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Giuseppe Giannaccare, Jayne S Weiss, Laura Sapigni, Cristina Bovone, Leila Mattioli, Emilio C Campos, Massimo Busin
PURPOSE: To evaluate the rate and outcomes of immunologic stromal rejection occurring after large deep anterior lamellar keratoplasty (DALK) and the effect of the underlying disease on the cumulative probability of rejection. METHODS: This was a retrospective chart review of all eyes that underwent a 9-mm DALK at Ospedali Privati Forlì (Forlì, Italy). On the basis of preoperative diagnosis, eyes were assigned to group 1: keratoconus, group 2: stromal disease with a low risk for rejection, or group 3: stromal disease with a high risk for rejection...
March 14, 2018: Cornea
Juliana Lopes Fávero, Rodrigo Dalke Meucci, Neice Müller Xavier Faria, Nadia Spada Fiori, Anaclaudia Gastal Fassa
This study aims to describe the prevalence of heavy drinking, high-risk alcohol consumption and associated factors among tobacco farmers. A cross-sectional study was carried out with 2,469 tobacco farmers over 18 years old in 2011. High-risk alcohol consumption was considered the intake of three or more standard doses per day for men or two or more for women. Heavy drinking was considered the intake of four or more standard doses per day for men and three or more for women. Hierarchical multivariate analysis was performed to investigate the association with socioeconomic, behavioral, and occupational variables...
March 2018: Ciência & Saúde Coletiva
Rodrigo Dalke Meucci, Angélica Ozório Linhares, Daniel Wenceslau Votto Olmedo, Ewerton Luiz Porto Cousin Sobrinho, Vlanice Madruga Duarte, Juraci Almeida Cesar
The scope of this article is to assess low back pain prevalence and associated factors in the last 12 months among adolescents in a city in the south of the State of Piauí. It was a cross-sectional study which included 1,112 adolescents aged 13-19 in the city of Caracol, Piauí. Demographic, socio-economic, nutritional, behavioral and comorbidty characteristics were investigated. The outcome was the occurrence of low back pain (LBP) in the last 12 months. The outcome prevalence was calculated in accordance with independent variables...
March 2018: Ciência & Saúde Coletiva
Wen-Jia Xie, Ye-Sheng Xu, Xia Zhang, Yu-Feng Yao
OBJECTIVE: To assess the lower tear meniscus height (LTMH), central tear film thickness (CTFT), and central corneal epithelial thickness (CCET) after deep anterior lamellar keratoplasty (DALK). METHODS: This was a retrospective cross-sectional study of 20 patients who had DALK in one eye over a three-month period. LTMH, CTFT, and CCET of the operated eyes and the unoperated fellow eyes were measured using high-definition optical coherence tomography (HD-OCT). Correlations between three OCT assessments and age, time following surgery, graft size, bed size, and the number of residual sutures were analyzed...
2018: Journal of Zhejiang University. Science. B
Oganes G Oganesyan, Vladimir V Neroev, Arthur A Grdikanyan, Vostan R Getadaryan
PURPOSE: To describe the feasibility of same-day, consecutive use of a single donor cornea in 5 patients with corneal pathology, who required anterior lamellar and endothelial keratoplasties. METHODS: Descemet membrane (DM) with endothelium was completely stripped from a single corneoscleral button and punched out from the endothelial side with a circular, standard punch. Using a custom-made punch for linear cutting of DM, we obtained 4 quarter-grafts (Q-graft)...
February 27, 2018: Cornea
Adi Einan-Lifshitz, Nir Sorkin, Tanguy Boutin, Zale Mednick, Mohammad Kreimei, Clara C Chan, David S Rootman
PURPOSE: To suggest a new surgical approach for posterior opacities or persistent Descemet membrane (DM) detachment in failed deep anterior lamellar keratoplasty (DALK) and to report the outcome of Descemet membrane endothelial keratoplasty (DMEK) in a series of patients with DALK failure. METHODS: In this retrospective case series of patients who underwent DMEK for failed DALK at Toronto Western Hospital, 4 patients with failed DALK who underwent DMEK surgery were included...
February 22, 2018: Cornea
Xiaolei Lin, Yue Wu, Yana Fu, Qi Dai
RATIONALE: To report a case of late spontaneous reattachment of Descemet membrane (DM) detachment after deep anterior lamellar keratoplasty (DALK). PATIENT CONCERNS: A 50-year-old woman with stromal corneal scarring underwent a DALK with the big bubble technique. The DM detachment and double anterior chamber were observed on the first day after operation. DIAGNOSES: Descemet membrane detachment after deep anterior lamellar keratoplasty [Oculus Dexter (OD), indicates right eye]...
February 2018: Medicine (Baltimore)
E Flockerzi, P Maier, D Böhringer, H Reinshagen, F Kruse, C Cursiefen, T Reinhard, G Geerling, N Torun, B Seitz
PURPOSE: The purpose of this retrospective panel study was to provide an overview of absolute numbers, trends in the types of and indications for corneal transplantation in Germany from 2001 to 2016. METHODS: A questionnaire about absolute numbers, types of transplantation and indications was sent to 111 ophthalmological departments in Germany out of which 94 (85%) provided their data. RESULTS: Since the year 2001, the number of corneal transplantations has increased by 1...
February 1, 2018: American Journal of Ophthalmology
Claudia Dalke, Frauke Neff, Savneet Kaur Bains, Scott Bright, Deborah Lord, Peter Reitmeir, Ute Rößler, Daniel Samaga, Kristian Unger, Herbert Braselmann, Florian Wagner, Matthias Greiter, Maria Gomolka, Sabine Hornhardt, Sarah Kunze, Stefan J Kempf, Lillian Garrett, Sabine M Hölter, Wolfgang Wurst, Michael Rosemann, Omid Azimzadeh, Soile Tapio, Michaela Aubele, Fabian Theis, Christoph Hoeschen, Predrag Slijepcevic, Munira Kadhim, Michael Atkinson, Horst Zitzelsberger, Ulrike Kulka, Jochen Graw
Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 weeks of age, determined lens opacities for up to 2 years and compared it with overall survival, cytogenetic alterations and cancer development. The highest dose was significantly associated with increased body weight and reduced survival rate...
January 11, 2018: Radiation and Environmental Biophysics
Uri Elbaz, Caitriona Kirwan, Carl Shen, Asim Ali
BACKGROUND/AIMS: To describe the visual and clinical outcomes of manual layer-by-layer deep anterior lamellar keratoplasty (DALK) in a paediatric population. METHODS: The charts of all children who underwent DALK surgery between January 2007 and January 2015 were reviewed retrospectively. Data collected included preoperative and postoperative spectacle-corrected distance visual acuity (CDVA), intraoperative and postoperative complications including graft rejection and failure...
January 4, 2018: British Journal of Ophthalmology
Bo-I Ku, Yi-Ting Hsieh, Fung-Rong Hu, I-Jong Wan, Wei-Li Chen, Yu-Chih Hou
PURPOSE: To compare endothelial cell density (ECD) loss rates in penetrating keratoplasty (PKP), Descemet's stripping automated endothelial keratoplasty (DSAEK), and deep anterior lamellar keratoplasty (DALK). DESIGN: Single-center, multiple-surgeon, retrospective cohort study. MATERIALS AND METHODS: Patients who received PKP, DSAEK, or DALK from 2009 to 2014 were analyzed (68 vs. 38 vs. 11 patients, respectively). We excluded patients with therapeutic PKP or regraft, infection, endothelial rejection, or uncontrolled glaucoma...
October 2017: Taiwan Journal of Ophthalmology
Yi-Ju Ho, Cheng-Hsiu Wu, Hung-Chi Chen, Chin-Shi Hsiao, Yi-Jen Hsueh, David Hui-Kang Ma
PURPOSE: To report our experience in air-assisted manual dissection deep anterior lamellar keratoplasty (DALK) for the treatment of corneal scar with previous inflammation and fibrosis. MATERIALS AND METHODS: We retrospectively reviewed the medical history of 21 patients (male:female = 13:8 mean age 41.9 years old) with corneal pathology from previous infection and inflammation. Trephination diameter ranged from 7.0 to 8.0 mm, and the graft was oversized by 0.25-0...
October 2017: Taiwan Journal of Ophthalmology
Vincenzo Scorcia, Valentina De Luca, Andrea Lucisano, Adriano Carnevali, Giovanna Carnovale Scalzo, Cristina Bovone, Massimo Busin
AIM: To report the outcomes of bubble formation obtained by means of intrastromal injection of ophthalmic viscoelastic device (OVD) after failure of pneumatic dissection for deep anterior lamellar keratoplasty (DALK). METHODS: DALK was performed in 140 keratoconic eyes of 130 patients by injecting air and OVD only secondarily, after pneumatic dissection had failed; the bubble formation rates after air and OVD injection were recorded; complications, best spectacle-corrected visual acuity (BSCVA) and corneal tomographic parameters were evaluated 3 months, 6 months and 12 months postoperatively, as well as after complete suture removal...
December 23, 2017: British Journal of Ophthalmology
Fouad anNakhli, Ashbala Khattak
PURPOSE: To compare the refractive and keratometric changes induced by femtosecond laser astigmatic keratotomy (AK) for suture-out post-keratoplasty astigmatism in deep anterior lamellar keratoplasty (group I) and penetrating keratoplasty (group II). SETTING: Dhahran Eye Specialist Hospital, Dhahran, Saudi Arabia. DESIGN: Retrospective, comparative, interventional study. METHODS: This study comprised 15 eyes in group I and 35 eyes in group II...
December 22, 2017: International Ophthalmology
Samir Jabbour, Adam Muzychuk, Younes Agoumi, Mona Harissi-Dagher
Purpose: To report the first case of acute angle closure due to a high-pressure Descemet membrane detachment following deep anterior lamellar keratoplasty (DALK) using the "big bubble" technique. Observations: A 25-year-old man underwent DALK surgery for keratoconus using the "big bubble" technique in which an air bubble is injected in deep stroma to promote dissection of underlying Descemet membrane from stroma. Surgery was uneventful and the patient was discharged home in good conditions...
September 2017: American Journal of Ophthalmology Case Reports
Sungwon Shin, Jung Kweon Bae, Yujin Ahn, Hyeongeun Kim, Geonho Choi, Young-Sik Yoo, Choun-Ki Joo, Sucbei Moon, Woonggyu Jung
Deep anterior lamellar keratoplasty (DALK) is an emerging surgical technique for the restoration of corneal clarity and vision acuity. The big-bubble technique in DALK surgery is the most essential procedure that includes the air injection through a thin syringe needle to separate the dysfunctional region of the cornea. Even though DALK is a well-known transplant method, it is still challenged to manipulate the needle inside the cornea under the surgical microscope, which varies its surgical yield. Here, we introduce the DALK protocol based on the position-guided needle and M-mode optical coherence tomography (OCT)...
December 2017: Journal of Biomedical Optics
F Sabatino, E Sarnicola, C Sarnicola, G M Tosi, P Perri, V Sarnicola
PurposeTo investigate the efficacy of early therapeutic deep anterior lamellar keratoplasty (DALK) in eradicating fungal keratitis that is poorly responsive to medical treatment.Patients and methodsTwenty-three eyes (23 patients) underwent early therapeutic DALK within 15 to 50 days from the onset of symptoms. The adopted eligibility criteria for early DALK included the following: active fungal keratitis affecting the optical zone with ulcer confined in the 6.00 mm central cornea; deeper than 150 μm but not exceeding 300 μm; and poorly responsive to medical treatment...
December 2017: Eye
J Hugo, E Granget, G Ho Wang Yin, M Sampo, L Hoffart
PURPOSE: To evaluate the biomechanical properties of the cornea and their impact on intraocular pressure (IOP) measurement after lamellar keratoplasty, compared to healthy eyes, using a non-contact tonometer with a Scheimpflug camera. METHODS: This study, from 2014 to 2015, included 22 primary DSAEK, 5 DALK, 6 DSAEK after PK, and 50 control eyes. Using a non-contact tonometer with a high-speed Scheimpflug camera (CORVIS ST, Oculus Optikgeräte GmbH, Wetzlar, Germany), several biomechanical parameters were recorded, including radius at highest concavity (Rhc ) and defomation amplitude (DA)...
January 2018: Journal Français D'ophtalmologie
Friederike Schaub, Philip Enders, Werner Adler, Björn O Bachmann, Claus Cursiefen, Ludwig M Heindl
BACKGROUND: To evaluate main features of donor tissue that may influence clinical outcome or complication rate after deep anterior lamellar keratoplasty (DALK). METHODS: Donor tissue parameters of 84 consecutive corneal donor grafts used for big-bubble DALK surgery between June 2011 and December 2014 in 84 eyes of 84 patients with disorders of anterior corneal stroma were correlated to clinical outcome parameters of recipient eyes 12 months after surgery and 3 months after total suture removal...
November 17, 2017: BMC Ophthalmology
Clàudia Garrido, Genís Cardona, Josep L Güell, Jaume Pujol
PURPOSE: A single-center, cross-sectional study was designed to assess and compare objective and subjective quality of vision of patients intervened with penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK) and Descemet membrane endothelial keratoplasty (DMEK). METHODS: Forty-six patients previously intervened with PK (22 eyes), DALK (7 eyes) and DMEK (17 eyes) were recruited. Visual evaluation included spherical and cylindrical refraction, distance corrected visual acuity (DCVA), photopic contrast sensitivity (CS), optical quality, measured with the HD Analyzer (objective scattering index [OSI], MTF cut-off and Strehl ratio), and ocular and corneal aberrometry, measured with the KR-1W Wavefront Analyzer...
November 13, 2017: Journal of Optometry
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