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Maryse Arendt, Annelies Allain
Annelies Allain has been at the forefront of global efforts to support and promote breastfeeding for more than 30 years. Her accomplishments continue to affect all of us who work with breastfeeding families. Born in the Netherlands in 1945, Annelies Allain-van Elk received a scholarship and completed a BA from the University of Minnesota, Duluth, USA. Back in Europe, she obtained a BA in French language and literature (University of Geneva, Switzerland) as well as a translator's diploma. After 4 years working in West Africa and visits to South America, she returned to Geneva to obtain an MA in development studies...
December 5, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
Elke J van Nieuwenhuijzen, Michael F Sailer, Edwin R van den Heuvel, Stephanie Rensink, Olaf C G Adan, Robert A Samson
Dark homogenous fungal-based layers called biofinishes and vegetable oils are key ingredients of an innovative wood protecting system. The aim of this study was to determine which of the vegetable oils that have been used to generate biofinishes on wood will provide carbon and energy for the biofinish-inhabiting fungus Aureobasidium melanogenum, and to determine the effect of the oil type and the amount of oil on the cell yield. Aureobasidium melanogenum was cultivated in shake flasks with different types and amounts of carbon-based nutrients...
December 4, 2018: MicrobiologyOpen
Jun J Yang, Michelle Whirl-Carrillo, Stuart A Scott, Amy J Turner, Matthias Schwab, Yoichi Tanaka, Guilherme Suarez-Kurtz, Elke Schaeffeler, Teri E Klein, Neil A Miller, Andrea Gaedigk
No abstract text is available yet for this article.
December 4, 2018: Clinical Pharmacology and Therapeutics
Amr Eisa, Osama Farouk, Dalia G Mahran, Mahmoud Badran, Mohammad K Abdelnasser, Michael Samir, Vasiliki Kalampoki, Anahi Hurtado-Chong, Elke Rometsch, Aly Mohamedean, Faisal Adam
PURPOSE: The primary objective was to identify the predictors of in-hospital mortality after pelvic ring injuries. Secondary objectives were to analyze the differences between adults and children and to analyze the causes and timing of death. METHODS: A retrospective cohort study from the pelvic registry of Assiut University Trauma Unit (AUTU), a level 1 trauma centre in Upper Egypt, was carried out. A total of 1188 consecutive patients with pelvic ring fractures treated from January 2010 to December 2013 were eligible for analysis...
December 4, 2018: International Orthopaedics
Lisa Dähnert, Martin Eiden, Josephine Schlosser, Christine Fast, Charlotte Schröder, Elke Lange, Albrecht Gröner, Wolfram Schäfer, Martin H Groschup
BACKGROUND: Hepatitis E virus (HEV) is one major cause of acute clinical hepatitis among humans throughout the world. In industrialized countries an increasing number of autochthonous HEV infections have been identified over the last years triggered by food borne as well as - to a much lower degree - by human to human transmission via blood transfusion. Pigs have been recognised as main reservoir for HEV genotype 3 (HEV-3), and zoonotic transmission to humans through undercooked/raw meat is reported repeatedly...
December 4, 2018: BMC Veterinary Research
Elke Rammant, Valérie Fonteyne, Karel Decaestecker, Renée Bultijnck, Benedicte Deforche, Ronny Pieters, Piet Ost, Sofie Verhaeghe, Ann Van Hecke
OBJECTIVE: To explore the determinants of physical activity in patients with bladder cancer before and after radical cystectomy. DESIGN: A qualitative research design using semi-structured face-to-face interviews. SETTING AND SUBJECTS: A total of 30 interviews were conducted with people diagnosed with bladder cancer and treated with radical cystectomy at Ghent University Hospital. MAIN MEASURES: The interviews were audiotaped and transcribed verbatim...
December 4, 2018: Clinical Rehabilitation
Ruth Steiger, Lisa-Maria Walchhofer, Andreas Rietzler, Katherina J Mair, Michael Knoflach, Bernhard Glodny, Elke R Gizewski, Astrid E Grams
With phosphorus magnetic resonance spectroscopy (31P MRS) energy metabolites can be visualised. In this case study, we report on a patient with stenosis and wall contrast enhancement in the left internal carotid and the right vertebral artery, due to giant cell arteritis. 31P MRS revealed a decreased inorganic phosphate-to-phosphocreatine ratio (Pi/PCr) in regions with a prolonged mean transit time (MTT). After systemic therapy and angioplasty of the right vertebral artery, the stenosis and the symptoms improved and the area of prolonged MTT became smaller...
2018: Case Reports in Radiology
Elke Parsi, Norman Bitterlich, Anne Winkelmann, Daniela Rösler, Christine Metzner
BACKGROUND: Cardiac arrhythmias (CA) are very common and may occur with or without heart disease. Causes of these disturbances can be components of the metabolic syndrome (MetS) or deficits of micronutrients especially magnesium, potassium, B vitamins and coenzyme Q10. Both causes may also influence each other. Insulin resistance (IR) is a risk factor for diastolic dysfunction. One exploratory outcome of the present pilot study was to assess the impact of a dietary intervention with specific micronutrients on the lowering of IR levels in patients with CA with the goal to improve the left ventricular (LV) function...
December 3, 2018: BMC Cardiovascular Disorders
Sidhartha Chaudhury, Elizabeth H Duncan, Tanmaya Atre, Casey K Storme, Kevin Beck, Stephen A Kaba, David E Lanar, Elke S Bergmann-Leitner
Adjuvants have long been critical components of vaccines, but the exact mechanisms of their action and precisely how they alter or enhance vaccine-induced immune responses are often unclear. In this study, we used broad immunoprofiling of antibody, cellular, and cytokine responses, combined with data integration and machine learning to gain insight into the impact of different adjuvant formulations on vaccine-induced immune responses. A Self-Assembling Protein Nanoparticles (SAPN) presenting the malarial circumsporozoite protein (CSP) was used as a model vaccine, adjuvanted with three different liposomal formulations: liposome plus Alum (ALFA), liposome plus QS21 (ALFQ), and both (ALFQA)...
November 30, 2018: Scientific Reports
Simone Kathemann, Elke Lainka, Johannes M Ludwig, Axel Wetter, Andreas Paul, Peter F Hoyer, Michael Forsting, Thomas Schlosser
PURPOSE: Extrahepatic portal vein thrombosis (EPVT) is one major cause of portal hypertension in children. Surgical reinstallation of portal venous flow can be achieved in patients with patent intrahepatic portal venous system/Rex recess. Our study aimed to compare the ability of magnetic resonance imaging (MRI) and retrograde portography (RP) to assess patency of the intrahepatic portal venous system in children with EPVT. METHODS: All pediatric patients with EPVT who were examined with contrast enhanced MRI (1...
October 30, 2018: Journal of Pediatric Surgery
Alsu Kuznetsova, Catherine Cullingham, Debbie McKenzie, Judd M Aiken
Chronic wasting disease (CWD), an environmentally transmissible, fatal prion disease is endemic in North America, present in South Korea and has recently been confirmed in northern Europe. The expanding geographic range of this contagious disease of free-ranging deer, moose, elk and reindeer has resulted in increasing levels of prion infectivity in the environment. Soils are involved in CWD horizontal transmission, acting as an environmental reservoir, and soil mineral and organic compounds have the ability to bind prions...
November 2018: PLoS Pathogens
Jelena Kornej, Petra Büttner, Elke Hammer, Beatrice Engelmann, Borislav Dinov, Philipp Sommer, Daniela Husser, Gerhard Hindricks, Uwe Völker, Andreas Bollmann
BACKGROUND: Left atrial (LA) electro-anatomical remodeling and diameter increase in atrial fibrillation (AF) indicates disease progression and is associated with poor therapeutic success. Furthermore, AF leads to a hypercoagulable state, which in turn promotes the development of a substrate for AF and disease progression in the experimental setting. The aim of this study was to identify pathways associated with LA remodeling in AF patients using untargeted proteomics approach. METHODS: Peripheral blood samples of 48 patients (62±10 years, 63% males, 59% persistent AF) undergoing AF catheter ablation were collected before ablation...
2018: PloS One
Thibaut Thery, Laila N Shwaiki, Yvonne C O'Callaghan, Nora M O'Brien, Elke K Arendt
The development of novel solutions to fight microbial food contaminants rests upon two pillars, which are the development of resistant strains and consumers' desire for a reduced consumption of synthetic drugs. Natural antimicrobial peptides possess the qualities to overcome these issues. De novo synthesis of novel antifungal compounds is a major progress that has been facilitated by the identification of parameters involved in the antimicrobial activity. A 14-residue peptide named KK14, with the sequence KKFFRAWWAPRFLK-NH2 , was designed and inhibited conidial germination and fungal growth of food contaminants within the range 6...
November 28, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
Peter Rieckmann, Matthias Schwab, Dieter Pöhlau, Iris-Katharina Penner, Torsten Wagner, Elke Schel, Antonios Bayas
INTRODUCTION: Patient adherence is a key determinant of treatment success in multiple sclerosis (MS). The RebiSmart® autoinjector facilitates patient self-injection of subcutaneous interferon β-1a (sc IFN β-1a) and allows quantitative measurement of adherence via its automated dosing log. We evaluated patient adherence and patient-reported cognitive and health-economic outcomes over 2 years in patients using RebiSmart® . METHODS: In this non-interventional, single-arm study, enrolled patients were 12-65 years of age, had relapsing-remitting MS or a single demyelinating event, and had been prescribed 44 or 22 μg sc IFN β-1a...
November 28, 2018: Advances in Therapy
Elke Hacker, Caitlin Horsham, Dimitrios Vagenas, Lee Jones, John Lowe, Monika Janda
BACKGROUND: Skin cancer is the most prevalent and most preventable cancer in Australia. Despite Australia's long-running public health campaigns, young Australian adults continue to report high levels of ultraviolet radiation (UVR) exposure and frequent sunburns. Young people are now increasingly turning away from traditional media, such as newspapers and TV, favoring Web-based streaming, which is challenging the health care sector to develop new ways to reach this group with targeted, personalized health promotion messages...
November 28, 2018: JMIR MHealth and UHealth
Daniel Schmidtke, Charlotte Lempp, Marko Dubicanac, Ute Radespiel, Elke Zimmermann, Wolfgang Baumgärtner, Sabine Kästner, Martin Meier, Anne Balkema-Buschmann, R Alan Harris, Muthuswamy Raveendran, Donna M Muzny, Kim C Worley, Jeffrey Rogers
Here we report a case of severe growth retardation and neurologic abnormalities in a female gray mouse lemur (Microcebusmurinus), a small NHP species for which the genomic sequence recently became available. The female lemur we present heredied on postnatal day 125. This lemur had impaired development of motor skills and showed severe ataxia and tremors. In addition, hearing seemed normal whereas ophthalmic examination revealed incipient bilateral cataracts, abnormal pigmentation in the lens of the left eye, and a missing optokinetic nystagmus, which indicated impaired vision...
November 28, 2018: Comparative Medicine
Olga Podolich, Olga Kukharenko, Andriy Haidak, Iryna Zaets, Leonid Zaika, Olha Storozhuk, Larysa Palchikovska, Iryna Orlovska, Oleg Reva, Tatiana Borisova, Ludmila Khirunenko, Mikhail Sosnin, Elke Rabbow, Volodymyr Kravchenko, Mykola Skoryk, Maksym Kremenskoy, Rene Demets, Karen Olsson-Francis, Natalia Kozyrovska, Jean-Pierre Paul de Vera
A kombucha multimicrobial culture (KMC) was exposed to simulated Mars-like conditions in low-Earth orbit (LEO). The study was part of the Biology and Mars Experiment (BIOMEX), which was accommodated in the European Space Agency's EXPOSE-R2 facility, outside the International Space Station. The aim of the study was to investigate the capability of a KMC microecosystem to survive simulated Mars-like conditions in LEO. During the 18-month exposure period, desiccated KMC samples, represented by living cellulose-based films, were subjected to simulated anoxic Mars-like conditions and ultraviolet (UV) radiation, as prevalent at the surface of present-day Mars...
November 28, 2018: Astrobiology
Felix Babatz, Elke Naffin, Christian Klämbt
The blood-brain barrier is crucial for nervous system function. It is established early during development and stays intact during growth of the brain. In invertebrates, septate junctions are the occluding junctions of this barrier. Here, we used Drosophila to address how septate junctions grow during larval stages when brain size increases dramatically. We show that septate junctions are preassembled as long, highly folded strands during embryonic stages, connecting cell vertices. During subsequent cell growth, these corrugated strands are stretched out and stay intact during larval life with very little protein turnover...
October 22, 2018: Developmental Cell
Elke Oberhofer
No abstract text is available yet for this article.
November 2018: MMW Fortschritte der Medizin
Elke Platz, Allison Merz, Montane Silverman, Eldrin Lewis, John D Groarke, Aaron Waxman, David Systrom
AIMS: Dyspnoea is common in heart failure (HF) but non-specific. Lung ultrasound (LUS) could represent a non-invasive tool to detect subclinical pulmonary congestion in patients with undifferentiated dyspnoea. METHODS AND RESULTS: We assessed the feasibility of an abbreviated LUS protocol (eight and two zones) in a prospective pilot study of 25 ambulatory patients with undifferentiated dyspnoea undergoing clinically indicated invasive cardiopulmonary exercise testing (iCPET) at rest (LUS 1) and after peak exercise (LUS 2)...
November 26, 2018: ESC Heart Failure
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