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Le Wang, Xiang Li, Yingnan Li, Wenying Liu, Xiaoyun Jia, Xiaoling Qiao, Chao Qu, Xiaoyu Cheng, Shouwei Wang
Xuanwei ham is especially rich in a large amount of peptides and free amino acids under the action of protein degradation. Some of these peptides can potentially exert bioactivities of interest for human health. Traditionally, Xuanwei ham should undergo Chinese household cooking treatments before eating. However, it has not been known how its bioactivity changes after cooking and gastrointestinal digestion. Herein, Xuanwei ham is analysed before and after cooking, as well as gastrointestinal digestion being simulated so as to evaluate and compare its effect on antioxidant and angiotensin I-converting enzyme (ACE) inhibitory activities...
July 2018: Royal Society Open Science
Loredana Maiuolo, Giordana Feriotto, Vincenzo Algieri, Monica Nardi, Beatrice Russo, Maria Luisa Di Gioia, Emilia Furia, Matteo Antonio Tallarida, Carlo Mischiati, Antonio De Nino
A series of ketonitrones derived from isatin and indanone (INs) were synthesized and evaluated for their antiproliferative activities against several human cancer cell lines. Then, the antioxidant properties of these substrates were measured by the DPPH test to report their biological activity in terms of their spin trapping action. In particular, one substrate has showed very high biological and scavenging activity, probably due to the strong correlation between its spin trapping activity and structure.
February 1, 2018: MedChemComm
Juan C Alvarado, Verónica Fuentes-Santamaría, María C Gabaldón-Ull, José M Juiz
The increasing rate of age-related hearing loss (ARHL), with its subsequent reduction in quality of life and increase in health care costs, requires new therapeutic strategies to reduce and delay its impact. The goal of this study was to determine if ARHL could be reduced in a rat model by administering a combination of antioxidant vitamins A, C, and E acting as free radical scavengers along with Mg++ , a known powerful cochlear vasodilator (ACEMg). Toward this goal, young adult, 3 month-old Wistar rats were divided into two groups: one was fed with a diet composed of regular chow ("normal diet," ND); the other received a diet based on chow enriched in ACEMg ("enhanced diet," ED)...
2018: Frontiers in Neuroscience
Kannika Permpoonputtana, Patlada Tangweerasing, Sujira Mukda, Parichart Boontem, Chutikorn Nopparat, Piyarat Govitrapong
Aging is often accompanied by a decline in cognitive function in conjunction with a variety of neurobiological changes, including neuroinflammation. Melatonin is a key endogenous indoleamine secreted by the pineal gland that plays a crucial role in the regulation of circadian rhythms, is a potent free radical scavenger, has anti-inflammatory activity and serves numerous other functions. However, the role of melatonin in sterile inflammation in the brain has not been fully investigated. In the present study, we investigated the neuroinflammation status in aged mouse brains...
2018: EXCLI Journal
Anne E Robinson, Jessica E Lowe, Eun-Ik Koh, Jeffrey P Henderson
Invasive gram-negative bacteria often express multiple virulence-associated metal ion chelators to combat host-mediated metal deficiencies. Escherichia coli , Klebsiella , and Yersinia pestis isolates encoding the Yersinia High Pathogenicity Island (HPI) secrete yersiniabactin (Ybt), a metallophore originally shown to chelate iron ions during infection. However, our recent demonstration that Ybt also scavenges copper ions during infection led us to question whether it might be capable of retrieving other metals as well...
August 14, 2018: Journal of Biological Chemistry
Won-Kyu Ju, Myoung Sup Shim, Keun-Young Kim, Jung Hyun Bu, Tae Lim Park, Sangphil Ahn, Robert N Weinreb
Coenzyme Q10 (CoQ10 ) protects retinal ganglion cells (RGCs) in experimental retinal ischemia and glaucoma by scavenging reactive oxygen species. We tested whether a diet supplemented with ubiquinol, the reduced form of CoQ10 , promotes RGC survival and blocks the apoptotic pathway in ischemic mouse retina induced by acute high intraocular pressure (IOP) elevation. Ubiquinol (1%) treatment significantly promoted RGC survival at 2 weeks after ischemia/reperfusion. The ubiquinol treatment significantly blocked activation of astroglial and microglial cells in the ischemic retina at 2 weeks...
August 11, 2018: Biochemical and Biophysical Research Communications
Zunlai Sheng, Jiahong Zhao, Ishfaq Muhammad, Ying Zhang
Ultrasonic-assisted extraction (UAE), using aqueous ethanol as the solvent, was firstly applied to extract phenolic compounds from Terminalia chebula Retz. fruits (T. chebula fruits). In this study, ethanol concentration (%), ultrasonic intensity (W/cm2), particle diameter (mm), extraction temperature (°C), ultrasonic time (min), liquid-solid ratio (mL/g) and extraction cycle were investigated by single-factor experiment and then optimized using a Box-Behnken design. The optimized result for UAE was 68% ethanol concentration, ultrasonic intensity of 3...
2018: PloS One
Ewelina Orlowska, Maria V Babak, Orsolya Dömötör, Eva A Enyedy, Peter Rapta, Michal Zalibera, Lukáš Bučinský, Michal Malček, Chinju Govind, Venugopal Karunakaran, Yusuf Chouthury Shaik Farid, Tara E McDonnell, Dominique Luneau, Dominik Schaniel, Wee Han Ang, Vladimir B Arion
With the aim of enhancing the biological activity of ruthenium-nitrosyl complexes, new compounds with four equatorially bound indazole ligands, namely, trans-[RuCl(Hind)4 (NO)]Cl2 ·H2 O ([3]Cl2 ·H2 O) and trans-[RuOH(Hind)4 (NO)]Cl2 ·H2 O ([4]Cl2 ·H2 O), have been prepared from trans-[Ru(NO2 )2 (Hind)4 ] ([2]). When the pH-dependent solution behavior of [3]Cl2 ·H2 O and [4]Cl2 ·H2 O was studied, two new complexes with two deprotonated indazole ligands were isolated, namely [RuCl(ind)2 (Hind)2 (NO)] ([5]) and [RuOH(ind)2 (Hind)2 (NO)] ([6])...
August 14, 2018: Inorganic Chemistry
Kohsuke Hagisawa, Manabu Kinoshita, Bonpei Takase, Kenichi Hashimoto, Daizoh Saitoh, Shuhji Seki, Yasuhiro Nishida, Hiromi Sakai
INTRODUCTION: We have developed hemoglobin vesicles (HbVs) as a substitute for red blood cells (RBCs). We investigated the efficacy of HbV transfusion in the treatment of massive hemorrhage in rabbits in the setting of thrombocytopenic coagulopathy, focusing on the efficacy of hemostasis by subsequent platelet transfusion. METHODS: Thrombocytopenic coagulopathy was induced in rabbits by repeated blood withdrawal and isovolemic retransfusion of autologous RBC (platelet counts <45,000/μL)...
September 2018: Shock
Aurore Lhonore, Pierre-Henri Commère, Elisa Negroni, Giorgia Pallafacchina, Bertrand Friguet, Jacques Drouin, Margaret Buckingham, Didier Montarras
Skeletal muscle regeneration depends on satellite cells. After injury these muscle stem cells exit quiescence, proliferate and differentiate to regenerate damaged fibres. We show that this progression is accompanied by metabolic changes leading to increased production of reactive oxygen species (ROS). Using Pitx2/3 single and double mutant mice that provide genetic models of deregulated redox states, we demonstrate that moderate overproduction of ROS results in premature differentiation of satellite cells while high levels lead to their senescence and regenerative failure...
August 14, 2018: ELife
Tao Lin, Jae Eun Lee, Jeong Won Kang, Reza K Oqani, Eun Seok Cho, Seong Bok Kim, Dong Il Jin
Poor-quality oocytes (those with 1 to 2 layers of cumulus cells) typically possess low meiotic competence and development. Prolonging the duration of in vitro maturation (IVM; 52 h) can enhance the maturation rate of poor-quality oocytes, but it does not improve subsequent embryonic development. This likely reflects the increased reactive oxygen species (ROS) production and apoptosis seen in these oocytes compared with the non-prolonged IVM (44 h) group. Melatonin is a free radical scavenger, anti-oxidant and anti-apoptotic agent that reported to enhance the quality of embryos by inhibiting ROS generation and apoptosis...
August 14, 2018: Molecular Reproduction and Development
Zeinab Nazarian-Samani, Robert D E Sewell, Zahra Lorigooini, Mahmoud Rafieian-Kopaei
PURPOSE OF REVIEW: This systematic review describes evidence concerning medicinal plants that, in addition to exerting hypoglycemic effects, decrease accompanying complications such as nephropathy, neuropathy, retinopathy, hypertension, and/or hyperlipidemia among individuals with diabetes mellitus (DM). RECENT FINDINGS: Studies on the antidiabetic mechanisms of medicinal plants have shown that most of them produce hypoglycemic activity by stimulating insulin secretion, augmenting peroxisome proliferator-activated receptors (PPARs), inhibiting α-amylase or α-glucosidase, glucagon-like peptide-1 (GLP-1) secretion, advanced glycation end product (AGE) formation, free radical scavenging plus antioxidant activity (against reactive oxygen or nitrogen species (ROS/RNS)), up-regulating or elevating translocation of glucose transporter type 4 (GLUT-4), and preventing development of insulin resistance...
August 13, 2018: Current Diabetes Reports
Jie Mei, Lirong Wang, Xiliang Jiang, Beilei Wu, Mei Li
Trichoderma spp. are important biocontrol filamentous fungi and have tremendous potential in soil bioremediation. In our previous studies, a C2H2 type transcription factor coding gene ( thmea1 ) was cloned from a biocontrol agent T. harzianum Th-33; the encoded sequence of thmea1 contained 3 conserved C2H2 domains with Swi5 and Ace2 in Saccharomyces cerevisiae . The thmea1 knockout mutant Δthmea1 showed 12.9% higher copper tolerance than the wild-type Th33. To elucidate the function of thmea1 and its relationship with copper stress response, we conducted transcriptome sequencing and analysis of wild-type Th33 and Δthmea1 under 0...
2018: BioMed Research International
Carolina María Viola, Romina Torres-Carro, Elena Cartagena, María Inés Isla, María Rosa Alberto, Mario Eduardo Arena
In this work, we intended to inhibit the biofilm synthesis and the metabolism of Gram-positive and Gram-negative bacteria using two highly available wastes (stem and marc) obtained after the manufacturing of Torrontes wine at Cafayate, Argentina. Wine wastes contain a significant amount of bioactive compounds, mainly phenolic compounds, which makes them a potential source of compounds with beneficial properties to human health, as they could inhibit the virulence of pathogenic bacteria or protect the tissue against oxidative stress...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Joseph Adetunji Elegbede, Agbaje Lateef, Musibau Adewuyi Azeez, Tesleem Babatunde Asafa, Taofeek Akangbe Yekeen, Iyabo Christianah Oladipo, Elijah Adegoke Adebayo, Lorika Selomi Beukes, Evariste Bosco Gueguim-Kana
Green synthesis of nanoparticles has fuelled the use of biomaterials to synthesise a variety of metallic nanoparticles. The current study investigates the use of xylanases of Aspergillus niger L3 (NEA) and Trichoderma longibrachiatum L2 (TEA) to synthesise silver nanoparticles (AgNPs). Characterisation of AgNPs was carried out using UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy, while their effectiveness as antimicrobial, antioxidant, catalytic, anticoagulant, and thrombolytic agents were determined...
September 2018: IET Nanobiotechnology
Eun-Young Jang, Yong-Jun Son, Soo-Yeun Park, Ji-Yeon Yoo, Dae-Youn Hwang, Hyean-Cheal Park, Hong-Joo Son
In the present study, silver nanoparticles (SNPs) were synthesised for the first time using Pseudomonas geniculata H10 as reducing and stabilising agents. The synthesis of SNPs was the maximum when the culture supernatant was treated with 2.5 mM AgNO3 at pH 7 and 40°C for 10 h. The SNPs were characterised by field emission scanning electron microscopy-energy-dispersive spectroscopy, transmission electron microscopy, dynamic light scattering, X-ray diffraction and UV-vis spectroscopy. Fourier transform infrared spectroscopy indicated the presence of proteins, suggesting they may have been responsible for the reduction and acted as capping agents...
September 2018: IET Nanobiotechnology
Deepika Singh, Vikas Kumar, Ekta Yadav, Neha Falls, Manvendra Singh, Ujendra Komal, Amita Verma
Facile green synthesis of silver nanoparticles (AgNPs) using an aqueous extract of Carissa carandas ( C. carandas ) leaves was studied. Fabrication of AgNPs was confirmed by the UV-visible spectroscopy which gives absorption maxima at 420 nm. C. carandas leaves are the rich source of the bioactive molecules, acts as a reducing and stabilising agent in AgNPs, confirmed by Fourier transforms infrared spectroscopy. The field emission scanning electron microscope revealed the spherical shape of biosynthesised AgNPs...
September 2018: IET Nanobiotechnology
Elias E Elemike, Damian C Onwudiwe, Anthony C Ekennia, Anine Jordaan
In this study, the conversion of silver ions into ∼30.74 nm sized silver nanoparticles (AgNPs) was achieved in 30 min at a reaction temperature of 80-90°C in aqueous leaf extract of Artemisia afra . The synthesised AgNPs showed surface plasmon resonance in the range of 423-438 nm. Spherical and face-centred cubic nanoparticles were confirmed by transmission electron microscope (TEM) and X-ray diffraction (XRD) analysis, respectively. Fourier transform infra-red (FTIR) results indicated that the obtained nanoparticles were stabilised and capped through the carbonyl and carboxylate ion groups possibly from flavonoids, terpenoids, phenolics and esters content of the extracts...
September 2018: IET Nanobiotechnology
Tzyy-Bin Tsay, Ming-Chieh Yang, Wan-Hsuan Chang, Pei-Hsuan Chen, Lee-Wei Chen
BACKGROUND: Widespread use of antibiotics in the intensive care unit is a potential cause of the emergence of hospital-acquired pneumonia. This study determined whether Lactobacillus salivarius feeding could reverse antibiotic-induced lung defense impairment in a ventilator model. METHODS: C57BL/6 wild-type (WT) mice received mechanical ventilation for 3 h after intramuscular antibiotic treatment for 6 days. Treatment with dead Lactobacillus salivarius and fructo-oligosaccharides (FOS) feeding were used to stimulate antibacterial protein expression in the intestine...
August 13, 2018: Journal of Translational Medicine
Juan C Mayo, Arturo Aguado, Rafael Cernuda-Cernuda, Alejandro Álvarez-Artime, Vanesa Cepas, Isabel Quirós-González, David Hevia, Rosa M Sáinz
Melatonin, N -acetyl-5-methoxytryptamine, is an indole mainly synthesized from tryptophan in the pineal gland and secreted exclusively during the night in all the animals reported to date. While the pineal gland is the major source responsible for this night rise, it is not at all the exclusive production site and many other tissues and organs produce melatonin as well. Likewise, melatonin is not restricted to vertebrates, as its presence has been reported in almost all the phyla from protozoa to mammals. Melatonin displays a large set of functions including adaptation to light: dark cycles, free radical scavenging ability, antioxidant enzyme modulation, immunomodulatory actions or differentiation⁻proliferation regulatory effects, among others...
August 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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