V Sidorenko, Leila Skakni, Ali M Somily, Muhammad Ali Syed, Alexander Thürmer, Edet E Udo, Teodora Vremerǎ, Jeannete Zurita, Ralf Ehricht
ST239-MRSA-III is probably the oldest truly pandemic MRSA strain, circulating in many countries since the 1970s. It is still frequently isolated in some parts of the world although it has been replaced by other MRSA strains in, e.g., most of Europe. Previous genotyping work (Harris et al., 2010; Castillo-Ramírez et al., 2012) suggested a split in geographically defined clades. In the present study, a collection of 184 ST239-MRSA-III isolates, mainly from countries not covered by the previous studies were characterized using two DNA microarrays (i) targeting an extensive range of typing markers, virulence and resistance genes and (ii) a SCC mec subtyping array...
2018: Frontiers in Microbiology
Wenfei Sun, Hua Dong, Anton S Becker, Dianne H Dapito, Salvatore Modica, Gerald Grandl, Lennart Opitz, Vissarion Efthymiou, Leon G Straub, Gitalee Sarker, Miroslav Balaz, Lucia Balazova, Aliki Perdikari, Elke Kiehlmann, Sara Bacanovic, Caroline Zellweger, Daria Peleg-Raibstein, Pawel Pelczar, Wolf Reik, Irene A Burger, Ferdinand von Meyenn, Christian Wolfrum
In the version of this article originally published, the bars in the mean temperature graph in Fig. 1a were incorrectly aligned. The left-most bar should have been aligned with the Apr label on the projected month of conception axis. The error has been corrected in the print, PDF and HTML versions of this article.
August 7, 2018: Nature Medicine
Wenfei Sun, Hua Dong, Anton S Becker, Dianne H Dapito, Salvatore Modica, Gerald Grandl, Lennart Opitz, Vissarion Efthymiou, Leon G Straub, Gitalee Sarker, Miroslav Balaz, Lucia Balazova, Aliki Perdikari, Elke Kiehlmann, Sara Bacanovic, Caroline Zellweger, Daria Peleg-Raibstein, Pawel Pelczar, Wolf Reik, Irene A Burger, Ferdinand von Meyenn, Christian Wolfrum
In the version of this article originally published, the months on the axis labeled projected month of conception in Fig. 1a were out of order. April and March should have been the first and last months listed, respectively. The error has been corrected in the print, PDF and HTML versions of this article.
August 7, 2018: Nature Medicine
Mathijs Drummen, Elke Dorenbos, Anita Ce Vreugdenhil, Anne Raben, Mikael Fogelholm, Margriet S Westerterp-Plantenga, Tanja Adam
AIMS: To assess the effects of a weight maintenance period comprising two diets differing in protein intake, after weight loss, on intrahepatic lipid content and implications for insulin sensitivity. MATERIALS AND METHODS: A total of 25 participants (BMI: 31.1±3.5 kg/m2; intrahepatic lipid (IHL): 8.7±8.3%; fasting glucose: 6.4±0.6 mmol/l; HOMA-IR: 3.7±1.6; Matsuda index: 3.4±2.9) started an 8-week low energy diet followed by a 2-year weight maintenance period with either high protein (HP) or medium protein (MP) dietary guidelines...
August 7, 2018: American Journal of Physiology. Endocrinology and Metabolism
Elke F Roovers, Lucas J T Kaaij, Stefan Redl, Alfred W Bronkhorst, Kay Wiebrands, António M de Jesus Domingues, Hsin-Yi Huang, Chung-Ting Han, Stephan Riemer, Roland Dosch, Willi Salvenmoser, Dominic Grün, Falk Butter, Alexander van Oudenaarden, René F Ketting
Phase separation represents an important form of subcellular compartmentalization. However, relatively little is known about how the formation or disassembly of such compartments is regulated. In zebrafish, the Balbiani body (Bb) and the germ plasm (Gp) are intimately linked phase-separated structures essential for germ cell specification and home to many germ cell-specific mRNAs and proteins. Throughout development, these structures occur as a single large aggregate (Bb), which disperses throughout oogenesis and upon fertilization accumulates again into relatively large assemblies (Gp)...
August 6, 2018: Developmental Cell
Julian A Steele, Pascal Puech, Masoumeh Keshavarz, Ruoxi Yang, Subhasree Banerjee, Elke Debroye, Cheol Woong Kim, Haifeng Yuan, Nam Ho Heo, Johan Vanacken, Aron Walsh, Johan Hofkens, Maarten B J Roeffaers
The room-temperature charge carrier mobility and excitation-emission properties of metal halide perovskites are governed by the electronic band structure and intrinsic lattice phonon scattering mechanisms. Establishing how charge carriers interact within this scenario will have far-reaching consequences for developing high-effciency materials for optoelectronic applications. Herein we evaluate the charge carrier scattering properties and conduction band environment of the double perovskite Cs2 AgBiBr6 via a combinatorial approach; single crystal X-ray diffraction, optical excitation and temperature dependent emission spectroscopy, resonant and non-resonant Raman scattering, further supported by first principles calculations...
August 7, 2018: ACS Nano
Kati Nowack, Elke Van Der Meer
The synchrony effect (i.e. superior performance at optimal, inferior performance at suboptimal times of day) has been broadly studied within the context of circadian rhythms. Whether one chronotype copes better with the synchrony effect than the other received only insufficient empirical attention. We report on an applied experimental study investigating the impact of chronotype on the synchrony effect in a semantic analogy task. To detect an analogy, 36 participants (12 males) aged between 18 and 40 had to decide whether the relation between events of a source pair was mirrored by the relation between events of a target pair (e...
August 7, 2018: Chronobiology International
Ina Filla, Matthew R Bailey, Elke Schipani, Vanessa Winiger, Chris Mezias, Peter D Balsam, Eleanor H Simpson
Deficits in goal-directed motivation represent a debilitating symptom for many patients with schizophrenia. Impairments in motivation can arise from deficits in processing information about effort and or value, disrupting effective cost-benefit decision making. We have previously shown that upregulated dopamine D2 receptor expression within the striatum (D2R-OE mice) decreases goal-directed motivation. Here, we determine the behavioral and neurochemical mechanisms behind this deficit. Female D2R-OE mice were tested in several behavioral paradigms including recently developed tasks that independently assess the impact of Value or Effort manipulations on cost-benefit decision making...
July 20, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Yuliya Stankevich, Ulrike Lueken, Monika Balzer-Geldsetzer, Richard Dodel, Susanne Gräber-Sultan, Daniela Berg, Inga Liepelt-Scarfone, Rüdiger Hilker-Roggendorf, Elke Kalbe, Oliver Kaut, Brit Mollenhauer, Kathrin Reetz, Eva Schäffer, Nele Schmidt, Jörg B Schulz, Annika Spottke, Karsten Witt, Katharina Linse, Alexander Storch, Oliver Riedel
BACKGROUND: Apathy is a frequent symptom in Parkinson's disease (PD), substantially aggravating the course of PD. Regarding the accumulating evidence of the key role of apathy in PD, time-efficient assessments are useful for fostering progress in research and treatment. The Apathy Evaluation Scale (AES) is widely used for the assessment of apathy across different nosologies. OBJECTIVE: To facilitate the application of the AES in PD, we reduced the AES to two-thirds its length and validated this abbreviated version...
June 30, 2018: American Journal of Geriatric Psychiatry
Elke Smith, Jessica Junger, Katharina Pauly, Thilo Kellermann, Birgit Dernt, Ute Habel
Several studies report sex differences in sensitivity to gendered stimuli. We assume many of these to reflect differences as to the sex to which one feels attracted rather than to biological sex per se. Investigating voice perception, a function of high social relevance, we show that the behavioural and neural (BOLD) responses to male and female voices are mediated by sex and sexual orientation. In heterosexual men and women, we found an opposite-sex effect, reflected in higher classification accuracy for and a response bias towards voices of the other sex, while the effect became apparent as same-sex effect in homosexual men and women...
August 3, 2018: Behavioural Brain Research
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