Elena Azzini, Sheila I Peña-Corona, Héctor Hernández-Parra, Deepak Chandran, Lejaniya Abdul Kalam Saleena, Yousef Sawikr, Ilaria Peluso, Sangram Dhumal, Manoj Kumar, Gerardo Leyva-Gómez, Miquel Martorell, Javad Sharifi-Rad, Daniela Calina
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-beta plaques and neurofibrillary tangles, leading to neuronal loss. Curcumin, a polyphenolic compound derived from Curcuma longa, has shown potential neuroprotective effects due to its anti-inflammatory and antioxidant properties. This review aims to synthesize current preclinical data on the anti-neuroinflammatory mechanisms of curcumin in the context of AD, addressing its pharmacokinetics, bioavailability, and potential as a therapeutic adjunct...
April 14, 2024: Phytotherapy Research: PTR