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Hoxc10

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https://www.readbyqxmd.com/read/30429891/overexpression-of-hoxc10-promotes-angiogenesis-in-human-glioma-via-interaction-with-prmt5-and-upregulation-of-vegfa-expression
#1
Zhanyao Tan, Kun Chen, Wenjiao Wu, Yanqing Zhou, Jinrong Zhu, Geyan Wu, Lixue Cao, Xin Zhang, Hongyu Guan, Yi Yang, Wei Zhang, Jun Li
High levels of angiogenesis are associated with poor prognosis in patients with gliomas. However, the molecular mechanisms underlying tumor angiogenesis remain unclear. Methods: The effect of homeobox C10 (HOXC10) on tube formation, migration, and proliferation of human umbilical vein endothelial cells (HUVECs) and on chicken chorioallantoic membranes (CAMs) was examined. An animal xenograft model was used to examine the effect of HOXC10 on xenograft angiogenesis or the effect of bevacizumab, a monoclonal antibody against vascular endothelial growth factor A (VEGFA), on HOXC10-overexpressing xenografts...
2018: Theranostics
https://www.readbyqxmd.com/read/30353595/hoxc10-regulates-osteogenesis-of-mesenchymal-stromal-cells-through-interaction-with-its-natural-antisense-transcript-lnchoxc-as3
#2
Bingzong Li, Huiying Han, Sha Song, Gao Fan, Hongxia Xu, Wenqi Zhou, Yingchun Qiu, Chen'ao Qian, Yijing Wang, Zihan Yuan, Yuan Gao, Yongsheng Zhang, Wenzhuo Zhuang
The characteristics of mesenchymal stromal cells (MSCs) which derived from multiple myeloma (MM) patients is typically impaired in osteogenic differentiation. However, the underlying molecular mechanisms need to be further investigated. Long noncoding RNAs (lncRNAs) are emerging as critical regulation molecules in oncogenic pathways. In this study, we identified that bioactive lncRNA HOXC-AS3, which is transcribed in opposite to HOXC10, was presented in MSCs derived from bone marrow (BM) of MM patients (MM-MSCs)...
October 23, 2018: Stem Cells
https://www.readbyqxmd.com/read/30343692/g-quadruplex-structures-at-the-promoter-of-hoxc10-regulate-its-expression
#3
Xiao Zhang, Bo Zhao, Ting Yan, Aixin Hao, Yang Gao, Dangdang Li, Guangchao Sui
As a member of the homeobox gene family, HOXC10 plays an important role in cell differentiation and embryonic development of mammals. Increasing evidence also suggests a regulatory role of HOXC10 in oncogenesis, but the regulation of HOXC10 gene expression is relatively understudied. In this report, we revealed that the HOXC10 promoter contains multiple G-tracts in its negative strand and has high potential of forming G-quadruplex structures. In circular dichroism studies, synthesized oligonucleotides based on the G-rich region of 241-297 base pairs upstream of the HOXC10 transcription start site showed molar ellipticity at specific wavelengths characteristic of G-quadruplex structures...
November 2018: Biochimica et biophysica acta. Gene regulatory mechanisms
https://www.readbyqxmd.com/read/30284400/effect-of-a-9-week-exercise-training-regimen-on-expression-of-developmental-genes-related-to-growth-dependent-fat-expansion-in-juvenile-rats
#4
Hisashi Kato, Takuya Shibahara, Nazibur Rahman, Hisashi Takakura, Yoshinobu Ohira, Tetsuya Izawa
This study examined the association between changes in mRNA expression of development-related genes including those of the homeobox (Hox) family and growth-dependent increases in inguinal, mesenteric, and epididymal white adipose tissue (WAT) at 4, 6, 10, and 14 weeks of age in rats. We also examined the effects of a 9-week exercise training regimen starting at 5 weeks of age on the mRNA levels of the genes of interest. HoxC8, HoxC9, Gpc4, Bmpr1a, Pparγ, Pgc1α, Adrb3, Hsl, leptin, and adiponectin in each type of WAT - except HoxA5, Gpc4, and Pgc1α in epididymal - showed a positive association between WAT weights and WAT mRNA levels; however, the slope of the regression lines exhibited fat depot-specific differences...
September 2018: Physiological Reports
https://www.readbyqxmd.com/read/30009641/thyroid-stimulating-hormone-receptor-expression-on-primary-cultured-human-extraocular-muscle-myoblasts
#5
Hee-Young Choi, HyeShin Jeon, Jae Wook Yang, Jeong Hyo Ahn, Jae Ho Jung
PURPOSE: To isolate and culture human extraocular muscle (EOM) myoblasts and facilitate their differentiation to myotubes in vitro, and to determine whether these myoblasts express thyroid-stimulating hormone receptor (TSHR). MATERIALS AND METHODS: Human EOM myoblasts were isolated from EOM samples, and identified by immunostaining for PAX7 and MYOD1 (markers of human skeletal myoblasts), and western blot for desmin (muscle marker). In addition, we investigated the expressions of SHOX2 (a genetic marker of EOM myoblasts) and HOXC10 (an exclusive marker of hind-limb muscle-derived myoblasts) by RT-PCR...
July 14, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29768063/overexpression-of-hoxc10-promotes-glioblastoma-cell-progression-to-a-poor-prognosis-via-the-pi3k-akt-signalling-pathway
#6
Yong Guan, Yajie He, Shaoping Lv, Xiaoqun Hou, Luo Li, Jianjun Song
OBJECTIVE: The HOX gene is expressed in neoplasias occurred in multiple tissues, such as the colon, lung and breast. However, the effects of the HOX gene on glioblastoma (GBM) remain poorly understood. We examined HOXC10 expression in GBM tissues and cells, analysed its effect on GBM prognosis, and finally assessed its possible underlying mechanisms in this study. METHODS: HOXC10 expression levels and its prognostic effects on GBM tissues were analysed based on The Cancer Genome Atlas (TCGA) and ONCOMINE database...
August 6, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29753747/hoxc10-promotes-gastric-cancer-cell-invasion-and-migration-via-regulation-of-the-nf-%C3%AE%C2%BAb-pathway
#7
Sheng Yao, Longjun He, Yi Zhang, Liping Ye, Yingrong Lai, Linlin Huang, Ling Wu, Guojun Wu, Senlin Zhu
Homeobox gene C10 (HOXC10), known to regulate cell differentiation and proliferation, is upregulated in gastric cancer (GC). The mechanism underlying HOXC10 involvement in GC metastasis is unclear. Herein, we found that HOXC10 is overexpressed in GC relative to normal controls. In the 73 GC patients tissue microarrays (TMA) tested, HOXC10 expression was closely related with tumor-node-metastasis (TNM) stage, lymph node metastasis, and distant metastasis. HOXC10 overexpression tended to associate with low 5-year cumulative survival...
June 27, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29676849/hoxc10-promotes-proliferation-and-invasion-and-induces-immunosuppressive-gene-expression-in-glioma
#8
Shu Li, Wenhao Zhang, Chao Wu, Hongliang Gao, Jun Yu, Xiaoqiang Wang, Bin Li, Zhong Jun, Wenchaun Zhang, Ping Zhou, Juanhong Shi, Lifeng Wang, Yunxing Gao, Shiting Li, Bangbao Tao
The prognosis for patients with malignant glioma is very poor and thus the identification of new potential therapeutic targets is critically important. In this work, we report a previously unknown role for the homeobox transcription factor HOXC10 in regulating immunosuppressive gene expression in glioma cell lines and their proliferative and invasive capacities. Although HOXC10 expression is dysregulated in several types of tumors, its potential function in glioma was not known. We found that HOXC10 expression was upregulated in glioma compared with normal tissue, and that HOXC10 expression positively associated with high grading of glioma...
June 2018: FEBS Journal
https://www.readbyqxmd.com/read/29490982/regulatory-integration-of-hox-factor-activity-with-t-box-factors-in-limb-development
#9
Deepak Jain, Stephen Nemec, Maëva Luxey, Yves Gauthier, Amandine Bemmo, Aurelio Balsalobre, Jacques Drouin
In tetrapods, Tbx4 , Tbx5 and Hox cluster genes are crucial for forelimb and hindlimb development and mutations in these genes are responsible for congenital limb defects. The molecular basis of their integrated mechanisms of action in the context of limb development remains poorly understood. We studied Tbx4 and Hoxc10 owing to their overlapping loss-of-function phenotypes and colocalized expression in mouse hindlimb buds. We report an extensive overlap between Tbx4 and Hoxc10 genome occupancy and their putative target genes...
March 22, 2018: Development
https://www.readbyqxmd.com/read/29403292/homeobox-c10-knockdown-suppresses-cell-proliferation-and-promotes-cell-apoptosis-in-osteosarcoma-cells-through-regulating-caspase-3
#10
Xiankuan Xie, Yuxiang Xiao, Xin Huang
Aim: Homeobox (HOX) genes and their protein products have been found to function as oncogenes in the progression of many cancers. But the role of Homeobox C10 (HOXC10) in osteosarcoma (OS) still remains less understood. In this study, we firstly determine the biologic functions of HOXC10 in OS. Materials and methods: We examined the expression of HOXC10 in OS tissues by quantitative real-time polymerase chain reaction and Western blot assays. We investigated the effects of HOXC10 on cell proliferation, apoptosis and caspase 3 activity in three OS cell lines by RNA interference, Cell Counting Kit-8, flow cytometry and colorimetric assays...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29353980/hoxc10-up-regulation-promotes-gastric-cancer-cell-proliferation-and-metastasis-through-mapk-pathway
#11
Chen Guo, Jianing Hou, Sheng Ao, Xingming Deng, Guoqing Lyu
Objective: As an important regulator of embryonic morphogenesis, homeodomain-containing gene 10 ( HOXC10 ) has been found to promote progression of human cancers and its expression indicates poor survival outcome. However, very few studies are available on the role of HOXC10 in gastric carcinoma. Therefore, the aim of this study was to determine the role of HOXC10 in gastric cancer and the potential mechanism underlying its function for cancer biology. Methods: A primary gastric cancer mouse model was obtained via intra-gastric wall injection of gastric cancer cells and was used to evaluate the function of HOXC10 during gastric cancer progression in vivo ...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29179492/identification-of-a-gene-signature-associated-with-radiotherapy-and-prognosis-in-gliomas
#12
Shu Li, Juanhong Shi, Hongliang Gao, Yan Yuan, Qi Chen, Zhenyu Zhao, Xiaoqiang Wang, Bin Li, LinZhao Ming, Jun Zhong, Ping Zhou, Hua He, Bangbao Tao, Shiting Li
Glioma is one of the most common primary brain tumors with poor prognosis. Although radiotherapy is an important treatment method for gliomas, the efficacy is still limited by the high occurrence of radioresistance and the underlying molecular mechanism is unclear. Here, we performed a data mining work based on four glioma expression datasets. These datasets were classified into training set and validation set. Radiotherapy-induced differential expressed genes and prognosis-associated genes were screened using different classifiers...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29159235/trimethylation-of-histone-3-lysine-27-h3k27me3-chip-pcr-and-transcriptional-expression-data-of-ef1-alpha-cyp26a-hoxc10-hoxd10-and-hoxd11-in-the-xenopus-xtc-cell-line
#13
Warren Vieira, Hande Sahin, Kaylee Wells, Catherine McCusker
Trimethylation of Histone 3 lysine 27 (H3K27me3) is a chromatin modification that is associated with transcriptional repression (Cao et al., 2002; Sarma et al., 2008; Pengelly et al., 2013) [1], [2], [3]. In this article we performed anti-H3K27me3 Chromosomal Immunoprecipitation (ChIP-PCR), to detect the abundance of H3K27me3 marks on Ef1-alpha, cyp26A, HoxC10, HoxD10 and HoxD11 in the Xenopus XTC cell line. We also performed RT-PCR for these genes to determine whether their expression is detectable in the XTC cell culture...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/28824453/hoxc10-promotes-the-metastasis-of-human-lung-adenocarcinoma-and-indicates-poor-survival-outcome
#14
Xiao-Lei Tang, Bang-Xian Ding, Ying Hua, Hao Chen, Tao Wu, Zhang-Quan Chen, Chun-Hui Yuan
Background: As master regulator of embryonic morphogenesis, homeodomain-containing gene 10 (HOXC10) has been found to promote progression of human cancers and indicates poor survival outcome. However, the role of HOXC10 in lung adenocarcinoma still unclear. Methods: HOXC10 expression was evaluated in 63 primary lung adenocarcinoma tissues from our local hospital, and further systematically confirmed in lung cancer tissues from six GEO datasets (GSE19188, GSE31210, GSE10072, GSE7670, GSE32863, GSE30219), and Kaplan-Meier plotter database...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28656883/mir-136-inhibits-gastric-cancer-specific-peritoneal-metastasis-by-targeting-hoxc10
#15
Jianyong Zheng, Peng Ge, Xiaonan Liu, Jiangpeng Wei, Guosheng Wu, Xiaohua Li
Functions of microRNAs have been characterized in the embryologic, physiologic, and oncogenic processes, but the role of microRNAs in mediating tumor-specific organ metastasis was addressed only recently and still absent in gastric cancer peritoneal metastasis. Here, we used the microarray analysis to define the gastric cancer peritoneal metastasis-related microRNAs from highly peritoneal metastatic derivatives (GC-9811P cells) and the parental GC-9811 human gastric cancer cells. MiR-136 was found to be decreased in all peritoneal metastatic sublines when compared with that in the parental line...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28605223/homeobox-c10-inhibits-the-osteogenic-differentiation-potential-of-mesenchymal-stem-cells
#16
Guoqing Li, Nannan Han, Haoqing Yang, Liping Wang, Xiao Lin, Shu Diao, Juan Du, Rui Dong, Songlin Wang, Zhipeng Fan
PURPOSE: Mesenchymal stem cells (MSCs) are a reliable cell source for tissue regeneration. However, the molecular mechanisms underlying the directed differentiation of MSCs remain unclear which impedes potential clinical applications. Recent studies have discovered that Homeobox (HOX) genes are involved in the differentiation regulation of MSCs and bone formation. In this study, we investigate the HOXC10 function in the osteogenic differentiation potential of MSCs. MATERIALS AND METHODS: Stem cells from apical papilla (SCAPs) and adipose-derived stem cells (ADSCs) were used in this study...
May 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/28474998/homeodomain-containing-gene-10-inhibits-cell-apoptosis-and-promotes-cell-invasion-and-migration-in-osteosarcoma-cell-lines
#17
Wen Xiong, Quan Zhou, Gang Liu, Xiang-Sheng Liu, Xin-Yu Li
Homeodomain-containing gene 10 (HOXC10) belongs to the homeobox family, which encodes a highly conserved family of transcription factors that plays an important role in morphogenesis in all multicellular organisms. Altered expressions of HOXC10 have been reported in several malignancies. This study was aimed to reveal the expression profile of HOXC10 in osteosarcoma and evaluated whether HOXC10 is a molecular target for cancer therapy. We found that HOXC10 was up-regulated in osteosarcoma tissues compared with bone cyst specimens from The Cancer Genome Atlas database...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28186086/hoxc10-suppresses-browning-of-white-adipose-tissues
#18
Yvonne Ng, Shi-Xiong Tan, Sook Yoong Chia, Hwee Yim Angeline Tan, Sin Yee Gun, Lei Sun, Wanjin Hong, Weiping Han
Given that increased thermogenesis in white adipose tissue, also known as browning, promotes energy expenditure, significant efforts have been invested to determine the molecular factors involved in this process. Here we show that HOXC10, a homeobox domain-containing transcription factor expressed in subcutaneous white adipose tissue, is a suppressor of genes involved in browning white adipose tissue. Ectopic expression of HOXC10 in adipocytes suppresses brown fat genes, whereas the depletion of HOXC10 in adipocytes and myoblasts increases the expression of brown fat genes...
February 10, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/27689016/dynamic-dna-methylation-landscape-defines-brown-and-white-cell-specificity-during-adipogenesis
#19
Yen Ching Lim, Sook Yoong Chia, Shengnan Jin, Weiping Han, Chunming Ding, Lei Sun
OBJECTIVE: DNA methylation may be a stable epigenetic contributor to defining fat cell lineage. METHODS: We performed reduced representation bisulfite sequencing (RRBS) and RNA-seq to depict a genome-wide integrative view of the DNA methylome and transcriptome during brown and white adipogenesis. RESULTS: Our analysis demonstrated that DNA methylation is a stable epigenetic signature for brown and white cell lineage before, during, and after differentiation...
October 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27689007/genetic-backgrounds-determine-brown-remodeling-of-white-fat-in-rodents
#20
Giulia Ferrannini, Maria Namwanje, Bin Fang, Manashree Damle, Dylan Li, Qiongming Liu, Mitchell A Lazar, Li Qiang
OBJECTIVE: Genetic background largely contributes to the complexity of metabolic responses and dysfunctions. Induction of brown adipose features in white fat, known as brown remodeling, has been appreciated as a promising strategy to offset the positive energy balance in obesity and further to improve metabolism. Here we address the effects of genetic background on this process. METHODS: We investigated browning remodeling in a depot-specific manner by comparing the response of C57BL/6J, 129/Sv and FVB/NJ mouse strains to cold...
October 2016: Molecular Metabolism
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