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https://www.readbyqxmd.com/read/28728453/incomplete-metabolism-of-phytoestrogens-by-gut-microbiota-from-children-under-the-age-of-three
#1
Pilar Gaya, Abel Sánchez-Jiménez, Ángela Peirotén, Margarita Medina, José Maria Landete
Phytoestrogens are plant-derived polyphenols with structural and functional similarities to mammalian oestrogens. The aim of this work was to study the metabolism of phytoestrogens by children's intestinal microbiota and to compare it with previous results in adults. Faecal samples of 24 healthy children were subjected to phytoestrogen fermentation assay. Only one child produced equol, while O-desmethylangolensin was found in all. Urolithin production was detected in 14 children and enterolactone in 10. Further comparison with the metabolism of phytoestrogens by adult intestinal microbiota reflected that glycitein, dihydrogenistein, urolithins D and E, enterolactone, secoisolariciresinol and arctigenin were the most important metabolites differentiating between adult and child microbial gut metabolism...
July 20, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28720470/molecular-docking-prediction-and-in-vitro-studies-elucidate-anti-cancer-activity-of-phytoestrogens
#2
Shreelekha Dutta, Prashant S Kharkar, Niteshkumar U Sahu, Aparna Khanna
AIM: The study is aimed at evaluating the chemosensitization and apoptotic effect of aglycone rich extracts of dietary phytoestrogens (derived from soybean and flaxseed) on estrogen receptor positive, MCF-7 and estrogen receptor negative, MDA-MB-231 cells. The extracts show potent activity on both the cell lines, hence, in silico studies have been carried out to find the possible reason for their activity. MAIN METHODS: MTT assay was carried to assess chemosensitization effect and activated caspase-3/7 activity was studied using flow-cytometry and western blotting...
July 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28718749/glycinol-enhances-osteogenic-differentiation-and-attenuates-the-effects-of-age-on-mesenchymal-stem-cells
#3
Amy L Strong, Robert B Jones, Julie Glowacki, Stephen M Boue, Matthew E Burow, Bruce A Bunnell
AIM: Phytoestrogens, such as glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential. METHODS: The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). RESULTS: BMSCs isolated from older donors demonstrated reduced osteogenesis...
July 18, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28706438/genistein-suppresses-retinoblastoma-cell-viability-and-growth-and-induces-apoptosis-by-upregulating-mir-145-and-inhibiting-its-target-abce1
#4
Dong Wei, Lieying Yang, Bo Lv, Lijuan Chen
PURPOSE: Retinoblastoma is a rare malignancy in developing retina tissue in children with limited therapeutic options. Here we sought to investigate the potential clinical value of genistein, the phytoestrogen derived from the soybean with antioxidant activity, in this disease. METHODS: Retinoblastoma cells were treated with genistein. Colony formation capacity was measured with soft agar assay. MiRNA was identified with microarray. Post-transcriptional regulation of gene expression was determined with dual-luciferase reporter assay...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28702975/spontaneous-retrospective-clinical-evaluation-of-a-new-phytoestrogen-based-cosmetic-gel-cream-on-postmenopausal-women%C3%A2-s-skin
#5
P Amori, J Lotti, T Lotti, G Vitiello
The purpose of this study is to evaluate the efficacy of daily application of a new phytoestrogen-based cosmetic gel cream on postmenopausal women’s skin. Sixty postmenopausal women were evaluated. Each subject was initially (T0) submitted to a hydration and sebometry test. A quantity of 50 ml of phytoestrogen-containing gel cream was given for one month to each patient. At the end of the month (T1), the tests were repeated. At the end of the study, 85% of the women showed an improvement of facial skin hydration...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28698543/genistein-protects-genioglossus-myoblast-against-hypoxia-induced-injury-through-pi3k-akt-and-erk-mapk-pathways
#6
Wanghui Ding, Xiaoyan Chen, Wen Li, Zhen Fu, Jiejun Shi
Obstructive sleep apnea and hypopnea syndrome (OSAHS) is a clinical syndrome characterized by recurrent episodes of obstruction of the upper airway during sleep that leads to a hypoxic condition. Genioglossus, an important pharyngeal muscle, plays an important role in maintaining an open upper airway for effective breathing. Our previous study found that genistein (a kind of phytoestrogen) protects genioglossus muscle from hypoxia-induced oxidative injury. However, the underlying mechanism is still unknown...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28692816/unique-oestrogen-receptor-ligand-binding-domain-sequence-of-native-parrots-a-possible-link-between-phytoestrogens-and-breeding-success
#7
Catherine E J Davis, Adrian H Bibby, Kevin M Buckley, Kenneth P McNatty, Janet L Pitman
The New Zealand (NZ) native parrots kākāpō, kākā and kea are classified as critically endangered, endangered and vulnerable respectively. Successful reproduction of kākāpō and kākā is linked to years of high levels of fruiting in native flora (mast years). To assess a possible hormonal link between native plants and reproductive success in these parrots in mast years, we examined the ligand-binding domains (LBD) of the progesterone receptor (PR), androgen receptor (AR), estrogen receptor 1 (ESR1) and estrogen receptor 2 (ESR2) in NZ native (kākāpō, kākā, kea and kākāriki) and non-native (Australian cockatiel) parrots and compared them with those in the chicken...
July 11, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28674520/endocrine-disruption-of-vasopressin-systems-and-related-behaviors
#8
REVIEW
Heather B Patisaul
Endocrine disrupting chemicals (EDCs) are chemicals that interfere with the organizational or activational effects of hormones. Although the vast majority of the EDC literature focuses on steroid hormone signaling related impacts, growing evidence from a myriad of species reveals that the nonapeptide hormones vasopressin (AVP) and oxytocin (OT) may also be EDC targets. EDCs shown to alter pathways and behaviors coordinated by AVP and/or OT include the plastics component bisphenol A (BPA), the soy phytoestrogen genistein (GEN), and various flame retardants...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28666461/glyceollins-trigger-anti-proliferative-effects-through-estradiol-dependent-and-independent-pathways-in-breast-cancer-cells
#9
Sylvain Lecomte, Frederic Chalmel, François Ferriere, Frederic Percevault, Nicolas Plu, Christian Saligaut, Claire Surel, Marie Lelong, Theo Efstathiou, Farzad Pakdel
BACKGROUND: Estrogen receptors (ER) α and β are found in both women and men in many tissues, where they have different functions, including having roles in cell proliferation and differentiation of the reproductive tract. In addition to estradiol (E2), a natural hormone, numerous compounds are able to bind ERs and modulate their activities. Among these compounds, phytoestrogens such as isoflavones, which are found in plants, are promising therapeutics for several pathologies. Glyceollins are second metabolites of isoflavones that are mainly produced in soybean in response to an elicitor...
June 30, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28662498/modulation-of-oxidative-stress-by-17-%C3%AE-estradiol-and-genistein-in-human-hepatic-cell-lines-in-vitro
#10
Daniela Surico, Alfredo Ercoli, Serena Farruggio, Giulia Raina, Davide Filippini, David Mary, Rosalba Minisini, Nicola Surico, Mario Pirisi, Elena Grossini
BACKGROUND/AIMS: estrogens and phytoestrogens exert hepatoprotection through mechanisms not clearly examined yet. Here, we investigated the protective effects exerted by 17β-estradiol and genistein against oxidative stress in hepatocytes and hepatic stellate cells (HSCs) and the involvement of specific receptors and the intracellular signalling. METHODS: Huh7.5 and LX-2, alone or in co-culture with Huh7.5, were treated with 17β-estradiol and genistein alone or in the presence of menadione and of estrogen receptors (ERs) and G protein-coupled-estrogenic-receptors (GPER) blockers...
June 28, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28660504/distribution-of-six-anticancer-drugs-and-a-variety-of-other-pharmaceuticals-and-their-sorption-onto-sediments-in-an-urban-japanese-river
#11
Takashi Azuma, Natsumi Arima, Ai Tsukada, Satoru Hirami, Rie Matsuoka, Ryogo Moriwake, Hirotaka Ishiuchi, Tomomi Inoyama, Yusuke Teranishi, Misato Yamaoka, Mao Ishida, Kanae Hisamatsu, Ayami Yunoki, Yoshiki Mino
The distributions of 31 pharmaceuticals grouped into nine therapeutic classes, including six anticancer drugs, were investigated in the waters and sediments of an urban river in Japan. The coefficients of sorption (logK d) to the river sediments were also determined from the results of a field survey and laboratory-scale experiment. Three anticancer drugs-bicalutamide, doxifluridine, and tamoxifen-were detected in the river sediments at maximum concentrations of 391, 392, and 250 ng/kg, respectively. In addition, the transformation products of psychotropic carbamazepine (2-hydroxy carbamazepine, acridine, and acridone) were detected in the range of 108 ng/kg (2-hydroxy carbamazepine) to 2365 ng/kg (acridine), and the phytoestrogen glycitein was detected in the range of N...
June 28, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28657580/phytochemicals-targeting-estrogen-receptors-beneficial-rather-than-adverse-effects
#12
REVIEW
Sylvain Lecomte, Florence Demay, François Ferrière, Farzad Pakdel
In mammals, the effects of estrogen are mainly mediated by two different estrogen receptors, ERα and ERβ. These proteins are members of the nuclear receptor family, characterized by distinct structural and functional domains, and participate in the regulation of different biological processes, including cell growth, survival and differentiation. The two estrogen receptor (ER) subtypes are generated from two distinct genes and have partially distinct expression patterns. Their activities are modulated differently by a range of natural and synthetic ligands...
June 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28655710/phytoestrogen-isoflavone-intervention-to-engage-the-neuroprotective-effect-of-glutamate-oxaloacetate-transaminase-against-stroke
#13
Savita Khanna, Richard Stewart, Surya Gnyawali, Hallie Harris, Maria Balch, James Spieldenner, Chandan K Sen, Cameron Rink
In the pathophysiologic setting of cerebral ischemia, excitotoxic levels of glutamate contribute to neuronal cell death. Our previous work demonstrated the ability of glutamate oxaloacetate transaminase (GOT) to metabolize neurotoxic glutamate in the stroke-affected brain. Here, we seek to identify small-molecule inducers of GOT expression to mitigate ischemic stroke injury. From a panel of phytoestrogen isoflavones, biochanin A (BCA) was identified as the most potent inducer of GOT gene expression in neural cells...
June 27, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28647515/a-phytoestrogen-supplement-prevents-the-altered-gene-expression-associated-with-pregnancy-implantation-induced-by-il-1%C3%AE-in-endometrial-epithelial-cells
#14
Sayaka Suzuki, Noe Nakashima, Masakatsu Kageyama, Kazuo Yamagata
Phytoestrogens stimulate expression of the uterine estrogen receptor and regulate uterine functions in reproductive tissues. However, comprehensive understanding of the beneficial impacts of phytoestrogens on uterine biology at the molecular level remains unexplored. Interleukin-1β (IL-1β) expression is increased in the inflamed decidua and is associated with first trimester pregnancy loss. AglyMax-Sup has the same composition as that of the phytoestrogen supplement AglyMax but with added vitamins and other components...
June 21, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28637300/commercial-rodent-diets-differentially-regulate-autoimmune-glomerulonephritis-epigenetics-and-microbiota-in-mrl-lpr-mice
#15
Michael R Edwards, Rujuan Dai, Bettina Heid, Thomas E Cecere, Deena Khan, Qinghui Mu, Catharine Cowan, Xin M Luo, S Ansar Ahmed
The course and severity of lupus in spontaneous murine lupus models varies among laboratories, which may be due to variations in diet, housing and/or local environmental conditions. In this study, we investigated the influence of common rodent diets while keeping other factors constant. Female lupus-prone MRL/lpr mice were subjected to the same housing conditions and given one of the three diets: Teklad 7013 containing isoflavone rich soy and alfalfa, Harlan 2018 isoflavone rich soy-based diet, or ResearchDiets Inc...
June 15, 2017: International Immunology
https://www.readbyqxmd.com/read/28629290/functional-foods-how-functional-are-they-a-case-report-of-supplement-induced-psychosis
#16
Priyanka Yadav, Kyle Stigall, Hannah E Johnson, Abner O Rayapati, Nitin Chopra
There is rising evidence of patients' use of alternative and complementary medicine. The percentage of the U.S. population who used at least one dietary supplement increased from 42% in 1988-1994 to 53% in 2003-2006. We present a case of an Asian female in her 40s, with no previous psychiatric illness, who presented to the emergency room following a brief psychotic episode, during which she self-amputated the tips of her fingers, after using multivitamins and herbal supplements including ginseng, gui yuan rou (Chinese herb), astaxanthin, goji (Chinese fruit), selenium, saw palmetto, grape seed extract, citrus bioflavanoid, lutein (zeaxantin), resvexatrol, sun chlorella, spirulina powder, phytoceramides, phytoestrogen, glucosatrin, bromelain plus, and American bee pollen...
August 2016: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28628373/association-between-urinary-phytoestrogens-and-c-reactive-protein-in-the-continuous-national-health-and-nutrition-examination-survey
#17
Michael K Reger, Terrell W Zollinger, Ziyue Liu, Josette Jones, Jianjun Zhang
OBJECTIVE: A reduced risk of some cancers and cardiovascular disease associated with phytoestrogen intake may be mediated through its effect on serum C-reactive protein (CRP; an inflammation biomarker). Therefore, this study examined the associations between urinary phytoestrogens and serum CRP. METHODS: Urinary phytoestrogen and serum CRP data obtained from 6009 participants aged ≥ 40 years in the continuous National Health and Nutrition Examination Survey during 1999-2010 were analyzed...
June 19, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28612709/potential-phytoestrogen-alternatives-exert-cardio-protective-mechanisms-via-estrogen-receptors
#18
Marthandam Asokan Shibu, Wei-Wen Kuo, Chia-Hua Kuo, Cecilia-Hsuan Day, Chia-Yao Shen, Li-Chin Chung, Chao-Hung Lai, Lung-Fa Pan, V Vijaya Padma, Chih-Yang Huang
The 17 beta-estradiol (E2) is a sex hormone that is most abundant and most active estrogen in premenopausal women. The importance of E2 in providing cardioprotection and reducing the occurrence of heart disease in women of reproductive age has been well recognized. There are three subtype of estrogen receptors (ERs), including ERα, ERβ and GPR30 have been identified and accumulating evidence reveal their roles on E2-mediated genomic and nongenomic pathway in cardiomyocytes against various cardiac insults...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28610434/isoflavones-and-gastrointestinal-infection-two-potential-triggers-for-reversible-cerebral-vasoconstriction-syndrome
#19
Björn Machner, Tobias Boppel, Thomas Münte
Background Reversible cerebral vasoconstriction syndrome (RCVS) is an important differential diagnosis of singular or recurrent thunderclap headache. Prognosis is generally good, however complications of the transient segmental vasospasms of cerebral arteries such as stroke, subarachnoidal hemorrhage and brain edema may worsen the clinical outcome. Although the exact pathomechanism is still unclear, various vasoactive substances and conditions (e.g. post partum) have been identified as triggering RCVS. Cases We report on the clinical course and management of two cases of typical RCVS that were associated with two different precipitants previously not described: A gastrointestinal infection and isoflavones, which are phytoestrogens used for menopausal vasomotor symptoms...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28605338/effect-of-hispolon-from-phellinus-lonicerinus-agaricomycetes-on-estrogen-receptors-aromatase-and-cyclooxygenase-ii-in-mcf-7-breast-cancer-cells
#20
Junzhi Wang, Beiyan Chen, Fang Hu, Xueling Zou, Haili Yu, Jinyu Wang, Hongqi Zhang, Haibo He, Wenfeng Huang
Phytoestrogen has previously been proposed as an alternative to hormone replacement therapy. Hispolon has been found to have phytoestrogenic properties. However, the possible effects of hispolon on estrogen receptors and other related molecules remain to be determined. This study was performed mainly to confirm the estrogenic function of hispolon as it relates to estrogen receptors, aromatase, and cyclooxygenase 2 (COX-2). Hispolon was shown to increase the serum 17β-estradiol in vivo. Immunohistochemical staining methods showed that hispolon exhibited a biphasic effect on ERα/β and aromatase expression in MCF-7 cells...
2017: International Journal of Medicinal Mushrooms
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