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https://www.readbyqxmd.com/read/28546303/intraocular-minocycline-for-the-treatment-of-ocular-pythiosis
#1
Fátima Ros Castellar, Carmen Sobrino Jiménez, Almudena Del Hierro Zarzuelo, Alicia Herrero Ambrosio, Ana Boto de Los Bueis
PURPOSE: A case of ocular pythiosis successfully treated with surgery and intraocular and oral minocycline is reported. SUMMARY: A 30-year-old man who wore corrective contact lenses traveled to Brazil and Colombia where he swam in salt and fresh waters while wearing contact lenses. He sought treatment at an emergency department after 2 weeks of suffering with a painful corneal ulcer, redness, and loss of vision in his right eye that had been treated at other centers with ophthalmic moxifloxacin for 10 days and with fortified topical antibiotics (amikacin and vancomycin) for 2 days...
June 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28544131/sclerocorneal-graft-and-sequential-removal-of-melted-cornea-after-severe-corneal-burn-with-perforation
#2
Anja Viestenz, Berthold Seitz, Hans-Gert Struck, Arne Viestenz
INTRODUCTION: Corneal burn grade IV usually leads to blindness. Several different surgical techniques remain challenging owing to the extensive tissue damage. Here, we introduce a novel technique with a 15 mm corneoscleral and limbal homologous graft combined with sequential autologous corneal removal ab interno, with a vitrectomy probe to save the anterior chamber angle. In vivo anatomy with optical coherence tomography is the surgical key. METHOD: A large 15 mm sclerocorneal graft is sutured on top of the remainder of the destroyed cornea and sclera after removal of the epithelium and conjunctiva, with anterior synechiolysis if necessary, peripheral iridectomy and conjunctivoplasty...
May 22, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28542087/validity-of-postmortem-glycated-hemoglobin-to-determine-status-of-diabetes-mellitus-in-corneal-donors
#3
Mark C Soper, Santica M Marcovina, Caroline K Hoover, Peter M Calhoun, Kristen E McCoy, Christopher G Stoeger, Gregory A Schmidt, Baha M Arafah, Marianne O Price, Loretta B Szczotka-Flynn, Jonathan H Lass
PURPOSE: To examine the stability of postmortem glycated hemoglobin (HbA1c) measurement and its relationship to premortem glycemia. METHODS: Postmortem blood samples were obtained from 32 donors (8 known diabetic) and shipped on ice to a central laboratory to examine the stability of HbA1c measurements during the first 9 postmortem days. Thirty-nine other suspected diabetic donors underwent comparison of premortem and postmortem HbA1c measurements. RESULTS: Postmortem HbA1c measurements remained stable after 9 postmortem days (all measurements within ±0...
May 23, 2017: Cornea
https://www.readbyqxmd.com/read/28542085/quantitative-analysis-of-depth-distribution-and-density-of-cysts-in-acanthamoeba-keratitis-using-confocal-microscopy
#4
Ping Huang, Tudor Tepelus, Laura A Vickers, Elmira Baghdasaryan, Jianyan Huang, John A Irvine, Hugo Y Hsu, Srinivas Sadda, Olivia L Lee
PURPOSE: To quantify the density, distribution, and depth of invasion of cysts in the corneas of eyes with acanthamoeba keratitis (AK) by in vivo confocal microscopy (IVCM) with a novel scanning pattern. METHODS: The medical records of patients with AK evaluated at the Doheny Eye Center UCLA between September 2014 and July 2016 were reviewed retrospectively. Patients with clinically diagnosed AK underwent IVCM at various time points during their clinical course...
May 23, 2017: Cornea
https://www.readbyqxmd.com/read/28540063/microrna-122-ameliorates-corneal-allograft-rejection-through-the-downregulation-of-its-target-cpeb1
#5
Ting Wang, Fengjie Li, Wenwen Geng, Qingguo Ruan, Weiyun Shi
Transplant rejection is a major cause of corneal transplantation failure. MicroRNAs (miRNAs) are a family of small RNAs that regulates gene expression in a sequence-specific manner. miRNAs have recently been shown to have important roles in human organ transplantation, but reports of miRNAs directly associated with corneal transplantation rejection remain limited. To investigate the role of miRNAs during corneal allograft rejection, we established a mouse penetrating keratoplasty model and used microarrays to screen for differentially expressed miRNAs...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28540006/office-based-relaxing-incision-procedure-for-correction-of-astigmatism-after-deep-anterior-lamellar-keratoplasty
#6
Mohammad Ali Javadi, Sepehr Feizi, Firooz Mirbabaee, Yousef Fekri
PURPOSE: To report the outcomes of a simple and effective office-based procedure for the correction of astigmatism after deep anterior lamellar keratoplasty (DALK). METHODS: This study enrolled 24 consecutive keratoconic eyes that developed an intolerable amount of graft astigmatism after DALK. The location and extension of steep semi-meridians were determined using corneal topography. Office-based relaxing incision procedures were performed at the slit-lamp biomicroscope using a 27-gauge needle...
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28534231/comparison-of-outcomes-and-complications-of-deep-anterior-lamellar-keratoplasty-and-penetrating-keratoplasty-performed-in-a-large-group-of-patients-with-keratoconus
#7
Ashbala Khattak, Fouad R Nakhli, Khaled M Al-Arfaj, Abdullah A Cheema
PURPOSE: To compare visual acuity, refraction, topography, and complications of deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PKP) performed in patients with keratoconus (KCN). METHODS: In this retrospective interventional non-randomized clinical study, patients with moderate to severe KCN that underwent either PKP or DALK for optical corrections were enrolled. The final outcome analysis was performed after complete suture removal for both groups of patients...
May 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28524886/fungal-keratitis-in-the-republic-of-ireland
#8
S Farrell, E McElnea, S Moran, S Knowles, C C Murphy
PurposeFungal keratitis is relatively rare in temperate climates with only one previous population-based study, which reported a minimum annual incidence of 0.32 per million population in the United Kingdom. We performed a nationwide study in the Republic of Ireland of cases over a 6-year period to establish the incidence, risk factors, treatment, and outcomes of fungal keratitis.Patients and methodsAll corneal scraping specimens positive for fungal species over a 6-year period were identified at the microbiology departments of the seven main ophthalmology units in the Republic of Ireland...
May 19, 2017: Eye
https://www.readbyqxmd.com/read/28524140/-influence-of-endothelial-graft-thickness-on-postoperative-visual-acuity
#9
S V Trufanov, S A Malozhen, V I Siplivyy, E P Salovarova
AIM: to assess the influence of the endothelial graft thickness on postoperative visual acuity following modified endothelial keratoplasty (UTDSAEK). MATERIAL AND METHODS: The study included 49 patients with pseudophakic bullous keratopathy and no concomitant disorders of either the retina or optic nerve. Ultrathin Descemet's stripping automated endothelial keratoplasty (UTDSAEK) was performed in all cases. Corneal graft thickness was measured 1 year after UTDSAEK by means of optical coherence tomography...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28520595/decreased-visual-acuity-by-an-irregular-corneal-posterior-surface-after-repeat-descemet-stripping-automated-endothelial-keratoplasty
#10
Hiroyuki Yazu, Takefumi Yamaguchi, Murat Dogru, Yoshiyuki Satake, Kazuo Tsubota, Jun Shimazaki
PURPOSE: To investigate the impact of higher-order aberrations (HOAs) on visual acuity after repeat Descemet stripping automated endothelial keratoplasty (DSAEK) in the same eyes. METHODS: This retrospective comparative case series includes 23 patients who underwent DSAEK twice in the same eyes (46 DSAEK in total). We evaluated the HOAs of the anterior and posterior corneal surfaces, and total cornea using the Fourier analysis data from anterior segment optical coherence tomography...
May 16, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28513490/coexistence-of-herpes-simplex-virus-infection-in-microsporidial-stromal-keratitis-associated-with-granulomatous-inflammation
#11
Ruchi Mittal, Praveen K Balne, Srikant Sahu, Sujata Das, Savitri Sharma
BACKGROUND: Microsporidial stromal keratitis poses several diagnostic challenges. Patients may present with corneal ulceration, marked stromal thinning, or even as a quite corneal scar. The presentation of microsporidial stromal keratitis commonly mimics viral keratitis. Microbiology scrapings are usually helpful; however, scraping and culture-negative cases pose a significant diagnostic dilemma. Histopathological examination is diagnostic but shows varying degree of inflammation, predominantly composed of polymorphonuclear leukocytes...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28509328/anatomy-based-dmek-wetlab-in-homburg-saar-novel-aspects-of-donor-preparation-and-host-maneuvers-to-teach-descemet-membrane-endothelial-keratoplasty
#12
B Seitz, L Daas, M Bischoff-Jung, N Szentmáry, S Suffo, M El-Husseiny, A Viestenz, G Milioti
INTRODUCTION: Use of Descemet Membrane Endothelial Keratoplasty (DMEK) has been limited because of problems with donor preparation, i.e. tearing of the Descemet membrane and difficulties in unfolding the Endothelium-Descemet-Membrane-Layer (EDML) in the anterior chamber (AC). The purpose of this work was to describe a novel approach to teaching anatomy-based donor and recipient preparation in a DMEK-Wetlab. MATERIAL AND METHODS: We teach successful mono-manual donor preparation of human corneas in organ culture not suitable for transplantation, including peripheral markers for orientation...
May 16, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28505675/-anti-lymph-angiogenic-strategies-to-improve-corneal-graft-survival
#13
Felix Bock, Claus Cursiefen
Corneal transplantation (keratoplasty) is the most frequently performed form of transplantation worldwide. A rejection reaction against the transplant is the main complication occurring after transplantation in an already vascularized, so-called "high-risk" recipient eye. Our group has shown that clinically invisible lymphatic vessels play a crucial role in the induction of a rejection reaction against the corneal graft, and that anti-(lymph)angiogenic therapies in the mouse model of keratoplasty can significantly improve transplant survival...
May 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28505034/pediatric-corneal-transplants
#14
Danielle Trief, Maria C Marquezan, Christopher J Rapuano, Christina R Prescott
PURPOSE OF REVIEW: Pediatric keratoplasty poses unique challenges in clinical and surgical management. However, successful transplantation can afford a child vision in an otherwise poorly seeing eye. This review will provide an update on recent advances in pediatric keratoplasty. RECENT FINDINGS: Although children who receive corneal transplants remain at increased risk of rejection, infection, and graft dehiscence compared with adult corneal transplant recipients, new surgical techniques, and advances in clinical management have led to better outcomes...
May 12, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28503733/long-term-safety-from-transmission-of-porcine-endogenous-retrovirus-after-pig-to-non-human-primate-corneal-transplantation
#15
Hyuk Jin Choi, Jiyeon Kim, Jae Young Kim, Hyun Ju Lee, Won Ryang Wee, Mee Kum Kim, Eung Soo Hwang
BACKGROUND: The risk of xenozoonosis mainly by porcine endogenous retrovirus (PERV) has been considered as one of the main hurdles in xenotransplantation and therefore should be elucidated prior to the clinical use of porcine corneal grafts. Accordingly, an investigation was performed to analyze the infectivity of PERVs from porcine keratocytes to human cells, and the long-term risk of transmission of PERVs was determined using pig-to-non-human primate (NHP) corneal transplantation models...
May 14, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28489805/first-experience-of-ndasek-with-heads-up-surgery-a-case-report
#16
Yasser Helmy Mohamed, Masafumi Uematsu, Daisuke Inoue, Takashi Kitaoka
PURPOSE: To report a case of non-Descemet Stripping Automated Endothelial Keratoplasty (nDSAEK) using heads-up surgery. CASE/INTERVENTION: The case was a 72-years-old man who had history of left eye blunt trauma since childhood. One year ago, the patient was diagnosed to have left posttraumatic bullous keratopathy. The patient underwent lt nDSAEK by using the heads-up three-dimensional (3D) system last July. The surgery was performed with a Rescan 700 surgical microscope (Carl Zeiss), which is integrated with intraoperative optical coherence tomography (iOCT) system...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28489792/eye-bank-prepared-versus-surgeon-cut-endothelial-graft-tissue-for-descemet-membrane-endothelial-keratoplasty-an-observational-study
#17
Marie Regnier, Céline Auxenfans, Delphine Maucort-Boulch, Anne-Sophie Marty, Odile Damour, Carole Burillon, Viridiana Kocaba
The purpose of this article is to examine outcomes of Descemet membrane endothelial keratoplasty (DMEK) performed with cornea bank (CB) prestripped tissue and surgeon stripped tissue (SST).This retrospective study examined subjects who underwent DMEK with CB or surgeon prepared tissue for Fuchs endothelial corneal dystrophy. Best-corrected visual acuity (BCVA), corneal thickness, endothelial cell count (ECC), and complications were examined before and throughout a 6-month postoperative period.Eleven CB and 22 SST subjects were included...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28489719/microkeratome-assisted-anterior-lamellar-keratoplasty-for-the-correction-of-high-degree-postkeratoplasty-astigmatism
#18
Shay Gutfreund, Pia Leon, Massimo Busin
PURPOSE: To describe the surgical technique and report the outcomes of patients treated with microkeratome-assisted anterior lamellar keratoplasty (MALK) for the correction of high-degree postkeratoplasty astigmatism. METHODS: Four eyes of 2 patients with extremely high (>10 D) and irregular [surface asymmetry index >1.0 D] post-penetrating keratoplasty astigmatism occurring after complete suture removal underwent MALK and were followed for at least 3 years after the procedure...
May 9, 2017: Cornea
https://www.readbyqxmd.com/read/28487301/a-double-descemet-s-stripping-endothelial-keratoplasty-on-a-penetrating-keratoplasty
#19
Li Yen Goh, Mohamed Elalfy, Noha Mohamed Ghoz, Harminder Dua
A patient with keratoconus underwent a penetrating keratoplasty (PK) in his right eye. This failed after 12 years following phacoemulsification surgery. A Descemet's stripping endothelial keratoplasty (DSEK) was carried out which failed and detached after 4 months. Subsequently, a second DSEK was performed which failed after 2 months but remained attached. This graft was retained in the cornea and a third DSEK button was placed without removing the failed DSEK graft. The cornea cleared well and patient's vision was 6/9 at 18 months postsurgery...
May 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28486726/management-of-interface-fluid-syndrome-after-lasik-by-descemet-membrane-endothelial-keratoplasty-in-a-patient-with-fuchs-corneal-endothelial-dystrophy
#20
Mehdi Shajari, Parviz Rafiezadeh, Ivana Pavlovic, Kate Barbara Kubiak, Thomas Kohnen, Ingo Schmack
PURPOSE: To report a case of interface fluid syndrome after LASIK in a patient with Fuchs' corneal endothelial dystrophy treated with Descemet membrane endothelial keratoplasty (DMEK). METHODS: Case report. RESULTS: A 74-year-old patient presented with interface fluid syndrome and was treated with DMEK. Its complications in the form of partial graft detachment and cystoid macular edema were successfully managed by rebubbling and topical treatment, respectively...
May 1, 2017: Journal of Refractive Surgery
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