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https://www.readbyqxmd.com/read/28103258/revisiting-greek-propolis-chromatographic-analysis-and-antioxidant-activity-study
#1
Konstantinos M Kasiotis, Pelagia Anastasiadou, Antonis Papadopoulos, Kyriaki Machera
Propolis is a bee product that has been extensively used in alternative medicine and recently has gained interest on a global scale as an essential ingredient of healthy foods and cosmetics. Propolis is also considered to improve human health and to prevent diseases such as inflammation, heart disease, diabetes and even cancer. However, the claimed effects are anticipated to be correlated to its chemical composition. Since propolis is a natural product, its composition is consequently expected to be variable depending on the local flora alignment...
2017: PloS One
https://www.readbyqxmd.com/read/28099150/elimination-of-quiescent-slow-cycling-cells-via-reducing-quiescence-depth-by-natural-compounds-purified-from-ganoderma-lucidum
#2
Jian Dai, Matthew A Miller, Nicholas J Everetts, Xia Wang, Peng Li, Ye Li, Jian-Hua Xu, Guang Yao
The medical mushroom Ganoderma lucidum has long been used in traditional Chinese medicine and shown effective in the treatment of many diseases including cancer. Here we studied the cytotoxic effects of two natural compounds purified from Ganoderma lucidum, ergosterol peroxide and ganodermanondiol. We found that these two compounds exhibited cytotoxicity not only against fast proliferating cells, but on quiescent, slow-cycling cells. Using a fibroblast cell-quiescence model, we found that the cytotoxicity on quiescent cells was due to induced apoptosis, and was associated with a shallower quiescent state in compound-treated cells, resultant from the increased basal activity of an Rb-E2F bistable switch that controls quiescence exit...
January 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28098857/anticancer-effects-of-ginsenoside-rg3-review
#3
Mengyao Sun, Ying Ye, Ling Xiao, Xinya Duan, Yongming Zhang, Hong Zhang
Cancer is a life-threatening disease with an alarmingly increased annual mortality rate globally. Although various therapies are employed for cancer, the final effect is not satisfactory. Chemotherapy is currently the most commonly used treatment option. However, the unsatisfactory efficacy, severe side-effects and drug resistance hinder the therapeutic efficacy of chemotherapeutic drugs. There is increasing evidence indicating that ginsenoside Rg3, a naturally occurring phytochemical, plays an important role in the prevention and treatment of cancer...
January 13, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28096961/polysaccharide-from-sepia-esculenta-ink-and-cisplatin-inhibit-synergistically-proliferation-and-metastasis-of-triple-negative-breast-cancer-mda-mb-231-cells
#4
Hua-Zhong Liu, Wei Xiao, Yi-Peng Gu, Ye-Xing Tao, Da-Yan Zhang, Hui Du, Jiang-Hua Shang
OBJECTIVES: This paper aims to investigate synergistic inhibition of polysaccharide from Sepia esculenta ink (SIP), a newly isolated marine polysaccharide in our laboratory, on breast cancer MDA-MB-231 cells exposed to cisplatin. MATERIALS AND METHODS: Cell viability of MDA-MB-231 cells was determined by CCK 8 assay. Median-effect concentration was analyzed using Chou-Talalay method that was also subjected to determine cell inhibition ratio and combined index, as well as interaction between SIP and cisplatin...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28087986/barriers-to-access-to-opioid-medicines-for-patients-with-opioid-dependence-a-review-of-legislation-and-regulations-in-eleven-central-and-eastern-european-countries
#5
Marjolein J M Vranken, Aukje K Mantel-Teeuwisse, Saskia Jünger, Lukas Radbruch, Willem Scholten, John A Lisman, Marija Subataite, Marie-Hélène D B Schutjens
BACKGROUND AND AIMS: Barriers linked to drug control systems are considered to contribute to inequitable access to controlled medicines, leaving millions of people in pain and suffering. Most studies focus on access to opioids for the treatment of severe (cancer) pain. This study aims to identify specific access barriers for patients with opioid dependence in legislation and regulations of 11 Central and Eastern European countries. METHODS: This study builds on a previous analysis of legislation and regulations as part of the EU 7th Framework Access To Opioid Medication in Europe (ATOME) project...
January 14, 2017: Addiction
https://www.readbyqxmd.com/read/28074433/partial-contribution-of-rho-kinase-inhibition-to-the-bioactivity-of-ganoderma-lingzhi-and-its-isolated-compounds-insights-on-discovery-of-natural-rho-kinase-inhibitors
#6
Yhiya Amen, Qinchang Zhu, Hai-Bang Tran, Mohamed S Afifi, Ahmed F Halim, Ahmed Ashour, Kuniyoshi Shimizu
Recent studies identified Rho-kinase enzymes (ROCK-I and ROCK-II) as important targets that are involved in a variety of diseases. Synthetic Rho-kinase inhibitors have emerged as potential therapeutic agents to treat disorders such as hypertension, stroke, cancer, diabetes, glaucoma, etc. Our study is the first to screen the total ethanol extract of the medicinal mushroom Ganoderma lingzhi with thirty-five compounds for Rho-kinase inhibitory activity. Moreover, a molecular binding experiment was designed to investigate the binding affinity of the compounds at the active sites of Rho-kinase enzymes...
January 10, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28073672/the-long-story-of-camptothecin-from-traditional-medicine-to-drugs
#7
REVIEW
Emanuela Martino, Serena Della Volpe, Elisa Terribile, Emanuele Benetti, Mirena Sakaj, Adriana Centamore, Andrea Sala, Simona Collina
20-(S)-Camptothecin (CPT) is a natural alkaloid extracted from the bark of Camptotheca acuminata (Chinese happy tree). It acts as a DNA topoisomerase 1 poison with an interesting antitumor activity and its use is limited by low stability and solubility and unpredictable drug-drug interactions. Since the late 20th century, it has been widely used in cancer therapy and, since extraction yields from plant tissues are very low, various synthetic routes have been developed to satisfy the increase in demand for CPT...
December 31, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28071013/the-industrial-potential-of-herbs-and-spices-a-mini-review
#8
Katarzyna B Leja, Katarzyna Czaczyk
Herbs and spices have been used for food and medicinal purposes for centuries - the first recorded evidence of their use dates back to 1500BC and the Ebers Papyrus, which mentioned spices such as anise, mustard, saffron, cinnamon, and cassia. Now, in the 21st century, a variety of secondary compounds produced by plants are used in many fields of industry, such as food production (to improve taste, to provide vitamins and macro- and microelements, and also to inhibit food spoilage caused by foodborne bacteria), in medicine (in the treatment of various diseases; in chemoprevention and cancer therapy; as a source of natural antimicrobials for the treatment of infectious disease), and in pharmacology and cosmetology (in dietary supplements, and as a result of the demand for preservative-free cosmetics, to reduce the risk of methylparaben allergies)...
October 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28068637/assembling-of-multifunctional-latex-based-hybrid-nanocarriers-from-calotropis-gigantea-for-sustained-doxorubicin-dox-releases
#9
Periyakaruppan Pradeepkumar, Dharman Govindaraj, Murugaraj Jeyaraj, Murugan A Munusamy, Mariappan Rajan
Natural rubber Latex (Lax) is a colloidal dispersion of polymer particles in liquid and shows good biodegradable, biocompatibility, and non-toxicity. Natural polymers are the most important materials used in food packaging, micro/nano-drug delivery, tissue engineering, agriculture, and coating. In the present study, natural compounds extracted from plant Lax were designed to function as drug carriers using various surfactants via emulation and solvent evaporation method. Calotropis gigantea belongs to the family Apocynaceae and has received considerable attention in modern medicine, ayurvedeic, siddha, and traditional medicine...
January 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28067791/ligands-of-therapeutic-utility-for-the-liver-x-receptors
#10
REVIEW
Rajesh Komati, Dominick Spadoni, Shilong Zheng, Jayalakshmi Sridhar, Kevin E Riley, Guangdi Wang
Liver X receptors (LXRs) have been increasingly recognized as a potential therapeutic target to treat pathological conditions ranging from vascular and metabolic diseases, neurological degeneration, to cancers that are driven by lipid metabolism. Amidst intensifying efforts to discover ligands that act through LXRs to achieve the sought-after pharmacological outcomes, several lead compounds are already being tested in clinical trials for a variety of disease interventions. While more potent and selective LXR ligands continue to emerge from screening of small molecule libraries, rational design, and empirical medicinal chemistry approaches, challenges remain in minimizing undesirable effects of LXR activation on lipid metabolism...
January 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28066114/antigenotoxic-and-apoptotic-activities-of-essential-oil-of-atalantia-monophylla-correa
#11
Ramaraj Thirugnanasampandan, Gunasekar Ramya, Madusudhanan Gogulramnath
OBJECTIVE: To study antigenotoxic and apoptotic activities of hydrodistilled essential oil from the leaves of Atalantia monophylla Correa. MATERIALS AND METHODS: Antigenotoxic activity of essential oil was tested against hydrogen peroxide (100 μM)-induced deoxyribonucleic acid (DNA) damage in 3T3-L1 cells. Cervical cancer cell (HeLa) growth inhibitory effect of essential oil was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay. Annexin V-fluorescein isothiocyanate/propidium iodide (FITC/PI), Hoechst 33258, and acridine orange/ethidium bromide (AO/EtBr) staining techniques were used to identify apoptosis...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28059040/natural-products-targeting-egfr-signaling-pathways-as-potential-anticancer-drugs
#12
Xiaoyu Wang, Linfeng Xu, Yuanzhi Lao, Hongmei Zhang, Hongxi Xu
The epidermal growth factor receptor (EGFR) belongs to ErbB family of tyrosine kinases, which plays an important role in the regulation of cell proliferation, survival, differentiation, and metastasis. In addition, tumors develop resistance to EGFR inhibitors due to the presence or development of point mutations in the tyrosine kinase domain of the receptor. There is an urgent need to develop new anti-EGFR agents with strong therapeutic activities. As the majority of anticancer drugs are of natural origin, natural products are a valuable source for the identification and development of novel treatment options for cancer...
January 5, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28056571/compounds-compositions-and-methods-of-agelastatin-alkaloids-patent-evaluation-of-wo2015042239-a1
#13
Takehiko Yoshimitsu, Han W Tun
Agelastatins are a family of tetracyclic alkaloids isolated from marine sponges. The patent examined in this publication covers the chemical synthesis of agelastatins A to F and eight analogues and their therapeutic use against hematologic malignancies. The claim on the chemical synthesis features a novel biomimetic cyclization of a tricyclic precursor, which streamlines scalable access to agelastatins and their analogues. This new synthetic approach can potentially expedite the research on these compounds for therapeutic use against cancers by making them more easily available...
January 5, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28050395/variation-of-cost-among-anti-cancer-drugs-available-in-indian-market
#14
Bhanu Prakash Kolasani, Divyashanthi Chellathambi Malathi, Raghunatha Rao Ponnaluri
INTRODUCTION: Although cancer remains a major health problem all over the world, its treatment is limited by affordability of patients in a developing country like India. Information generated from cost analysis studies will be helpful for both the doctors in choosing the correct medicine for their patients and also for policy makers in successfully utilizing the meager resources that are available. AIM: The aim of the present observational study was to analyse the price variations of anti-cancer drugs available in India...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28048615/tu-h-202-04-the-vampire-challenge-preliminary-results-from-a-multi-institutional-study-of-ct-ventilation-image-accuracy
#15
J Kipritidis
: CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048557/tu-h-202-00-ct-ventilation-imaging-the-new-clinical-reality-of-functional-avoidance-and-response-assessment-in-lung-cancer-radiation-therapy
#16
Paul Keall
: CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047895/tu-h-202-01-introduction-to-ct-ventilation-imaging-principles-validation-and-clinical-translation
#17
T Yamamoto
: CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047233/tu-h-202-02-applications-validation-clinical-endpoints-and-opportunities-for-ct-ventilation
#18
Y Vinogradskiy
: CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046563/tu-h-202-03-spatial-distributions-of-radiation-induced-pulmonary-changes-can-be-modeled-and-utilized-for-image-guided-planning-and-therapy-to-improve-pulmonary-function-preservation-and-hence-the-therapeutic-ratio-for-lung-cancer
#19
J Bayouth
: CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044297/microfluidic-platform-for-parallel-single-cell-analysis-for-diagnostic-applications
#20
Séverine Le Gac
Cell populations are heterogeneous: they can comprise different cell types or even cells at different stages of the cell cycle and/or of biological processes. Furthermore, molecular processes taking place in cells are stochastic in nature. Therefore, cellular analysis must be brought down to the single cell level to get useful insight into biological processes, and to access essential molecular information that would be lost when using a cell population analysis approach. Furthermore, to fully characterize a cell population, ideally, information both at the single cell level and on the whole cell population is required, which calls for analyzing each individual cell in a population in a parallel manner...
2017: Methods in Molecular Biology
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