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https://www.readbyqxmd.com/read/28742620/comparison-of-5-sulfur-hexafluoride-versus-100-air-tamponade-in-descemet-membrane-endothelial-keratoplasty
#1
Paraskevas Ampazas, Konstantinos Droutsas, Eleftherios Giallouros, Frank M Schroeder, Walter Sekundo
PURPOSE: To compare the rebubbling rate and clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) with 5% sulfur hexafluoride (SF6) gas versus 100% air as a tamponade for graft attachment. METHODS: Retrospective, comparative, interventional case series including 368 consecutive pseudophakic eyes with Fuchs endothelial dystrophy or pseudophakic bullous keratopathy that underwent DMEK in a tertiary referral center between October 2010 and August 2015 using either air (group 1, 191 eyes) or 5% SF6 (group 2, 177 eyes) as a tamponade...
July 24, 2017: Cornea
https://www.readbyqxmd.com/read/28742617/simple-single-pass-technique-for-ultrathin-descemet-stripping-automated-endothelial-keratoplasty-a-pilot-study
#2
Maria E S Dimitry, Adam D Lewis, Fani Zacharaki, Manju Chandran, Deana Robson, Geeta Menon, Thomas R G Poole
PURPOSE: To assess intraoperative and postoperative graft thickness (GT) after donor deturgescence for ultrathin Descemet stripping automated endothelial keratoplasty and to evaluate visual outcomes, endothelial cell density, and patient satisfaction at 1 year. METHODS: Prospective interventional case series of patients with Fuchs endothelial dystrophy, Fuchs endothelial dystrophy and cataract, and pseudophakic bullous keratopathy (n = 12 grafts). The donor cornea was allowed to thin out by simple evaporation on an artificial anterior chamber, to the required precut thickness, before a single microkeratome pass...
July 24, 2017: Cornea
https://www.readbyqxmd.com/read/28739420/long-term-visual-outcomes-comparing-descemet-stripping-automated-endothelial-keratoplasty-and-penetrating-keratoplasty
#3
Matthias Fuest, Marcus Ang, Hla Myint Htoon, Donald Tan, Jodhbir S Mehta
PURPOSE: To compare 5-year visual acuity and refraction outcome in Descemet stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PK) for Fuchs endothelial dystrophy (FED) or bullous keratopathy (BK) in Asian eyes. DESIGN: Prospective interventional case series. METHODS: We analyzed 828 consecutive cases of DSAEK (423) or PK (405) for FED and BK from the Singapore Cornea Transplant Registry performed from 1991 to 2011...
July 21, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28739402/graft-detachment-and-re-bubbling-rate-in-descemet-membrane-endothelial-keratoplasty
#4
REVIEW
Mohit Parekh, Pia Leon, Alessandro Ruzza, Davide Borroni, Stefano Ferrari, Diego Ponzin, Vito Romano
Descemet Membrane Endothelial Keratoplasty (DMEK) is a selective replacement of dysfunctional endothelium with healthy donor Descemet's membrane and endothelium. Although the donor preparation and surgical methods still remain a challenge, DMEK is gaining popularity in terms of early rehabilitation and visual outcomes. New and improved donor preparation techniques like pre-stripped DMEK tissues are taken up rapidly due to less manipulation that is required in the surgical theatre. Donor graft delivery in the recipient eye has also been improved due to new products like pre-stripped and pre-loaded membranes...
July 21, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28736341/tfos-dews-ii-iatrogenic-report
#5
REVIEW
José Alvaro P Gomes, Dimitri T Azar, Christophe Baudouin, Nathan Efron, Masatoshi Hirayama, Jutta Horwath-Winter, Terry Kim, Jodhbir S Mehta, Elisabeth M Messmer, Jay S Pepose, Virender S Sangwan, Alan L Weiner, Steven E Wilson, James S Wolffsohn
Dry eye can be caused by a variety of iatrogenic interventions. The increasing number of patients looking for eye care or cosmetic procedures involving the eyes, together with a better understanding of the pathophysiological mechanisms of dry eye disease (DED), have led to the need of a specific report about iatrogenic dry eye within the TFOS DEWS II. Topical medications can cause DED due to their allergic, toxic and immuno-inflammatory effects on the ocular surface. Preservatives, such as benzalkonium chloride, may further aggravate DED...
May 5, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28734818/preoperative-aqueous-cytokine-levels-are-associated-with-a-rapid-reduction-in-endothelial-cells-after-penetrating-keratoplasty
#6
Yukari Yagi-Yaguchi, Takefumi Yamaguchi, Kazunari Higa, Terumasa Suzuki, Hiroyuki Yazu, Naohiko Aketa, Yoshiyuki Satake, Kazuo Tsubota, Jun Shimazaki
PURPOSE: To evaluate the influence of preoperative inflammatory cytokine levels in the aqueous humor (AqH) on the endothelial cell density (ECD) after penetrating keratoplasty (PKP). DESIGN: Prospective interventional, consecutive case series. METHODS: This study includes 70 consecutive patients (mean age 73.7 ± 10.6), who underwent PKP (37 eyes) or cataract surgery (controls, 33 eyes). A total of 70 AqH samples were collected at the beginning of each surgery...
July 19, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28732604/artificial-iris-implantation-in-various-iris-defects-and-lens-conditions
#7
Christian Mayer, Tamer Tandogan, Andrea E Hoffmann, Ramin Khoramnia
We describe 6 surgical techniques used to implant a silicone iris prosthesis: sector-shaped iris segments that require suturing, injector-assisted sulcus fixation, injector-assisted capsular bag fixation with an intraocular lens (IOL) and capsular tension ring, folded iris tissue implanted with a forceps and sutured to the sclera with a scleral-fixated IOL, "sandwich" or "backpack" implantation with an IOL, and open-sky implantation with a perforating keratoplasty. The results of the techniques performed in 51 patients are discussed...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28730110/incidence-of-cystoid-macular-edema-after-descemet-s-stripping-automated-endothelial-keratoplasty
#8
Eduard Pedemonte-Sarrias, Toni Salvador Playà, Irene Sassot Cladera, Oscar Gris, Joan Ribas Martínez, José García-Arumí, Núria Giménez
AIM: To determine the incidence of cystoid macular edema (CME) after Descemet's stripping automated endothelial keratoplasty (DSAEK). METHODS: This study included all consecutive patients operated in a Spanish tertiary reference hospital over a period of four years. A total of 55 eyes from 47 patients matched the selection criteria. CME was diagnosed clinically at the slit-lamp and confirmed by optical coherence tomography. RESULTS: Six cases of CME were diagnosed postoperatively, which represented an incidence of 11%...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730097/recurrence-of-keratoconus-after-deep-anterior-lamellar-keratoplasty-following-pregnancy
#9
Zisis Gatzioufas, Georgios D Panos, Evangelia Gkaragkani, Stylianos Georgoulas, Romesh Angunawela
No abstract text is available yet for this article.
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730071/effect-of-sorafenib-in-a-murine-high-risk-penetrating-keratoplasty-model
#10
Yang Kyung Cho, Eun Young Shin, Hironori Uehara, Balamurali K Ambati
AIM: To evaluate the effect of sorafenib in murine high risk keratoplasty model. METHODS: Graft survival, corneal neovascularization, and corneal lymphangiogenesis were compared among the sorafenib, dexamethasone, dimethyl sulfoxide (DMSO), and phosphate buffered saline (PBS) groups following subconjunctival injection in mice that underwent high risk penetrating keratoplasty (HRPK). Real-time polymerase chain reaction was performed to quantify the expression of inflammatory cytokines and vascular endothelial growth factor (VEGF)-A, VEGF-C, vascular endothelial growth factor receptor (VEGFR)-2, VEGFR-3...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28728288/-descemet-s-membrane-endothelial-keratoplasty-for-treatment-of-patients-with-corneal-endothelial-decompensation
#11
T Huang, C Ouyang, J Zhan, L Jiang
Objective: To evaluate the clinical outcomes of Descemet's membrane endothelial keratoplasty (DMEK) for treatment of patients with corneal endothelial decompensation in China. Methods: Interventional case series. Ten patients (10 eyes) with the diagnosis of corneal endothelial decompensation received DMEK during July 2016 and September 2016 in Zhongshan Ophthalmic Center. Descemet's membrane of the donor tissue was carefully stripped from the underlying stroma manually and cut with a 7.75- or 8.0-mm-diameter donor punch...
July 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28727885/sustained-activation-of-the-unfolded-protein-response-induces-cell-death-in-fuchs-endothelial-corneal-dystrophy
#12
Naoki Okumura, Miu Kitahara, Hirokazu Okuda, Keisuke Hashimoto, Emi Ueda, Makiko Nakahara, Shigeru Kinoshita, Robert D Young, Andrew J Quantock, Theofilos Tourtas, Ursula Schlötzer-Schrehardt, Friedrich Kruse, Noriko Koizumi
Purpose: The unfolded protein response (UPR) is believed to play a role in the pathogenesis of Fuchs' endothelial corneal dystrophy (FECD). The purpose of this study was to investigate whether unfolded proteins accumulate in the corneal endothelium in FECD and if they are involved in triggering cell death. Methods: Descemet's membranes with corneal endothelial cells (CECs) were obtained during keratoplasty, and expression of aggresomes, type 1 collagen, fibronectin, and agrin was evaluated...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28726355/combined-cataract-dsek-dmek-changing-expectations
#13
Francis W Price, Marianne O Price
Endothelial keratoplasty (EK) has revolutionized corneal transplant surgery by providing rapid visual recovery and improved visual outcomes. In parts of the world with Fuchs endothelial dystrophy, many patients may present with both cataracts and corneal degeneration requiring surgery. Other forms of endothelial decompensation may also present with cataracts. The staging or combination of transplant surgery and cataract surgery depend on both the abilities of the surgeon and the surgical techniques being considered...
July 18, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28724824/late-onset-descemet-s-membrane-detachment-20-years-after-penetrating-keratoplasty
#14
Sharon D'Souza, Narpat Solanki, K R Sushma, Priyank Solanki
This paper reports a case of spontaneous Descemet's Membrane (DM ) detachment 20-years after penetrating keratoplasty (PK). The patient presented with acute onset blurred vision in the right eye associated with mild ocular discomfort. There was no prior history of trauma. The patient had undergone PK in the right eye 20 years back. Detailed ophthalmic examination showed best corrected visual acuity of hand movements close to face in the right eye and 20/80 in the left eye. The right eye showed diffuse graft edema but no congestion, epithelial defect, or loss of continuity of graft-host junction to suggest a traumatic etiology...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28724814/comparison-of-intraocular-pressure-measurements-using-goldmann-tonometer-i-care-pro-tonopen-xl-and-schiotz-tonometer-in-patients-after-descemet-stripping-endothelial-keratoplasty
#15
Oded Ohana, David Varssano, Gabi Shemesh
PURPOSE: Post-Descemet stripping endothelial keratoplasty (DSEK) patients are prone for intraocular pressure (IOP) elevations and glaucoma. Corneal characteristics influence various IOP measuring devices in various ways. The aim of this study was to evaluate the agreement between four different IOP measuring devices: Goldmann applanation tonometer (GAT), I-care pro, Tonopen XL, and Schiotz tonometr in patients who underwent DSEK. METHODS: This was a prospective comparative study using a convenience cohort of post-DSEK patients with compact grafts...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28724813/correlation-between-the-graft-host-junction-of-penetrating-keratoplasty-by-anterior-segment-optical-coherence-tomography-and-the-magnitude-of-postoperative-astigmatism
#16
Ghada Azab Nassar, Shaimaa Abd El Salam Arfeen
PURPOSE: This study aimed to evaluate the alignment pattern of the graft-host junction after penetrating keratoplasty (PK) by anterior segment-optical coherence tomography (AS-OCT) and to correlate this pattern with the magnitude of postoperative astigmatism. METHODS: This retrospective observational study was carried out on forty patients who underwent PK from February 2013 to August 2014. AS-OCT was performed, and the graft-host junctions were classified into well-apposed junction, malapposed junction, and equally apposed junction...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28724812/use-of-glycerol-preserved-corneas-for-corneal-transplants
#17
Neeti Gupta, Prerna Upadhyay
PURPOSE: This study was carried out to see the results of glycerol-preserved cornea (GPC) in emergency situation when fresh corneal tissue was not available. The aim was to study the outcome of corneal transplantation using GPC. METHODS: This was a retrospective study. The medical records of all the patients were reviewed, who underwent keratoplasty using "GPC" during the period from October 2011 to December 2015. The indication of keratoplasty, duration of preservation of the GPC, and its outcome were analyzed...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28723714/vent-incisions-to-facilitate-peripheral-unfolding-of-the-dmek-graft
#18
Christopher Liu, Alfonso Vasquez-Perez, Jordan Vassileff Chervenkoff, Venkata Avadhanam
PURPOSE: To present the results of 15 cases in which a modified technique of Descemet membrane endothelial keratoplasty (DMEK) with vent incisions was used to assist unfolding of tight peripheral inward folds. METHODS: This is a retrospective case series of 15 consecutive eyes that underwent a modified vent incision technique for DMEK. Six oblique, small-size (1 mm) vent incisions parallel to the limbus and 3.5 mm from the center were performed after descemetorhexis...
July 17, 2017: Cornea
https://www.readbyqxmd.com/read/28700252/modified-allogenic-simple-limbal-epithelial-transplantation-followed-by-keratoplasty-as-treatment-for-total-limbal-stem-cell-deficiency
#19
Alfonso Vasquez-Perez, Mayank A Nanavaty
PURPOSE: To describe a modified allogenic simple limbal epithelial transplant (SLET) technique with large donor tissue explants followed by keratoplasty. METHODS: A 69-year-old with conjunctival melanoma on her left eye developed total limbal stem cell deficiency (LSCD) after multiple cycles of topical mitomycin. She also had herpes stromal keratitis while on treatment with mitomycin. She underwent modified allogenic SLET with large donor limbal tissue explants glued on the cornea directly and the amniotic membrane placed over the limbal explants...
July 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28697678/ek-dlek-dsek-dmek-new-frontier-in-cornea-surgery
#20
Marianne O Price, Pankaj Gupta, Jonathan Lass, Francis W Price
Endothelial keratoplasty (EK) has revolutionized treatment of corneal endothelial dysfunction. Compared with penetrating keratoplasty (PK), EK provides faster and more reliable visual rehabilitation while maintaining the eye's structural integrity. The number of EK procedures is growing annually and surpassed PK in the United States in 2012. The most widely used iteration, Descemet stripping endothelial keratoplasty (DSEK), implants healthy donor endothelium, Descemet membrane, and posterior stroma. Descemet membrane endothelial keratoplasty (DMEK) eliminates the donor stromal layer...
July 11, 2017: Annual Review of Vision Science
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