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phytoestrogen

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https://www.readbyqxmd.com/read/29226152/the-phytoestrogen-genistein-produces-similar-effects-as-17%C3%AE-estradiol-on-anxiety-like-behavior-in-rats-at-12-weeks-after-ovariectomy
#1
Juan Francisco Rodríguez-Landa, Jonathan Cueto-Escobedo, Abraham Puga-Olguín, Eduardo Rivadeneyra-Domínguez, Blandina Bernal-Morales, Emma Virginia Herrera-Huerta, Andrea Santos-Torres
The phytoestrogen genistein produces anxiolytic-like effects in ovariectomized rats, which highlights its potential therapeutic effect in ameliorating anxiety in surgical menopausal women. However, no studies have directly compared the effects of identical doses of genistein and 17β-estradiol, the main estrogen used in hormone replacement therapy in menopausal women. The present study evaluated the anxiolytic-like effects of identical doses of genistein and 17β-estradiol (0.045, 0.09, and 0.18 mg/kg/7 days, s...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29219853/effects-of-a-soybean-milk-product-on-feto-neonatal-development-in-rats
#2
Eun Suk An, Dongsun Park, Young-Hwan Ban, Choi Jieun, Da Woom Seo, Yoon Bok Lee, Mi Yae Shon, Ehn-Kyoung Choi, Yun-Bae Kim
Since estrogenic pollutants and phytoestrogens can cause the disorder of the reproductive system, the effects of a soybean milk product (Vegemil<sup>®</sup> containing 162 ppm isoflavones) on the feto-neonatal development, including male reproductive function, were investigated. Pregnant rats were fed the soybean milk (5% or 100% in drinking water) from gestational day (GD) 6 to parturition or to post-natal day (PND) 56. Specifically, the rats were divided into 4 groups: the control group (drinking water), the GD5% group (5% soybean milk during only the GD period), the GD-PND5% group (5% soybean milk during the GD and PND periods), and the GD-PND100% group (100% soybean milk instead of water during the GD and PND periods)...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29218931/-research-progress-in-phytoestrogens-of-traditional-chinese-medicine
#3
REVIEW
Yuan Zhao, Hong-Xia Zheng, Ying Xu, Na Lin
Phytoestrogens are plant-derived compounds, which have a similarity in structure with human endogenous estrogen 17-β-estradiol. Structural likeness enables phytoestrogens to interact with estrogen receptors, not simply mimicking the effects of human steroidal estrogen but also exhibiting similar and divergent actions. The global literature relating to phytoestrogen in recent years was systematically summarized in this paper. Chemical compositions of phytoestrogens were mainly flavonoids, coumarins, lignans, terpenoids, steroids, etc...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29194365/the-role-of-resveratrol-in-cancer-therapy
#4
REVIEW
Jeong-Hyeon Ko, Gautam Sethi, Jae-Young Um, Muthu K Shanmugam, Frank Arfuso, Alan Prem Kumar, Anupam Bishayee, Kwang Seok Ahn
Abstract: Natural product compounds have recently attracted significant attention from the scientific community for their potent effects against inflammation-driven diseases, including cancer. A significant amount of research, including preclinical, clinical, and epidemiological studies, has indicated that dietary consumption of polyphenols, found at high levels in cereals, pulses, vegetables, and fruits, may prevent the evolution of an array of diseases, including cancer. Cancer development is a carefully orchestrated progression where normal cells acquires mutations in their genetic makeup, which cause the cells to continuously grow, colonize, and metastasize to other organs such as the liver, lungs, colon, and brain...
December 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29189005/phytoestrogens-weaken-the-blood-milk-barrier-in-lactating-mammary-epithelial-cells-by-affecting-tight-junctions-and-cell-viability
#5
Yusaku Tsugami, Kota Matsunaga, Takahiro Suzuki, Nishimura Takanori, Ken Kobayashi
During lactation, mammary epithelial cells (MECs) form the blood-milk barrier by less-permeable tight junctions (TJs) to prevent leakage of milk components. Phytoestrogens affect proliferation, differentiation and apoptosis of MECs. However, it remains unclear whether phytoestrogens involve in the blood-milk barrier. Therefore, we investigated the influence of phytoestrogens (coumestrol, genistein, daidzein) by using in vitro mouse MEC culture model. The results showed that coumestrol or genistein changed the expression of TJ proteins (claudin-3, -4, occludin) and weakened the barrier function with reduction of β-casein production...
November 30, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29188893/therapeutic-role-of-punica-granatum-pomegranate-seed-oil-extract-on-bone-turnover-and-resorption-induced-in-ovariectomized-rats
#6
N Z Shaban, I M Talaat, F H Elrashidy, A Y Hegazy, A S Sultan
CONTEXT: Postmenopausal osteoporosis is mostly caused by increased bone remodeling resulting from estrogen deficiency. Hormone replacement therapy (HRT) is used to prevent osteoporosis, but it increases the risk for breast cancer, thromboembolism, strokes, and heart attacks. Pomegranate seed oil extract (SOE) is rich in phytoestrogen and antioxidant compounds. OBJECTIVES: To evaluate the therapeutic role of SOE against bone turnover, resorption and osteoporosis induced in ovariectomized rats as a postmenopausal model and comparing the results with those from Generic CycloProgynova drug (D)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29183775/novel-effects-of-phytoestrogenic-soy-isoflavones-on-serum-calcium-and-chloride-in-premenopausal-women-a-2-year-double-blind-randomized-placebo-controlled-study
#7
Lee-Jane W Lu, Nai-Wei Chen, Fatima Nayeem, V-M Sadagopa Ramanujam, Yong-Fang Kuo, Donald G Brunder, Manubai Nagamani, Karl E Anderson
BACKGROUND: Soy phytoestrogens are potential alternatives to postmenopausal hormone replacement therapy (HRT). Adverse effects of HRT such as myocardial infarction, stroke, and pulmonary embolism are mediated by calcium-induced signaling. OBJECTIVE: To determine whether soy isoflavones affect serum calcium in healthy female subjects. DESIGN: In a double-blind trial, 197 premenopausal women were randomly assigned to either isoflavone (N = 99) or placebo pills (N = 98) 5 days per week for up to 2 years, plus prenatal vitamins...
November 11, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29171786/bidirectional-regulation-of-genistein-on-the-proliferation-and-differentiation-of-c2c12-myoblasts
#8
Mailin Gan, Dongli Yang, Yuan Fan, Jingjing Du, Linyuan Shen, Qiang Li, Yanzhi Jiang, Guoqing Tang, Mingzhou Li, Jinyong Wang, Xuewei Li, Shunhua Zhang, Li Zhu
1. Genistein is a widely studied phytoestrogen. The effects of genistein on myoblasts were reported long ago, but the conclusions are controversial. In the current study, we evaluated the effects of different concentrations of genistein on C2C12 myoblasts. 2. Genistein treatment promoted myoblast proliferation in a dose-development manner in the 0-2 µM/L range, reaching its maximum effect at 2 µM/L. Proliferation then declined, and a concentration higher than 20 µM/L showed significant inhibition. Additionally, genistein treatment promoted myoblast differentiation at a dose of 10 µM/L...
November 24, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29168580/resveratrol-pterostilbene-and-dementia
#9
REVIEW
Klaus W Lange, Shiming Li
Resveratrol is a natural phytoestrogen with neuroprotective properties. Polyphenolic compounds including resveratrol exert in vitro antioxidant, anti-inflammatory, and antiamyloid effects. Resveratrol and its derivative pterostilbene are able to cross the blood-brain barrier and to influence brain activity. The present short review summarizes the available evidence regarding the effects of these polyphenols on pathology and cognition in animal models and human subjects with dementia. Numerous investigations in cellular and mammalian models have associated resveratrol and pterostilbene with protection against dementia syndromes such as Alzheimer's disease (AD) and vascular dementia...
November 23, 2017: BioFactors
https://www.readbyqxmd.com/read/29168310/a-pilot-pharmacokinetic-study-of-miroestrol-and-deoxymiroestrol-on-rabbit-sera-using-polyclonal-antibody-based-icelisa-analysis
#10
Tharita Kitisripanya, Orapin Udomsin, Jukrapun Komaikul, Chadathorn Inyai, Supattra Limsuwanchote, Gorawit Yusakul, Waraporn Putalun
Miroestrol (ME) and deoxymiroestrol (DME) are the most potent phytoestrogens and bioactive markers in Pueraria candollei var. mirifica tuberous roots. To understand their pharmacokinetic profiles, a pharmacokinetic study of ME and DME, at 0.43 and 0.21 mg per kg body weight, respectively, in three rabbits was performed after orally administering a single dose of P. candollei var. mirifica enriched fraction extract. Two established polyclonal antibody-based indirect competitive enzyme-linked immunosorbent assays were validated to determine ME and DME in rabbit sera...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29167771/somatic-vegetative-symptoms-evolution-in-postmenopausal-women-treated-with-phytoestrogens-and-hormone-replacement-therapy
#11
Delia Mirela Ţiţ, Annamaria Pallag, Ciprian Iovan, Gheorghe Furău, Cristian Furău, Simona Bungău
Background: The purpose of this study was to compare the effects of the phytoestrogens in relieving and/or suppressing the specific somatic-vegetative symptoms of menopause with those of the hormone therapy, administered in small doses. Methods: The study was conducted in the County Clinical Emergency Hospital Oradea - Obstetric-Gynecological Ambulatory, and in private obstetrics-gynecology cabinets from Bihor County (NW Romania), from November 2011 to January 2014...
November 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29167726/effects-of-hydroalcoholic-extract-of-soy-on-learning-memory-and-synaptic-plasticity-deficits-induced-by-seizure-in-ovariectomized-rats
#12
Mehdi Khodamoradi, Majid Asadi-Shekaari, Saeed Esmaeili-Mahani, Fariba Sharififar, Vahid Sheibani
Introduction: Previous studies have shown that seizure can induce cognitive impairment. On the other hand, soy phytoestrogens, which are mainly found in soybean (Glycine max (L.) Merr.), have beneficial effects on the nervous system. However, little is known about their probable effects on seizure. The present study aimed to examine the probable effects of soy extract, containing the phytoestrogen genistein on seizure-induced cognitive and synaptic plasticity impairment in Ovariectomized (OVX) rats...
September 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/29166278/interactions-between-plant-derived-oestrogenic-substances-and-the-mycoestrogen-zearalenone-in-a-bioassay-with-mcf-7-cells
#13
Sabine Hessenberger, K Botzi, C Degrassi, P Kovalsky, C Schwab, D Schatzmayr, G Schatzmayr, J Fink-Gremmels
Human and animal diets may contain several non-steroidal oestrogenic compounds which originate either from plants (phytoestrogens) or from fungi that infect plants (mycoestrogens such as zearalenone (ZEN)). Phytoestrogens may compete with ZEN in binding to the oestrogen receptor β and thereby may counteract the oestrogenic activity of ZEN. Using a modified version of the E-screen assay, plant-derived oestrogenic substances were tested for their proliferative or anti-proliferative effect on oestrogen-dependent MCF-7 cells...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29156930/-benefits-of-soy-in-women-s-health
#14
Carmen Martín Salinas, Ana M López-Sobaler
A great interest has been developed last decades on the role of phytoestrogens as an alternative to hormone replacement therapy. In fact, numerous studies have shown the effects of soy isoflavones on climacteric symptomatology by significantly reducing the frequency and intensity of hot flashes, as well on cardiovascular health. The aim of this paper was to review the last studies, mainly randomized controlled trials, on the effect of isoflavones on climacteric symptoms and their impact on women's quality of life, as well as on other health markers...
October 15, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29154112/pre-diagnostic-plasma-enterolactone-concentrations-and-breast-cancer-prognosis-among-postmenopausal-women-the-danish-diet-cancer-and-health-cohort
#15
Cecilie Kyrø, Louise Hansen, Kirsten Frederiksen, Natalja P Nørskov, Knud Erik Bach Knudsen, Anne Kirstine Eriksen, Marianne Holm, Anne Tjønneland, Anja Olsen
BACKGROUND & AIMS: High intakes of the phytoestrogen lignans and high blood concentrations of its main biomarker, enterolactone, has been associated with a better breast cancer prognosis. We investigated the association between pre-diagnostic plasma concentrations of enterolactone and breast cancer prognosis (i.e. recurrence, breast cancer-specific mortality and all-cause mortality). METHODS: Plasma and data was available from the Danish Diet, Cancer and Health cohort...
November 8, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29152682/estrogenicity-of-halogenated-bisphenol-a-in-vitro-and-in-silico-investigations
#16
Jie Zhang, Tiezhu Li, Tuoyi Wang, Cuiping Yuan, Shuning Zhong, Tianzhu Guan, Zhuolin Li, Yongzhi Wang, Hansong Yu, Quan Luo, Yongjun Wang, Tiehua Zhang
The binding interactions of bisphenol A (BPA) and its halogenated derivatives (halogenated BPAs) to human estrogen receptor α ligand binding domain (hERα-LBD) was investigated using a combined in vitro and in silico approach. First, the recombinant hERα-LBD was prepared as a soluble protein in Escherichia coli BL21(DE3)pLysS. A native fluorescent phytoestrogen, coumestrol, was employed as tracer for the fluorescence polarization assay. The results of the in vitro binding assay showed that bisphenol compounds could bind to hERα-LBD as the affinity ligands...
November 20, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29141545/main-isoflavones-found-in-dietary-sources-as-natural-anti-inflammatory-agents
#17
Corina Danciu, Stefana Avram, Ioana Pavel, Roxana Ghiulai, Cristina Dehelean, Alexa Ersilia, Daliana Minda, Cristina Petrescu, Elena Moaca, Codruta Soica
BACKGROUND: Isoflavones are natural compounds belonging to the class of isoflavonoids, molecules with a chemical structure based on the 3-phenyl chromen-4-one backbone. As a particular element, the isoflavones are called also phytoestrogens, due to the structural similarity with 17-β estradiol, the primary female sex hormone, presenting both estrogen-agonist and estrogen-antagonist properties. This class of secondary plant metabolites has been extensively reported in the literature for a wide range of therapeutic activities including antioxidant, chemopreventive, anti-inflammatory, anti-allergic, antibacterial, cardio preventive effects...
November 9, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29137685/nutrition-research-in-cognitive-impairment-dementia-with-a-focus-on-soya-and-folate
#18
Eef Hogervorst, Shelina Kassam, Atik Kridawati, Mira Soni, Xu Xin, Xiao Shifu, Tri Budi Rahardjo
Observational studies and treatment trials investigating nutrition and cognitive function, with a focus on folate and soya and dementia, were reviewed. Data suggested that effects of folic acid based interventions may only be shown before cognitive decline is evident and/or if people are folate deficient. In older people in Indonesia, Hawai'i and China, tofu, which can contain high levels of phytoestrogens, was found to increase dementia risk. This association was not mediated by a vegetarian diet, socioeconomic status, formaldehyde, thyroid function, or loss of teeth...
November 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29132837/prepubertal-chrysin-exposure-upregulates-either-ar-in-male-ventral-prostate-or-ar-and-er%C3%AE-in-skene-s-paraurethral-gland-of-pubertal-and-adult-gerbils
#19
Naiara C S Ribeiro, Mônica S Campos, Mariana B Santos, Gabriela M Ayusso, Patrícia S L Vilamaior, Luis O Regasini, Sebastião R Taboga, Manoel F Biancardi, Ana P S Perez, Fernanda C A Santos
Chrysin is a plant-derived polyphenol that has the potential to increase endogenous testosterone levels both by inhibiting the aromatase enzyme and by stimulating testicular steroidogenesis. The effects of chrysin on the prostate are unknown, especially during its development and functional maturation. Thus, the aim of this study was to evaluate the effects of chrysin prepubertal exposure on the male and female prostates of both pubertal and adult gerbils. To evaluate the possible androgenic responses of chrysin, gerbils were also exposed to testosterone...
November 10, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29125642/genistein-ameliorates-fat-accumulation-through-ampk-activation-in-fatty-acid-induced-brl-cells
#20
Huijia Zhong, Huanhuan Liu, Zhuoqin Jiang
Genstein is the most abundant phytoestrogen in soybean that was reported to play positive roles in menopausal syndrome and metabolic syndrome. In the present study, we investigated the effects and potential mechanisms of genistein against progression of nonalcoholic fatty liver disease (NAFLD) in BRL cells treated with fatty acid mixture (oleate/palmitate, 2:1 ratio). Our data demonstrated that genistein remarkably improved fatty acid mixture-induced hepatocelluler fat accumulation, inhibited upregulation of genes expression related to fatty acid synthesis, and derepressed those associated with fatty acid oxidation...
November 2017: Journal of Food Science
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